Scientific and technological prospection of norbixin and dapsone with emphasis on wound healing
DOI:
https://doi.org/10.33448/rsd-v11i7.28067Keywords:
Wound Healing; Norbixin; Dapsone.Abstract
The wound healing is a complex process that depends on many factors. Thus, the search for speed and efficiency in the repair of injuries that characterize the healing has always been a target of interest in medicine. This study has as goal to map information about the biological activity of the carotenoid norbixin and the drug dapsone, aiming at the treatment of wound healing, through scientific and technological prospection in databases of publication of articles and patent deposits. The keywords “norbixin”, “dapsone” and “wound healing”, in Portuguese and English, were used with the help of the boolean operator AND. The results obtained reported a greater number of publications for the keyword “wound healing” (>95% for articles, >98% for patents). Searches involving the keyword “norbixin” show the existence of scientific and technological productions that explore the use of this carotenoid in biotechnological applications. However, just two articles and one patent report the use of this natural product for healing purposes. Fifteen articles highlighted the healing potential of the drug dapsone, associated with other drugs, in wounds resulting from rare diseases. No patent was found showing technology that had made use of this drug as a healing agent. The research developed about the compounds norbixin and dapsone contribute significantly to the opening of possibilities for new formulations and applications of these substances and, although there are still few productions relating these substances to wound healing, the scientific and technological scenario show hope for the development of studies and technologies for healing purposes.
References
Aberg, A. K. G., Zolotoy, A., & Bain, A. I. (2003). Galenical preparations of dapsone and related sulphones, and method of therapeutic and preventative treatment of disease (U.S. Patente Nº. 2003092635A1). https://worldwide.espacenet.com/patent/search/family/026846473/publication/US2003092635A1?q=pn%3DUS2003092635A1.
Alese, O. B., & Irabor, D. O. (2008). Pyoderma gangrenosum and ulcerative colitis in the tropics. Revista da Sociedade Brasileira de Medicina Tropical, 41 (6), 664 – 667. https://doi.org/10.1590/S0037-86822008000600020.
Alves de Lima, R. O., Azevedo, L., Ribeiro L. R., & Salvadori D. M. F. (2003). Study on themutagenicity and antimutagenicity of a natural food colour (annatto) in mouse bone marrow cells. Food and Chemical Toxicology, v. 41, p. 189–192. https://doi.org/10.1016/S0278-6915(02)00208-9.
Amparo, K. K. D. S., Ribeiro, M. D. C. O., & Guarieiro, L. L. N. (2012). Estudo de caso utilizando mapeamento de prospecção tecnológica como principal ferramenta de busca científica. Perspectivas em Ciência da Informação, 17 (4), 195-209. https://www.scielo.br/j/pci/a/TqkZ6MwqNMX7dSrsPvDwvLn/?format=pdf&lang=pt.
Bastos, R. S., Araújo, J. L., Azevedo, V. S., Ferreira, M. D. L. D. A. S., Lima, L. R. D., & Rocha, J. A. (2021). Cadmio complexes with biological activity: Scientific and technological prospection. Research, Society and Development, 10 (5). https://doi.org/10.33448/rsd-v10i5.15152.
Berce, C., Muresan, MS., Soritau, O., Petrushev, B., Tefas,L., Rigo, I., Ungureanu, G., Catoi, C., Irimie, A., & Tomuleasa, C. (2018). Cutaneous wound healing using polymeric surgical dressings based on chitosan, sodium hyaluronate and resveratrol. A preclinical experimental study. Colloids and Surfaces B: Biointerfaces, 163, 155-166. https://doi.org/10.1016/j.colsurfb.2017.12.041.
Beilman, G. J., Winslow, C. L., & Teslow, T. W. (1994). Experimental brown spider bite in the guinea pig: Results of treatment with dapsone or hyperbaric oxygen. Journal of Wilderness Medicine, 5 (3), 287-294. https://doi.org/10.1580/0953-9859-5.3.287.
