Antidepressant use during pregnancy and gestational diabetes: a systematic review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i2.26278

Keywords:

Antidepressive Agents; Diabetes, Gestational; Pregnancy; Systematic Review.

Abstract

A high number of women are exposed to antidepressants during pregnancy. Considering that an association between exposure to antidepressants and type 2 diabetes was found in the general population and pregnant women are inherently susceptible to insulin resistance, this study aimed to investigate data in the scientific literature on the association between antidepressant use during pregnancy and the risk of developing gestational diabetes mellitus (GDM). This systematic review was conducted according to the PRISMA guidelines. PubMed, Virtual Health Library (VHS), and Web of Science databases were searched to identify observational studies reporting the association between antidepressant use during pregnancy and GDM. Review articles, case reports, case series, clinical trials, and animal studies were excluded. In total, 67 studies were retrieved, of which 3 were included in the systematic review: one case-control and two cohort studies. According to the Newcastle-Ottawa Scale, the three studies were considered high-quality. Through this systematic review, selective serotonin reuptake inhibitors (SSRI) use during pregnancy is not significantly associated with a higher risk of developing GDM. There are still controversies about the association between serotonin and norepinephrine reuptake inhibitors (SNRI) and GDM. The use of tricyclic, tetracyclic, and atypical antidepressants by pregnant women appears to be associated with GDM. Therefore, the available information about the topic is scarce and the condition of further studies is needed.

References

American Diabetes Association. (2020). 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2021. Diabetes Care, 44(Supplement_1), S15–S33. https://doi.org/10.2337/dc21-S002

Baeyens, L., Hindi, S., Sorenson, R. L., & German, M. S. (2016). β-Cell adaptation in pregnancy. Diabetes, Obesity and Metabolism, 18(S1), 63–70. https://doi.org/10.1111/dom.12716

Behboudi-Gandevani, S., Amiri, M., Bidhendi Yarandi, R., & Ramezani Tehrani, F. (2019). The impact of diagnostic criteria for gestational diabetes on its prevalence: A systematic review and meta-analysis. Diabetology & Metabolic Syndrome, 11(1), 11. https://doi.org/10.1186/s13098-019-0406-1

Carvalho, F., Barros, D., Silva, J., Rezende, E., Soares, M., Fregoneze, J., & De Castro e Silva, E. (2004). Hyperglycemia induced by acute central fluoxetine administration: Role of the central CRH system and 5-HT3 receptors. Neuropeptides, 38(2), 98–105. https://doi.org/10.1016/j.npep.2004.04.004

Chen, S., Zhao, S., Dalman, C., Karlsson, H., & Gardner, R. (2021). Association of maternal diabetes with neurodevelopmental disorders: Autism spectrum disorders, attention-deficit/hyperactivity disorder and intellectual disability. International Journal of Epidemiology, 50(2), 459–474. https://doi.org/10.1093/ije/dyaa212

Dandjinou, M., Sheehy, O., & Bérard, A. (2019). Antidepressant use during pregnancy and the risk of gestational diabetes mellitus: A nested case–control study. BMJ Open, 9(9), e025908. https://doi.org/10.1136/bmjopen-2018-025908

Dubovicky, M., Belovicova, K., Csatlosova, K., & Bogi, E. (2017). Risks of using SSRI / SNRI antidepressants during pregnancy and lactation. Interdisciplinary Toxicology, 10(1), 30–34. https://doi.org/10.1515/intox-2017-0004

Gonçalves, A. M. C., Teixeira, M. T. B., Gama, J. R. de A., Lopes, C. S., Silva, G. A. e, Gamarra, C. J., Duque, K. de C. D., & Machado, M. L. S. M. (2018). Prevalência de depressão e fatores associados em mulheres atendidas pela Estratégia de Saúde da Família. Jornal Brasileiro de Psiquiatria, 67, 101–109. https://doi.org/10.1590/0047-2085000000192

Haque, M. R., Khan, M. M. A., Rahman, M. M., Rahman, M. S., & Begum, S. A. (2022). Mental health status of informal waste workers during the COVID-19 pandemic in Bangladesh. PLOS ONE, 17(1), e0262141. https://doi.org/10.1371/journal.pone.0262141

Hennings, J. M., Schaaf, L., & Fulda, S. (2012). Glucose Metabolism and Antidepressant Medication. Current Pharmaceutical Design, 18(36), 5900–5919.

