Bioactive properties in vitro and in vivo of the genus Waltheria belonging to the family Malvaceae: a literature review
DOI:
https://doi.org/10.33448/rsd-v11i4.27351Keywords:
Waltheria; Malvaceae; Anti-inflammatory activity; Neuroprotective; Anticarcinogenic.Abstract
Waltheria corresponds to a genus belonging to the subfamily called sterculiaceae of the Malvaceae family. This genus is widely used in folk medicine with antifebrile, diuretic, anti-inflammatory purposes, in the treatment of rheumatism, asthma, gastrointestinal, among others. The purpose of this review is to provide a broad view of the bioactive properties of the Waltheria genus in vivo and in vitro tests. The data of the present work were collected from scientific journals using the literature of the electronic portal SciELO, PubMed, MEDLINE and LILACS. The works included in this review were published in internationally recognized indexed journals. It can be observed that the studies presented in this narrative review of the literature with the genus Waltheria elucidated antifungal, anti-inflammatory, anticarcinogenic, antitrypanosomal, antichagastic, nematocidal, larvicidal, anticonvulsant, antitrypanosomal, antimicrobial, acetylcholinesterase, cardioprotective and antidiarrheal activity. However, the Waltheria indica represents 64.7% of the findings and with a higher prevalence for anti-inflammatory activity, bioactivity is also observed in W. douradinha.
References
Ahmed, Z., Kazmi, S. N. H. & Malik, A. (1990). Phytochemical investigation of Abutilon pakistanicum. Journal of Natural Products, 62(4), 349-352.
Arseculeratne, S. N., Gunatilaka, A. L., & Panabokke, R. G. (1981). Studies on medicinal plants of Sri Lanka: occurrence of pyrrolizidine alkaloids and hepatotoxic properties in some traditional medicinal herbs. Journal of Ethnopharmacology, 4(2), 159-177.
Barroso, G. M., Peixoto, A. L., Ichaso, C. L., Costa, C. G., Guimarães, E. F. (1978). Sistemática de angiospermas do Brasil. Livros Técnicos e Científicos Editora.
Basiru, A., Akorede, G. J., Soetan, K., & Olayemi, F. O. (2019). Adverse reproductive effects of ethanolic root extract of Waltheria indica in male Wistar rats. Journal of Complementary and Integrative Medicine, 16(4).
Billeter, M., Meier, B., & Sticher, O. (1991). 8-Hydroxyflavonoid glucuronides from Malva sylvestris. Phytochemistry, 30(3), 987-990.
Corrêa, M. P. (1931). Dicionário de plantas úteis do Brasil e das exóticas cultivadas. Ministério da Agricultura, Instituto Brasileiro de Desenvolvimento Florestal.
Corrêa, M. P. (1984). Dicionário de plantas úteis do Brasil e das exóticas cultivadas. Ministério da Agricultura, Instituto Brasileiro de Desenvolvimento Florestal.
Cretton, S., Breant, L., Pourrez, L., Ambuehl, C., Marcourt, L., Ebrahimi, S. N., & Christen, P. (2014). Antitrypanosomal quinoline alkaloids from the roots of Waltheria indica. Journal of natural products, 77(10), 2304-2311.
Cretton, S., Bréant, L., Pourrez, L., Ambuehl, C., Perozzo, R., Marcourt, L., Kaiser, M., Cuendet, M., & Christen, P. (2015). Chemical constituents from Waltheria indica exert in vitro activity against Trypanosoma brucei and T. cruzi. Fitoterapia, 105, 55–60.
Cretton, S., Dorsaz, S., Azzollini, A., Favre-Godal, Q., Marcourt, L., Ebrahimi, S. N., ... & Christen, P. (2016). Antifungal quinoline alkaloids from Waltheria indica. Journal of Natural Products, 79(2), 300-307.
Cretton, S., Kaiser, M., Karimou, S., Ebrahimi, S. N., Maser, P., Cuendet, M., & Christen, P. (2020). Pyridine-4 (1 H)-one Alkaloids from Waltheria indica as Antitrypanosomatid Agents. Journal of Natural Products, 83(11), 3363-3371.
do Amaral, J. F., Silva, M. I. G., de Aquino Neto, M. R. A., Neto, P. F. T., Moura, B. A., de Melo, C. T. V., ... & de Sousa, F. C. F. (2007). Antinociceptive effect of the monoterpene R-(+)-limonene in mice. Biological and Pharmaceutical Bulletin, 30(7), 1217-1220.
Elliger, C. A. (1984). Sexangularetin 3-glucoside-7-rhamnoside from Gossypium hirsutum. Phytochemistry, 23(5), 1199-1201.
Ferreira, M. D. L., Fernandes, D. A., Nunes, F. C., Teles, Y. C., Rolim, Y. M., Silva, C. M. D., ... & de Souza, M. D. F. (2019). Phytochemical study of Waltheria viscosissima and evaluation of its larvicidal activity against Aedes aegypti. Revista Brasileira de Farmacognosia, 29, 582-590.
