Pregnant women with breast cancer under chemotherapy treatment with doxorubicin, cyclophosphamide and docetaxel at a reference oncology hospital: two cases report
DOI:
https://doi.org/10.33448/rsd-v10i16.24129Keywords:
Pregnancy; Breast Cancer; Antineoplastics; Drug-related side effects and adverse reactions.Abstract
The objective of this report of two cases of pregnancy-associated breast cancer (PBC) is to contribute to the theoretical empirical gap about the repercussions for the mother-child binomial, resulting from the association of cancer during pregnancy. Two breast cancer patients receiving doxorubicin, cyclophosphamide and docetaxel therapy were recruited for pharmacotherapeutic follow-up. Patient 1, 42 years old, 26 weeks pregnant, mixed race, street sweeper, mother of six, diagnosed with left breast cancer of the invasive ductal carcinoma (IDC), stage III-B, grade III, hormone receptor (RH) negative, HER-2 positive, with high blood pressure, smoker for 20 years with tobacconist, former alcoholic. Presented adverse drug reactions (ADR) during chemotherapy (CT): constipation; fatigue; hyperpigmentation; mucositis and anemia; hyperglycemia and increased alkaline phosphatase. Patient 2, 39 years old, 30 weeks pregnant, unemployed, mother of three, diagnosed with ICD-type right breast cancer, stage III-A, grade II, RH negative, HER-2 negative, triple negative, has a history of Immune thrombocytopenic purpura (ITP) and no social history of smoking or drinking. Presented ADR during QT: dry mouth; fatigue; change of taste; diarrhea; hyperpigmentation; anemia; hyperglycemia; increase in alkaline phosphatase and oxaloacetic transaminase (GOT). PBC is considered a challenging and rare event, although the incidence with delayed pregnancy beyond the age of 30 is increasing. In addition, the active participation of the multidisciplinary team focused on maternal-fetal well-being is important. In this study, the main ADR presented by the patients were mild, mainly gastrointestinal and biochemical.
References
Avery, M. & Williams, F. (2015). The importance of pharmacist providing patient education in oncology. Journal of Oncology Pharmacy Practice, 28(1): 26-30. http://journals.sagepub.com/doi/10.1177/0897190014562382
Bae, S. Y., Kim, K. S., Kim, J. S., Lee, S. B., Park, B., Lee, S. W., Lee, H. J., Kim, H. K., You, J., & Jung, S. P. (2018). Neoadjuvant Chemotherapy and Prognosis of Pregnancy-Associated Breast Cancer: A Time-Trends Study of the Korean Breast Cancer Registry Database. Journal of Breast Cancer, 21(4): 425-432.https://doi.org/10.4048/jbc.2018.21.e58
Bell, R. J., Fradkin, P., Parathithasan, N., Robinson, P. J., Schwarz, M., & Davis, S. R. (2013). Pregnancy-associated breast cancer and pregnancy following treatment for breast cancer, in a cohort of women from Victoria, Australia, with a first diagnosis of invasive breast cancer. Breast, 22(5):980-985.https://doi.org/10.1016/j.breast.2013.05.013
Bezerra, A. L. R., Bezerra, M. C. M., Santos, A. F. F. L., Lima, F. M., Almeida, I. T. B., & Ferreira, L. M. G. (2019). Evaluation of delays in diagnosis and treatment of breast cancer in a reference center: a retrospective analysis Mastology, 29(3): 144–51. http://www.mastology.org/wp-content/uploads/2019/10/MAS-v29n3_144-151.pdf
Biganzoli, L., Aapro, M., Loibl, S., Wildiers, H., & Brain, E. (2016). Taxanes in the treatment of breast cancer: Have we better defined their role in older patients? A position paper from a SIOG Task Force. Cancer Treatment Reviews, 43: 19–26. https://linkinghub.elsevier.com/retrieve/pii/S0305737215002285
Case, A. S. (2016). Pregnancy-associated Breast Cancer. Clinical Obstetrics and Gynecology, 59(4): 779–788. http://doi.org/10.1097/GRF.0000000000000235
Castro, I. J., Busom, M. P., Cabañas, G. I. B., Montero, E. R., Méndez, A. A., Chivato, R. C., & Ruiz, M. C. (2013). Estudio de las reacciones adversas relacionadas con la infusión de paclitaxel y docetaxel. Farmacia Hospitalaria, 37(2):88–94. http://doi.org/10.7399/FH.2013.37.2.374
