The benefits of phytotherapy in Dentistry
DOI:
https://doi.org/10.33448/rsd-v11i3.27050Keywords:
Phytotherapy; Dentistry; Herbal Medicine; Alternative medicine.Abstract
The biological properties of plants have always aroused curiosity in the scientific community because, since ancient times, man has used phytotherapy to prevent and cure diseases. Currently, many studies prove the pharmacological effects of vegetables and medicinal applications ranging from pain relief, control of inflammation and infections, antioxidant action to antitumor action. In dentistry, the use of phytotherapy has grown and research into the use of plant derivatives on periodontal and endodontic infections, caries, and oral candidiasis, for example, is expanding. The objective of the present review was to diagnose the current panorama of research on herbal medicine in dentistry based on scientific evidence present in the literature. Works available in the PUBMED, BVS, Google academic, and Scielo databases were used. In the present review, it was found that many in vitro, in vivo, and clinical trials are being carried out to prove the efficacy and safety of plant compounds and in dentistry, it is observed that the study and use of phytotherapy are increasingly broad. Among the main therapeutic applications of plants in dentistry, we can mention the analgesic, anti-inflammatory, antimicrobial (including antibacterial and antifungal action), and anxiolytic activity, and the main phytotherapeutics frequently used are: Malva sylvestris, Camellia sinensis, propolis, Carica papaya, Glycyrrhiza glabra, Valeriana officinalis, and Passiflora incarnata. Thus, it can be concluded that the benefits of phytotherapy in dentistry are numerous and the continuity of research is essential for plant products to reach dental clinics in all regions of Brazil.
References
Abbasi, A. J., Mohammadi, F., Bayat, M., Gema, S. M., Ghadirian, H., Seifi, H., Bayat, H., & Bahrami, N. (2018). Applications of Propolis in Dentistry: A Review. Ethiopian Journal of Health Sciences, 28(4), 505. https://doi.org/10.4314/EJHS.V28I4.16
Hartkopf, A. C. L., Zanna, C. F. D., G. Z., & Ferreira, C. H. R. (2021). Comparação do efeito da valeriana officinalis l. E da passiflora incarnata em exodontia de terceiros molares inferiores: estudo duplo-cego, boca dividida e randomizado. Anais Do Encontro Internacional de Produção Científica Da Unicesumar.
Anibal, P. C., Peixoto, I. T. A., Foglio, M. A., & Höfling, J. F. (2013). Antifungal activity of the ethanolic extracts of Punica granatum L. and evaluation of the morphological and structural modifications of its compounds upon the cells of Candida spp. Brazilian Journal of Microbiology, 44(3), 839–848. https://doi.org/10.1590/S1517-83822013005000060
Araújo, J. D. O., Bergamaschi, C. D. C., Lopes, L. C., Guimarães, C. C., De Andrade, N. K., Ramacciato, J. C., & Motta, R. H. L. (2021). Original research: Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review. BMJ Open, 11(1). https://doi.org/10.1136/BMJOPEN-2020-043363
Bassiri-Jahromi, S., Pourshafie, M., Ardakani, E. M., Ehsani, A. H., Doostkam, A., Katirae, F., & Mostafavi, E., (2018). In Vivo Comparative Evaluation of the Pomegranate (Punica granatum) Peel Extract as an Alternative Agent to Nystatin against Oral Candidiasis. Iranian Journal of Medical Sciences, 43(3), 296.
Bezerra, C. R. F., Borges, K. R. A., Alves, R. de N. S., Teles, A. M., Rodrigues, I. V. P., Da Silva, M. A. C. N., Nascimento, M. D. D. S. B., & De Barros Bezerra, G. F. (2020). Highly efficient antibiofilm and antifungal activity of green propolis against Candida species in dentistry materials. PloS One, 15(12). https://doi.org/10.1371/JOURNAL.PONE.0228828
Bhadoria, N., Gunwal, M. K., Suryawanshi, H., & Sonarkar, S. (2019). Antiadherence and antimicrobial property of herbal extracts ( Glycyrrhiza glabra and Terminalia chebula) on Streptococcus mutans: An in vitro experimental study. Journal of Oral and Maxillofacial Pathology : JOMFP, 23(1), 73–77. https://doi.org/10.4103/JOMFP.JOMFP_103_18
Bottega, F., Bussadori, S. K., Battisti, I. D. E., Vieira, E. P., Pompeo, T. S., & Winkelmann, E. R. (2018). Costs and benefits of Papacarie in pediatric dentistry: a randomized clinical trial. Scientific Reports, 8(1). https://doi.org/10.1038/S41598-018-36092-X
Braga, C. de M. (2011). Histórico da utilização de plantas medicinais. Universidade de Brasília e Universidade Estadual de Goiás.
