Quality of life in patients with long-term Ventricular Assist Devices





Ventricular Assist Device; Quality of life; Cardiology.


For advanced heart failure refractory to clinical therapy, heart transplantation is the gold standard of treatment. However, due to the difficulty of available donors and the capture of viable organs, Ventricular Assistance Devices (VAD) emerged, offering mechanical circulatory support as an alternative method for these patients, aiming to improve quality of life and survival rate. The study aimed to identify, in the scientific literature, the perspective on the quality of life of patients who use VAD and its impacts, in studies published nationally and internationally. This is an integrative literature review of narrative analysis, carried out in national and international databases using the PICO strategy. The search was carried out with the help of a professional librarian and the selection was made in pairs by two researchers, obtaining a final sample of 21 studies. There are positive and negative factors that must be considered with the history, clinical condition, therapy, motivation, fear, coping, emotional and social support, among others. Patients using VAD show improvement in symptoms, reduce clinical decompensation resulting from heart failure and, consequently, improve quality of life.


Abshire, M., Prichard, R., Cajita, M., DiGiacomo, M., & Dennison Himmelfarb, C. (2016). Adaptation and coping in patients living with an LVAD: A metasynthesis. Heart & lung: the journal of critical care, 45(5), 397–405. https://doi.org/10.1016/j.hrtlng.2016.05.035

Alonso, W. W., Faulkner, K. M., Pozehl, B. J., Hupcey, J. E., Kitko, L. A., & Lee, C. S. (2020). A longitudinal comparison of health-related quality of life in rural and urban recipients of left ventricular assist devices. Research in nursing & health, 43(4), 396–406. https://doi.org/10.1002/nur.22052

Asleh, R., Schettle, S. S., Khan, F. W., & Kushwaha, S. S. (2019). Left ventricular assist devices as destination therapy in stage D heart failure. Journal of geriatric cardiology: JGC, 16(8), 592–600. https://doi.org/10.11909/j.issn.1671-5411.2019.08.009

Ayub-Ferreira, S. M., Souza, J. D., Neto, Almeida, D. R., Biselli, B., Avila, M. S., Colafranceschi, A. S., Stefanello, B., Carvalho, B. M., Polanczyk, C. A., Galantini, D. R., Bocchi, E. A., Chamlian, E. G., Hojaij, E. M., Gaiotto, F. A., Pinton, F. A., Jatene, F. B., Ramires, F., Atik, F. A., Figueira, F., Bacal, F., & Issa, V. S. (2016). Diretriz de Assistência Circulatória Mecânica da Sociedade Brasileira de Cardiologia. Arquivos brasileiros de cardiologia, 107(2 Suppl 2), 1–33. https://doi.org/10.5935/abc.20160128

Barbosa, R. R., Franklin, R. V., Stefenoni, A. V., Moraes, V. D., Jacques, T. M., Serpa, R. G., Calil, O. A., &Barbosa, L. F. M. (2014). Análise da qualidade de vida em homens e mulheres portadores de insuficiência cardíaca. Revista Brasileira de Cardiologia, 27(2), 97-103. https://www.onlineijcs.com/detalhes/15/quality-of-life-analysis-among-men-and-women-with-heart-failure

Bidwell, J. T., Lyons, K. S., Mudd, J. O., Gelow, J. M., Chien, C. V., Hiatt, S. O., Grady, K. L., & Lee, C. S. (2017). Quality of Life, Depression, and Anxiety in Ventricular Assist Device Therapy: Longitudinal Outcomes for Patients and Family Caregivers. The Journal of cardiovascular nursing, 32(5), 455–463. https://doi.org/10.1097/JCN.0000000000000378

Bidwell, J. T., Lyons, K. S., Mudd, J. O., Grady, K. L., Gelow, J. M., Hiatt, S. O., Chien, C. V., & Lee, C. S. (2018). Patient and Caregiver Determinants of Patient Quality of Life and Caregiver Strain in Left Ventricular Assist Device Therapy. Journal of the American Heart Association, 7(6), e008080. https://doi.org/10.1161/JAHA.117.008080

