Guarana (Paullinia cupana Kunth), marapuama (Ptychopetalum olacoides Benth.), gentian (Gentiana lutea L.), quassia (Quassia amara L.) and their properties: a brief review
DOI:
https://doi.org/10.33448/rsd-v11i2.24592Keywords:
Guarana; Marapuama; Gentian; Quassia; Phytotherapy.Abstract
The discovery and management of natural resources are essential in the social development process. For thousand years, humanity has been using plants for the most diverse purposes, such as the relief and cure of illnesses. The Brazilian floristic diversity also enabled native communities to acquire and to develop knowledge associated with the usage of numerous plants. This brief literature review aims to survey the properties of four plant species – guarana (Paullinia cupana Kunth), marapuama (Ptychopetalum olacoides Benth.), gentian (Gentiana lutea L.), quassia (Quassia amara L.) – widely used by natives of the Amazon region, especially due to their therapeutic properties. Finally, it is possible to highlight the existence of great potential for furthering research on the revised plant species, especially regard to herbal medicine usage – once these have shown, according to consulted sources, to assist in the most diverse health conditions.
References
Aberham, A., Pieri, V., Croom, E. M., Ellmerer, E., & Stuppner, H. (2011). Analysis of iridoids, secoiridoids and xanthones in Centaurium erythraea, Frasera caroliniensis and Gentiana lutea using LC–MS and RP-HPLC. Journal of Pharmaceutical and Biomedical Analysis, 54(3), 517–525. 10.1016/j.jpba.2010.09.030
Aberham, A., Schwaiger, S., Stuppner, H., & Ganzera, M. (2007). Quantitative analysis of iridoids, secoiridoids, xanthones and xanthone glycosides in Gentiana lutea L. roots by RP-HPLC and LC–MS. Journal of Pharmaceutical and Biomedical Analysis, 45(3), 437–442. 10.1016/j.jpba.2007.07.001
Aftab, T., & Hakeem, K. R. (Orgs.). (2021). Bioactive secondary metabolites of medicinal and aromatic plants and their disease-fighting properties. In Medicinal and Aromatic Plants: Healthcare and Industrial Applications. New York, United States: Springer International Publishing. 10.1007/978-3-030-58975-2
Agência Nacional de Vigilância Sanitária. (2019). Farmacopéia brasileira (6a ed.), 1–1. Agência Nacional de Vigilância Sanitária. https://www.gov.br/anvisa/pt-br/assuntos/farmacopeia/farmacopeia-brasileira/arquivos/7985json-file-1
Ajaiyeoba, E., Abalogu, U., Krebs, H., & Oduola, A. (1999). In vivo antimalarial activities of Quassia amara and Quassia undulata plant extracts in mice. Journal of Ethnopharmacology, 67(3), 321–325. 10.1016/S0378-8741(99)00073-2
Albuquerque, J. de. (1989). Plantas medicinais de uso popular. ABEAS/MEC.
Alonso, J. (2007). Tratado de fitofármacos y nutracéuticos. Corpus.
Andersen, T., & Fogh, J. (2001). Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients. Journal of Human Nutrition and Dietetics, 14(3), 243–250. 10.1046/j.1365-277X.2001.00290.x
Ando, H., Hirai, Y., Fujii, M., Hori, Y., Fukumura, M., Niiho, Y., Nakajima, Y., Shibata, T., Toriizuka, K., & Ida, Y. (2007). The chemical constituents of fresh Gentian Root. Journal of Natural Medicines, 61(3), 269–279. 10.1007/s11418-007-0143-x
Araújo, J. A., Araújo, J. A., Araújo, T. P., Anjos, D. F., & Vieira, J. S. C. (2010). Avaliação físico-química do guaraná (Paullinia cupana) em pó utilizado na produção de bebidas estimulantes comercializadas em Zé Doca – MA. Anais do Congresso Norte Nordeste de Pesquisa e Inovação. Congresso Norte Nordeste de Pesquisa e Inovação, Maceió, AL.
Atkinson, J. E., Gupta, P., & Lewis, J. R. (1969). Some phenolic constituents of Gentiana lutea. Tetrahedron, 25(7), 1507–1511. 10.1016/S0040-4020(01)82723-X
Atroch, A. L. (2009). Avaliação de progênies de meios irmãos de guaranazeiro (Paullinia cupana var. Sobilis (Mart.) Ducke) utilizando caracteres morfo- agronômicos [Tese de Doutorado]. Universidade Federal do Amazonas.
