Resistance of filamental fungi in opportunistic mycoses: literature review
DOI:
https://doi.org/10.33448/rsd-v11i4.26198Keywords:
Opportunistic mycoses; Cryptococcus spp.; Candida spp.; Aspergillus spp.; Pneumocystis spp.Abstract
Fungal diseases need to be better known and studied, as they are not the first diagnostic hypotheses and are the main causes of morbidity and mortality among immunocompromised patients. Main agents involved in opportunistic mycoses: Cryptococcus spp., Candida spp., Aspergillus spp. and Pneumocystis spp., present epidemiological data of these infections are modest, due to incorrect or incomplete diagnoses. adding to this the indiscriminate use of antifungal agents contributed to a change in the epidemiological profile and selecting resistant fungal strains, increasing the mortality rate in affected patients. Thus, this study aims to review the literature on the main opportunistic fungi and address important aspects of the resistance profile of filamentous opportunistic fungi. A search was carried out in the scientific literature based on the electronic database Pubmed, MedlinePlus, Scientific Electronic Library Online (Scielo), Academic Google., using as descriptors: Filamentous Fungi, Antifungals; Aspergillus spp.; Candida albicans; Cryptococcus neoformans; Sporothrixs chenckii; resistance, resistance in opportunistic mycoses and resistance profile. Studies indicate that rapid diagnosis and the choice of the correct drug can increase the recovery rates of patients with fungal infections. The delay in diagnosis and even the use of drugs with low efficiency has aggravated and, at the same time, increased the mortality of patients infected with these mycoses. This study aims to increase the bibliographic base on opportunistic mycoses cases and their resistance to the main antifungal drugs available.
References
Alastruey-Izquierdo, A., Melhem, M. S., Bonfietti, L. X. & Rodriguez-Tudela, J. L. (2015). Susceptibility test for fungi: clinical and laboratorial correlations in medical mycology. Revista do Instituto de Medicina Tropical de São Paulo, 57, 57-64. https://doi.org/10.1590/S0036-46652015000700011
Rokas A. (2021). Aspergillus. Aspergillus e Aspergilosis. Disponível em: https://www.aspergillus.org.uk/article_database/aspergillus/. Acessado em: 21 outubro 2021.
ANVISA (2017). Microbiologia Clínica Para O Controle De Infecção Relacionada À Assistência À Saúde https://www.saude.go.gov.br/images/imagens_migradas/upload/arquivos/2017-02/modulo-8---deteccao-e-identificacao-de-fungos-de-importancia-medica.pdf
Avila-Aguero, M. L., Canas-Coto, A., Ulloa-Gutierrez, R., Caro, M. A., Alfaro, B. & Paris, M. M. (2005). Risk factors for Candida infections in a neonatal intensive care unit in Costa Rica. International journal of infectious diseases, 9(2), 90-95. https://doi.org/10.1016/j.ijid.2004.05.007
Bennet, J. W. (2010). An overview of the genus Aspergillus. In: M. Machida, & K. Gomi, (Eds.), Aspergillus. molecular biology and genomics Norfolk: Caister Academic Press. (pp. 1–18).
Benchimol, J. L. & Sá, M. R. (2004). Adolpho Lutz-Dermatologia e Micologia, SciELO-Editora FIOCRUZ. v. 1, Livro 3.
Castro, T. L., Coutinho, H. D. M., Gedeon, C. C., Santos, J. D., Santana, W. J., & Souza, L. D. (2006). Mecanismos de resistência da Candida sp. Wwa antifúngicos. Infarma, 18(9), 10.
Bentubo, H. D. L., Moreira, G. S., de Paula, C. D., Miranda, F. R. & Coutinho, S. D. A. (2022). Identification of keratinophilic fungi in the coat microbiota of anteaters retained in captivity in two Brazilian Zoos. Research, Society and Development, 11(2), e11311225497-e11311225497.
Berto, C., Wirth, F., Barth, N., & Hermes, D. M. (2018). Bases da resistência antifúngica: uma revisão comentada. RevistaUningá, 55(3), 52-71.
Bortolotto, G. D. S., Bortolotto, T., Costa, F. V., Rabelo, B. D., Negro-Dellacqua, M., & de Sousa, I. F. (2022). Ensino complementar de micologia médica na modalidade a distância em meio à pandemia da COVID-19: um relato de experiência. Research, Society and Development, 11(1), e40611125237-e40611125237.
Brown, G. D., Denning, D. W., Gow, N. A., Levitz, S. M., Netea, M. G., & White, T. C. (2012). Hidden killers: human fungal infections. Science translational medicine, 4(165), 165rv13-165rv13.
Cattana, M. E., Tracogna, M. F., Fernández, M. S., Rey, C., Sosa, M. A., & Giusiano, G. E. (2013). Genotyping of Cryptococcus neoformans/ Cryptococcus gattii complex clinical isolates from Hospital" Dr. Julio C. Perrando", Resistencia city (Chaco, Argentina). Revista Argentina de microbiologia, 45(2), 89-92.