Bell, K. A. (2006). Topical compositions for the treatment of chronic wounds (U.S. Patente Nº. 2006286108A1).
Bernstein, M. L., & Wetzel, S. L. (2021). Clinical pathologic conference case 3: multiple deep oral ulcers. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 131 (1), 29-33. https://doi.org/10.1016/j.oooo.2020.09.016.
Botelho, L. L. R., Cunha, C. J. C. A., & Macedo, M. (2011). O método da revisão integrativa nos estudos organizacionais. Revista Eletrônica Gestão e Sociedade, 5 (11), 121-136. https://doi.org/10.21171/ges.v5i11.1220.
Brown, R. E., Lay, L., & Graham, D. (1993). Bilateral Pyoderma Gangrenosum of the Hand: Treatment with Dapsone. Journal of Hand Surgery, 18 (1), 119-121. https://doi.org/10.1016/0266-7681(93)90209-X.
Calderon, O. W., Cisternas, V. J. P., Calderón, M. D., EulufI, M. A., Guler, G. K., Jaramillo, R. L., Tapia, L. R., & Saavedra U. T., (2013). Pioderma gangrenoso en mamoplastía de reducción con pedículo inferior. Revista Chilena de Cirurgía, 65 (6), 541-548. https://dx.doi.org/10.4067/S0718-40262013000600013.
Carvalho, L. F. M., Viana, V. G. F., Sousa, R. C., Costa, C. L. S., & Viana, D. S. F. (2017). Obtenção de membrana de polihidroxibutirato e norbixina como biomaterial para fins cicatrizantes (BR. Patente Nº. 10 2017 028640 1 A2). https://busca.inpi.gov.br/pePI/servlet/ImagemDocumentoPdfController?CodDiretoria=200&NumeroID=7d261ded140864228d49d83d581cb1d909458fff4b34624cfc53905c74d3f61a&certificado=undefined&numeroProcesso=&ipasDoc=undefined&codPedido=1441084.
Cohen, J. B. (2002). Cutaneous involvement of dermatomyositis can respond to dapsone therapy. Int J Dermatol, 41, 182-184. https://doi.org/10.1046/j.1365-4362.2002.01409.x.
De Carvalho Vieira, T., Nascimento, M. G. P., Bittencourt, C. B., & de Andrade, I. M. (2020). Prospecção Científica e Tecnológica de Malpighia emarginata DC.(Malpighiaceae): espécie economicamente importante do Brasil. Cadernos de Prospecção, 13 (3), 862-862. https://doi.org/10.9771/cp.v13i2.32946.
Din, R. S., Tsiaras W. G., Li D. G., & Mostaghimi A. (2018). Efficacy of Systemic Dapsone Treatment for Pyoderma Gangrenosum: A Retrospective Review. Journal of Drugs in Dermatology. 17 (10), 1058-1060. https://jddonline.com/articles/efficacy-of-systemic-dapsone-treatment-for-pyoderma-gangrenosum-a-retrospective-review-S1545961618P1058X/.
Garrett, J. S. (2009). Dapsone to treat rosascea (WO. Patente Nº. 2009/108147 A1). https://patentscope.wipo.int/search/en/detail.jsf?docId=EP11199189&_cid=P10-KY1XO5-08071-1.
Guglielmetti, A; Jahr, C., & Gompertz-mattar, M. (2019). Autologous fibroblasts for the treatment of cutaneous loxoscelism: First experience. International Wound Journal, 16 (6), 1503-1505. https://doi.org/10.1111/iwj.13222.
Hindka, A., Huynh, D., & Verghese, P. S. (2021). Dapsone-induced methemoglobinemia in pediatrics post-renal transplant. Pediatric Transplantation, 25 (3). https://doi.org/10.1111/petr.13921.
Joshi, A. M. (2004). Behcet's syndrome with pyoderma-gangrenosum-like lesions treated successfully with dapsone monotherapy. Journal of Dermatology, 31 (10), 806-810. https://doi.org/10.1111/j.1346-8138.2004.tb00604.x.
