Global Burden of Disease: Estimate and time trend of the burden of leprosy in the state of Alagoas, Brazil from 2001 to 2019

Authors

DOI:

https://doi.org/10.33448/rsd-v11i2.25528

Keywords:

Leprosy burden; Time series; Degree of physical disability.

Abstract

The leprosy burden continues to grow in Brazil, especially in endemic areas, causing a large number of patients with physical disabilities. Thus, we aim to measure and characterize the burden related to leprosy and analyze its temporal patterns in Alagoas, Brazil, between 2001 and 2019. For this, we measure years of life lost (YLL), years lived with disability (YLD) and years of Disability-Adjusted Life (DALY) for leprosy in Alagoas from 2001 to 2019. The metrics were also presented as rates per 100,000 population. In addition, we use the segmented log-linear regression model to assess temporal trends. We estimate for the state about 968.48 YLLs, 88.02 YLDs, and 1056.49 DALYs for leprosy in grade 1 and 2 disability. The highest rates per 100,000 inhabitants of the leprosy burden were in males. However, women showed a very high relative percentage increase in DALY between 2001 and 2019. As the age group increases, there was also an increase in YLD rates for grade 1 and 2 disability. In addition, the time trend of YLDs in the general population was increasing for disability grade 1 and 2 and grade 1. Our data highlight the still existing impact of leprosy and may contribute to reducing the burden and improving disease control in Brazil.

References

Antunes, J. L. F., & Cardoso, M. R. A. (2015). Using time series analysis in epidemiological studies. Epidemiol Serv Saúde, 24(3), 565–576. 10.5123/S1679-49742015000300024

Brasil, Ministério da Saúde. Secretaria de Vigilângia em Saúde. (2020). Estratégia Nacional para Enfrentamento da Hanseníase 2019-2022 (1st ed.). Brasilía: Departamento de Doenças de Condições Crônicas e Infecções Sexualmente Transmissíveis.

Damasceno, D. M., Silva da Paz, W., Dornels Freire de Souza, C., Dantas dos Santos, A., & Bezerra‐Santos, M. (2021). High‐risk transmission clusters of leprosy in an endemic area in the Northeastern Brazil: a retrospective spatiotemporal modelling (2001 ‐ 2019). Tropical Medicine & International Health, tmi.13657. 10.1111/tmi.13657

Ferreira, A. F., de Souza, E. A., Lima, M. da S., García, G. S. M., Corona, F., Andrade, E. S. N., Neto, S. A. de S., Filha, C. R., Reis, A. da S. dos, Teixeira, L. G., & Ramos Jr., A. N. (2019). Mortalidade por hanseníase em contextos de alta endemicidade: análise espaço-temporal integrada no Brasil. Revista Panamericana de Salud Pública, 43, 1. 10.26633/RPSP.2019.87

Hotez, P. J., Alvarado, M., Basáñez, M.-G., Bolliger, I., Bourne, R., Boussinesq, M., Brooker, S. J., Brown, A. S., Buckle, G., Budke, C. M., Carabin, H., Coffeng, L. E., Fèvre, E. M., Fürst, T., Halasa, Y. A., Jasrasaria, R., Johns, N. E., Keiser, J., King, C. H., & Naghavi, M. (2014). The Global Burden of Disease Study 2010: Interpretation and Implications for the Neglected Tropical Diseases. PLoS Neglected Tropical Diseases, 8(7), e2865. 10.1371/journal.pntd.0002865

IBGE, Instituto Brasileiro de Geografia e Estatística. (2021). Instituto Brasileiro de Geografia e Estatística.

Kim, H.-J., Fay, M. P., Feuer, E. J., & Midthune, D. N. (2000). Permutation tests for joinpoint regression with applications to cancer rates. Statistics in Medicine, 19(3), 335–351. 10.1002/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z

Martins-Melo, F. R., Assunção-Ramos, A. V., Ramos, A. N., Alencar, C. H., Montenegro, R. M., Wand-Del-Rey de Oliveira, M. L., & Heukelbach, J. (2015). Leprosy-related mortality in Brazil: a neglected condition of a neglected disease. Transactions of The Royal Society of Tropical Medicine and Hygiene, 109(10), 643–652. 10.1093/trstmh/trv069

Martins-Melo, F. R., Carneiro, M., Ramos, A. N., Heukelbach, J., Ribeiro, A. L. P., & Werneck, G. L. (2018). The burden of Neglected Tropical Diseases in Brazil, 1990-2016: A subnational analysis from the Global Burden of Disease Study 2016. PLOS Neglected Tropical Diseases, 12(6), e0006559. 10.1371/journal.pntd.0006559

Martins-Melo, F. R., Ramos, A. N., Alencar, C. H., & Heukelbach, J. (2016). Mortality from neglected tropical diseases in Brazil, 2000–2011. Bulletin of the World Health Organization, 94(2), 103–110. 10.2471/BLT.15.152363