Chimelli, P. A. V., Sofiatti, A. D. A., Nunes, R. S., & Martins, J. E. D. C. (2003). Dermatophyte agents in the city of São Paulo, from 1992 to 2002. Revista do Instituto de Medicina Tropical de São Paulo, 45, 259-263.
Colombo, A. L., & Guimarães, T. (2007). Candidúria: uma abordagem clínica e terapêutica. Revista da Sociedade Brasileira de Medicina Tropical, 40, 332-337.
Corrêa, A.E. (2019.) Identificação, Resistência e Sensibilidade de Cepas de Cryptococcus neoformans e de Candida sp., Presentes em Excretas de Pombos no Município de Porto Velho, RO–Brasil. South American Journal of Basic Education, Technical and Technological, v. 6, n. 1.
Cuenca-Estrella, M., & Rodríguez-Tudela, J.L. (2002) Should antifungal treatments be based upon results of antifungal susceptibility testing?, Revista Ibero americana de Micologia, v. 19, n. 3, p. 133-138.
Dignani, M. C. (2014) Epidemiology of invasive fungal diseases on the basis of autopsy reports. F1000Prime Reports, n. 6, p. 81.
Espinel-Ingroff, A., Arthington-Skaggs, B., Iqbal, N., Ellis, D., Pfaller, M. A., Messer, S., & Wang, A. (2007). Multicenter evaluation of a new disk agar diffusion method for susceptibility testing of filamentous fungi with voriconazole, posaconazole, itraconazole, amphotericin B, and caspofungin. Journal of clinical microbiology, 45(6), 1811-1820.
Ferreira, B. F. F., Ragazzini, L. J., & Andrade, M. C. (2012). Investigação da Sensibilidade ao Fluconazol e Produção de Enzimas Hidrolíticas por Candida sp. Isoladas do Trato Respiratório de Pacientes Internados em um Hospital no Sul de Minas Gerais/Investigation of Fluconazole Sensibility and Hydrolytic Enzimes Pro. Health Sciences Journal, 2(1), 48-56.
Fioravanti, C. (2016) O ataque silencioso. Pesquisa Fapesp, [s. l.], v. 243, p. 42–45.
Fungos. (2021) Detecção e Identificação dos Fungos de Importância Médica. http://www.anvisa.gov.br/servicosaude/microbiologia/mod_7_2004.pdf.
Goulart, L. S., Souza, W. W. R. D., Vieira, C. A., Lima, J. S. D., Olinda, R. A. D., & Araújo, C. D. (2018). Oral colonization by Candida species in HIV-positive patients: association and antifungal susceptibility study. Einstein (São Paulo), 16.
Gavronski, S., Botelho, T. K. R., & Cordova, C. M. M. (2016). Diagnóstico laboratorial de aspergilose invasiva: avaliação de métodos moleculares e detecção de antígenos. Revista Brasileira de Análises Clínicas, 48(2), 96-109.
Giacomazzi, J., Baethgen, L., Carneiro, L. C., Millington, M. A., Denning, D. W., Colombo, A. L., & in association with the LIFE program. (2016). The burden of serious human fungal infections in Brazil. Mycoses, 59(3), 145-150. https://doi.org/10.1111/myc.12427
Goldman, L., & Schafer A.I. (2014). Goldman- Cecil Medicina. 24. ed. Rio de Janeiro: Elsevier. 1120-1125.
Guarner, J. (2017, July). Human immunodeficiency virus and fungal infections. In Seminars in diagnostic pathology, WB Saunders, (Vol. 34, No. 4, pp. 325-331).
Hazen, K. C., & Howell, S. A. (2007). Candida, Cryptococcus and other yeasts of medical importance. Manual of Clinical Microbiology, 2, 1762-1788.
Jesus, W. A. de Galinari, C. B., Arita, G. S., Mosca, V. A. B., de Souza Bonfim-Mendonça, P., & Svidzinski, T. I. E. (2021). Estudo sobre a presença simultânea de dermatomicoses e diabetes em pacientes residentes em zona rural de um município do Estado do Paraná. Research, Society and Development, 10(9), e14810917781-e14810917781.
Karam, R. G., Cury, F. S., Ambrósio, C. E. & Mançanares, C. A. F. (2016). Uso da glicerina para a substituição do formaldeído na conservação de peças anatômicas. Pesquisa Veterinária Brasileira, 36, 671-675.
Kauffman, C. A., Pappas, P. G., Sobel, J. D. & Dismukes, W. E. (Eds.). (2011). Essentials of clinical mycology New York: Springer New York. (pp. 321-335).
Köche, J. C. (2016). Fundamentos de metodologia científica: teoria da ciência e iniciação à pesquisa. Vozes
Magill, S. S., Edwards, J. R., Bamberg, W., Beldavs, Z. G., Dumyati, G., Kainer, M. A. & Fridkin, S. K. (2014). Multistate point-prevalence survey of health care–associated infections. New England Journal of Medicine, 370(13), 1198-1208.
