Periodontitis and pulmonary repercussions: Is the casual relationship between them well clarified in the literature?
DOI:
https://doi.org/10.33448/rsd-v11i4.27693Keywords:
Periodontitis; Inflammation; Lung disease.Abstract
Introduction: The oral cavity is a potential reservoir of respiratory pathogens. The mechanisms of infection that can be cited are the aspiration of bacteria that normally reside in the oropharynx, the colonization of dental plaque by respiratory pathogens followed by aspiration, and the ease of colonization of periodontal pathogens in the upper airway, thus providing a link between periodontitis and respiratory/pulmonary conditions also of an inflammatory nature. However, the causal relationship between periodontitis and the development of pulmonary disorders is not well understood. This research aims to verify the advances in the discussions of the relationship between periodontitis and pulmonary diseases. Metodology: This is an sistematic literature review study. The guiding question of the research was elaborated using the strategy of the acronym PICO. Searches for eligible studies were carried out from January 31, 2022 to February 16, 2022, in the databases: PubMed and BVS Library, using elements from the PICO acronym to obtain specific and controlled descriptors, available in Descriptors in Health Sciences/Medical Subject Headings (DeCS/MeSH): periodontitis, inflammation, lung diseases, which were combined during the search by the boolean AND operator. Case reports, clinical study, clinical trial, observational study, randomized controlled trial, available in English, Chinese and Portuguese, were selected, attributing a time cut of 12 years (2010-2022). Inclusion criteria were: original and review articles whose main subject was related to periodontitis and its relationship with pulmonary disorders. The following were excluded: duplicate works, incomplete works, studies that omitted the sample size, study protocols, articles outside the time frame of the research, works without relevant results or out of context, articles whose research addressed studies in animals and articles with conflict of interest. interests among the authors. 69 articles were identified in the databases defined for the search. After the process of selection and analysis of the works found, 21 articles were selected for review. Results and discussion: The results are organized according to the presentation of the sample variables (sample size, characteristics of the participants regarding: age, sex, presence of periodontitis, presence of COPD, presence of periodontitis concomitant with COPD), research design, type of intervention (description of procedures in relation to treatment, assessment of periodontal status and respiratory functions), type of control for the treatment group, and description of the main outcomes (changes in quality of life, oral hygiene status and functioning of respiratory functions evaluated in the participants, before and after the intervention). Conclusion: The relationship between periodontitis and lung conditions is well elucidated in the literature, especially in patients who have both conditions (periodontitis and lung disorders). However, it can also be observed that there is no clear and substantial evidence that explains the causal mechanisms between them. This review alludes and points to better clarifications in this field.
References
Agado, B. E., Crawford, B., DeLaRosa, J., Bowen, D. M., Peterson, T., Neill, K., & Paarmann, C. (2012). Effects of periodontal instrumentation on quality of life and illness in patients with chronic obstructive pulmonary disease: a pilot study. American Dental Hygienists' Association, 86(3), 204-214.
Brasil. Ministério da Saúde, Secretaria de Atenção à Saúde, Departamento de Atenção Básica. (2008). Saúde Bucal. Brasília: Ministério da Saúde.
Brasil. Ministério da Saúde, Secretaria de Atenção à Saúde, Departamento de Atenção Básica. (2010). Doenças respiratórias crônicas. Brasília: Ministério da Saúde.
Cury, P. R., Joly, J. C., Araújo, V. C. D., Wassall, T., & Araújo, N. S. (2003). Periodontite: fator de risco para doenças sistêmicas?. RGO (Porto Alegre), 210-214.
Chung, P. C., & Chan, T. C. (2020). Association between periodontitis and all-cause and cancer mortality: retrospective elderly community cohort study. BMC Oral Health, 20(1), 1-11.
Dev, Y. P., & Goyal, O. P. (2013). Recurrent lung infection due to chronic peri-odontitis. Journal of the Indian Medical Association, 111(2), 127-129.
Flemmig, T. F. (1999). Periodontitis. Annals of periodontology, 4(1), 32-37.
Ishikawa, S., Yamamori, I., Takamori, S., Kitabatake, K., Edamatsu, K., Sugano, A., ... & Iino, M. (2021). Evaluation of effects of perioperative oral care intervention on hospitalization stay and postoperative infection in patients undergoing lung cancer intervention. Supportive Care in Cancer, 29(1), 135-143.
Jia, C., Luan, Y., Li, X., Zhang, X., & Li, C. (2021). Effects of periodontitis on postoperative pneumonia in patients with lung and esophageal cancer. Thoracic Cancer, 12(6), 768-774.
Kucukcoskun, M., Baser, U., Oztekin, G., Kiyan, E., & Yalcin, F. (2013). Initial periodontal treatment for prevention of chronic obstructive pulmonary disease exacerbations. Journal of periodontology, 84(7), 863-870.
Lawal, F. J., & Baer, S. L. (2021). Capnocytophaga gingivalis Bacteremia After Upper Gastrointestinal Bleeding in Immunocompromised Patient. Journal of investigative medicine high impact case reports, 9, 23247096211020672.