Hinkle, S. N., Buck Louis, G. M., Rawal, S., Zhu, Y., Albert, P. S., & Zhang, C. (2016). A longitudinal study of depression and gestational diabetes in pregnancy and the postpartum period. Diabetologia, 59(12), 2594–2602. https://doi.org/10.1007/s00125-016-4086-1

Isaac, R., Boura-Halfon, S., Gurevitch, D., Shainskaya, A., Levkovitz, Y., & Zick, Y. (2013). Selective Serotonin Reuptake Inhibitors (SSRIs) Inhibit Insulin Secretion and Action in Pancreatic β Cells*. Journal of Biological Chemistry, 288(8), 5682–5693. https://doi.org/10.1074/jbc.M112.408641

Johns, E. C., Denison, F. C., Norman, J. E., & Reynolds, R. M. (2018). Gestational Diabetes Mellitus: Mechanisms, Treatment, and Complications. Trends in Endocrinology & Metabolism, 29(11), 743–754. https://doi.org/10.1016/j.tem.2018.09.004

Katon, J. G., Russo, J., Gavin, A. R., Melville, J. L., & Katon, W. J. (2011). Diabetes and Depression in Pregnancy: Is There an Association? Journal of Women’s Health, 20(7), 983–989. https://doi.org/10.1089/jwh.2010.2662

Kozhimannil, K. B., Pereira, M. A., & Harlow, B. L. (2009). Association between diabetes and perinatal depression among low-income mothers. JAMA, 301(8), 842–847. https://doi.org/10.1001/jama.2009.201

Levkovitz, Y., Ben-shushan, G., Hershkovitz, A., Isaac, R., Gil-Ad, I., Shvartsman, D., Ronen, D., Weizman, A., & Zick, Y. (2007). Antidepressants induce cellular insulin resistance by activation of IRS-1 kinases. Molecular and Cellular Neuroscience, 36(3), 305–312. https://doi.org/10.1016/j.mcn.2007.05.009

Lopez-Yarto, M., Ruiz-Mirazo, E., Holloway, A. C., Taylor, V. H., & McDonald, S. D. (2012). Do psychiatric medications, especially antidepressants, adversely impact maternal metabolic outcomes? Journal of Affective Disorders, 141(2–3), 120–129. https://doi.org/10.1016/j.jad.2012.01.043

Lupattelli, A., Barone-Adesi, F., & Nordeng, H. (2021). Association between antidepressant use in pregnancy and gestational diabetes mellitus: Results from the Norwegian Mother, Father and Child Cohort Study. Pharmacoepidemiology and Drug Safety. https://doi.org/10.1002/pds.5388

Messerlian, C., & Basso, O. (2018). Cohort studies in the context of obstetric and gynecologic research: A methodologic overview. Acta Obstetricia et Gynecologica Scandinavica, 97(4), 371–379. https://doi.org/10.1111/aogs.13272

Molenaar, N. M., Bais, B., Lambregtse-van den Berg, M. P., Mulder, C. L., Howell, E. A., Fox, N. S., Rommel, A.-S., Bergink, V., & Kamperman, A. M. (2020). The international prevalence of antidepressant use before, during, and after pregnancy: A systematic review and meta-analysis of timing, type of prescriptions and geographical variability. Journal of Affective Disorders, 264, 82–89. https://doi.org/10.1016/j.jad.2019.12.014

Molenaar, N. M., Kamperman, A. M., Boyce, P., & Bergink, V. (2018). Guidelines on treatment of perinatal depression with antidepressants: An international review. Australian & New Zealand Journal of Psychiatry, 52(4), 320–327. https://doi.org/10.1177/0004867418762057

Molyneaux, E., Poston, L., Khondoker, M., & Howard, L. M. (2016). Obesity, antenatal depression, diet and gestational weight gain in a population cohort study. Archives of Women’s Mental Health, 19(5), 899–907. https://doi.org/10.1007/s00737-016-0635-3

Moraczewski, J., & Aedma, K. K. (2021). Tricyclic Antidepressants. In StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK557791/

Neal, B. S., Lack, S. D., Lankhorst, N. E., Raye, A., Morrissey, D., & van Middelkoop, M. (2019). Risk factors for patellofemoral pain: A systematic review and meta-analysis. British Journal of Sports Medicine, 53(5), 270–281. https://doi.org/10.1136/bjsports-2017-098890