Cordeiro, A. M., de Oliveira, G. M., Rentería, J. M., & Guimarães, C. A. (2007). Revisão sistemática: uma revisão narrativa. Revista Do Colégio Brasileiro de Cirurgiões, 34(6), 428–431. https://doi.org/10.1590/S0100-69912007000600012
da Silva, P. M., de Moura, M. C., Gomes, F. S., da Silva Trentin, D., Silva de Oliveira, A. P., de Mello, G. S. V., da Rocha Pitta, M. G., de Melo Rego, M. J. B., Coelho, L. C. B. B., Macedo, A. J., de Figueiredo, R. C. B. Q., Paiva, P. M. G., & Napoleão, T. H. (2018). PgTeL, the lectin found in Punica granatum juice, is an antifungal agent against Candida albicans and Candida krusei. International Journal of Biological Macromolecules, 108, 391–400. https://doi.org/10.1016/J.IJBIOMAC.2017.12.039
Dantas, L. P., de Oliveira-Ribeiro, A., de Almeida-Souza, L. M., & Groppo, F. C. (2017). Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction. Medicina Oral Patologia Oral y Cirugia Bucal, 22(1), e95–e101. https://doi.org/10.4317/medoral.21140
De Oliveira E Silva, A. M., Machado, I. D., Santin, J. R., De Melo, I. L. P., Pedrosa, G. V., Genovese, M. I., Farsky, S. H. P., & Mancini-Filho, J. (2015). Aqueous extract of Rosmarinus officinalis L. inhibits neutrophil influx and cytokine secretion. Phytotherapy Research, 29(1), 125–133. https://doi.org/10.1002/ptr.5238
de Oliveira, J. R., de Jesus, D., Figueira, L. W., de Oliveira, F. E., Pacheco Soares, C., Camargo, S. E. A., Jorge, A. O. C., & de Oliveira, L. D. (2017). Biological activities of Rosmarinus officinalis L. (rosemary) extract as analyzed in microorganisms and cells. Experimental Biology and Medicine, 242(6), 625–634. https://doi.org/10.1177/1535370216688571
de Sousa, T. J. D., Araujo, L. K. O., Filho, A. C. M. L., Gonçalves, C. A., Freitas, M. S., Ribeiro, M. R. G., de Lucena, J. E., Silva, A. B., Pereira, D. M. S., & Figueiredo, C. S. S. e S. (2021). O uso de plantas medicinais em infecções bucais: uma alternativa eficaz. Revista Eletrônica Acervo Saúde, 13(4), e6880. https://doi.org/10.25248/reas.e6880b.2021
Dovigo, Lívia N., Pavarina, A. C., Ribeiro, A. P. D., Brunetti, I. L., Costa, C. A. D. S., Jacomassi, D. P., Bagnato, V. S., & Kurachi, C. (2011). Investigation of the photodynamic effects of curcumin against Candida albicans. Photochemistry and Photobiology, 87(4), 895–903. https://doi.org/10.1111/J.1751-1097.2011.00937.X
Dovigo, Lívia Nordi, Carmello, J. C., De Souza Costa, C. A., Vergani, C. E., Brunetti, I. L., Bagnato, V. S., & Pavarina, A. C. (2013). Curcumin-mediated photodynamic inactivation of Candida albicans in a murine model of oral candidiasis. Medical Mycology, 51(3), 243–251. https://doi.org/10.3109/13693786.2012.714081
Duarte, C.-M.-E., Quirino, M.-R.-S., Patrocínio, M.-C., Anbinder, A.-L., Engenheiro, R., & Longo, F. J. (2011). Med Oral Patol Oral Cir Bucal. 16(6), 716–737. https://doi.org/10.4317/medoral.17029
Emami, F., Ali-Beig, H., Farahbakhsh, S., Mojabi, N., Rastegar-Moghadam, B., Arbabian, S., Kazemi, M., Tekieh, E., Golmanesh, L., Ranjbaran, M., Jalili, C., Noroozzadeh, A., & Sahraei, H. (2013). Hydroalcoholic extract of Rosemary (Rosmarinus officinalis L.) and its constituent carnosol inhibit formalin-induced pain and inflammation in mice. Pakistan Journal of Biological Sciences : PJBS, 16(7), 309–316. https://doi.org/10.3923/PJBS.2013.309.316
