Effects of short term acidogenic diet feeding on metabolic parameters of dairy cows with induced subclinical hypocalcemia
DOI:
https://doi.org/10.33448/rsd-v11i4.27081Keywords:
Acidosis; Calcium; Prepartum.Abstract
The objective of was to evaluate whether the provision of an acidogenic diet in late gestation influences the metabolism of cows with experimentally induced subclinical hypocalcemia. Nine multiparous Holstein cows were divided into 3 groups according to the duration of supply of the acidogenic diet: G0 = without acidogenic diet; G9 = nine days and G15 = fifteen days. All animals underwent an experimental induction of subclinical hypocalcemia for 6 hours, performed after the last day of feeding with the diet. Urine samples were collected weekly to evaluate the effectiveness of the diet and blood samples were collected performed one day (-1) and immediately (0) before the induction, every hour until 6 h after the induction and at the end of 72 hours for the evaluation of metabolic parameters. During INDUCTION, G15 had the lowest concentration of CaT, globulins, TP, HCO¬¬ 3, pCO2, K and the highest concentration of creatinine (P < 0.05); G9 and G15 had the lowest concentration of iCa and higher concentration of Mg (P <0.05). In the POST-INDUCTION period, G15 again had the lowest concentration of globulins, TP, HCO¬- 3 and lowest serum pH, in addition to having the highest concentration of creatinine, glucose, and Na (P <0.05). G9 and G15 had the lowest CaT and K concentration and the highest Mg (P < 0.05) in that period. Provision of 15 days of an acidogenic diet to cows with induced hypocalcemia modulated other parameters besides calcium, demonstrated may not be suitable for animals.
References
Albornoz, L., Albornoz, J. P., Morales, M. & Fidalgo, L. E. (2016). Hipocalcemia Puerperal Bovina. Revisión. Veterinaria (Montevideo) 52, 28–38.
Boudon, A., Johan, M., Narcy, A., Boutinaud, M., Lamberton, P. & Hurtaud, C. (2016). Dietary cation-anion difference and day length have an effect on milk calcium content and bone accretion of dairy cows. Journal of Dairy Science 99, 1527–1538. https://doi.org/10.3168/jds.2015-9664
Campion, K. L., McCormick, W. D., Warwicker, J., Khayat, M. E. B., Atkinson-Dell, R., Steward, M. C., Delbridge, L. W., Mun, H. -C., Conigrave, A. D. & Ward, D. T. (2015). Pathophysiologic Changes in Extracellular pH Modulate Parathyroid Calcium-Sensing Receptor Activity and Secretion via a Histidine-Independent Mechanism. JASN 26, 2163–2171. https://doi.org/10.1681/ASN.2014070653
F. C. Cardoso, K. F. Kalscheur & J. K. Drackley. (2020) Symposium review: Nutrition strategies for improved health, production, and fertility during the transition period, Journal of Dairy Science, 103(6), 5684-5693, https://doi.org/10.3168/jds.2019-17271.
Desmecht, D. J-M, Linden, A. S. & Lekeux, P. M. (1996). Ruminal cardiorespiratory and adrenocortical sequelae of Na2EDTA-induced hypocalcaemia in calves. Veterinary Research Communications 47–60.
Dirksen, D., Gründer, H. D. & Stöber, M. (1993). Rosenberger: Exame Clínico dos Bovinos, (3a ed.), ed. Guanabara Koogang S.A.
Feijó, J., Pereira, R. A., Montagner, P., Del Pino, F. A. B., Schmitt, E. & Corrêa, M. N. (2017). Dynamics of acute phase proteins in dairy cows with subclinical hypocalcemia. Can. J. Anim. Sci. CJAS-2016-0184. https://doi.org/10.1139/CJAS-2016-0184
Feijó, J., Londero, U. S., Pizoni, C., Alvarado-Rincón, J., Barbosa, A. A., Schmitt, E., Pereira, R. A., Del Pino, F. A. & Corrêa, M. N. (2021). Hemogasometric and biochemical changes caused by diets with high negative cation-anion balance in dairy cows. Ciência Animal Brasileira, 22, e-67426. https://doi.org/10.1590/1809-6891v22e-67426.
Fernandez, R., Giebisch, G. & Geibel, J. P. (2005). Intracellular Ca2+ modulates H+ ATPase activity in intercalated cells from mouse cortl collecting duct (CCD). FASEB Journal 139.
Goff, J. P. (2014). Calcium and Magnesium Disorders. Veterinary Clinics of North America: Food Animal Practice 30, 359–381. https://doi.org/10.1016/j.cvfa.2014.04.003
Goff, J. P., Liesegang, A. & Horst, R. L. (2014). Diet-induced pseudohypoparathyroidism: A hypocalcemia and milk fever risk factor. Journal of Dairy Science 97, 1520–1528. https://doi.org/10.3168/jds.2013-7467
Heron, V. S., Tremblay, G. F. & Oba, M. (2009). Timothy hays differing in dietary cation–anion difference affect the capability of dairy cows to maintain their calcium homeostasis. Journal of Dairy Science 238–246.
Kaneko, J. J, Harvey, J. W & Bruss, M. L. (2008). Clinical biochemistry of domestic animals, (6a ed.), ed. Academic Press, San Diego.
Kimura, K., Reinhardt, T. A. & Goff, J. P. (2006). Parturition and Hypocalcemia Blunts Calcium Signals in Immune Cells of Dairy Cattle. Journal of Dairy Science 89, 2588–2595. https://doi.org/10.3168/jds.S0022-0302(06)72335-9
Lecker, S. H., Goldberg, A. L. & Mitch, W. E. (2006). Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. Journal of the American Society of Nephrology 1807–1819.