Kapadia, G. J., Tokoda, H., Konoshima, T., Takasaki, M., & Nishino, H. (2001). Inhibitory effect of synthetic and natural colorants on carcinogenesis (U.S. Patente Nº. 5935581A). https://patentscope.wipo.int/search/en/detail.jsf?docId=US39345087&_cid=P20-KZY8BQ-08005-1.
Lan, CC. E., Wu, CS., Huang, SM., Wu, IH., & Chen, GS. (2013). High-Glucose Environment Enhanced Oxidative Stress and Increased Interleukin-8 Secretion From Keratinocytes: New Insights Into Impaired Diabetic Wound Healing. Diabetes, 62 (7), 2530-2538. https://doi.org/10.2337/db12-1714.
Lourido Perez, H. de la C., & Martínez Sánchez, G. (2010). La Bixa orellana L. en el tratamiento de afecciones estomatológicas, un tema aún por estudiar. Revista Cubana de Farmacia, 44 (2), 231-244. http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75152010000200012.
Mark, L. B., & Stephanie, L. W. (2021). Clinical pathologic conference case 3: multiple deep oral ulcers. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 131, 29-33. https://doi.org/10.1016/j.oooo.2020.09.016.
Mervak, J. E., Gan, S. D., Smith, E.H., & Wang, F. (2017). Facial Erosive Pustular Dermatosis After Cosmetic Resurfacing. Jama Dermatology, 153 (10), 1021-1025. https://doi.org/10.1001/jamadermatol.2017.2880.
Menting, Z., & Li. M. (2017). Dapsone-containing gel preparation and preparation method thereof (CN. Patente Nº. 106265489A).
Møller, A. H., Jahangiri, A., Danielsen, M., Madsen, B., Joernsgaard, B., Vaerbak, S., Hammershøj, M., & Dalsgaard, T. K. (2020). Mechanism behind the degradation of aqueous norbixin upon storage in light and dark environment. Food Chemistry, 310, 125967. https://doi.org/10.1016/j.foodchem.2019.125967.
Muthukumar, T., Dharmlingam, S., Selvi T., & Sastry, T. P. (2014). Preparation, characterization, and in vitro bioactivity of Bixa Orellana extract-impregnated collagen microspheres. Journal of Materials Science, 49, 5730-5737. https://doi.org/10.1007/s10853-014-8291-3.
Neto, M. L. C. B., Filho, J. M. R, Malafaia, O., Oliveira Filho, M. A., Czeczko, N. G., Aoki, S., Cunha, R., Fonseca, V. R., Teixeira, H. M., & Farion, L. R. (2006). Avaliação do extrato hidroalcoólico de Aroeira (Schinus terebinthifolius Raddi) no processo de cicatrização de feridas em pele de ratos. Acta Cirúrgica Brasileira, 21, 17-22. https://doi.org/10.1590/S0102-86502006000800004.
Oh, K. C. (2008). Antifungal pharmaceutical compositions containing dapsone as efficacious componente (KR. Patente Nº. 100806051B1). https://worldwide.espacenet.com/patent/search/family/039382912/publication/KR100806051B1?q=pn%3DKR100806051B1.
Okur, N. Ü., Hökenek, N., Okur, M. E., Ayla, Ş., Yoltaş, A., Siafaka P. I., & Cevher E. (2019). An alternative approach to wound healing field; new composite films from natural polymers for mupirocin dermal delivery. Saudi Pharmaceutical Journal, 27, 738-752. https://doi.org/10.1016/j.jsps.2019.04.010.
Osborne, D. W. (2004). A protectant for uv-induced skin damage (WO. Patente Nº. 2004041178A2). https://worldwide.espacenet.com/patent/search/family/032174931/publication/WO2004041178A2?q=pn%3DWO2004041178A2.
Osborne, D. W. (2003). Topical dapsone for the treatment of acne (WO. Patente N°. 03072071A1). https://worldwide.espacenet.com/patent/search/family/027733245/publication/WO03072071A1?q=pn%3DWO03072071A1.