Gressler, V., Stüker, C. Z., de OC Dias, G., Dalcol, I. I., Burrow, R. A., Schmidt, J., ... & Morel, A. F. (2008). Quinolone alkaloids from Waltheria douradinha. Phytochemistry, 69(4), 994-999.
Grings, M., & Boldrini, I. I. (2011). Sphaeralcea bonariensis (Cav.) Griseb.(Malvaceae): nova ocorrência para o Brasil. Revista Brasileira de Biociências, 9(3), 382.
Heywood, V.H. (1993). Flowering plants of world. B. T. Batsford Ltd.
Hossain, M. M., Even, A. I. H., Akbar, M. A., Ganguly, A., & Rahman, S. A. (2013). Evaluation of analgesic activity of Sterculia villosa Roxb.(Sterculiaceae) bark in swiss-albino mice. Dhaka University Journal of Pharmaceutical Sciences, 12(2), 125-129.
Jang, J. Y., Le Dang, Q., Choi, G. J., Park, H. W., & Kim, J. C. (2019). Control of root‐knot nematodes using Waltheria indica producing 4‐quinolone alkaloids. Pest management science, 75(8), 2264-2270.
Laczko, R., Chang, A., Watanabe, L., Petelo, M., Kahaleua, K., Bingham, J. P., & Csiszar, K. (2020). Anti-inflammatory activities of Waltheria indica extracts by modulating expression of IL-1B, TNF-α, TNFRII and NF-κB in human macrophages. Inflammopharmacology, 28(2), 525-540.
Lima, J. B., & Conceição, A. D. S. (2016). Malvoideae Burnett (Malvaceae) in the Environmental Protection Area Serra Branca, Raso da Catarina, Jeremoabo, Bahia, Brazil. Biota Neotropica, 16(4).
Lima, M. M., López, J. A., David, J. M., Silva, E. P., Giulietti, A. M., de Queiroz, L. P., & David, J. P. (2009). Acetylcholinesterase activity of alkaloids from the leaves of Waltheria brachypetala. Planta medica, 75(04), 335-337.
Monteillier, A., Cretton, S., Ciclet, O., Marcourt, L., Ebrahimi, S. N., Christen, P., & Cuendet, M. (2017). Cancer chemopreventive activity of compounds isolated from Waltheria indica. Journal of ethnopharmacology, 203, 214-225.
Mundo, J., Villeda-Hernández, J., Herrera-Ruiz, M., del Carmen Gutiérrez, M., Arellano-García, J., León-Rivera, I., & Perea-Arango, I. (2017). Neuropharmacological and neuroprotective activities of some metabolites produced by cell suspension culture of Waltheria americana Linn. Biomedicine & Pharmacotherapy, 94, 129-139.
Owemidu, I. O., Olubori, M. A., Faborode, O. S., Stephen, O., & Oloyede, S. A. O. (2018). Anti-nociceptive and anti-inflammatory activities of the methanol extract of Waltheria americana Linn. leaf in experimental animals. J Complement Med Res, 9(2), 47-54.
Schmidt, C., Fronza, M., Goettert, M., Geller, F., Luik, S., Flores, E. M. M., & Merfort, I. (2009). Biological studies on Brazilian plants used in wound healing. Journal of ethnopharmacology, 122(3), 523-532.
Schmidt, C., Fronza, M., Goettert, M., Geller, F., Luik, S., Flores, E. M. M., & Merfort, I. (2009). Biological studies on Brazilian plants used in wound healing. Journal of ethnopharmacology, 122(3), 523-532.
Sharma, P. V., & Ahmad, Z. A. (1989). Two sesquiterpene lactones from Abutilon indicum. Phytochemistry, 28(12), 3525.
Silva, D. A., Chaves, M. C. O., Costa, D. A., de Moraes, M. R. R., da Nobrega, F. B. P., & de Souza, M. F. V. (2005). Flavonoids from Herissantia tiubae. Pharmaceutical biology, 43(3), 197-200.
Vasques, C. A., Côrtes, S. F., Silva, M. S., & de Medeiros, I. A. (1999). Muscarinic agonist properties of the hydrobutanol extract from aerial parts of Waltheria viscosissima St. Hil.(Sterculiaceae) in rats. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 13(4), 312-317.
Yin, F., Liu, Q., Zhang, B., Zhang, X., He, J., Xie, J., & Sun, R. (2021). Microemulsion preparation of Waltheria indica extracts and preliminary antifungal mechanism exploration. Industrial Crops and Products, 172, 114000.
Yougbare-Ziebrou, M. N., Lompo, M., Ouedraogo, N., Yaro, B., & Guissoun, I. P. (2016). Antioxidant, analgesic and anti-inflammatory activities of the leafy stems of Waltheria indica L.(Sterculiaceae). Journal of Applied Pharmaceutical Science, 6(02), 124-129.
Zavala, M. A., Perez, S., Perez, C., Vargas, R., & Perez, R. M. (1998). Antidiarrhoeal activity of Waltheria americana, Commelina coelestis and Alternanthera repens. Journal of Ethnopharmacology, 61(1), 41-47.
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