Lopera, C., Zimpel, R., Vieira-Neto, A., Lopes, F. R., Ortiz, W., Poindexter, M., Faria, B. N., Gambarini, M. L., Block, E., Nelson, C. D. & Santos, J. E. P. (2018). Effects of level of dietary cation-anion difference and duration of prepartum feeding on performance and metabolism of dairy cows. Journal of Dairy Science 101, 7907–7929. https://doi.org/10.3168/jds.2018-14580
Martinez, N., Risco, C. A., Lima, F. S., Bisinotto, R. S., Greco, L. F., Ribeiro, E. S., Maunsell, F., Galvão, K. & Santos, J. E. P. (2012). Evaluation of peripartal calcium status, energetic profile, and neutrophil function in dairy cows at low or high risk of developing uterine disease. Journal of Dairy Science 95, 7158–7172. https://doi.org/10.3168/jds.2012-5812
Martinez, N., Sinedino, L. D. P., Bisinotto, R. S., Daetz, R., Lopera, C., Risco, C. A., Galvão, K. N., Thatcher, W. W. & Santos, J. E. P. (2016). Effects of oral calcium supplementation on mineral and acid-base status, energy metabolites, and health of postpartum dairy cows. Journal of Dairy Science 99, 8397–8416. https://doi.org/10.3168/jds.2015-10527
Martinez, N., Sinedino, L. D. P., Bisinotto, R. S., Ribeiro, E. S., Gomes, G. C., Lima, F. S., Greco, L. F., Risco, C. A., Galvão, K. N., Taylor-Rodriguez, D., Driver, J. P., Thatcher, W. W. & Santos, J. E. P. (2014). Effect of induced subclinical hypocalcemia on physiological responses and neutrophil function in dairy cows. Journal of Dairy Science 97, 874–887. https://doi.org/10.3168/jds.2013-7408
Melendez, P., Bartolome, J. & Soto, B. (2019). Association of prepartum urine pH and postpartum disorders in Holstein cows fed anionic diets. Journal of Dairy Science, (Suplem 1) 102, 472.
Mellau, L. S. B., Jørgensen, R. J. & Enemark, J. M. D. (2001). Plasma Calcium, Inorganic Phosphate and Magnesium During Hypocalcaemia Induced by a Standardized EDTA Infusion in Cows. Acta Vet Scand, 42, 10.
Oetzel, G. R. (2013). Oral Calcium Supplementation in Peripartum Dairy Cows. Veterinary Clinics of North America: Food Animal Practice 29, 447–455. https://doi.org/10.1016/j.cvfa.2013.03.006
Reinhardt, T. A., Horst, R. L. & Goff, J. P. (1988). Calcium, phosphorus, and magnesium homeostasis in ruminants. Veterinary Clinics of North America: Food Animal Practice 331–350.
Santos, J. E. P. (2011). Distúrbios metabólicos, in: BERCHIELLI T.T., Pires A.V. & Oliveira S.G. (Eds), Nutrição de Ruminantes. Funep, Jaboticabal, pp. 459–472.
Santos, J. E. P., Lean, I. J., Golder, H. & Block, E. (2019). Meta-analysis of the effects of prepartum dietary cation-anion difference on performance and health of dairy cows. Journal of Dairy Science 102, 2134–2154. https://doi.org/10.3168/jds.2018-14628
Spanghero, M. (2004). Prediction of urinary and blood pH in non-lactating dairy cows fed anionic diets. Animal Feed Science and Technology 116, 83–92. https://doi.org/10.1016/j.anifeedsci.2004.04.002
Vagnoni, D. B. & Oetzel, G. R. (1998). Effects of Dietary Cation-Anion Difference on the Acid-Base Status of Dry Cows. Journal of Dairy Science 81, 1643–1652. https://doi.org/10.3168/jds.S0022-0302(98)75732-7
Vieira-Neto, A., Leao, I. M. R., Prim, J. G., Zimpel, R., Almeida, K. V., Nehme, M. M., Bollatti, J., Silva, A. C. M., Revilla-Ruiz, A., Nelson, C. D. & Santos, J. E. P. (2019). Effect of duration of exposure to diets differing in DCAD on calcium metabolism after a parathyroid hormone challenge in dairy cows. Journal of Dairy Science (Abstr) 472.
Weich, W., Block, E. & Litherland, N. B. (2013). Extended negative dietary cation-anion difference feeding does not negatively affect postpartum performance of multiparous dairy cows. Journal of Dairy Science 96, 5780–5792. https://doi.org/10.3168/jds.2012-6479
Zimpel, R., Poindexter, M. B., Vieira-Neto, A., Block, E., Nelson, C. D., Staples, C. R., Thatcher, W. W. & Santos, J. E. P. (2018). Effect of dietary cation-anion difference on acid-base status and dry matter intake in dry pregnant cows. Journal of Dairy Science 101, 8461–8475. https://doi.org/10.3168/jds.2018-14748
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Copyright (c) 2022 Camila Pizoni; Antônio Amaral Barbosa; Kauani Borges Cardoso; Bruna Velasquez; Karen Cruz Freitas; Eduardo Gulart Xavier; Fabiane Pereira de Moraes; Francisco Del Pino; Viviane Rabassa ; Josiane Feijó; Eduardo Schmitt; Cássio Brauner; Marcio Nunes Corrêa
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