Antimicrobial activity and effects of Citral in species that cause oral diseases: literature review
DOI:
https://doi.org/10.33448/rsd-v11i5.28170Keywords:
Citral; Plants, Medicinal; Phytotherapy; Dentistry.Abstract
Oral thrush is a common fungal infection in immunosuppressed patients. Studies demonstrate the activity of compounds from essential oils against involved microorganisms. This research carried out a literature review on the antimicrobial action of citral in species of interest to Dentistry. A search was carried out in the following databases: Pubmed, Science direct, Scielo, Lilacs and Cochrane. Articles from the last 15 years that investigated the antimicrobial and antifungal effect of citral in species of interest to Dentistry, as well as its mechanism of action and toxicity, were included. Eleven scientific articles were included for this review. Among the species studied, citral showed activity against Candida spp and bacteria such as Staphylococcus aureus, Streptoccocus mutans, Lactobacillus spp. Its mechanism of action has not been determined, and one of the studies reported low cytotoxicity. It is concluded that citral has antimicrobial and antifungal activity in species that cause oral diseases.
References
Almeida, C. M. de, Lima, R, de F., Costa, T. K. V. L. da, Sousa, I. M. de O., Cabral, E. C., Basting, R. T., et al. (2018). Antifungal, antibiofilm, and antiproliferative activities of Guapira graciliflora Mart. Braz Oral Res., 32(0).
Bakkali, F., Averbeck, S., Averbeck, D., Idaomar, M. (2008). Biological effects of essential oils - A review. Food Chem Toxicol., 46, p. 446–75.
Cardoso, J., Soares, M. J. In vitro effects of citral on trypanosoma cruzi metacyclogenesis. Mem Inst Oswaldo Cruz. 2010;105(8):1026–32.
Chatrath, A., Gangwar, R., Kumari, P., Prasad, R. (2019). In vitro anti-biofilm activities of citral and thymol against Candida tropicalis. J Fungi., 5(1):13.
Chaves-Quirós, C., Usuga-Usuga, J. S., Morales-Uchima, S. M., Tofiño-Rivera, A. P., Tobón-Arroyave, S.I., Martínez-Pabón, M. C. (2020). Assessment of cytotoxic and antimicrobial activities of two components of Cymbopogon citratus essential oil. J Clin Exp Dent., 12(8):e749–54.
Chouhan, S., Kallianpur, S., Prabhu, K. T, Tijare, M., Kasetty, S., Gupta, S. (2019). Candida prevalence in diabetics and its species identification. Int J Appl basic Med Res.,9(1):49–54.
Dias, I .J., Trajano, E. R .I. S., Castro, R. D., Ferreira, G. L. S., Medeiros, H. C. M., Gomes, D. Q. C. (2018). Antifungal activity of linalool in cases of candida spp. isolated from individuals with oral candidiasis. Brazilian J Biol., 78(2):368–74.
Ferreira, E. D. S., Rosalen, P. L., Benso, B., De Cássia Orlandi, Sardi. J., Denny, C., Alves De, Sousa. S., et al. (2021). The use of essential oils and their isolated compounds for the treatment of oral candidiasis: a literature review, Evidence-based Complementary and Alternative Medicine. 2021.
Freire, J. C. P., Júnior, J. K. de O., Silva, D. de F., Sousa, J. P., de Guerra, F. Q. S., de Oliveira-Lima, E. (2017). Antifungal activity of essential oils against Candida albicans strains isolated from users of dental prostheses. Evidence-Based Complement Altern Med., 2017:1–9.
Gao, S., Liu, G., Li, J., Chen, J.; Li, L., Li, Z.; et al. (2020). Antimicrobial activity of Lemongrass essential oil (Cymbopogon flexuosus) and its active component citral against dual-species biofilms of Staphylococcus aureus and Candida species. Front Cell Infect Microbiol., 10:603858.
Hoyle, G. E.; Sharma, V.; MacLullich, A.; Seymour, D. G. (2008). Clinical aspects of delirium. J R Coll Physicians Edinb., 38(2):154–7.
Iosif, L., Preoteasa, C. T., Murariu-Măgureanu, C., Preoteasa, E. Clinical study on thermography, as modern investigation method for Candida-associated denture stomatitis. Rom J Morphol Embryol. 2016;57(1):191–5.
Kaur, H., Chakrabarti, A. (2017). Strategies to reduce mortality in adult and neonatal candidemia in developing countries. J fungi (Basel, Switzerland)., 3(3).
Khan, M. S. A., Malik, A., Ahmad, I. (2012). Anti-candidal activity of essential oils alone and in combination with amphotericin B or fluconazole against multi-drug resistant isolates of Candida albicans. Med Mycol., 50(1):33–42.
Khedri. S., Santos, A. L. S., Roudbary, M., Hadighi, R., Falahati, M., Farahyar, S., et al. (2018). Iranian HIV/AIDS patients with oropharyngeal candidiasis: identification, prevalence and antifungal susceptibility of Candida species. Lett Appl Microbiol., 67(4):392–9.