Chiu, N., Chiu, L., Chow, R., Lam, H., Verma, S., Pasetka, M., Chow, E., & DeAngelis, C. (2017). Taxane-induced arthralgia and myalgia: A literature review. Journal of Oncology Pharmacy Practice, 23(1): 56–67. http://journals.sagepub.com/doi/10.1177/1078155215627502
Cieto, J. F., Santos, L. A. C., & Gozzo, T. O. (2021). Câncer durante a gravidez: análise dos casos com ênfase nos resultados obstétricos e neonatais. Revista de Enfermagem do Centro-Oeste Mineiro, 11: 1-10.http://doi.org/10.19175/recom.v10i0.4096
Cipriano, P., & Oliveira, C. (2016). Gestação e câncer de mama: proposta de guia de orientações. Fisioterapia Brasil, 17(2):148-57.https://doi.org/10.33233/fb.v17i2.202
Cordeiro, C. N., & Gemignani, M. L. (2017). Breast Cancer in Pregnancy: Avoiding Fetal Harm When Maternal Treatment Is Necessary. The Breast Journal, 23(2): 200–205.https://doi.org/10.1111/tbj.12780
Ferlay, J., Colombet, M., Soerjomataram, I., Mathers, C., Parkin, D. M., Piñeros, M., Znaor, A., & Bray, F. (2018). Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. International Journal of Cancer. https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.31937
Kettelhut, J. C., & Modena, M. A. B. (2008). Câncer de mama e gestação. Revista Faculdade de Ciências Médicas Sorocaba, 10(4): 1-4. https://revistas.pucsp.br/index.php/RFCMS/article/view/985/984
Merviel, P., Jouvance, O., Naepels, P., Fauvet, R., Cabry-Goubret, R., Gagneur, O., & Gondry, J. (2011). Existe-t-il encore desfacteurs de risqué de survenue d’um câncer dusein? Gynécologie Obstétrique & Fertilité, 39(9):486-490.
https://10.1016/j.gyobfe.2010.10.015
Ministério da Saúde. Instituto Nacional de Câncer José Alencar Gomes da Silva. Estimativa 2020: Incidência de Câncer no Brasil. Rio de Janeiro; 2020. https://www.inca.gov.br/sites/ufu.sti.inca.local/files/media/document/estimativa-2020-incidencia-de-cancer-no-brasil.pdf
Monteiro, D. L. M., Nunes, C. L., Rodrigues, N. C. P, Antunes, C. A., Almeida, E. M., Barmpas, D. B. S., Magalhães, A. L. C., & Trajano, A. J. B. (2019). Fatores associados ao câncer de mama gestacional: estudo caso-controle. Ciência & Saúde Coletiva, 24(6):2361-2369.https://doi.org/10.1590/1413-81232018245.18392017
Prado, N., Loiola, P., Guimarães, T., Ohara, E. C. C., & Oliveira, L. D. R. (2020). Gestante com diagnóstico de câncer de mama: prevenção, diagnóstico e assistência. Brazilian Journal of Health Review, 3(1): 1109-1131. https://doi.org/10.34119/bjhrv3n1-086
Silva, K. M., Rockenbach, B. F., Moura, J. E., & Souza, A. B. A. (2018). Câncer de mama na gestação: abordagem diagnóstica e terapêutica. Acta medica, 39(2): 61-69. https://pesquisa.bvsalud.org/portal/resource/pt/biblio-987625
Souza, C. B., Fustinoni, S. M., & Amorim, M. H. C. (2015). Estudo do tempo entre o diagnóstico e início do tratamento do câncer de mama em idosas de um hospital de referência em São Paulo, Brasil. Ciência saúde coletiva, 20(12): 3805–16. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232015001203805&lng=pt&tlng=pt
Suzuki, H., Suzuki, S., Kamata, H., Sugama, Y., Demachi, K., Kiwako, I., Igarashi, T., & Yamaguchi, M. (2019). Impact of pharmacy collaborating services in an outpatient clinic on improving adverse drug reactions in outpatient cancer chemotherapy Journal of Oncology Pharmacy Practice, 25(7): 1558–63. http://journals.sagepub.com/doi/10.1177/1078155218798138
Walker, L. G., Eremin, J. M., Aloysius, M. M., Vassanasiri, W., Walker, M. B., El-Sheemy, M., Cowley, G., Beer, J., Samphao, S., Wiseman, J., Jibril, J. A., Valerio, D., Clarke, D. J., Kamal, M., Thorpe, G. W., Baria, K., & Eremin, O. (2011). Effects on quality of life, anti-cancer responses, breast conserving surgery and survival with neoadjuvant docetaxel: a randomised study of sequential weekly versus three-weekly docetaxel following neoadjuvant doxorubicin and cyclophosphamide in women with primary breast cancer. BMC Cancer, 11: 179. http://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-179
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Copyright (c) 2021 Paula Nogueira da Silva; Patricia Marques Soares Valente; Selma Rodrigues de Castilho; Juliana de Oliveira Miguel; Maria Fernanda Barbosa; Flavia Campos Barcelos
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