Ornoy, A., Weinstein-Fudim, L., & Ergaz, Z. (2017). Antidepressants, Antipsychotics, and Mood Stabilizers in Pregnancy: What Do We Know and How Should We Treat Pregnant Women with Depression. Birth Defects Research, 109(12), 933–956. https://doi.org/10.1002/bdr2.1079

Ouzzani, M., Hammady, H., Fedorowicz, Z., & Elmagarmid, A. (2016). Rayyan—A web and mobile app for systematic reviews. Systematic Reviews, 5(1). https://doi.org/10.1186/s13643-016-0384-4

Oyebode, F., Rastogi, A., Berrisford, G., & Coccia, F. (2012). Psychotropics in pregnancy: Safety and other considerations. Pharmacology & Therapeutics, 135(1), 71–77. https://doi.org/10.1016/j.pharmthera.2012.03.008

Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., … Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, n71. https://doi.org/10.1136/bmj.n71

Pereira, P. K., & Lovisi, G. M. (2008). Prevalência da depressão gestacional e fatores associados. Archives of Clinical Psychiatry (São Paulo), 35, 144–153. https://doi.org/10.1590/S0101-60832008000400004

Reis, M., & Källén, B. (2010). Delivery outcome after maternal use of antidepressant drugs in pregnancy: An update using Swedish data. Psychological Medicine, 40(10), 1723–1733. https://doi.org/10.1017/S0033291709992194

Santos, G. de B. V. dos, Alves, M. C. G. P., Goldbaum, M., Cesar, C. L. G., & Gianini, R. J. (2019). Prevalência de transtornos mentais comuns e fatores associados em moradores da área urbana de São Paulo, Brasil. Cadernos de Saúde Pública, 35. https://doi.org/10.1590/0102-311X00236318

Sheffler, Z. M., & Abdijadid, S. (2021). Antidepressants. In StatPearls [Internet]. StatPearls Publishing. http://europepmc.org/abstract/MED/30844209

Szmuilowicz, E. D., Josefson, J. L., & Metzger, B. E. (2019). Gestational Diabetes Mellitus. Endocrinology and metabolism clinics of North America, 48(3), 479–493. https://doi.org/10.1016/j.ecl.2019.05.001

Wartko, P. D., Weiss, N. S., Enquobahrie, D. A., Chan, K. C. G., Stephenson-Famy, A., Mueller, B. A., & Dublin, S. (2019). Antidepressant continuation in pregnancy and risk of gestational diabetes. Pharmacoepidemiology and Drug Safety, 28(9), 1194–1203. https://doi.org/10.1002/pds.4799

Wells, G., Shea, B., O’Connell, D., Peterson, J., Welch, V., Losos, M., & Tugwell, P. (2012). The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp

Woody, C. A., Ferrari, A. J., Siskind, D. J., Whiteford, H. A., & Harris, M. G. (2017). A systematic review and meta-regression of the prevalence and incidence of perinatal depression. Journal of Affective Disorders, 219, 86–92. https://doi.org/10.1016/j.jad.2017.05.003

Yeong, C., Worsley, R., Gilbert, H., & Kulkarni, J. (2014). Gestational diabetes in women with mental illness. The Australian and New Zealand journal of psychiatry, 48. https://doi.org/10.1177/0004867414528591

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05/02/2022

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CASTRO, B. T. de; AZEVEDO, A. O.; QUARESMA, A. L. P.; NEPOMUCENO, A. F. S. F.; FIGUEIREDO, M. S.; SILVA, L. S. C. da; GAMA, R. S.; CASTRO, C. T. de. Antidepressant use during pregnancy and gestational diabetes: a systematic review. Research, Society and Development, [S. l.], v. 11, n. 2, p. e53911226278, 2022. DOI: 10.33448/rsd-v11i2.26278. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/26278. Acesso em: 22 dec. 2024.

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Vol. 11 No. 2

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Health Sciences

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Copyright (c) 2022 Beatriz Tianeze de Castro; Andressa Oliveira Azevedo; Anna Luzia Pinho Quaresma; Ana Flávia Souto Figueiredo Nepomuceno; Mariana Souto Figueiredo; Lucas Santana Coelho da Silva; Romana Santos Gama; Caroline Tianeze de Castro

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