Audi, E., & Mello, J. (2000). Efeito antidepressivo do extrato da droga vegetal guaraná (Paullinia cupana var. Sorbilis (Martius) Ducke). Fundação Universidade Estadual de Maringá, BR Patent# PI00066389, Cl. Int. A61P, 25(24), A61K.
Barbetti, P., Grandolini, G., Fardella, G., & Chiappini, I. (1987). Indole alkaloids from Quassia amara. Planta medica, 53(03), 289–290. 10.1055/s-2006-962709
Barbetti, P., Grandolini, G., Fardella, G., & Chiappini, I. (1993). Quassinoids from Quassia amara. Phytochemistry, 32(4), 1007–1013. 10.1016/0031-9422(93)85245-M
Barbetti, P., Grandolini, G., Fardella, G., Chiappini, I., & Mastalia, A. (1990). New canthin-6-one alkaloids from Quassia amara. Planta medica, 56(02), 216–217. 10.1055/s-2006-960928
Barroso, G. M. (1991). Sistemática de angiospennas do Brasil. (Vol. 2). FV/Imprensa Universitária.
Basile, A., Ferrara, L., Pezzo, M. D., Mele, G., Sorbo, S., Bassi, P., & Montesano, D. (2005). Antibacterial and antioxidant activities of ethanol extract from Paullinia cupana Mart. Journal of Ethnopharmacology, 102(1), 32–36. 10.1016/j.jep.2005.05.038
Basso, L. A., Silva, L. H. P. da, Fett-Neto, A. G., Azevedo Junior, W. F. de, Moreira, Í. de S., Palma, M. S., Calixto, J. B., Astolfi Filho, S., Santos, R. R. dos, Soares, M. B. P., & Santos, D. S. (2005). The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: A review. Memórias do Instituto Oswaldo Cruz, 100(6), 475–506. 10.1590/S0074-02762005000600001
Berg, M. E. (1982). Plantas medicinais na Amazônia: Contribuição ao seu conhecimento sistemático. CNPq/Programa Trópico Úmido.
Bhattacharjee, I., Chatterjee, S. K., Chatterjee, S., & Chandra, G. (2006). Antibacterial potentiality of Argemone mexicana solvent extracts against some pathogenic bacteria. Memórias do Instituto Oswaldo Cruz, 101(6), 645–648. 10.1590/S0074-02762006000600011
Bittencourt, L. da S., Zeidán-Chuliá, F., Yatsu, F. K. J., Schnorr, C. E., Moresco, K. S., Kolling, E. A., Gelain, D. P., Bassani, V. L., & Moreira, J. C. F. (2014). Guarana (Paullinia cupana Mart.) prevents β-amyloid aggregation, generation of advanced glycation-end products (AGEs), and acrolein-induced cytotoxicity on human neuronal-like cells. Phytotherapy Research, 28(11), 1615–1624. 10.1002/ptr.5173
Bydlowski, S., Yunker, R., & Subbiah, M. (1988). A novel property of an aqueous guaraná extract (Paullinia cupana): Inhibition of platelet aggregation in vitro and in vivo. Brazilian Journal of Medical and Biological Research, 21(3), 535–538.
Campos, A. R., Barros, A. I. S., Santos, F. A., & Rao, V. S. N. (2003). Guarana (Paullinia cupana Mart.) offers protection against gastric lesions induced by ethanol and indomethacin in rats. Phytotherapy Research, 17(10), 1199–1202. 10.1002/ptr.1212
Charam, I. (1987). Há açöes afrodisiácas nas plantas medicinais do Brasil? Folha méd, 303–309. https://pesquisa.bvsalud.org/portal/resource/pt/lil-42338
Citová, I., Ganzera, M., Stuppner, H., & Solich, P. (2008). Determination of gentisin, isogentisin, and amarogentin in Gentiana lutea L. by capillary electrophoresis. Journal of Separation Science, 31(1), 195–200. 10.1002/jssc.200700325
Corrêa, A. D., Batista, R. S., & Quintas, L. E. M. (1998). Plantas medicinais: Do cultivo à terapêutica. Vozes. https://books.google.com.br/books?id=wQmYMwEACAAJ
Corrêa, M. P. (1984). Dicionário das plantas úteis do Brasil e das exóticas cultivadas. (Vol. 2). Rio de Janeiro, Brasil: Imprensa Nacional.