Enioutina, E. Y., Teng, L., Fateeva, T. V., Brown, J. C. S., Job, K. M., Bortnikova, V. V., Krepkova, L. V., Gubarev, M. I., & Sherwin, C. M. T. (2017). Phytotherapy as an alternative to conventional antimicrobials: combating microbial resistance. Expert Review of Clinical Pharmacology, 10(11), 1203–1214. https://doi.org/10.1080/17512433.2017.1371591
Farooq, S., Shaheen, G., Asif, H. M., Aslam, M. R., Zahid, R., Rajpoot, S. R., Jabbar, S., & Zafar, F. (2022). Preliminary Phytochemical Analysis: In-Vitro Comparative Evaluation of Anti-arthritic and Anti-inflammatory Potential of Some Traditionally Used Medicinal Plants. Dose-Response : A Publication of International Hormesis Society, 20(1). https://doi.org/10.1177/15593258211069720
Figueira, L. W., de Oliveira, J. R., Camargo, S. E. A., & de Oliveira, L. D. (2020). Curcuma longa L. (turmeric), Rosmarinus officinalis L. (rosemary), and Thymus vulgaris L. (thyme) extracts aid murine macrophages (RAW 264.7) to fight Streptococcus mutans during in vitro infection. Archives of Microbiology, 202(8), 2269–2277. https://doi.org/10.1007/S00203-020-01945-5
Ghorbani, A., Sadrzadeh, A., Habibi, E., Dadgar, K., Akbari, J., Moosazadeh, M., Bakhshi, H., Ahangarkani, F., & Vaezi, A. (2018). Efficacy of Camellia sinensis extract against Candida species in patients with denture stomatitis. Current Medical Mycology, 4(3), 15–18. https://doi.org/10.18502/CMM.4.3.174
Goes, P., Dutra, C. S., Lisboa, M. R. P., Gondim, D. V., Leitão, R., Brito, G. A. C., & Rego, R. O. (2016). Clinical efficacy of a 1% Matricaria chamomile L. mouthwash and 0.12% chlorhexidine for gingivitis control in patients undergoing orthodontic treatment with fixed appliances. Journal of Oral Science, 58(4), 569–574. https://doi.org/10.2334/JOSNUSD.16-0280
Gonçalves, Z. A., Macedo, M., Lima, E., Aranha, A. M. F., Pereira, I. C. L., & Lenza, J. B. (2014). Alternativas terapêuticas para tratamento de afecções bucais no idoso. 23(66), 130–134.
Jahangir, M. A., Anand, C., Muheem, A., Gilani, S. J., Taleuzzaman, M., Zafar, A., Jafar, M., Verma, S., & Barkat, M. A. (2020). Nano Phytomedicine Based Delivery System for CNS Disease. Current Drug Metabolism, 21(9), 661–673. https://doi.org/10.2174/1389200221666200523161003
Junior, Jonas Ildefonso.Monteiro, Á. B. (2020). Plantas Medicinais E Fitoterápicos Úteis Na Odontologia Clínica : Uma Revisão. 47–56.
Leite, K. L. de F., Martins, M. L., de Medeiros, M. M. D., Bezerra, N. V. F., Brito, C. S. de M., de Almeida, L. de F. D., & Cavalcanti, Y. W. (2020). Red propolis hydroalcoholic extract inhibits the formation of Candida albicans biofilms on denture surface. Journal of Clinical and Experimental Dentistry, 12(7), e626–e631. https://doi.org/10.4317/JCED.56843
Millar, B. C., Rao, J. R., & Moore, J. E. (2021). Fighting antimicrobial resistance (AMR): Chinese herbal medicine as a source of novel antimicrobials – an update. Letters in Applied Microbiology, 73(4), 400–407. https://doi.org/10.1111/LAM.13534
Minaiyan, M., Ghannadi, A. R., Afsharipour, M., & Mahzouni, P. (2011). Effects of extract and essential oil of Rosmarinus officinalis L. on TNBS-induced colitis in rats. Research in Pharmaceutical Sciences, 6(1), 13.
