Leptin-related genetic variants and their impact on obesogenesis

Authors

DOI:

https://doi.org/10.33448/rsd-v11i3.25922

Keywords:

Leptin; Disorders; Metabolism; Polymorphisms; Obesity.

Abstract

This work aims to carry out an integrative review of the literature, in order to gather studies that show the relationship between the presence of genetic polymorphisms associated with leptin and the development of obesity. This is an integrative literature review, based on the following steps: elaboration of the guiding question, literature search or sampling, data collection, critical analysis of the included studies, discussion of the results and presentation of the integrative review (Souza, Silva & oak, 2010). The guiding question was: Can leptin-associated genetic variants exert effects on the development of obesity? Initially, the strategy for the search for studies consisted of a combination of controlled descriptors (leptin, disorders, metabolism, polymorphisms and obesity) indexed in the Health Sciences Descriptors (DeCS/MeSH). In the first screening, based on the inclusion and exclusion criteria, 14073 studies were eliminated. After eligibility/critical evaluation of the full texts of 360 records, 5 met the inclusion criteria and proceeded to the data extraction, exhaustive reading and knowledge synthesis phase. The results presented and discussed indicate a relationship between the presence of genetic variants and changes in the process of leptin synthesis, as well as changes in the process of binding the hormone to its receptors, impacting metabolic processes that favor obesogenesis.

References

Boumaiza, I., Omezzine, A., Rejeb, J., Rebhi, L., Ouedrani, A., Ben Rejeb, N., ... & Bouslama, A. (2012). Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian volunteers. Genetic testing and molecular biomarkers, 16(7), 726-733.

Chagnon, Y. C., Wilmore, J. H., Borecki, I. B., Gagnon, J., Pérusse, L., Chagnon, M., ... & Bouchard, C. (2000). Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study. The Journal of Clinical Endocrinology & Metabolism, 85(1), 29-34.

De Luis, D. A., JL, P. C., & Duenas, A. (2008). Leptin and obesity. Minerva medica, 100(3), 229-236.

Duan, D. M., Jhang, J. Y., Wu, S., Teng, M. S., Hsu, L. A., & Ko, Y. L. (2020). Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women. Molecular genetics & genomic medicine, 8(3), e1113.

Friedlander, Y., Li, G., Fornage, M., Williams, O. D., Lewis, C. E., Schreiner, P., ... & Siscovick, D. S. (2010). Candidate molecular pathway genes related to appetite regulatory neural network, adipocyte homeostasis and obesity: results from the CARDIA Study. Annals of human genetics, 74(5), 387-398.

Guizar-Mendoza, J. M., Amador-Licona, N., Flores-Martinez, S. E., Lopez-Cardona, M. G., Ahuatzin-Tremary, R., & Sanchez-Corona, J. (2005). Association analysis of the Gln223Arg polymorphism in the human leptin receptor gene, and traits related to obesity in Mexican adolescents. Journal of human hypertension, 19(5), 341-346.

Hastuti, P., Zukhrufia, I., Padwaswari, M. H., Nuraini, A., & Sadewa, A. H. (2016). Polymorphism in leptin receptor gene was associated with obesity in Yogyakarta, Indonesia. Egyptian journal of medical human genetics, 17(3), 271-276.

Jiao, H., Kaaman, M., Dungner, E., Kere, J., Arner, P., & Dahlman, I. (2008). Association analysis of positional obesity candidate genes based on integrated data from transcriptomics and linkage analysis. International journal of obesity, 32(5), 816-825.

Kumari, P., Gautam, S., Jaiswar, S. P., Shankhwar, P. L., Ahmad, M. K., & Mahdi, A. A. (2020). Association of leptin receptor genetic variants (LEPR) with obesity and leptin level in unexplained infertility in northern Indian population. Clinical Epidemiology and Global Health, 8(2), 361-364.

Madeira, I., Bordallo, M. A., Rodrigues, N. C., Carvalho, C., Gazolla, F., Collett-Solberg, P., ... & Ribeiro, R. (2016). Leptin as a predictor of metabolic syndrome in Madeira prepubertal children. Archives of endocrinology and metabolism, 61, 07-13.

Mizuta, E., Kokubo, Y., Yamanaka, I., Miyamoto, Y., Okayama, A., Yoshimasa, Y., ... & Morisaki, T. (2008). Leptin gene and leptin receptor gene polymorphisms are associated with sweet preference and obesity. Hypertension Research, 31(6), 1069-1077.

Moll, P. P., Burns, T. L., & Lauer, R. M. (1991). The genetic and environmental sources of body mass index variability: the Muscatine Ponderosity Family Study. American journal of human genetics, 49(6), 1243.

Nesrine, Z., Haithem, H., Imen, B., Fadoua, N., Asma, O., Fadhel, N. M., & Ali, B. (2018). Leptin and Leptin receptor polymorphisms, plasma Leptin levels and obesity in Tunisian volunteers. International journal of experimental pathology, 99(3), 121-130.

Souza, M. T. D., Silva, M. D. D., & Carvalho, R. D. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8, 102-106.

Voigtmann, F., Wolf, P., Landgraf, K., Stein, R., Kratzsch, J., Schmitz, S., ... & Körner, A. (2021). Identification of a novel leptin receptor (LEPR) variant and proof of functional relevance directing treatment decisions in patients with morbid obesity. Metabolism, 116, 154438.

Yiannakouris, N., Yannakoulia, M., Melistas, L., Chan, J. L., Klimis-Zacas, D., & Mantzoros, C. S. (2001). The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. The Journal of Clinical Endocrinology & Metabolism, 86(9), 4434-4439.

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Published

06/03/2022

How to Cite

COSTA, J. A. da .; CARNEIRO, C. R. .; SILVA, L. C. da .; FONTINELE, R. R. C. .; MENDES, T. de S. R. .; BARROS, G. M. de .; RODRIGUES, N. A. C. .; DAMASCENO, D. L. L. .; FREIRE , L. M. .; LIMA , D. de O. .; MACEDO, K. V. .; TORRES, R. R. .; SOUSA, F. M. de .; CUNHA, E. F. N. da . Leptin-related genetic variants and their impact on obesogenesis. Research, Society and Development, [S. l.], v. 11, n. 3, p. e52011325922, 2022. DOI: 10.33448/rsd-v11i3.25922. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/25922. Acesso em: 28 mar. 2025.

Issue

Vol. 11 No. 3

Section

Review Article

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Copyright (c) 2022 Jardel Alves da Costa; Cláudia Resende Carneiro; Lilian Carvalho da Silva; Renata Rodrigues Costa Fontinele; Taynara de Sousa Rego Mendes; Gabrielly Martins de Barros; Natanael Alison Carvalho Rodrigues; Dênaba Luyla Lago Damasceno; Layanna Moreira Freire ; Diêgo de Oliveira Lima ; Kelly Vanderlei Macedo; Renata Rios Torres; Francisca Maria de Sousa; Erico Fabrício Nunes da Cunha

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