Costa Krewer, C., Ribeiro, E. E., Ribeiro, E. A. M., Moresco, R. N., Ugalde Marques da Rocha, M. I., Santos Montagner, G. F. F., Machado, M. M., Viegas, K., Brito, E., & Cruz, I. B. M. (2011). Habitual intake of guaraná and metabolic morbidities: An epidemiological study of an elderly amazonian population. Phytotherapy Research, 1367–1374. 10.1002/ptr.3437
Costa, P. R. C., Santos, S. M. B. P., Silva, L. E. W., & Menezes, C. S. (1991). Plantas medicinais climatizadas da região amazônica. Governo do Estado do Amazonas.
da Silva, A. L., Bardini, S., Nunes, D. S., & Elisabetsky, E. (2002). Anxiogenic properties of Ptychopetalum olacoides Benth. (Marapuama). Phytotherapy Research, 16(3), 223–226. 10.1002/ptr.825
da Silva, A. L., Piato, Â. L. S., Bardini, S., Netto, C. A., Nunes, D. S., & Elisabetsky, E. (2004). Memory retrieval improvement by Ptychopetalum olacoides in young and aging mice. Journal of Ethnopharmacology, 95(2–3), 199–203. 10.1016/j.jep.2004.07.019
da Silva, W. G., Rovellini, P., Fusari, P., & Venturini, S. (2015). Guaraná-Paullinia cupana, (HBK): Estudo da oxidação das formas em pó e em bastões defumados. Revista de Ciências Agroveterinárias, 14(2), 117–123. Obtido de: https://www.revistas.udesc.br/index.php/agroveterinaria/article/view/5637
Dalonso, N., & de Oliveira Petkowicz, C. L. (2012). Guarana powder polysaccharides: Characterisation and evaluation of the antioxidant activity of a pectic fraction. Food Chemistry, 134(4), 1804–1812. 10.1016/j.foodchem.2012.03.088
Derkach, T., & Tarasenko, H. (2021). Chemistry of medicinal plants as an integral part of ecological education. E3S Web of Conferences, 280, 11015. 10.1051/e3sconf/202128011015
Duarte, M. C. T. (2006). Atividade antimicrobiana de plantas medicinais e aromáticas utilizadas no Brasil. Revista MultiCiência, 7(1), 1–16. www.ccs.ufpb.br/nephf/contents/documentos/artigos/fitoterapia/atividade-antimicrobiana-de-plantas/@@download/file/Atividade%20Antimicrobiana%20de%20Plantas.pdf
Duke, J. A., & Vásquez, V. M. (1994). Amazonian ethnobotanical dictionary: English version. Boca Raton, USA: CRC Press. https://books.google.com.br/books?id=jswluAAACAAJ
EMA (European Medicines Agency). (2010a). Assessment report on Gentiana lutea l., radix (EMA/HMPC/578322/2008). European Medicines Agency.
EMA (European Medicines Agency). (2010b). Community herbal monograph on Gentiana lutea l., radix (EMA/HMPC/578324/2008). European Medicines Agency.
EMBRAPA. (2005). Cultura do guaranazeiro no Amazonas (4o ed). Manaus, Brasil: EMBRAPA da Amazônia Oriental. https://www.infoteca.cnptia.embrapa.br/bitstream/doc/678408/1/SistemaProdGuarana.pdf
Espinola, E. B., Dias, R. F., Mattei, R., & Carlini, E. A. (1997). Pharmacological activity of Guarana (Paullinia cupana Mart.) in laboratory animals. Journal of Ethnopharmacology, 55(3), 223–229. 10.1016/S0378-8741(96)01506-1
Finley Ellingwood, M. (1919). American materia medica, therapeutics and pharmacognosy. Chicago, USA: Ellingwood’s Therapeutist. O. http://swsbm.henriettesherbal.com/Ellingwoods/Ellingwoods_plants_only.pdf
Fintelmann, V., Weiss, R. F., & Fintelmann, V. (2010). Manual de fitoterapia (11o ed). São Paulo, Brasil: Guanabara Koogan.
Firmo, W. da C. A., de Menezes, V. de J. M., de Castro Passos, C. E., Dias, C. N., Alves, L. P. L., Dias, I. C. L., Neto, M. S., & Olea, R. S. G. (2011). Contexto histórico, uso popular e concepção científica sobre plantas medicinais. Cadernos de pesquisa, 18(Especial), 90–95. http://www.periodicoseletronicos.ufma.br/index.php/cadernosdepesquisa/article/view/746
Forgacs, P. (1983). Etudes phytochimiques et activités biologiques de 18 plantes de la Guyane Françäíse. Plantes Médicinales et Phytothérapie, 17(1), 22–32. https://core.ac.uk/download/pdf/39873902.pdf
Fukumasu, H., Avanzo, J. L., Nagamine, M. K., Barbuto, J. A., Rao, K. V., & Dagli, M. L. Z. (2008). Paullinia cupana Mart var. Sorbilis, guaraná, reduces cell proliferation and increases apoptosis of B16/F10 melanoma lung metastases in mice. Brazilian Journal of Medical and Biological Research, 41(4), 305–310. 10.1590/S0100-879X2008000400008
Gaebler, H. (1970). Revival of the drug Muira puama. Deut. Apoth, 22(3), 94–96.