Casida, J. M., Wu, H. S., Abshire, M., Ghosh, B., & Yang, J. J. (2017). Cognition and adherence are self-management factors predicting the quality of life of adults living with a left ventricular assist device. The Journal of heart and lung transplantation, 36(3), 325–330. https://doi.org/10.1016/j.healun.2016.08.023

Cerqueira, A. C. D. R., Cardoso, M. V. L. M. L., Viana, T. R. F., &Lopes, M. M. C. O. (2018). Revisão integrativa da literatura: sono em lactentes que frequentam creche. Revista Brasileira de Enfermagem, 71(2), 424-430. https://doi.org/10.1590/0034-7167-2016-0480.

Cowger, J. A., Naka, Y., Aaronson, K. D., Horstmanshof, D., Gulati, S., Rinde-Hoffman, D., Pinney, S., Adatya, S., Farrar, D. J., Jorde, U. P., & MOMENTUM 3 Investigators (2018). Quality of life and functional capacity outcomes in the MOMENTUM 3 trial at 6 months: A call for new metrics for left ventricular assist device patients. The Journal of heart and lung transplantation, 37(1), 15–24. https://doi.org/10.1016/j.healun.2017.10.019

Emin, A., Rogers, C. A., Banner, N. R., & Steering Group, UK Cardiothoracic Transplant Audit (2016). Quality of life of advanced chronic heart failure: medical care, mechanical circulatory support and transplantation. European journal of cardio-thoracic surgery, 50(2), 269–273. https://doi.org/10.1093/ejcts/ezw054

Fernandes, A. D. F., Fernandes, G. C., Mazza, M. R., Knijnik, L. M., Fernandes, G. S., Vilela, A. T., Badiye, A., & Chaparro, S. V. (2020). Insuficiência cardíaca no Brasil subdesenvolvido: análise de tendência de dez anos. Arquivos Brasileiros de Cardiologia, 114(2), 222-231 https://doi.org/10.36660/abc.20180321

Galvão, T. F., Pansani, T. S. A., & Harrad, D. (2015). Principais itens para relatar revisões sistemáticas e meta-análises: a recomendação PRISMA. Epidemiologia e Serviços de Saúde, 24(2), 335-342 https://doi.org/10.5123/S1679-49742015000200017

Garlet, A. B., Cardoso, D. M., Santos, T. D., Pereira S. N. & Albuquerque, I. M. (2017). Relação entre classe funcional e fração de ejeção do ventrículo esquerdo em pacientes com doença coronariana candidatos à reabilitação cardíaca. Scientia Medica, 27(3) https://doi.org/10.15448/1980-6108.2017.3.26652

Grady, K. L., Naftel, D., Stevenson, L., Dew, M. A., Weidner, G., Pagani, F. D., Kirklin, J. K., Myers, S., Baldwin, T., & Young, J. (2014). Overall quality of life improves to similar levels after mechanical circulatory support regardless of severity of heart failure before implantation. The Journal of heart and lung transplantation, 33(4), 412–421. https://doi.org/10.1016/j.healun.2013.10.017

Jakovljevic, D. G., Yacoub, M. H., Schueler, S., MacGowan, G. A., Velicki, L., Seferovic, P. M., Hothi, S., Tzeng, B. H., Brodie, D. A., Birks, E., & Tan, L. B. (2017). Left Ventricular Assist Device as a Bridge to Recovery for Patients With Advanced Heart Failure. Journal of the American College of Cardiology, 69(15), 1924–1933. https://doi.org/10.1016/j.jacc.2017.02.018

Kato, N. P., Okada, I., Imamura, T., Kagami, Y., Endo, M., Nitta, D., Fujino, T., Muraoka, H., Minatsuki, S., Maki, H., Inaba, T., Kinoshita, O., Nawata, K., Hatano, M., Yao, A., Kyo, S., Ono, M., Jaarsma, T., & Kinugawa, K. (2015). Quality of Life and Influential Factors in Patients Implanted With a Left Ventricular Assist Device. Circulation journal, 79(10), 2186–2192. https://doi.org/10.1253/circj.CJ-15-0502