Lee, W. C., Fu, E., Li, C. H., Huang, R. Y., Chiu, H. C., Cheng, W. C., & Chen, W. L. (2020). Association between periodontitis and pulmonary function based on the Third National Health and Nutrition Examination Survey (NHANES III). Journal of Clinical Periodontology, 47(7), 788-795.
Lin, M., Wang, Y. Y., Wang, L., & Wang, Z. M. (2021). Study of B10 cells in the pathogenesis of the interaction between chronic obstructive pulmonary disease and periodontal disease. Zhonghua kou Qiang yi xue za zhi= Zhonghua Kouqiang Yixue Zazhi= Chinese Journal of Stomatology, 56(6), 525-531.
Mojon, P., Budtz‐Jørgensen, E., Miche, J. P., & Limeback, H. (1997). Oral health and history of respiratory tract infection in frail institutionalised elders. Gerodontology, 14(1), 9-16.
Peter, K. P., Mute, B. R., Doiphode, S. S., Bardapurkar, S. J., Borkar, M. S., & Raje, D. V. (2013). Association between periodontal disease and chronic obstructive pulmonary disease: a reality or just a dogma?. Journal of periodontology, 84(12), 1717-1723.
Qian, Y., Yuan, W., Mei, N., Wu, J., Xu, Q., Lu, H., & Wang, X. (2020). Periodontitis increases the risk of respiratory disease mortality in older patients. Experimental Gerontology, 133, 110878.
Saba-Chujfi, E. (2007). Cirurgias plásticas periodontais e periimplantares: atlas simplificado das propostas técnicas. Santos. Sapey, E., Yonel, Z., Edgar, R., Parmar, S., Hobbins, S., Newby, P., ... & Stockley, R. (2020). The clinical and inflammatory relationships between periodontitis and chronic obstructive pulmonary disease. Journal of clinical periodontology, 47(9),
-1052.
Sattar, S. B. A., & Sharma, S. (2018). Bacterial pneumonia.
Sharma, S., Gupta, A., Verma, A. K., Pathak, A., Verma, S., Chaudhary, S. C., ... & Verma, U. P. (2021). Impact of Non- surgical Periodontal Therapy on Pulmonary functions, Periodontal Health and Salivary Matrix Metalloproteinase-8 of COPD Patients with Chronic Periodontitis: A Clinico-biochemical Study. Turk Toraks Dergisi/Turkish Thoracic Journal, 22(4).
Takeuchi, K., Matsumoto, K., Furuta, M., Fukuyama, S., Takeshita, T., Ogata, H., ... & Yamashita, Y. (2019). Periodontitis is associated with chronic obstructive pulmonary disease. Journal of Dental Research, 98(5), 534-540.
Turner, E., Hastie, T., & Sundaresan, P. D. (2021). Pulmonary Aggregatibacter actinomycetemcomitans infection masquerades as malignancy in a patient with periodontitis. BMJ Case Reports CP, 14(2), e239636.
Winning, L., Polyzois, I., Sanmartin Berglund, J., & Renvert, S. (2020). Periodontitis and airflow limitation in older Swedish individuals. Journal of Clinical Periodontology, 47(6), 715-725.
Yang, L. C., Suen, Y. J., Wang, Y. H., Lin, T. C., Yu, H. C., & Chang, Y. C. (2020). The association of periodontal treatment and decreased pneumonia: A nationwide population-based cohort study. International journal of environmental research and public health, 17(1), 356.
Zhou, X., Han, J., Liu, Z., Song, Y., Wang, Z., & Sun, Z. (2014). Effects of periodontal treatment on lung function and exacerbation frequency in patients with chronic obstructive pulmonary disease and chronic periodontitis: A 2‐year pilot randomized controlled trial. Journal of clinical periodontology, 41(6), 564-572.
Zhou, X., Liu, Z. Q., Li, W., & Wang, Z. M. (2019). Influence of non-surgical periodontal treatment on the quality of life in chronic obstructive pulmonary disease patients with chronic periodontitis. Zhonghua kou Qiang yi xue za zhi= Zhonghua Kouqiang Yixue Zazhi= Chinese Journal of Stomatology, 54(3), 151-156.
Zhou, X., Wang, J., Liu, W., Huang, X., Song, Y., Wang, Z., & Jia, X. (2020). Periodontal Status and Microbiologic Pathogens in Patients with Chronic Obstructive Pulmonary Disease and Periodontitis: A Case–Control Study. International Journal of Chronic Obstructive Pulmonary Disease, 15, 2071.
Zhou, X., Wang, Z., Song, Y., Zhang, J., & Wang, C. (2011). Periodontal health and quality of life in patients with chronic obstructive pulmonary disease. Respiratory medicine, 105(1), 67-73.
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Copyright (c) 2022 Antonio de Pádua Rocha Nóbrega Neto; Bianca Sampaio Lima; Júlia Rachel Ferreira Meneses; Brenda Ellen Meneses Cardoso; Larissa dos Santos Pessoa; Even Herlany Pereira Alves; Hélio Mateus Silva Nascimento; Paulo Roberto Carneiro Gomes; John Arlley Sousa Pinho de Lira; Any Carolina Cardoso Guimarães Vasconcelos; Daniel Fernando Pereira Vasconcelos
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