Moshrefi, A. (2002). Chlorhexidine. The Journal of the Western Society of Periodontology/Periodontal Abstracts, 50(1), 5–9.
Motta, L. J., Bussadori, S. K., Campanelli, A. P., Da Silva, A. L., Alfaya, T. A., De Godoy, C. H. L., & De Navarro, M. F. L. (2014). Efficacy of Papacarie® in reduction of residual bacteria in deciduous teeth: a randomized, controlled clinical trial. Clinics, 69(5), 319. https://doi.org/10.6061/CLINICS/2014(05)04
Najafi, S., Koujan, S. E., Manifar, S., Kharazifard, M. J., Kidi, S., Hajheidary, S., & Hajheidary, S. (2017). Preventive Effect of Glycyrrhiza Glabra Extract on Oral Mucositis in Patients Under Head and Neck Radiotherapy: A Randomized Clinical Trial. Journal of Dentistry (Tehran, Iran), 14(5), 267.
Nimma, V. L., Talla, H. V., Bairi, J. K., Gopaldas, M., Bathula, H., & Vangdoth, S. (2017). Holistic Healing Through Herbs: Effectiveness of Aloe Vera on Post Extraction Socket Healing. Journal of Clinical and Diagnostic Research : JCDR, 11(3), ZC83–ZC86. https://doi.org/10.7860/JCDR/2017/21331.9627
Oliveira, J. R. de, de Jesus Viegas, D., Martins, A. P. R., Carvalho, C. A. T., Soares, C. P., Camargo, S. E. A., Jorge, A. O. C., & de Oliveira, L. D. (2017). Thymus vulgaris L. extract has antimicrobial and anti-inflammatory effects in the absence of cytotoxicity and genotoxicity. Archives of Oral Biology, 82, 271–279. https://doi.org/10.1016/J.ARCHORALBIO.2017.06.031
Patil, K., Guledgud, M. V., Kulkarni, P. K., Keshari, D., & Tayal, S. (2015). Use of Curcumin Mouthrinse in Radio-Chemotherapy Induced Oral Mucositis Patients: A Pilot Study. Journal of Clinical and Diagnostic Research : JCDR, 9(8), ZC59. https://doi.org/10.7860/JCDR/2015/13034.6345
Pinheiro, M. L. P., Alcântara, C. E. P., De Moraes, M., & De Andrade, E. D. (2014). Valeriana officinalis L. for conscious sedation of patients submitted to impacted lower third molar surgery: A randomized, double-blind, placebo-controlled split-mouth study. Journal of Pharmacy & Bioallied Sciences, 6(2), 109–114. https://doi.org/10.4103/0975-7406.129176
Pulikottil, S., & Nath, S. (2015). Potential of clove of Syzygium aromaticum in development of a therapeutic agent for periodontal disease: A review. South African Dental Journal, 70(3), 108–115.
