Influence of ozone therapy as an adjunct in the treatment of ulcerative lesions in patients with diabetes mellitus

Authors

DOI:

https://doi.org/10.33448/rsd-v11i4.27512

Keywords:

Ozone; Complementary therapies; Diabetic foot; Diabetes Mellitus.

Abstract

Introduction: diabetes mellitus is characterized by being a problem of great global disorder, with the capacity for acute and chronic morbidities. One of the main disorders is ulcerative lesions in the extremities, as in the feet, and when there is a bad evolution of the patient's condition, it can result in amputation of the affected limb. Ozone therapy is an alternative treatment option for these types of injuries due to its performance in oxidative stress, which results in a good recovery of the individual, with subsequent angiogenesis and wound healing, and can be used in addition to conventional treatment, since has antimicrobial action. Objective: To verify from the available literature what is the influence of ozone therapy as an adjuvant in the treatment of ulcerous wounds of diabetic foot. Methods: Integrative literature review based on the descriptors "Ozone", "Complementary Therapies", "Diabetic Foot" and "Diabetes Mellitus", using the PubMed and BSV database, resulting in 17 articles for complete analysis and selecting 11 with greater relevance. Results: Ozone therapy can be used as an adjunctive treatment in the treatment of diabetic foot ulcers, as concluded in 8 (72.7%) studies analyzed, but 3 (27.2%) concluded that there were not enough studies for an outcome on the subject, in addition to warning that adjuvant therapies are only used when conventional treatments are not effective. Despite the positive evidence observed in relation to the use of ozone as an adjuvant in the treatment of diabetic foot ulcers, in Brazil, the Federal Council of Medicine (CFM) establishes ozone therapy only as an experimental procedure. Conclusion: Most articles analyzed in this literature review indicate that ozone therapy is efficient in the treatment of ulcerated lesions in diabetic patients, however the number of studies carried out in these areas is still reduced, making a larger and more diverse range of studies necessary studies referring to this alternative practice.

Author Biography

Débora Luana Ribeiro Pessoa, Universidade Federal do Maranhão

Coordenação do curso de Medicina

Campus Pinheiro

Universidade Federal do Maranhão

References

Anzolin, A. P., & Bertol, C. D. (2018). Ozone therapy as an integrating therapeutic in osteoartrosis treatment: A systematic review. Brazilian Journal Of Pain, 1(2).

ABOZ. (2021). Os avanços da regulamentação da Ozonioterapia nos Conselhos de Classes. Associação Brasileira de Ozonioterapia (ABOZ). https://www.aboz.org.br/noticias/os-avancos-da-regulamentacao-da-ozonioterapia-nos-conselhos-de-classes-/138/.

Brasil. (2013). Ministério da Saúde. Secretaria de Atenção à Saúde. Departamento de Atenção Básica. Estratégias para o cuidado da pessoa com doença crônica: diabetes mellitus. Brasília.

Cardoso, C. C., Dias Filho, E., Pichara, N. L., Campos, E. G. C., Pereira, M. A. & Fiorini, J. E. (2010). Ozonioterapia como tratamento adjuvante na ferida de pédiabético. Rev Méd Minas Gerais. 20(N.Esp.): 442-45.

Cardoso, N. A, Cisneiros, L. D. L, Machado, C. J., Cenedezi, J. M., Procópio, R. J., & Navarro, T. P. (2017). Gênero bacteriano é fator de risco para amputação maior em pacientes com pé diabético. Revista do Colégio Brasileiro de Cirurgiões, 44 (2), 147–153.

CPPAS. (2021). Protocolo de manejo do pé diabético na atenção primária e especializada de saúde. Comissão Permanente de Protocolos de Atenção à Saúde da SES-DF (CPPAS). http://www.saude.df.gov.br/wp-conteudo/uploads/2018/04/PROTOCOLO-PE DIABETICO.pdf.

CRM-PR. (2021). Ozonioterapia não é válida para nenhuma doença, inclusive a Covid-19. Conselho Regional de Medicina do Estado do Paraná (CRM-PR). https://www.crmpr.org.br/Ozonioterapia-nao-e-valida-para-nenhuma-doenca-inclusive-a Covid19-11-54491.shtml.

CFM. (2021). Resolução CFM nº 2.181/2018. Conselho Federal de Medicina (CFM). https://sistemas.cfm.org.br/normas/visualizar/resolucoes/BR/2018/2181.

De Oliveira, M. A. P., & Parente, R. C. M. (2010). Entendendo ensaios clínicos randomizados. Brazilian Journal of Videoendoscopic Surgery, v. 3, n. 4, p. 176-180.

Duarte, N., & Gonçalves, A. (2011). Pé diabético. Angiologia e Cirurgia Vascular, [s. l], v. 7, n. 2, p. 65-79, jun.

Elvis, A., & Ekta, J. (2011). Ozonetherapy: A clinical review. Journal of Natural Science, Biology and Medicine, 2 (1), 66.

Gao, L., Li, T., Wang, S., & Wang, J. (2019). Comprehensive treatment of diabetic hallux gangrene with lower extremity vascular disease: A case report. Journal of International Medical Research, 47 (12), 6374-6384.

International Diabetes Federation. (2021). Diabetes atlas update 2012: Regional & Country Facctsheets. http://www.idf.org/diabetes-atlas-update-2012-regional-countryfactsheets.

Izadi, M., Kheirjou, R., Mohammadpour, R., Aliyoldashi, M. H., Moghadam, S. J., Khorvash, F., Jafari, N. J., et al. (2019). Efficacy of comprehensive ozone therapy in diabetic foot ulcer healing. Diabetes & Metabolic Syndrome: Clinical Research & Reviews: Clinical Research & Reviews, 13 (1), 822–825.

Karatieieva, S., Makarova, O., Yurkiv, O., Semenenko, S., & Berezova, M. (2018). Treatment of pyoinflammatory complications with individually selected ozone dose in patients with diabetes. Georgian Medical News, (Issue), 91–94.

Kushmakov, R., Gandhi, J., Seyam, O., Jiang, W., Joshi, G., Smith, N., & Khan, S. (2018). Ozone therapy for diabetic foot. Medical Gas Research, 8(3), 111.

Liu, J., Zhang, P., Tian, J., Li, L., Li, J., Tian, J. H., & Yang, K. (2015). Ozone therapy for treating foot ulcers in people with diabetes. (Cochrane Wounds Group, Org.) Cochrane Database of Systematic Reviews, 2015(10).

Oliveira, J. O. J. A utilização do óleo ozonizado para o tratamento tópico de lesões em porquinho da índia (cavia porcellus) – relato de caso. (2008). Trabalho de Conclusão de Curso. Universidade Castelo Branco. Centro de Ciências da Saúde e Biológicas. Curso de Medicina Veterinária. Itatiba, SP.

Ramirez-Acuña, J. M., Cardenas-Cadena, S. A., Marquez-Salas, P. A., Garza-Veloz, I., Perez-Favila, A., Cid-Baez, M. A., Flores-Morales, V., et al. (2019). Diabetic foot ulcers: Current advances in antimicrobial therapies and emerging treatments. Antibiotics, 8(4), 193.

Ramirez-Perdomo, C., Perdomo-Romero, A., & Rodríguez-Vélez, M. (2019). Conhecimentos e práticas para prevenção do pé diabético. Revista Gaúcha de Enfermagem, 40, e20180161.

Rosul, M. V., & Patskan, B. M. (2016). Ozone therapy effectiveness in patients with ulcerous lesions due to diabetes mellitus. Wiadomosci Lekarskie (Warsaw, Poland: 1960), 69(1), 7–9.

Silva, V., Peirone, C., Amaral, J. S., Capita, R., Alonso-Calleja, C., Marques-Magallanes, J. A., Martins, Â., et al. (2020). High efficacy of ozonated oils on the removal of biofilms produced by methicillin-resistant staphylococcus aureus (Mrsa) from infected diabetic foot ulcers. Molecules, 25(16), 3601.

Souza, R. F. (2009). O que é um estudo clínico randomizado?. Medicina (Ribeirão Preto), v. 42, n. 1, p. 3-8.

Teixeira, S. (2021). Ministério da Saúde inclui 10 novas práticas integrativas no SUS. http://bibliosus.saude.gov.br/index.php/artigos/14-noticias/209-ministerio-da-saude-inclui-10-novas-praticas-integrativas-no-sus.

Uzun, G., Mutluoğlu, M., Karagöz, H., Memiş, A., Karabacak, E., & Ay, H. (2012). Pitfalls of intralesional ozone injection in diabetic foot ulcers: A case study. Journal of the American College of Clinical Wound Specialists, 4(4), 81–83.

Zhang, J., Guan, M., Xie, C., Luo, X., Zhang, Q., & Xue, Y. (2014). Increased growth factors play a role in wound healing promoted by noninvasive oxygen-ozone therapy in diabetic patients with foot ulcers. Oxidative Medicine and Cellular Longevity, 2014, 1–8.

Published

21/03/2022

How to Cite

COSTA, B. F. .; OLIVEIRA, L. C. M. de .; RAMALHO, J. B. F. .; COSTA, K. B. .; PEREIRA RODRIGUES, K.; COSTA, S. de S. .; PESSOA, D. L. R. Influence of ozone therapy as an adjunct in the treatment of ulcerative lesions in patients with diabetes mellitus. Research, Society and Development, [S. l.], v. 11, n. 4, p. e39511427512, 2022. DOI: 10.33448/rsd-v11i4.27512. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/27512. Acesso em: 18 nov. 2024.

Issue

Section

Review Article