Murray, C. J. L., Vos, T., Lozano, R., Naghavi, M., Flaxman, A. D., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., Aboyans, V., Abraham, J., Ackerman, I., Aggarwal, R., Ahn, S. Y., Ali, M. K., AlMazroa, M. A., Alvarado, M., Anderson, H. R., & Lopez, A. D. (2012). Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet, 380(9859), 2197–2223. 10.1016/S0140-6736(12)61689-4

Ribeiro, M. D., Silva, J. C., & Oliveira, S. (2018). Estudo epidemiológico da hanseníase no Brasil: reflexão sobre as metas de eliminação. Revista Panamericana de Salud Pública, 42, 1–7. 10.26633/RPSP.2018.42

Rocha, M. C. N., Lima, R. B. de, Stevens, A., Gutierrez, M. M. U., & Garcia, L. P. (2015). Óbitos registrados com causa básica hanseníase no Brasil: uso do relacionamento de bases de dados para melhoria da informação. Ciência & Saúde Coletiva, 20(4), 1017–1026. 10.1590/1413-81232015204.20392014

Rodrigues, R. N., Leano, H. A. de M., Bueno, I. de C., Araújo, K. M. da F. A., & Lana, F. C. F. (2020). High-risk areas of leprosy in Brazil between 2001-2015. Revista Brasileira de Enfermagem, 73(3), 1–7. 10.1590/0034-7167-2018-0583

Roth, G. A., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., Abdollahpour, I., Abdulkader, R. S., Abebe, H. T., Abebe, M., Abebe, Z., Abejie, A. N., Abera, S. F., Abil, O. Z., Abraha, H. N., & Murray, C. J. L. (2018). Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet, 392(10159), 1736–1788. 10.1016/S0140-6736(18)32203-7

Tiwari, A., & Richardus, J. H. (2016). Investment case concepts in leprosy elimination: A systematic review. Leprosy Review, 87(1), 2–22. 0305-7518/16/064053+21

Vieira, M. C. A., Nery, J. S., Paixão, E. S., Freitas de Andrade, K. V., Oliveira Penna, G., & Teixeira, M. G. (2018). Leprosy in children under 15 years of age in Brazil: A systematic review of the literature. PLOS Neglected Tropical Diseases, 12(10), e0006788. 10.1371/journal.pntd.0006788

Vos, T., Lim, S. S., Abbafati, C., Abbas, K. M., Abbasi, M., Abbasifard, M., Abbasi-Kangevari, M., Abbastabar, H., Abd-Allah, F., Abdelalim, A., Abdollahi, M., Abdollahpour, I., Abolhassani, H., Aboyans, V., Abrams, E. M., Abreu, L. G., Abrigo, M. R. M., Abu-Raddad, L. J., Abushouk, A. I., & Murray, C. J. L. (2020). Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet, 396(10258), 1204–1222. 10.1016/S0140-6736(20)30925-9

Wang, H., Abbas, K. M., Abbasifard, M., Abbasi-Kangevari, M., Abbastabar, H., Abd-Allah, F., Abdelalim, A., Abolhassani, H., Abreu, L. G., Abrigo, M. R. M., Abushouk, A. I., Adabi, M., Adair, T., Adebayo, O. M., Adedeji, I. A., Adekanmbi, V., Adeoye, A. M., Adetokunboh, O. O., Advani, S. M., & Murray, C. J. L. (2020). Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019. The Lancet, 396(10258), 1160–1203. 10.1016/S0140-6736(20)30977-6

WHO, World Health Organization.. (2016). Global Leprosy Strategy 2016-2020: Accelerating towards a leprosy-free world. Monitoring and Evaluation Guide. Geneva: New Delhi.

WHO, World Health Organization. (2020a). Global Health Estimates 2020: Disease burden by Cause, Age, Sex, by Country and by Region, 2000-2019. Retrieved from https://apps.who.int/gho/data/node.main.CODWORLD?lang=en

WHO, World Health Organization. (2020b). Global leprosy (Hansen disease) update, 2019: time to step-up prevention initiatives. Weekly Epidemiological Record, 95(36), 417–440.

WHO, World Health Organization. (2021). Towards zero leprosy. Global leprosy (‎Hansen’s Disease)‎ strategy 2021–2030 (D. E. A. Cooreman/Leprosy (ed.)). Geneva: World Health Organization.

Published

31/01/2022

How to Cite

CABRAL, J. S. da .; MATOS, D. F. .; BEZERRA, L. P. .; RAMOS, R. E. S. .; AQUINO, M. L. P. .; ARAÚJO, Q. M. dos S. .; MELO, R. L. B. .; FREIRE, Éverton S. .; PAZ, W. S. da .; ALMEIDA, D. H. de . Global Burden of Disease: Estimate and time trend of the burden of leprosy in the state of Alagoas, Brazil from 2001 to 2019. Research, Society and Development, [S. l.], v. 11, n. 2, p. e44511225528, 2022. DOI: 10.33448/rsd-v11i2.25528. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/25528. Acesso em: 25 apr. 2024.

Issue

Section

Health Sciences