Rees, R., Campbell, D., Rieger, E., & King, L. E. (1987). The diagnosis and treatment of brown recluse spider bites. Annals of Emergency Medicine, 16 (9), 945-949. https://doi.org/10.1016/S0196-0644(87)80738-2.
Santos Junior, J. R., & Rodrigues, J, S. (2019). Processo de obtenção de filme amido-melamina com extrato de Bixa Orellana L., filme amido-melamina com extrato de Bixa Orellana L. e sua aplicação como cicatrizante em lesões cutâneas (BR. Patente Nº. 10 2019 004032 7 A2). https://busca.inpi.gov.br/pePI/servlet/ImagemDocumentoPdfController?CodDiretoria=200&NumeroID=fad5a9aa406c6e297a274d5171c4a5ee8d233e2f9e2b2f6f0eb9b6e78f1d5442&certificado=undefined&numeroProcesso=&ipasDoc=undefined&codPedido=1503626.
Santos, J. A. A., Sousa, M. F. A. M., Silva, E. L. V., & Aguiar Júnior, F. C. A. (2014). Avaliação histomorfométrica do efeito do extrato aquoso de urucum (norbixina) no processo de cicatrização de feridas cutâneas em ratos. Revista Brasileira de Plantas Medicinais, 16 (3), 637 – 643. https://doi.org/10.1590/1983-084x/12_120.
Shevchenko, R. V., James, S. L., & James, S. E. (2010). A review of tissue-engineered skin bioconstructs available for skin reconstruction. JR Soc. Interface, 7, 229 – 258. https://doi.org/10.1098/rsif.2009.0403.
Sousa, P. S. De A., Nogueira, S. S., Ayala, K. N. R., Silva, P. C., Santos, E. Da S., Sá, R. E., De Lima Neto, F. E. M., Lima, J. R. Da C., Rodrigues, K. A. Da F., Rocha, J. A., & Véras, L. M. C. (2021). Prospecção científica e tecnológica de Pilocarpus microphyllus e do alcalóide epiisopiloturina com ênfase na atividade antileishmania. Research, Society and Development, 10 (7), e59810716984. http://dx.doi.org/10.33448/rsd-v10i7.16984.
Sousa, P. S. A., Rodrigues, M. G., & Alvarenga, E. M. (2020). Prospecção Tecnológica, com Ênfase nas Atividades Biológicas Nematicida e Larvicida, do Óleo Essencial do Cravo-da-Índia e do Eugenol. Cadernos de Prospecção, 13 (1), 154-170. https://doi.org/10.9771/cp.v13i1.29624.
Sousa, R. C., Carvalho, L. F. M., Maia Filho, A. L. M., Ferreira, D. C. L., Amaral, F. P. M. D., Mendes, L. M. S., & Viana, V. G. F. (2020). Characterization and assessment of the genotoxicity and biocompatibility of poly (hydroxybutyrate) and norbixin membranes. Acta Cirúrgica Brasileira, 35 (7), e202000706. https://doi.org/10.1590/s0102-865020200070000006.
Wright, S. W., Wrenn, K. D., Murray, L., & Seger D. (1997). Clinical Presentation and Outcome of Brown Recluse Spider Bite. Annals of Emergency Medicine, 30 (1), 28-32. https://doi.org/10.1016/S0196-0644(97)70106-9.
Zhu, D., Yang, Z., Zhang, C., Wu, Z., & Wei, Y. (2008). Flexible transparent polyimide film material and method for producing the same (CN. Patente Nº. 101195682A). https://worldwide.espacenet.com/patent/search/family/039546320/publication/CN101195682A?q=pn%3DCN101195682A.
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Copyright (c) 2022 Abraão Leal Alves; Leiz Maria Costa Véras; Vicente Galber de Freitas Viana; Tetisuelma Leal Alves; Paulo Sérgio de Araújo Sousa; Leandro Josuel da Costa Santos; Deuzuita dos Santos Freitas Viana; José Roberto da Cunha Lima
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