Rayati, F., Hajmanouchehri, F., & Najafi, E. (2017). Comparison of anti-inflammatory and analgesic effects of Ginger powder and Ibuprofen in postsurgical pain model: A randomized, double-blind, case–control clinical trial. Dental Research Journal, 14(1), 1. https://doi.org/10.4103/1735-3327.201135
Sahebkar, A., Saboni, N., Pirro, M., & Banach, M. (2017). Curcumin: An effective adjunct in patients with statin-associated muscle symptoms? Journal of Cachexia, Sarcopenia and Muscle, 8(1), 19–24. https://doi.org/10.1002/JCSM.12140
Saira Siraj, E., Pushpanjali, K., & Manoranjitha, B. S. (2019). Efficacy of stevioside sweetener on pH of plaque among young adults. Dental Research Journal, 16(2), 104. https://doi.org/10.4103/1735-3327.250966
Seyyedi, S. A., Sanatkhani, M., Pakfetrat, A., & Olyaee, P. (2014). The therapeutic effects of chamomilla tincture mouthwash on oral aphthae: A Randomized Clinical Trial. Journal of Clinical and Experimental Dentistry, 6(5), e535–e538. https://doi.org/10.4317/JCED.51472
Shahakbari, R., Eshghpour, M., Rajaei, A., Rezaei, N. M., Golfakhrabadi, P., & Nejat, A. (2014). Effectiveness of green tea mouthwash in comparison to chlorhexidine mouthwash in patients with acute pericoronitis: a randomized clinical trial. International Journal of Oral and Maxillofacial Surgery, 43(11), 1394–1398. https://doi.org/10.1016/J.IJOM.2014.05.017
Sharma, A., Chawla, R., Kaur, J., & Madaan, R. (2021). An Overview of Phytotherapy Used in the Management of Type II Diabetes. Current Diabetes Reviews, 17. https://doi.org/10.2174/1573399817666210617154535
Sidhu, P., Shankargouda, S., Rath, A., Hesarghatta Ramamurthy, P., Fernandes, B., & Kumar Singh, A. (2020). Therapeutic benefits of liquorice in dentistry. Journal of Ayurveda and Integrative Medicine, 11(1), 82–88. https://doi.org/10.1016/J.JAIM.2017.12.004
Siomara da Cruz Monteiro, C. L. C. B. (2017). Farmacobotânica: aspectos teóricos e aplicação.
Soldatelli, M. V., Ruschel, K., Maria, T., Isolan, P., Maria, T., & Isolan, P. (2010). Para O Controle Da Ansiedade Odontológica ? 16, 89–97.
Takanche, J. S., Lee, Y. H., Kim, J. S., Kim, J. E., Han, S. H., Lee, S. W., & Yi, H. K. (2018). Anti-inflammatory and antioxidant properties of Schisandrin C promote mitochondrial biogenesis in human dental pulp cells. International Endodontic Journal, 51(4), 438–447. https://doi.org/10.1111/IEJ.12861
Tasneem, S., Liu, B., Li, B., Choudhary, M. I., & Wang, W. (2019). Molecular pharmacology of inflammation: Medicinal plants as anti-inflammatory agents. Pharmacological Research, 139, 126–140. https://doi.org/10.1016/J.PHRS.2018.11.001
Valera, M. C., Da Rosa, J. A., Maekawa, L. E., De Oliveira, L. D., Carvalho, C. A. T., Koga-Ito, C. Y., & Jorge, A. O. C. (2010). Action of propolis and medications against Escherichia coli and endotoxin in root canals. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 110(4). https://doi.org/10.1016/J.TRIPLEO.2010.01.029
Veloso, D. J., Abrão, F., Martins, C. H. G., Bronzato, J. D., Gomes, B. P. F. A., Higino, J. S., & Sampaio, F. C. (2020). Potential antibacterial and anti-halitosis activity of medicinal plants against oral bacteria. Archives of Oral Biology, 110, 104585. https://doi.org/10.1016/j.archoralbio.2019.104585
W Figueira, L., De Oliveira, J. R., Netto, A. A. L., S Zamarioli, L. Dos, Marcucci, M. C., Camargo, S. E. A., & De Oliveira, L. D. (2020). Curcuma longa L. helps macrophages to control opportunistic micro-organisms during host-microbe interactions. Future Microbiology, 15(13), 1237–1248. https://doi.org/10.2217/fmb-2019-0297
Zhao, L., Chen, X., Shao, X., Wang, Z., Du, Y., Zhu, C., Du, W., Tang, D., & Ji, S. (2022). Prenylated phenolic compounds from licorice ( Glycyrrhiza uralensis) and their anti-inflammatory activity against osteoarthritis. Food & Function, 13(2), 795–805. https://doi.org/10.1039/D1FO03659A
Zulhendri, F., Felitti, R., Fearnley, J., & Ravalia, M. (2021). The use of propolis in dentistry, oral health, and medicine: A review. Journal of Oral Biosciences, 63(1), 23–34. https://doi.org/10.1016/J.JOB.2021.01.001
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Vanessa Marques Meccatti; Maria Cristina Marcucci Ribeiro; Luciane Dias de Oliveira
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
