Hospitalizations and deaths associated with Herpes Simplex Virus (HSV) infection in Brazil from 2012 to 2021

Authors

DOI:

https://doi.org/10.33448/rsd-v11i4.27737

Keywords:

Hospitalization; Unified health system; Aged.

Abstract

The present study aimed to carry out an analysis of cases of hospitalizations and deaths by HSV in Brazil. For this, a descriptive, retrospective and cross-sectional study was carried out, based on the 10th revision of the International Classification of Diseases (ICD-10): B00 - Herpes virus infections (herpes simplex). The information was retrieved from Departamento de Informática do Sistema Único de Saúde (DATASUS), and “Morbidade Hospitalar do SUS (SIH/SUS)” was accessed. Between 2012 and 2021, in Brazil, 13,417 hospitalizations for herpes simplex were reported, especially in the Southeast region (n=5,077), however, the Northeast region was also highlighted with the increase in the number of hospitalizations after 2020. São Paulo was the state with the highest number of hospitalizations, with females being the most prevalent. Considering the age group, there was a prevalence in children aged 1 to 4 years, followed by the group ≥ 60 years of age. The internment regime was predominantly public and white breed. Regarding expenses, a large part was directed to the elderly, who also recorded the highest number of deaths, among females and white breed. Thus, the data presented and discussed provide important information for an assessment of the characteristics of hospitalizations and deaths from herpes simplex, providing evidence that can serve as a basis for the formulation of public policies aimed at this infection.

Author Biography

Evaldo Hipólito de Oliveira, Universidade Federal do Piauí

Possui graduação em Farmácia pela Universidade Federal da Paraíba (1990), graduação em Farmácia e Bioquímica pela Universidade Federal da Paraíba (1991), graduação em Direito pela Universidade Federal do Piauí (1999), Doutorado em Biologia de Agentes Infecciosos e Parasitários (2010), mestrado em Administração pela Universidade Federal da Paraíba (2002), especialização em Vigilância Sanitária e Epidemiológica (1997) e Citologia Clínica (2005). Foi Diretor do Laboratório Central de Saúde Pública do Estado do Piauí-LACEN-PI (2003 a 2007). Atualmente é professor Associado da Universidade Federal do Piauí de microbiologia clínica e imunologia clínica (1994). Tem experiência na área de Farmácia (Interdisciplinaridade), atuando principalmente nos seguintes temas: análises clínicas ( bacteriologia, virologia, imunologia, citologia e hematologia ) e Vírus Linfotrópico de Células T Humanas-1/2-HTLV-1/2, HIV, HBV e HCV (Epidemiologa, Imunologia e Análise Molecular).

References

Almukdad, S., Harfouche, M., Wettstein, A. & Abu-Raddad, L. J. (2021). Epidemiology of herpes simplex virus type 2 in Asia: A systematic review, meta-analysis, and meta-regression. The Lancet Regional Health-Western Pacific. 12: 100176. https://doi.org/10.1016/j.lanwpc.2021.100176

Apolinário, J. M. dos S. da S., & Cândido, P. B. (2021). MANEJO CLÍNICO DA INFECÇÃO PELO VIRUS HERPES SIMPLES NA ÁREA NEONATAL. Revista Multidisciplinar Em Saúde, 2(4), 108. https://doi.org/10.51161/rems/2732

Araújo Carvalho, A. C., Tavares Mendes, M. L., Santos, V. S., Tanajura, D. M., Prado Nunes, M. A., & Martins-Filho, P. (2018). Association between human herpes virus seropositivity and frailty in the elderly: A systematic review and meta-analysis. Ageing research reviews, 48, 145–152. https://doi.org/10.1016/j.arr.2018.10.009

Avila, E. C., Jardim, F. F.; Gonçalves, C. V., Hora, V. P. D.,Soares M. A. & Martinez, A. M. B. D. (2020). Alta incidência do vírus herpes simplex 1 em sangue de cordão e infecção na placenta de mulheres no sul do Brasil. Revista Brasileira de Ginecologia e Obstetrícia, 42(01): 5-11. https://doi.org/10.1055/s-0039-1700794

Holt, M., & Zerden, M. (2022). Adolescent Primary Genital Herpes Simplex Virus Type 1 Infection with Sepsis Secondary to Streptococcus pyogenes Bacteremia. Journal of Pediatric and Adolescent Gynecology, 35(1), 91-93.

