Ear damage caused by Cryptococcus spp. in guinea pigs: case report
DOI:
https://doi.org/10.33448/rsd-v11i4.27293Keywords:
Cryptococcosis; Cavia porcellus; Diagnosis; Treatment.Abstract
Cryptococcus spp affects mainly dogs and cats, however, there are reports in other animal species, such as guinea pigs. The objective of this study is to report a case of a lesion by cryptococcosis in a guinea pig's auricles. The animal had firm nodules under the touch in both auricles, being one of them with a granulomatous aspect, both ulcerated, with serosanguineous secretion, pain, and associated itching. For the diagnosis, a biopsy was performed for histopathological examination and after a result suggestive of fungal dermatitis by Cryptococcus spp., treatment with itraconazole and adjuvant therapy with Echinacea angustifolia 6CH and Carduus marianus 6CH was initiated, which demonstrated to be effective. Furthermore, we suggest the inclusion of cryptococcosis as a differential diagnosis in cases of auricular lesions in this species.
References
Betty, M. J. (1977). Spontaneous cryptococcal meningitis in a group of guinea pigs caused by a hyphae-producing strain. Journal of Comparative Pathology, 87(3), 377-382. https://doi.org/10.1016/0021-9975(77)90027-5.
Brandes, K., Stierstorfer, B., Werckenthin, C. & Hermanns, W. (2003). Generalisierte spontane Kryptokokkose bei einem Meerschweinchen. Schattauer GmbH Tierärztl Prax, 31(K), 377-382. http://dx.doi.org/10.1055/s-0037-1622374.
Carvalho, S. P.; Paula, I. H. & Kanayama, C. Y. (2017). Criptococose em Cavia porcellus (Porquinho da índia)- Relato de caso. In Congresso MEDVEP Internacional de Especialidades Veterinárias (pp. 131-133). MEDVEP.
Diamond, R. D. (1977). Effects of Stimulation and Suppression of Cell-Mediated Immunity on Experimental Cryptococcosis. Infection and Immunity, 17(1), 187-194. https://doi.org/10.1128/iai.17.1.187-194.1977.
Ecco, R., Langohr, I. M., Schossler, J. E. W., Barros, S. S. & Barros, C. S. L. (2000). Leishmaniose cutânea em cobaias (Cavia porcellus). Ciência Rural, 30(3), 525-528. https://doi.org/10.1590/S0103-84782000000300027.
Fernandes, S. P. C. (2020). Criptococose em Cavia porcellus (porquinho da índia): Relato de Caso. In F. C. Barbosa, Medicina Veterinária: princípios fundamentais (1st ed, pp. 163-171). Conhecimento Livre. https://doi.org/10.37423/201003128.
Honsho, C. S., Mine, S. Y., Oriá, A. P., Benato, N., Camacho, A. A., Alessi, A. C. & Laus, J. L. (2003). Generalized systemic cryptococcosis in a dog after immunosuppressive corticotherapy. Arquivo Brasileiro de Medicina Veteterinária e Zootecnia; 55(2), 155-159. https://doi.org/10.1590/S0102-09352003000200005.
Jungerman, P. F. & Schwartzman, R. M. (1972). Veterinary Medical Mycology (1st ed.). Lea & Febiger.
Kirkpatrick, W. R., Najvar, L. K., Bocanegra, R., Patterson, T. F. & Graybill, J. R. (2007). New Guinea Pig Model of Cryptococcal Meningitis. Antimicrobial Agents and Chemotherapy, 51(8), 3011–3013. https://doi.org/10.1128/AAC.00085-07.
Lima, I. H. (2018). Infecção natural por Cryptococcus gattii em porquinho-da índia (Cavia porcellus): relato de caso [Monography, Federal University of Mato Grosso]. Federal University of Mato Grosso. http://bdm.ufmt.br/handle/1/1550.
Malik, R., Dill-Macky, E., Martin, P., Wigney, D. I., Muirs, D. B. & Love, D. N. (1995). Cryptococcosis in dogs: a retrospective study of 20 consecutive cases. Journal of Medical & Veterinary Mycology, v. 33(5), 291-7. https://doi.org/10.1080/02681219580000601.
Malik, R. & Sykes, J. E. (2014). Crytococcosis. In S. Jane. Canine and Feline Infectious Disease (1st ed., pp. 599-612) St Louis: Elsevier.
Maziarz, E. K. & Perfect, J. R. (2016). Cryptococcosis. Infectious Disease Clinics of North America, 30(1), 179–206. https://doi.org/10.1016/j.idc.2015.10.006.