Griebel, C. (1912). Detection of muira-puama extract. Z. Nahr. Genussm, 24, 687.
Harland, B. F. (2000). Caffeine and nutrition. Nutrition (Burbank, Los Angeles County, Calif.), 16(7–8), 522–526. 10.1016/s0899-9007(00)00369-5
Harrold, J. A., Hughes, G. M., O’Shiel, K., Quinn, E., Boyland, E. J., Williams, N. J., & Halford, J. C. G. (2013). Acute effects of a herb extract formulation and inulin fibre on appetite, energy intake and food choice. Appetite, 62, 84–90. 10.1016/j.appet.2012.11.018
Haskell, C. F., Kennedy, D. O., Wesnes, K. A., Milne, A., & Scholey, A. (2007). A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guaraná in humans. Journal of psychopharmacology, 21(1), 65–70. 10.1177%2F0269881106063815
Hayashi, T., & Yamagishi, T. (1988). Two xanthone glycosides from Gentiana lutea. Phytochemistry, 27(11), 3696–3699. 10.1016/0031-9422(88)80805-7
Heckman, M. A., Weil, J., & de Mejia, E. G. (2010). Caffeine (1, 3, 7-trimethylxanthine) in foods: A comprehensive review on consumption, functionality, safety, and regulatory matters. Journal of Food Science, 75(3), R77–R87. 10.1111/j.1750-3841.2010.01561.x
Henman, A. R. (1982). Guaraná (Paullinia cupana var. sorbilis): Ecological and social perspectives on an economic plant of the central amazon basin. Journal of Ethnopharmacology, 6(3), 311–338. 10.1016/0378-8741(82)90054-X
Hertz, E., Cadoná, F. C., Machado, A. K., Azzolin, V., Holmrich, S., Assmann, C., Ledur, P., Ribeiro, E. E., De Souza Filho, O. C., Mânica-Cattani, M. F., & Da Cruz, I. B. M. (2015). Effect of Paullinia cupana on MCF-7 breast cancer cell response to chemotherapeutic drugs. Molecular and Clinical Oncology, 3(1), 37–43. 10.3892/mco.2014.438
Hostettmann, K., Bellmann, G., Tabacchi, R., & Jacot-Guillarmond, A. (1973). Phytochemistry of the Gentiana genus III. Flavonic and xanthonic compounds in the leaves of Gentiana lutea. Helv Chim Acta, 56(8), 3050–3054.
Huang, S.-H., Agrawal, D. C., Wu, F.-S., & Tsay, H.-S. (2014). In vitro propagation of Gentiana scabra Bunge – an important medicinal plant in the chinese system of medicines. Botanical Studies, 55(1), 56. 10.1186/s40529-014-0056-4
IBGE (Instituto Brasileiro de Geografia e Estatística). (2016). Levantamento sistemático da produção agrícola (in Portuguese). In: CONAGRO (Ed) (p. 1–113). https://www.ibge.gov.br/estatisticas/economicas/agricultura-e-pecuaria/9201-levantamento-sistematico-da-producao-agricola.html?=&t=o-que-e
Júnior, S. (1981). Plantas eróticas. Rio de Janeiro, Brasil: Codecri. https://books.google.com.br/books?id=n_1GAAAAYAAJ
Kaur, N., & Ahmed, T. (2021). Bioactive secondary metabolites of medicinal and aromatic plants and their disease-fighting properties. In Medicinal and Aromatic Plants: Healthcare and Industrial Applications (p. 783). Basingstoke, United Kingdom: Springer Nature. https://books.google.com.br/books?hl=pt-BR&lr=&id=LRomEAAAQBAJ&oi=fnd&pg=PA113&dq=Bioactive+Secondary+Metabolites+of+Medicinal+and+Aromatic+Plants+and+Their+Disease-Fighting+Properties&ots=q-RcUyefo8&sig=e09mRQidEiBAz0-3ZRReR_MxuHA#v=onepage&q=Bioactive%20Secondary%20Metabolites%20of%20Medicinal%20and%20Aromatic%20Plants%20and%20Their%20Disease-Fighting%20Properties&f=false
Khan, H. (2014). Medicinal plants in light of history: Recognized therapeutic modality. Journal of Evidence-Based Complementary & Alternative Medicine, 19(3), 216–219. 10.1177/2156587214533346
Khare, C. P. (2011). Indian herbal remedies: Rational Western therapy, ayurvedic, and other traditional usage, Botany. Berlin, Germany: Springer science & business media.