Kirti, YK. (2019). Prevalence of oral candidiasis in Indian HIV sero-positive patients with CD4+ Cell count correlation. Indian J Otolaryngol Head Neck Surg.,71(1):124–7.
Laskar, A. A., Khan, M. A., Ahmad, S., Hashmi, A., Younus, H. Citral inhibition of human salivary aldehyde dehydrogenase. Cell Biochem Biophys., 78(1):31–42.
Lavaee, F., Motaghi, D., Jassbi, A. R., Jafarian, H., Ghasemi, F., Badiee, P. (2019). Antifungal effect of the bark and root extracts of Punica granatum on oral Candida strains isolated from liver recipients. Curr Med Mycol., 4(4):20–4.
Leite, M. C. A., Bezerra, A. P. de B., Sousa, J. P. de, Guerra, F. Q. S., Lima, E. de O. (2014). Evaluation of Antifungal Activity and Mechanism of Action of citral against Candida albicans. Evidence-Based Complement Altern Med., 2014:1–9.
Lewis, M. A. O.; Williams, D. W. (2017). Diagnosis and management of oral candidosis. Br Dent J., 223(9):675–81.
Li, W., Gao, J., Wei, S., Wang, D. (2016). Application values of clinical nursing pathway in patients with acute cerebral hemorrhage. Exp Ther Med., 11(2):490–4.
Lima, I.O., de Medeiros Nóbrega, F., de Oliveira, W. A., de Oliveira Lima, E., Albuquerque Menezes, E., Afrânio Cunha, F., et al. (2012). Anti- Candida albicans effectiveness of citral and investigation of mode of action. Pharm Biol., 50(12):1536–41.
Lu, W. C., Huang, D. W., Wang, C. C. R., Yeh, C. H., Tsai, J. C., Huang, Y. T., et al. (2018). Preparation, characterization, and antimicrobial activity of nanoemulsions incorporating citral essential oil. J Food Drug Anal., 26(1):82–9.
Mangprayool, T., Kupittayanant, S., Chudapongse, N. (2013). Participation of citral in the bronchodilatory effect of ginger oil and possible mechanism of action. Fitoterapia., 89:68–73.
Mello, J. C. P., de Simões, C. M. O., Schenkel, E. P., Gosmann, G. Farmacognosia da Planta ao Medicamento [Internet]. 6th ed. 1999.
Miranda-Cadena, K., Dias, M., Costa-Barbosa, A., Collins, T., Marcos-Arias, C., Eraso, E., et al. (2021). Development and characterization of monoolein-based liposomes of carvacrol, cinnamaldehyde, citral, or thymol with anti-candida activities. Antimicrob Agents Chemother., 65(4).
de Oliveira, M. A. C., Borges, A. C., Brighenti, F. L., Salvador, M. J., Gontijo, A. V. L., Koga-Ito, C. Y. (2017). Cymbopogon citratus essential oil: effect on polymicrobial caries-related biofilm with low cytotoxicity. Braz Oral Res.,31.
Pour, A. H, Salari, S., Almani, P. G. N. (2019). Oropharyngeal candidiasis in HIV/AIDS patients and HIVfree subjects in the Southeast of Iran. Curr Med Mycol.,4(4):1–6.
Silva C, de B. da., Guterres, S. S., Weisheimer, V., Schapoval, E. E. S. (2008). Antifungal activity of the lemongrass oil and citral against Candida spp. Braz J Infect Dis., 12(1):63–6.
Silva, D. R., Rosalen, P. L., Freires, I. A., Sardi, J. de C. O., Lima, R .F., Lazarini, J. G., et al. (2019). Anadenanthera Colubrina vell Brenan: anti-Candida and antibiofilm activities, toxicity and therapeutical action. Braz Oral Res., 33(0):e023.
Tao, N., OuYang, Q., Jia, L. (2014). Citral inhibits mycelial growth of Penicillium italicum by a membrane damage mechanism. Food Control., 41:116–21.
Treviño-Rangel, R. de J., Peña-López, C. D., Hernández-Rodríguez, P. A., Beltrán-Santiago, D., González, G. M. (2018). Association between Candida biofilm-forming bloodstream isolates and the clinical evolution in patients with candidemia: an observational nine-year single center study in Mexico. Rev Iberoam Micol., 35(1):11–6.
Vasireddy, L., Bingle, L. E. H., Davies, M. S. (2018). Antimicrobial activity of essential oils against multidrug-resistant clinical isolates of the burkholderia cepacia complex. PLoS One., 13(8).
Xia, H., Liang, W., Song, Q., Chen, X., Chen, X., Hong, J. (2013). The in vitro study of apoptosis in NB4 cell induced by citral. Cytotechnology., 65(1):49–57.
Wang, W. P., Yan, X. L., Ni, Y.F., