Evaluation of low-intensity laser photobiomodulation in the treatment of traumatic oral ulcer: na integrative literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i4.27325

Keywords:

Oral Ulcers; Low-Level Light Therapy; Wound healing; Lasers; Mouth.

Abstract

Traumatic ulcers are one of the most common injuries in the dental clinic and are caused by several factors, such as: occlusion trauma, poorly adapted prostheses, orthodontic appliances, among others. The present study sought to evaluate the photobiomodulatory effect of low-level laser in the treatment of traumatic oral ulcers through a qualitative, exploratory and descriptive literature review. Data collection was carried out in the Scielo, PubMed and BVS databases, and the descriptors chosen for the search were: Oral Ulcers, Low-Intensity Light Therapy, Lasers, Healing and Mouth. Studies between 2011 and 2021 written in English or Portuguese, published in indexed or unindexed journals, with full availability were selected. The selection of the corresponding works judiciously followed the sequence of reading the titles, abstracts and full reading of the articles. In Excel software, tables were built with the studies included in this review, including data regarding the type of study, published journal, database, language, author, year of publication, study objective, treatments used, sample, study groups, euthanasia time and laser parameters. At the end of the search, 13 clinical trials were selected. Totaling 654 samples of clinical results and their studied articles. It is concluded that low-level laser therapy proved to be an alternative capable of inducing photobiomodulation of traumatic oral ulcers.

References

Andisheh-Tadbir, A., Yaghoubi, A., Tanideh, N. & Mardani, M. (2020). The effect of indocyanine green-mediated photodynamic therapy in healing of experimentally induced oral mucosal traumatic ulcer in rat. Lasers in Medical Science, 36 (3), 611-618.

Arany, P. R (2016). Craniofacial Wound Healing with Photobiomodulation Therapy. Journal of Dental Research, New York, 95 (9), 977–984.

Assis, V. K., Cardoso, F. L. & Silva, B. P (2019). Aplicabilidade da laserterapia no cenário odontológico: uma terapêutica em ascensão-revisão de literatura. IV Jornada de iniciação científica, Manhuaçu, 5, 1-6.

Avci, P., Gupta , A., Sadasivam, M., Vecchio, D. & Pam, Z. (2013). Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. Semin Cutan Med Surg, 32 (1), 41–52.

Baart, J. A & Van Der Waal, I (2013). Oral medicine 6. Ulcerations of the oral mucosa. Ned Tijdschr Tandheelkd, 120 (5), 246-9.

Bainbridge, P. (2013). Wound healing and the role of fibroblasts. Journal of Wound Care, 22 (8), 407–412.

Barris, B. F., Costa, C. M., Mattos, G. M., Corrêa, N. de C. & Casanovas, R. C (2021). Use of low power laser in the treatment of oral injuries in patients with neurological diseases: Case report. Research, Society and Development. 10 (6), p. e47110616083.

Belenguer-Guallar, I., Jiménez-Soriano, Y. & Claramunt-Lozano, A. (2014). Treatment of recurrent aphthous stomatitis. A literature review. J Clin Exp Dent., Valencia, 6 (2), 168-74.

Biasoli, E. R., Myahara, G. I., Bernabé, D. G., Furuse, C. F. & Tjioe, K. C. (2015). Roteiro de aula da disciplina de estomatologia. Faculdade Estadual Paulista, 1º edição, 98.

Bordin-Aykroyd, S, Dias, R. B & Lynch, E. (2019). Laser-Tissue Interaction. EC Dental Science, São Paulo, p.2303-08.

Bruce, A. J., Dabade, T.S. & Burkemper, N.M. (2015). Diagnosing oral ulcers. Journal of the American Academy of Physician Assistants, Boston, 28 (2), 1-10.

Cavalcanti, T. M., Alameida-Barros, R. Q. de, Catão, M. H. C. de V., Feitosa, A. P. A. & Lins, R. D. A. U. (2011). Conhecimento das propriedades físicas e da interação do laser com os tecidos biológicos na odontologia. Anais Brasileiros de Dermatologia, Campina Grande, 86 (5), 955–60.

Calazans, T. A, De Campos, P. H., Melo, A. V. G., Oliveira, AVA, Amaral, S. F. et al. (2020). Protocol for Low-level laser therapy in traumatic ulcer after troncular anesthesia: Case report in pediatric dentistry. J Clin Exp Dent., São Paulo,12 (2), 201–203.

Chaves, M. E. de A., Araújo, A. R. de, Piancastelli, A. C. C., & Pinotti, M. (2014). Effects of low-power light therapy on wound healing: LASER x LED. Anais Brasileiros de Dermatologia, Belo Horizonte, 89 (4), 616–623.

Choi, S. C., Park, J. H., Choi, Y. C & Kim, G. (2009). Sublingual traumatic ulceration (a Riga-Fede disease): report of two cases. Dent Traumatol, Seul, 25(3),48-50.

Chung, T. Y., Peplow, P. V., & Baxter, G. D. (2010). Laser Photobiomodulation of Wound Healing in Diabetic and Non-Diabetic Mice: Effects in Splinted and Unsplinted Wounds. Photomedicine and Laser Surgery, 28 (2), 251–261.

Curi, M. M, Costa, B. E, Zardetto, C., Koga, D. H. & Moreira, R. (2017). Lesão traumática severa em paciente internado em ITU. Salusvita, Bauru, 36(3), 725-735.

Da Silva, D.C, De Freitas, P. M., Calvo, A. N. B., Gimenez, T. & Zanola, M. (2017). Tratamento de lesão de Riga-Fede com laserterapia: relato de caso clínico. Rev Gaúch. Odontol., São Paulo, 65(1).

Da Silva, E. A., Santana, J. F., Castro, L. C., Flores, K. A., Mundim- Picoli, M. B. & Gomes, C. C (2019). Laserterapia no tratamento de ulcerações aftosas recorrentes: relato de caso-clínico. Anais da Jornada Odontológica de Anápolis - JOA. 214- 217.

De Carvalho, N. M. (2010). Laser aplicações na odontologia. Rev. ABO Nac., (104 ed.), 18 (5), 271.

De Carvalho, F. B., Andrade, A. S., Rasquin, L. C., De Castro, I. V. & Cangussu, M.C. (2015). Effect of laser (λ 660 nm) and LED (λ 630 nm) photobiomodulation on formocresol-induced oral ulcers: a clinical and histological study on rodents. Lasers in Medical Science, Salvador, 30(1), 389–96.

Dederich, D. N. (1991). Laser/tissue interaction. Alpha Omegan. 84 (4), 33-6.

De Farias Gabriel, A., Wagner, V. P., Correa, C., Webber, L. P. & Pilar, E. F. (2019). Photobiomodulation therapy modulates epigenetic events and NF-κB expression in oral epithelial wound healing. Lasers in Medical Science. 34 (7), 1465-72.

De Moraes, J. M., Mendonça, D.E.O., Moura, V.B.L., Oliveira, M. A. P. & Afonso, C. L. (2012). Anti-inflammatory effect of low-intensity laser on the healing of third-degree burn wounds in rats. Lasers in Medical Science, 28(4), p.1169–76.

De Lima, A. A. S & De Araújo, M. R. (2019). Terapêutica aplicada à Odontologia: Manejo farmacológico de lesões ulceradas bucais. Acervo digital da UFPR, Paraná, 3.

De Melo, L. A. S. (2019). Controle de Qualidade físico-químico e efeito cicatrizante de uma pomada orabase de extrato de Libidibia ferrea L. para tratamento de úlceras da cavidade bucal. Biblioteca Digital de Teses e Dissertações, Manuas, 21.

De Sousa, R. G. & Batista, K. de N. M. Laser therapy in wound healing associated with diabetes mellitus - Review. Anais Brasileiros de Dermatologia, Belém, 91(4), 489–493.

De Sousa, A. C. T., Da Rocha, Í. B. P., De Carvalho, A. F. M., De Freitas Coelho, N. P. M. & Feitosa, M. C. P (2018). Comparative Study Between Low Level Laser and Therapeutic Ultrasound in Second Intention Ulcers Repair in Mice. Journal of Lasers in Medical Sciences, 9 (2), 134–8.

De Sousa, A. P. C., Santos, J. N., Dos Reis, J. A., Ramos, T. A. & De Souza, J. (2010). Effect of LED Phototherapy of Three Distinct Wavelengths on Fibroblasts on Wound Healing: A Histological Study in a Rodent Model. Photomedicine and Laser Surgery, 28 (4), p. 547–552.

Deyhimi, P., Khademi, H., Birang, R & Akhoondzade, M. (2016). Histological Evaluation of Wound Healing Process after Photodynamic Therapy of Rat Oral Mucosal Ulcer, J Dent (Shiraz), Isfahan, 17 (1), 43–48.

Delgado, G. K., Mendes, P. C., Sampaio, G. B., Cavalcante, F. D. & Anjos, A. A (2019). Doença de riga-fede em bebê: relato de caso. Revista ACBO, Maceió, 8(1), 16-19.

Dompe, C., Moncrieff, L., Matys, J., Grzech-Lesniak, K. & Kocherova, I. (2020). Photobiomodulation—Underlying Mechanism and Clinical Applications. Journal of Clinical Medicine, Poznań, 9 (6), 1724.

Domene, C., Jorgensen, C. & Abbasi, S.W. (2016). A perspective on structural and computational work on collagen. Physical Chemistry Chemical Physics, London, 18 (36), p. 24802–11.

Donoso-Martínez, F. A, Bizcar, B., Sandoval, C. & Sandoval-Vidal, P. (2018). Application of Low Power Laser in Pediatric Patients: Review of the Literature in a Series of Cases. Int. J. Odontostomat, Temuco,12 (3).

Erdemli, M. E., Ekhteiari Salmas, R.; Durdagi, S., Akagul, H. & Demirkol, M. (2017). Biochemical changes induced by grape seed extract and low level laser therapy administration during intraoral wound healing in rat liver: an experimental and in silico study. Journal of Biomolecular Structure and Dynamics, Nigde, 36(4), 993–1008.

Escudero, J. S. B., Perez, M. G. B., De Oliveira Rosso, M. P., Buchaim, D. V. & Pomini, K. T. (2019). Photobiomodulation therapy (PBMT) in bone repair: A systematic review. Injury, Bauru, p.23-58.

Faruk, E. M., Nafea, O. E., Fouad, H., Ebrahim, U. F. A. & Hasan, R. A. A. (2020). Possible healing effects of Salvadora persica extract (MISWAK) and laser therapy in a rabbit model of a caustic-induced tongue ulcers: histological, immunohistochemical and biochemical study. J Mol Histol, Benha, 51(4),341-352.

Fahimipour, F., Housahmand, B., Alemi, P., Asnaashari, M. & Tafti, M. A. (2016). The effect of He–Ne and Ga–Al–As lasers on the healing of oral mucosa in diabetic mice. Journal of Photochemistry and Photobiology B: Biology, Tehran, 159, 149–154.

Fekrazad, R., Mirmoezzi, A., Kalhori, K. A. & Arany, P. (2015). The effect of red, green and blue lasers on healing of oral wounds in diabetic rats. Journal of Photochemistry and Photobiology B: Biology, Tehran, 148, 242–5.

Felix, D. H., Luker, J. & Scully, C. (2012). Oral medicine: 2. ulcers: serious ulcers. Dental Update, London, 3(8), 594–8.

Freitas, A. O., Alves, A. P. N. Silva, P. G. B., De Oliveira, C. C. & Ferreira Junior, A. E. (2014). Composto Antibiótico acelera cicatrização de úlceras traumáticas orais em ratos. Anais - XVII CIOBA, Salvador, p. 152.

Firat, E. T., Dag, A., Gunay, A., Kaya, B. & Karadede, M. İ. (2013). The Effects of Low-Level Laser Therapy on Palatal Mucoperiosteal Wound Healing and Oxidative Stress Status in Experimental Diabetic Rats. Photomedicine and Laser Surgery, Diyarbakir, 31 (7), 315–321.

Fitzpatrick, S. G. (2019). Ulcerated Lesions of the Oral Mucosa: Clinical and Histologic Review. Head Neck Pathol., Florida, 3 (1) ,91-102.

Gomes, M. N., Clementino, M. A., Araújo, T. K., Granville-Garcia, A. F., Catão, M. H. & Gomes, D.Q. (2013). O ensino da terapia a laser de baixa intensidade em Odontologia no Brasil. RFO UPF, 18 (1).

Gomes, D. A., Gomes, E. A., Picciani, B. L. & Fontes, K. B. (2019). Aplicações da laserterapia no tratamento de lesões orais ulceradas. Revista brasileira de odontologia, Nova Friburgo, 76 (2), 68.

Ghaemi, M., Sharifi, D., Mokmeli, S., Kowsari, G. & Mortazavi, P. (2019). Comparison and Evaluation of the Low-Level Laser and the Red and Blue LED Effects on Wound Healing in Rabbit. J Lasers Med Sci, Tehran, 10(3), 189-193.

Hoop, C., Zhu, J., Nunes, A., Case, D. & Baum, J.(2017). Revealing Accessibility of Cryptic Protein Binding Sites within the Functional Collagen Fibril. Biomolecules, Piscataway, 7(4), 76.

Jamadar, N., Nagoba, B., Davane, M., Ahmed, A. & Tangsal, A. (2019). Citric acid treatment of oral ulcers refractory to conventional treatment: a case study. Journal of Wound Care, Latur, 28 (7), 461–3.

Jorge, A. C., Cassoni, A. & Rodrigues, J. A. (2010). Aplicações dos lasers de alta potência em odontologia. Revista saúde UNG-SER, Guarulhos, 4(3).

Kalhori, K. A. M., Vahdatinia, F., Jamalpour, M. R., Vescovi, P. & Fornaini, C. (2019). Photobiomodulation in Oral Medicine. Photobiomodulation, Photomedicine, and Laser Surgery, Tehran, 37 (12) ,837–861.

Kuffler, D. P. (2016). Photobiomodulation in promoting wound healing: a review. Regenerative Medicine, San Juan, 11(1), 107–122.

Kurtulmus-Yilmaz, S., Yilmaz, H. G., Tumer, H. & Sadettinoglu, K. (2015). Clinical Evaluation of the Er,Cr:YSGG Laser Therapy in the Treatment of Denture-Related Traumatic Ulcerations: A Randomized Controlled Clinical Study. Photomedicine and Laser Surgery, Mersin, 33(4), p. 224–9.

Layegh, E. R., Fathabadi, F. F., Lotffinia, M. & Zare, F. (2020). Photobiomodulation therapy improves the growth factor and cytokine secretory profile in human type 2 diabetic fibroblasts. Journal of Photochemistry and Photobiology B: Biology, Tehran.111962.

Lee, S. T., Jang, S. B., Kwon, T. G. & Choi, S. Y. (2018). Oral tuberculosis mimicking a traumatic denture ulcer. The Journal of Prosthetic Dentistry, Daegu, 121 (2), 225-8.

Lee, H. S., Le, Y., Jeong, U., Oh, S. & Hwang, C. W. (2020). Transoral Low‐Level Laser Therapy Via a Cylindrical Device to Treat Oral Ulcers in a Rodent Model. Lasers in Surgery and Medicine, Busan, 52, (7), 647-52.

Lins, R.D., Dantas, E.M., Lucena, K.C., Catão, M.H., Granville-Garcia, A.F. & Carvalho Neto, L.G. (2010). Efeitos bioestimuladores do laser de baixa potência. An. Bras. Dermatol, Campina Grande, 85(6), 849-55.

Lima, T. C. & Barcessat, A. R (2020). Estudo comparativo dos efeitos da terapia fotodinâmica e da laserterapia no processo de cicatrização e reparo de úlceras induzidas em modelos de roedores. Ciências da Saúde: resultados dos projetos de iniciação científica da Universidade Federal do Amapá, Macapá, 129-43.

Lopes, J. C., Pereira, L. P. & Bacelar, I. A (2018). Laser de baixa potência na estética-revisão de literatura. Revista Saúde em Foco, São Lourenço, 10, 429-37.

Marrero, Y.B. & Salgado, V.S. (2016). Acrylic Plate with Vestibular Hanse to Prevent Tramautic Oral Ulcer in a Mental Retarded Patient. Correo Científico Médico, Holguín, 20(2).

Maya, R., Ladeira, L. L. C., Maya, J. E. P., Mail, L. M. G. & Bussadori, S. K (2020). The Combination of Antimicrobial Photodynamic Therapy and Photobiomodulation Therapy for the Treatment of Palatal Ulcers: A Case Report. J Lasers Med Sci, São Luís, 11(2) ,228-33.

Mester, A. (2013). Laser Biostimulation. Photomedicine and Laser Surgery, Budapest, 31(6), 237–9.

Michalik, M., Szymanczyk, J., Stajnke, M., Ochrymiuk, T. & Cenian, A. (2021). Medical Applications of Diode Lasers: Pulsed versus Continuous Wave (cw) Regime. Micromachines, Warszawa, 12 (6), 710.

Moreira, F. C., Véras, L. G., Moreira, S. C. & Roriz, V. M. (2020). Manual prático para uso dos lasers na odontologia. Cegraf UFG, 1 ed., Goiânia, 19.

Mosca, R. C., Ong, A. A., Albasha, O., Bass, K. & Arany, P. (2019). Photobiomodulation Therapy for Wound Care. Advances in Skin & Wound Care, New York, 32(4), 157–167.

Mussttaf, R. A., Jenkins, D. F. L. & Jha, N. A. (2019). Assessing the impact of low level laser therapy (LLLT) on biological systems: a review. Int J Radiat Biol, Plymouth, 95(2), 120-43.

Nadhreen, A. A., Alamoudi, N. M. & Elkhodary, H. M. (2019). Low-level laser therapy in dentistry: Extra-oral applications. Niger J Clin Pract, Jeddah, 22 (10),1313-8.

Nunes, A. B., Bezerra, A. P., Moreira, A. C., Kitakawa, D. & Cavaliere, D. (2017). Estomatologia para Clínicos da Atenção Básica do Munícipio de São Paulo. Prefeitura de São Paulo, 5.

Olivera, M. A. (2018). Relatório de estágio: Aplicações da Terapia de Laser de Baixa Intensidade em Tecidos Moles da Cavidade Oral, Cespu. repository, Gandra, 5.

Orgel, J. P. R. O., San Antonio, J. D. & Antipova, O. (2010). Molecular and structural mapping of collagen fibril interactions. Connective Tissue Research, Chicago, 52(1), 2–17.

Parent, D. (2011). Oral ulcerations. Rev Med Brux, 32 (4), 210-8.

Parent, D. & Vaillant, L. (2008). Aftas, aftosis, enfermedad de Behçet, Bruxelles.

Peixoto A. P. & Peixoto, G. C.; Alessandretti, R. (2015). Relação entre o uso de prótese removível e úlcera traumática - revisão de literatura. Journal of Oral Investigations, Passo Fundo, 4(1), 26-32.

Peplow, P. V., Chung, T. Y., Ryan, B. & Baxter, G. D. (2011). Laser photobiostimulation of wound healing: Reciprocity of irradiance and exposure time on energy density for splinted wounds in diabetic mice. Lasers in Surgery and Medicine, Dunedin, 43(8), 843–850.

Piancentini, M., Borghetti, R. L., Zancanaro de Figueredo, M. A. & Cherubini, K. (2019). Doxycycline: An option in the treatment of ulcerated oral lesions? Journal of Clinical Pharmacy and Therapeutics, Porto Alegre, 44(6) ,838-43.

Prabhu, V., Rao, S. B., Chandra, S., Kumar, P. & Rao, L. (2011). Spectroscopic and histological evaluation of wound healing progression following Low Level Laser Therapy (LLLT). Journal of Biophotonics, Karnataka, 5(2), p.168–84.

Ribeiro, T. E. & Marangoni, A. F. (2020). Avaliação do efeito da fotobiomodulação em úlcera traumática em crianças: relato de caso clínico. Revista Científica UMC, Mogi das Cruzes, 5(1).

Rocha, L. L., Rodrigues, M. F., Da Rocha, C. C., Da Silva, B. A. & Startari, D. M. (2020). Úlceras orais provocadas por metotrexato: relato de caso. Brazilian Journal of Development, Curitiba, 6(9),70544-52.

Rocha, R. G. (2013). Clínica Integrada em Odontologia: Série Abeno: Odontologia Essencial, Editora Artes Médicas, 108.

Rodriguez-Pascual, F. & Slatter, D. A. (2016). Collagen cross-linking: insights on the evolution of metazoan extracellular matrix. Scientific Reports, Madrid, 6(1).

Sardari, F. & Aharari, F. (2016). The effect of low-level helium-neon laser on oral wound healing. Dent Res J., Rafsanjan, 13(1), 24–9.

Spanemberg, J.C., Figueiredo, M.A.Z., Cherubini, K. & Salum, F.G. (2016). Low-level Laser Therapy: A Review of Its Applications in the Management of Oral Mucosal Disorders. Altern Ther Health Med., 22 (6), 24-31.

Schemel-Suárez, M., López-López, J. & Chimenos-Kustner, E. (2015). Úlceras orales: diagnóstico diferencial y tratamiento. Medicina Clínica, Barcelona, 145(11), p.499–503.

Santos, L. T. O., Santos, L. O. & Guedes, C. C. F. V (2021). Laserterpia na odontologia: efeitos e aplicabilidades. Scientia Generalis. Patos de Minas, 2(2), 29-46.

Santos, C. M. C., Pimenta, C. A. M. & Nobre, M. R. C. (2007). The PICO strategy for the research question construction and evidence search. Rev Latino-Am Enfermagem, 15(3), 508-11.

Silva Neto, J. M. A., Dos Santos, J. K. B., Gomes, N. M. A., Silva, C. C. C. & Barros, J. V. B. (2020). Aplicação da laserterapia de baixa intensidade na odontologia: revisão integrativa. Revista Eletrônica Acervo Saúde, Maceió. (39), 1-10.

Soares, M. A., Ferreira, P. B., Neres, A. T., Bernardino, A. & Martins, A. P. (2016). Reações adversas gastrointestinais úlceras orais. Guia de reações adversas a medicamentos. Lisboa, p.1-5.

Soleimani, H., Amini, A., Abdollahifar, M. A., Norouzian, M. & Kouhkheil, R. (2020). Combined effects of photobiomodulation and curcumin on mast cells and wound strength in wound healing of streptozotocin-induced diabetes in rats. Lasers in Medical Science, London, 36 (2), 375- 86.

Sukhitashvili, N., Imnadze, I., Tabaghua, G., Gogilashvili, Q. & Amiranashvili, I. (2012). Characterization of oral ulcer and pathological scar in nude mice model. Georgian Med News, 205, 82-7.

Tamiozzo, M.E. (2021). Uso de laserterapia de baixa potência para tratamento de lesões bucais: Revisão de literatura. Unicesumar - Universidade Cesumar, Maringá.

Teixeira, D.S. (2017). Efeito da aplicação de clorexidina, iodopovidona e eritromicina no reparo de úlceras traumáticas em ventre lingual de ratos: análise clínica, histológica e microbiológica. Biblioteca Digital de Teses e Dissertações PUCRS, Porto Alegre, tese, p.9.

Una-sus UFMA (2021). Lesões orais comuns na Adolescência. Saúde do Adolescente questões da prática Assistencial para Dentistas, módulo 2,1-13.

Una-sus UNIFESP (2021). Módulo de caso complexos caso 6 Dona Margarida. Especialização em saúde da família modalidade a distância, 4.

Umpierre, R. N. & Gonçalves, M. R (2020). Curso de estomatologia para cirurgiões dentistas da rede pública de atenção à saúde modulo 4: lesões ulceradas agudas. Curso EAD de estomatologia, (7a ed.), 5.

Valle, L. A., Karam, P. S., Rezende, M. L. & Zangrando, M. S. (2017). Laser de baixa intensidade no tratamento de úlceras traumáticas e queilite angular: relatos de casos. Rev. Assoc. Paul. Cir. Dent, São Paulo,71(1), 30-4.

Vaillant, L. & Samimi, M. (2016). Aphtes et ulcérations buccales. Presse Med., Tours, 45(2), 215-26.

Vazzoller, R. M., Fernandes, R. D., De Sena, R. M. M. & De Senna, A. M. (2016). Tratamento do herpes simples por meio da laserterapia - Relato de casos. Revista Científica do ITPAC, Araguaína, 9(1).

Wagner, V. P., Curra, M., Webber, L. P.; Nor, C. & Matte, U. (2016). Photobiomodulation regulates cytokine release and new blood vessel formation during oral wound healing in rats. Lasers in Medical Science, Porto Alegre, 31(4), 665–71.

Wagner, V. P., Meurer, L., Martins, M. A., Danilezicz, C. K. & Magnusson, A. S. (2013). Influence of different energy densities of laser phototherapy on oral wound healing. Journal of Biomedical Optics, Porto Alegre, 18(12), p.128002.

Yáñez, M., Escobar, E., Oviedo, C., Stillfried, A. & Pennacchiotti, G. (2016). Prevalence of Oral Mucosal Lesions in Children. International Journal of Odontostomatology, Temuco, 10(3),463–8.

Zhou, Z., Chen, Y., Chai, M., Tao, R. & Lei, Y. (2019). Adipose extracellular matrix promotes skin wound healing by inducing the differentiation of adipose derived stem cells into fibroblasts. International Journal of Molecular Medicine, Beijing, 890-900.

Published

15/03/2022

How to Cite

BARROS, D. D. de .; CATÃO, M. H. C. de V. . Evaluation of low-intensity laser photobiomodulation in the treatment of traumatic oral ulcer: na integrative literature review. Research, Society and Development, [S. l.], v. 11, n. 4, p. e18811427325, 2022. DOI: 10.33448/rsd-v11i4.27325. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/27325. Acesso em: 20 apr. 2024.

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Health Sciences