Kuskoski, E. M., Fett, R., García Asuero, A., & Troncoso González, A. M. (2005). Propiedades químicas y farmacológicas del fruto guaraná (Paulllinia cupana). Vitae, 12(2), 45–52. http://www.scielo.org.co/pdf/vitae/v12n2/v12n2a06.pdf?
Lameira, O. A., & Pinto, J. E. B. P. (1995). Indução de calós em quina (Quassia amara L.) e erva baleeira. Anais do 5o Congresso Brasileiro de Biologia Vegetal. Congresso Brasileiro de Biologia Vegetal, Lavras, MG.
Le Cointe, P. (1947). Amazônia Brasileira: Árvores e plantas úteis (indígenas e aclimatadas). (2a ed). Editora Nacional.
Leung, A. Y. (1980). Encyclopedia of common natural ingredients used in food, drugs, and cosmetics.
Lima, N. da S., Caria, C. R. e P., Gambero, A., & Ribeiro, M. L. (2019). The effect of guarana (Paullinia cupana) on metabolic and inflammatory parameters in adult male mice programmed by maternal obesity. European Journal of Nutrition, 58(2), 765–774. 10.1007/s00394-018-1686-1
Lima, N. H. Q., Oliveira, L. V., Coelho, A. L., & Dantas, C. (2018). Estudo teórico da atividade antioxidante de compostos fenólicos do buriti (Mauritia flexuosa L. f.) oor diferentes mecanismos vista por DFT. 58o Congresso Brasileiro de Química. Obtido em: http://www.abq.org.br/cbq/2018/trabalhos/3/1738-26800.html
Lima, N., Numata, E., Mesquita, L., Dias, P., Vilegas, W., Gambero, A., & Ribeiro, M. (2017). Modulatory effects of guarana (Paullinia cupana) on adipogenesis. Nutrients, 9(6), 635. 10.3390/nu9060635
Lima, P. G. C., Coelho–Ferreira, M., & da Silva Santos, R. (2016). Perspectives on medicinal plants in public markets across the Amazon: A review. Economic Botany, 70(1), 64–78. 10.1007/s12231-016-9338-y
Lima, W., Carnevalijr, L., Eder, R., Costarosa, L., Bacchi, E., & Seelaender, M. (2005). Lipid metabolism in trained rats: Effect of guarana (Mart.) supplementation. Clinical Nutrition, 24(6), 1019–1028. 10.1016/j.clnu.2005.08.004
Lloyd Brothers. (1907). Dose book of Specific Medicines. Lloyd Brothers.
Macedo, E. G., Potiguara, R. de V., & Rocha Neto, O. da. (2005). Anatomia foliar de Quassia amara L. (Simaroubaceae), uma espécies medicinal e inseticida. Embrapa Amazônia Oriental-Artigo em periódico indexado (ALICE). Obtido em: http://www.alice.cnptia.embrapa.br/alice/handle/doc/577889
Machado, K. N., Freitas, A. A. de, Cunha, L. H., Faraco, A. A. G., Pádua, R. M. de, Braga, F. C., Vianna-Soares, C. D., & Castilho, R. O. (2018). A rapid simultaneous determination of methylxanthines and proanthocyanidins in Brazilian guaraná (Paullinia cupana Kunth.). Food Chemistry, 239, 180–188. 10.1016/j.foodchem.2017.06.089
Majhenič, L., Škerget, M., & Knez, Ž. (2007). Antioxidant and antimicrobial activity of guarana seed extracts. Food Chemistry, 104(3), 1258–1268. 10.1016/j.foodchem.2007.01.074
Marques, L. L. M., Panizzon, G. P., Aguiar, B. A. A., Simionato, A. S., Cardozo-Filho, L., Andrade, G., de Oliveira, A. G., Guedes, T. A., & Mello, J. C. P. de. (2016). Guaraná (Paullinia cupana) seeds: Selective supercritical extraction of phenolic compounds. Food Chemistry, 212, 703–711. 10.1016/j.foodchem.2016.06.028
Martins, C. A. (2010). Avaliação da atividade antioxidante in vitro e in vivo do guaraná (Paullinia cupana) em pó [Dissertação de Mestrado]. Universidade de São Paulo.
Mehr, C. B., Biswal, R. N., Collins, J. L., & Cochran, H. D. (1996). Supercritical carbon dioxide extraction of caffeine from Guarana. The Journal of Supercritical Fluids, 9(3), 185–191. 10.1016/S0896-8446(96)90031-5
Menković, N., Živković, J., Šavikin, K., Janković, T., Zdunić, G., & Pljevljakušić, D. (2016). Optimization of ultrasound-assisted extraction of isogentisin from Gentiana lutea L. roots by response surface methodology. Planta Medica, 81(S 01), S1–S381. 10.1055/s-0036-1597014
Mirzaee, F., Hosseini, A., Jouybari, H. B., Davoodi, A., & Azadbakht, M. (2017). Medicinal, biological and phytochemical properties of Gentiana species. Journal of Traditional and Complementary Medicine, 7(4), 400–408. 10.1016/j.jtcme.2016.12.013
Montrucchio, D. P. (2001). Estudo Fitoquímico e de Atividade Antimicrobiana de Ptychopetalum olacoides Bentham [Dissertação de Mestrado]. Universidade Federal do Paraná.
Montrucchio, D. P., Miguel, O. G., & Miguel, M. D. (2002). Ptychopetalum olacoides Bentham: Principais características botânicas, fitoquímicas e farmacológicas. Rev. ciênc. farm, 11–24.
Njar, V. C., Alao, T. O., Okogun, J. I., & Holland, H. L. (1993). 2-Methoxycanthin-6-one: A new alkaloid from the stem wood of Quassia amara. Planta medica, 59(03), 259–261. 10.1055/s-2006-959664
Ogawa, N., & Ueki, H. (2007). Clinical importance of caffeine dependence and abuse. Psychiatry and Clinical Neurosciences, 61(3), 263–268. 10.1111/j.1440-1819.2007.01652.x
Olivier, D. K., & van Wyk, B.-E. (2013). Bitterness values for traditional tonic plants of southern Africa. Journal of Ethnopharmacology, 147(3), 676–679. 10.1016/j.jep.2013.03.059
Otobone, F. J., Sanches, A. C., Nagae, R. L., Martins, J. V. C., Obici, S., Mello, J. C. P. de, & Audi, E. A. (2005). Effect of crude extract and its semi purified constituents from guaraná seeds [Paullinia cupana var. Sorbilis (Mart.) lucke] on cognitive performance in Morris water maze in rats. Brazilian Archives of Biology and Technology, 48, 723–728. 10.1590/S1516-89132005000600007
Paiva, L., Rao, V., & Silveira, E. (1998). Effects of Ptychopetalum olacoides extract on mouse behaviour in forced swimming and open field tests. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 12(4), 294–296. 10.1002/(SICI)1099-1573(199806)12:4%3C294::AID-PTR230%3E3.0.CO;2-3
Pan, Y., Zhao, Y.-L., Zhang, J., Li, W.-Y., & Wang, Y.-Z. (2016). Phytochemistry and pharmacological activities of the genus Gentiana (Gentianaceae). Chemistry & biodiversity, 13(2), 107–150. 10.1002/cbdv.201500333
Pankow, E., & Auterhoff, H. (1969). Inhaltsstoffe von Muira puama. 2. Mitteilung. Archiv der Pharmazie, 302(3), 209–212. 10.1002/ardp.19693020309
Portella, R. de L., Barcelos, R. P., da Rosa, E. J. F., Ribeiro, E. E., da Cruz, I. B. M., Suleiman, L., & Soares, F. A. A. (2013). Guaraná (Paullinia cupana Kunth) effects on LDL oxidation in elderly people: An in vitro and in vivo study. Lipids in Health and Disease, 12(1), 12. 10.1186/1476-511X-12-12
Prakash, O., Singh, R., Kumar, S., Srivastava, S., & Ved, A. (2017). Gentiana lutea Linn.(Yellow Gentian): A comprehensive. Journal of Ayurvedic and Herbal Medicine, 3(3), 175–181. Obtido em ahttps://www.innerpath.com.au/matmed/research/Gentiana%5Elutea.pdf http://www.innerpath.com.au/matmed/r esearch/Gentiana%5Elutea.pdf
Proença da Cunha, A., Pereira da Silva, A., & Roque, O. R. (2009). Plantas e produtos vegetais em fitoterapia (3a ed). Fundação Calouste Gulbenkian.
Rangel, M. P., Mello, J. C. P. de, & Audi, E. A. (2013). Evaluation of neurotransmitters involved in the anxiolytic and panicolytic effect of the aqueous fraction of Paullinia cupana (guaraná) in elevated T maze. Revista Brasileira de Farmacognosia, 23, 358–365. 10.1590/S0102-695X2013005000024
Remya, E., & Goyal, M. (2017). Therapeutic evaluation of Quassia amara Linn.-A critical review. Global Journal of Research on Medicinal Plants & Indigenous Medicine, 6(9), 100–113. Obtido em: https://www.proquest.com/openview/15f1b12d7df1867e3b4d14bf62bfee20/1?pq-origsite=gscholar&cbl=2026661
Ribeiro, J. E. L. da S. (Org.). (1999). Flora da Reserva Ducke: Guia de identificação das plantas vasculares de uma floresta de terra-firme na Amazônia Central. Manaus, Brasil: INPA DFID.
Rocha Neto, O. G., Lameira, O. A., Vieigas, I. J. M., & Carvalho, C. R. J. (1997). Estudos agronômicos e fisiológicos visando a propagação e domesticação da quina (Quassia amara L.) (Programa de Matérias-Prirnas/Subprojeto 07.0.95.005.03.). EMBRAPA- CPATUl.
Roncon, C., Biesdorf de Almeida, C., Klein, T., Palazzo de Mello, J., & Audi, E. (2011). Anxiolytic effects of a semipurified constituent of guaraná seeds on rats in the elevated T-Maze test. Planta Medica, 77(03), 236–241. 10.1055/s-0030-1250315
Roncon, C. M. (2009). Effect of semi-purified constituent from guaraná seeds [Paullinia cupana var. Sorbilis (Mart.) Ducke] on performance of rats in elevated T maze [Dissertação de Mestrado]. Universidade Estadual de Maringá.
Rossetti, V., Lombard, A., Sancin, P., Buffa, M., & Menghini, A. (1984). Composition of Gentiana lutea L. dried roots harvested at different altitudes. Plant Med Phytother, 18, 15–23.
Schenkel, E. P., Gosmann, G., & Petrovick, P. R. (2004). Produtos de origem vegetal e o desenvolvimento de medicamentos. In C. M. O. Simões, E. P. Schenkel, G. Gosmann, J. C. P. Mello, L. A. Mentz, & P. R. Petrovick, Farmacognosia da Planta ao Medicamento (5a ed,), 1102. Editora da UFSC.
Shah, C. (2009). Textbook of pharmacognosy and phytochemistry (p. 273–274). Elsevier.
Sharma, V., Kaushik, R., Majee, C., & Jain, J. (2021). Natural products against coronaviruses. International Journal of Pharmaceutical Sciences and Research, 4143–4150. 10.13040/IJPSR.0975-8232.12(8).4143-50
Silva, R. da. (1925). Plantas medicinais brasileiras: Estudo botânico e pharmacognóstico–Muirapuama. Rev Bras Med Pharm, 1(1), 37–41.
Silva, N. C. S., Vítor, A. M., da Silva Bessa, H. H., & Barros, R. M. S. (2017). A utilização de plantas medicinais e fitoterápicos em prol da saúde. Única cadernos acadêmicos, 3(1).
Siqueira, I. R., Fochesatto, C., Torres, I. L. S., da Silva, A. L., Nunes, D. S., Elisabetsky, E., & Netto, C. A. (2007). Antioxidant activities of Ptychopetalum olacoides (“muirapuama”) in mice brain. Phytomedicine, 14(11), 763–769. 10.1016/j.phymed.2006.12.007
Siqueira, I. R., Lara, D. R., Silva, D., Gaieski, F. S., Nunes, D. S., & Elisabetsky, E. (1998). Psychopharmacological properties of Ptychopetalum olacoides Bentham (Olacaceae). Pharmaceutical Biology, 36(5), 327–334. 10.1076/phbi.36.5.327.4657
Steinmetz, E. (1971). Muira Puama (‘Potenzholz’). Quarterly Journal of Crude Drug Research, 11(3), 1787–1789. 10.3109/13880207109082398
SUFRAMA. (2013). Potencialidades estudo de viabilidade econômica: Guaraná. In Superintendência da zona franca de Manaus. Instituto superior de administração e economia ISAE/Fundação Getúlio Vargas (FGV). Obtido em: http://www.suframa.gov.br/publicacoes/proj_pot_regionais/sumario/guarana.pdf
Tang, W., Kubo, M., Harada, K., Hioki, H., & Fukuyama, Y. (2009). Novel NGF-potentiating diterpenoids from a brazilian medicinal plant, Ptychopetalum olacoides. Bioorganic & Medicinal Chemistry Letters, 19(3), 882–886. 10.1016/j.bmcl.2008.11.100
Tfouni, S. A. V., Camargo, M. C. R., Vitorino, S. H. P., Menegário, T. F., & Toledo, M. C. de F. (2007). Contribuição do guaraná em pó (Paullinia cupana) como fonte de cafeína na dieta. Revista de Nutrição, 20(1), 63–68. 10.1590/S1415-52732007000100007
Toma, W., Gracioso, J. de S., Hiruma-Lima, C., Andrade, F. de, Vilegas, W., & Brito, A. S. (2003). Evaluation of the analgesic and antiedematogenic activities of Quassia amara bark extract. Journal of Ethnopharmacology, 85(1), 19–23. 10.1016/S0378-8741(02)00334-3
Toyota, A. (1979). Studies of brazilian crude drugs .1. Muira-puama. Shoyakugaku Zasshi, 33(2), 57–64.