Donda, K., Sharma, M., Amponsah, J. K., Bhatt, P., Okaikoi, M., Chaudhari, R., & Dapaah-Siakwan, F. (2019). Trends in the incidence, mortality, and cost of neonatal herpes simplex virus hospitalizations in the United States from 2003 to 2014. Journal of perinatology: official journal of the California Perinatal Association, 39(5), 697–707. https://doi.org/10.1038/s41372-019-0352-7

Silva, Maísa Almeida et al (2021). Infecções Sexualmente Transmissíveis (ISTs) conhecimento e prevenção: análise da atual situação em escolares de Campina Grande-PB–Relato de experiência. Brazilian Journal of Development. 7(8): 78754-78765, 2021. DOI:10.34117/bjdv7n8-208

George, B. P., Schneider, E. B., & Venkatesan, A. (2014). Encephalitis hospitalization rates and inpatient mortality in the United States, 2000-2010. PloS one, 9(9), e104169. https://doi.org/10.1371/journal.pone.0104169

Hansen, M. A., & Hasbun, R. (2021). US Hospitalizations and 60-Day Readmission Rates Associated with Herpes simplex virus Encephalitis: Analysis of All Cause Readmissions and Encephalopathy Associated Readmissions. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, ciab613. Advance online publication. https://doi.org/10.1093/cid/ciab613

Harfouche, M., Maalmi, H., & Abu-Raddad, LJ (2021). Epidemiologia do vírus herpes simplex tipo 2 na América Latina e Caribe: revisão sistemática, metanálises e metaregressões. Infecções sexualmente transmissíveis , 97 (7), 490-500. https://doi.org/10.1136/sextrans-2021-054972

Ishihara, T., Yanagi, H., Ozawa, H., & Takagi, A. (2018). Severe herpes simplex virus pneumonia in an elderly, immunocompetent patient. BMJ case reports, 2018, bcr2017224022. https://doi.org/10.1136/bcr-2017-224022

James, C., Harfouche, M., Welton, NJ, Turner, KM, Abu-Raddad, LJ, Gottlieb, SL, & Looker, KJ (2020). Vírus herpes simplex: prevalência global de infecção e estimativas de incidência, 2016. Boletim da Organização Mundial da Saúde , 98 (5), 315–329. https://doi.org/10.2471/BLT.19.237149

Leite, I. C. M. et al. (2021). Características Gerais das Internações Hospitalares por Dengue Clássica no Estado do Pará, Brasil. Guarujá: Editora cientifica. 87-97.

Lignani, L. O. & Villela, L. C. M. (2013). Estudo descritivo sobre a morbidade hospitalar por causas externas em Belo Horizonte, Estado de Minas Gerais, Brasil, 2008-2010. Epidemiologia e Serviços de Saúde, v. 22, n. 2, p. 225-234. https://doi.org/10.5123/S1679-49742013000200004

Lima, L., Padalecki, G., Castro, C., Cordeiro, J., & De Paula, V. (2017). Seroprevalence of human herpesvirus type 2 in a reference center for pregnant women in Rio de Janeiro, Brazil. Virus Rev Res, 22(1), 20-21. https://doi.org/10.17525/vrrjournal.v22i1.327

Lotufo, P. A. & Bensenor, I. J. M. (2013). Raça e mortalidade cerebrovascular no Brasil. Revista de Saúde Pública, 47: 1201-1204. https://doi.org/10.1590/S0034-8910.2013047004890