Paranaiba, L. F., Pinheiro, L. J., Macedo, D. H., Menezes-Neto, A., Torrecilhas, A. C., Tafuri, W. L. & Soares, R. P. (2018). An overview on Leishmania (Mundinia) enriettii: biology, immunopathology, LRV and extracellular vesicles during the host–parasite interaction. Parasitology, 145(10), 1265-1273. https://doi.org/10.1017/S0031182017001810.
Pastor, F. M., Dastre, M., Guimarães, G. H., Notário, F. O., Silva, G. M. F. & Medeiros-Ronchi, A. A. (2021, July 26-30). Criptococose palpebral em porquinho-da-índia (Cavia porcellus): Relato de caso [Poster presentation]. 6º Congresso Brasileiro de Patologia Veterinária, Uberlândia, Brasil.
Pennisi, M. G., Hartmann, K., Lloret, A., Ferrer, L., Addie, D., Belák, S., Boucraut-Baralon, C., Egberink, H., Frymus, T., Gruffydd-Jones, T., Hosie, M. J., Lutz, H., Marsilio, F., Möstl, K., Radford, A. D., Thiry, E., Truyen, U. & Horzinek, M. C. (2013). Cryptococcosis in Cats: ABCD guidelines on prevention and management. Journal of Feline Medicine and Surgery, 15(7), 611-618. https://doi.org/10.1177/1098612X13489224.
Ponzio, V. & Chen, Y. (2019). Genotypic diversity and clinical outcome of cryptococcosis in renal transplant recipients in Brazil. Emerging Microbes & Infections, 8(1), 119–129. https://doi.org/10.1080/22221751.2018.1562849.
Rambaldi, A., Jacobs, B. P., Laquinto, G. & Gluud, C. (2005). Milk thistle for alcoholic and/or hepatitis B or C liver diseases – a systematic Cochrane Hepato-Biliary Group Review with metaanalyses of randomized clinical trials. American Journal of Gastroenterology, 100(11), 2583–2591. https://doi.org/10.1111/j.1572-0241.2005.00262.x.
Riera, C. M., Masih, D. T. & Nobile, R. (1983). Experimental cryptococcosis in guinea pigs. Mycopathologia, 82(3), 179-184. https://doi.org/10.1007/BF00439224.
Shourian, M. & Qureshi, S. T. (2019). Resistance and tolerance to cryptococcal infection: an intricate balance that controls the development of disease. Frontiers in Immunology, 10(66), 1-11. http://dx.doi.org/10.3389/fimmu.2019.00066.
Souza, C. O., Peracoli, M. T., Weel, I. C., Bannwart, C. F., Romão, M., Nakaira‐Takahagi, E., Medeiros, L. T. L., Silva, M. G. & Peraçoli, J. C. (2012). Hepatoprotective and anti‐inflammatory effects of silibinin on experimental preeclampsia induced by L‐NAME in rats. Life Science, 91(5-6), 159–165. https://doi.org/10.1016/j.lfs.2012.06.036.
Thomaz-Soccol, V., Pratlong, F., Langue, R., Castro, E., Luz, E. & Dedet, J. P. (1996). New isolation of Leishmania enriettii Muniz and Medina, 1948 in Parana State, Brazil, 50 years after the first description, and isoenzymatic polymorphism of the L. enriettii taxon. Annals of Tropical Medicine & Parasitology, 90(5), 491-495. https://doi.org/10.1080/00034983.1996.11813074.
Van Cutsem, J., Van Gerven, F. & Janssen, P. A. J. (1987). Activity of orally, topically, and parenterally administered itraconazole in the treatment of superficial and deep mycoses: animal models. Reviews of Infectious Disease, 9(1), 15-32. https://doi.org/10.1093/clinids/9.supplement_1.s15.
Van Herck, H., Van Den Ingh, TH. S. G. A. M., Van Der Hage, M. H. & Zwart, P. (1988). Dermal cryptococcosis in a guinea pig. Laboratory Animals, 22(1), 88-91. https://doi.org/10.1258/002367788780746494.
Vercelli, C., Peano, A., Piovano, G., Corona, A., Gambino, G. & Re, G. (2021). Diagnostic and therapeutic management of Cryptococcosis in a kitten with practical considerations to veterinary pediatric therapeutic approach. Medical Mycology Case Reports, 32(1), 61-63. https://doi.org/10.1016/j.mmcr.2021.04.001.
Yehia, B. R. & Eberlein, M. (2009). Disseminated cryptococcosis with meningitis, peritonitis, and cryptococcemia in a HIV-negative patient with cirrhosis: A case report. Cases Journal, 2(170), 1-4. https://doi.org/10.1186/1757-1626-2-170.
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