Tricaud, S., Pinton, F., & Pereira, H. dos S. (2016). Saberes e práticas locais dos produtores de guaraná (Paullinia cupana Kunth var. sorbilis) do médio Amazonas: Duas organizações locais frente à inovação. Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas, 11(1), 33–53. 10.1590/1981.81222016000100004
Velasco, M., Maciel, C., Sarruf, F., Consiglieri, V., Kaneko, T., & Baby, A. (2008). Desenvolvimento e teste preliminar da estabilidade de formulações cosméticas acrescidas de extrato comercial de Trichilia catigua Adr. Juss (e) Ptychopetalum olacoides Bentham. Revista de Ciências Farmacêuticas Básica e Aplicada, 29(2). Obtido em: http://rcfba.fcfar.unesp.br/index.php/ojs/article/view/485/483
Velayutham, P., Babu, A., & Liu, D. (2008). Green tea catechins and cardiovascular health: An update. Current medicinal chemistry, 15(18), 1840. Obtido em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748751/
Verotta, L. (1985). Isolation and HPLC determination of the active principles of Rosmarinus officinalis and Gentiana lutea. Fitoterapia, 56, 25–29.
Vicentini, A., & Rossi, L. (1999). Olacaceae. In J. E. L. S. Ribeiro, M. J. G. Hopkins, A. Vicentini, C. A. Sothers, M. A. S. Costa, J. M. Brito, M. A. D. Souza, L. H. P. Martins, L. G. Lohmann, P. A. C. L. Assunção, E. C. Pereira, C. F. Silva, M. R. Mesquita, & L. Procópio, Flora da Reserva Ducke (p. 799). Manaus, Brasil: INPA ; DFID.
Webb, G. P. (2008). Dietary Supplements and Functional Foods. Bridgewater, Willey.
Weigel, G. (1907). The wood and root of muira-puama. Pharm Cent, 190(49), 139–141.
Wu, S., Ning, Y., Zhao, Y., Sun, W., Thorimbert, S., Dechoux, L., Sollogoub, M., & Zhang, Y. (2016). Research progress of natural product gentiopicroside—A secoiridoid compound. Mini-Reviews in Medicinal Chemistry, 17(1), 62–77. 10.2174/1389557516666160624124127
Yamaguchi, K. K. de L., & Souza, A. de O. (2020). Antioxidant, hypoglycemic and neuroprotective activities of extracts from fruits native to the amazon region: A review. Biotechnology Journal International, 9–31. 10.9734/bji/2020/v24i630119
Yamaguti-Sasaki, E., Ito, L., Canteli, V., Ushirobira, T., Ueda-Nakamura, T., Filho, B., Nakamura, C., & Palazzo de Mello, J. (2007). Antioxidant capacity and in vitro prevention of dental plaque formation by extracts and condensed tannins of Paullinia cupana. Molecules, 12(8), 1950–1963. 10.3390/12081950
Yonekura, L., Martins, C. A., Sampaio, G. R., Monteiro, M. P., César, L. A. M., Mioto, B. M., Mori, C. S., Mendes, T. M. N., Ribeiro, M. L., Arçari, D. P., & Torres, E. A. F. da S. (2016). Bioavailability of catechins from guaraná (Paullinia cupana) and its effect on antioxidant enzymes and other oxidative stress markers in healthy human subjects. Food & Function, 7(7), 2970–2978. 10.1039/C6FO00513F
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