Martinez R. (2006). Atualização no Uso de Agentes Antifúngicos. Jornal Brasileiro de Pneumologia. ;32(5):449-60.
Oliveira, J.C. (2014). Tópicos em Micologia Médica. 4.ed. Rio de Janeiro.
Oliveira, D.C., Loreto, É.S.D., Mario, D.A.N., Lopes, P.G.M., Neves, L.V., Rocha, M.P.D., & Alves, S.H. (2015). Sporothrixschenckii complex: susceptibilities to combined antifungal agents and characterization of enzymatic profiles. Revista do Instituto de Medicina Tropical de São Paulo, 57, 289-294.
Pappas, P. G., Lionakis, M. S., Arendrup, M. C., Ostrosky-Zeichner, L., & Kullberg, B. J. (2018). Invasive candidiasis. Nature Reviews Disease Primers, 4(1), 1-20.
Pfaller, M. A., Diekema, D. J., Rinaldi, M. G., Barnes, R., Hu, B., Veselov, A. V. & Gibbs, D. L. (2005). Results from the ARTEMIS DISK Global AntifungalSurveillance Study: a 6.5-Year Analysis of Susceptibilitiesof Candida and Other Yeast Species to Fluconazole andVoriconazole by Standardized Disk Diffusion Testing. Journal of clinical microbiology, 43(12), 5848-5859.
Pitt, J. I. (2000). A laboratory guide to common Penicillium species. Australia: Food Science Australia a Joint Venture of CSIRO and AFISC, p. 197.
Queiroz-Fernandes, G. (2021). Perfil De Resistência De Agentes De Micoses Oportunistas No Brasil. Inter American Journal of Medicine and Health, 4.
Ribeiro, S. A., Cavalcanti, M. A., Fernandes, M. J. & Lima, D. M. (2003). Fungos filamentosos isolados de produtos derivados do milho comercializados em Recife, Pernambuco. Brazilian Journal of Botany, 26, 223-229.
Rocha, W. R. V. da, Nunes, L. E., Neves, M. L. R., de Azevedo Ximenes, E. C. P. & de Azevedo Albuquerque, M. C. P. (2021). Gênero Candida-Fatores de virulência, Epidemiologia, Candidíase e Mecanismos de resistência. Research, Society and Development, 10(4), e43910414283-e43910414283.
Roilides, E., Farmaki, E., Evdoridou, J., Dotis, J., Hatziioannidis, E., Tsivitanidou, M. & Kremenopoulos, G. (2004). Neonatal candidiasis: analysis of epidemiology, drug susceptibility, and molecular typing of causative isolates. European Journal of Clinical Microbiology and Infectious Diseases, 23(10), 745-750.
Sabatelli, F., Patel, R., Mann, P. A., Mendrick, C. A., Norris, C. C., Hare, R., ... & McNicholas, P. M. (2006). In vitro activities of posaconazole, fluconazole, itraconazole, voriconazole, and amphotericin B against a large collection of clinically important molds and yeasts. Antimicrobial agents and chemotherapy, 50(6), 2009-2015.
Seghir, A., Boucherit-Otmani, Z., Boucherit, K. & Sari-Belkharroubi, L. (2017). Étude de l’infectivité dês Candida surcathé ters vasculaires périphériques prélevés du Centre Hospitalier Universitaire de Tlemcen. Journal de Mycologie Médicale, 27(4), 457-462.
Silva, R. F. E. (2010) Infecções Fungícas em imunocomprometidos. Jornal Brasileiro Pneumologia, [s. l.], v. 36, n. 1, p. 142–147.
Valero, C., de la Cruz-Villar, L., Zaragoza, Ó. & Buitrago, M. J. (2016). New panfungal real-time PCR assay for diagnosis of invasive fungal infections. Journal of Clinical microbiology, 54(12), 2910-2918.
Vujanovic, V., Smoragiewicz, W. & Krzysztyniak, K. (2001). Airborne fungal ecological niche determination as one of the possibilities for indirect mycotoxin risk assessment in indoor air. Environmental Toxicology: An International Journal, 16(1), 1-8.
Wattier, R. L., Dvorak, C. C., Hoffman, J. A., Brozovich, A. A., Bin-Hussain, I., Groll, A. H., ..., & Steinbach, W. J. (2015). A Prospective, International Cohort Study of Invasive Mold Infections in Children. Journal of the Pediatric Infectious Diseases Society, 4(4), 313-322.
Zuo, T., Zhan, H., Zhang, F., Liu, Q., Tso, E. Y. K., Lui, G. C. Y., Chen, N., Li, A., Lu, W., Chan, F. K. L., Chan, P. K. S. & Ng, S. C. (2020). Alterations in
Fecal Fungal Microbiome of Patients With COVID-19 During Time of Hospitalization until Discharge. Gastroenterology, 159(4), 1302-1310.
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