MatosK. G. L., & CorreaI. M. (2021). Avaliação das principais causas de morbidade hospitalar na região metropolitana de Belém - PA no período de 2014 a 2018. Revista Eletrônica Acervo Saúde, 13(7), e7516. https://doi.org/10.25248/reas.e7516.2021

Samies, N. L., James, S. H., & Kimberlin, D. W. (2021). Neonatal Herpes Simplex Virus Disease: Updates and Continued Challenges. Clinics in perinatology, 48(2), 263–274. https://doi.org/10.1016/j.clp.2021.03.003.

Shirani, K., Khorvash, F., Naeini, A. E., Valiyan Boroujeni, M., & Yazdani, M. (2019). Prevalence of herpes simplex virus-1 in hospitalized adult patients with clinical diagnosis of meningoencephalitis using real-time polymerase chain reaction: A single-center, cross-sectional study. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 24, 7. https://doi.org/10.4103/jrms.JRMS_370_17

Sousa, L. M. O., Pinheiro, R. S. (2011). Óbitos e internações por tuberculose não notificados no município do Rio de Janeiro. Revista de Saúde Pública. 45(1): 31-39. https://doi.org/10.1590/S0034-89102011000100004

Srinivasan, D., Kaul, C. M., Buttar, A. B., Nottingham, F. I., & Greene, J. B. (2021). Disseminated Herpes Simplex Virus-2 (HSV-2) as a Cause of Viral Hepatitis in an Immunocompetent Host. The American journal of case reports, 22, e932474. https://doi.org/10.12659/AJCR.932474

Sukik, L., Alyafei, M., Harfouche, M. & Abu-Raddad, L. J. (2019). Herpes simplex virus type 1 epidemiology in Latin America and the Caribbean: Systematic review and meta-analytics. PloS one. 14(4): e0215487. https://doi.org/10.1371/journal.pone.0215487

Wang, G. C., Han, C., Detrick, B., Casolaro, V., Levine, D. M., Fried, L. P., & Walston, J. D. (2016). Herpesvirus Infections and Risk of Frailty and Mortality in Older Women: Women's Health and Aging Studies. Journal of the American Geriatrics Society, 64(5), 998–1005. https://doi.org/10.1111/jgs.14090

Ramos, Mauro Cunha et al. Brazilian Protocol for Sexually Transmitted Infections, 2020: infections that cause genital ulcers. Revista da Sociedade Brasileira de Medicina Tropical, v. 54, 2021. https://doi.org/10.1590/0037-8682-663-2020

World Health Organization. (2016). Guidelines for the Treatment of Genital Herpes Simplex Virus. World Health Organization.

World Health Organization. (2022). Herpes Simplex Virus. World Health Organization. Disponível em: https://www.who.int/news-room/fact-sheets/detail/herpes-simplex-virus Acesso em 20 fev. 2022.

Downloads

Published

27/03/2022

How to Cite

ANDRADE, S. M. de .; COSTA, P. R. C. .; ROSA, L. M. V. .; PIRES, L. G. de F. .; RODRIGUES, Ítalo S. M. .; TAMINATO, R. L. .; OLIVEIRA, E. H. de . Hospitalizations and deaths associated with Herpes Simplex Virus (HSV) infection in Brazil from 2012 to 2021. Research, Society and Development, [S. l.], v. 11, n. 4, p. e58511427737, 2022. DOI: 10.33448/rsd-v11i4.27737. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/27737. Acesso em: 3 apr. 2025.

Issue

Vol. 11 No. 4

Section

Health Sciences

License

Copyright (c) 2022 Sâmia Moreira de Andrade; Plínio Robson Cavalcante Costa; Luís Marcelo Vieira Rosa; Luiz Gustavo de Freitas Pires; Ítalo Sávio Mendes Rodrigues; Rodrigo Luís Taminato; Evaldo Hipólito de Oliveira

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.