Kilic A. (2015). The future of left ventricular assist devices. Journal of thoracic disease, 7(12), 2188–2193. https://doi.org/10.3978/j.issn.2072-1439.2015.11.01

Ko, K., Straker, K., Dunn, J. L., & Wrigley, C. (2020). What Really Matters? Understanding Quality of Life Determinants Impacting Ventricular Assist Device Stakeholders. ASAIO journal (American Society for Artificial Internal Organs), 66(6), 626–636. https://doi.org/10.1097/MAT.0000000000001175

Maciver, J., & Ross, H. J. (2012). Quality of life and left ventricular assist device support. Circulation, 126(7), 866–874. https://doi.org/10.1161/CIRCULATIONAHA.111.040279

Modica, M., Ferratini, M., Torri, A., Oliva, F., Martinelli, L., De Maria, R., & Frigerio, M. (2015). Quality of life and emotional distress early after left ventricular assist device implant: a mixed-method study. Artificial organs, 39(3), 220–227. https://doi.org/10.1111/aor.12362

Rohde, L., Montera, M. W., Bocchi, E. A., Clausell, N. O., Albuquerque, D. C., Rassi, S., Colafranceschi, A. S., Freitas, A. F., Junior, Ferraz, A. S., Biolo, A., Barretto, A., Ribeiro, A., Polanczyk, C. A., Gualandro, D. M., Almeida, D. R., Silva, E., Figueiredo, E. L., Mesquita, E. T., Marcondes-Braga, F. G., & Martins, W. A. (2018). Diretriz Brasileira de Insuficiência Cardíaca Crônica e Aguda. Arquivos brasileiros de cardiologia, 111(3), 436–539. https://doi.org/10.5935/abc.20180190

Sampaio, S. M. L., Sousa, A. A. S., Queiroz, I. B. S., Luna, C. A., Gurgel, L. C., Luna, T. B., Sousa, C. M. S., Sousa, F. R. S., Luz, D. C. R. P., & Santana, W. J. (2020). Atuação de enfermagem frente ao atendimento ao paciente hipertenso. Revista Eletrônica Acervo Saúde, 50. https://doi.org/10.25248/reas.e3526.2020

Santos, M. C., Pimenta, C. A. M., & Nobre, M. R. C. (2007). A estratégia PICO para a construção da pergunta de pesquisa e busca de evidências. Revista Latino-Americana de Enfermagem, 15(3) https://doi.org/10.1590/S0104-11692007000300023

Shah, S. R., Issa Najim, N., Shah, S. A., Shahnawaz, W., & Ahmed Jangda, M. (2018). Using left ventricular assist devices in advanced heart failure patients. Journal of community hospital internal medicine perspectives, 8(6), 357–359. https://doi.org/10.1080/20009666.2018.1536240

Slaughter, M. S., & Singh, R. (2012). The role of ventricular assist devices in advanced heart failure. Revista espanola de cardiologia (English ed.), 65(11), 982–985. https://doi.org/10.1016/j.recesp.2012.02.030

Sousa, M. M., Oliveira, J. S., Soares, M. J. G. O., Bezerra, S. M. M. S., Araújo, A. A., & Oliveira, S. H. S. (2017). Associação das condições sociais e clínicas à qualidade de vida de pacientes com insuficiência cardíaca. Revista Gaúcha de Enfermagem, 38(2):e65885. https://doi.org/10.1590/1983-1447.2017.02.65885

Souza, M. T., Silva, M. D., & Carvalho, R. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8(1): 102-106. https://doi.org/10.1590/S1679-45082010RW1134



How to Cite

SILVA, A. V. C. da .; SARAIVA, E. L. .; BALESTRA, N. Quality of life in patients with long-term Ventricular Assist Devices. Research, Society and Development, [S. l.], v. 10, n. 17, p. e168101724466, 2021. DOI: 10.33448/rsd-v10i17.24466. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/24466. Acesso em: 25 jan. 2022.



Health Sciences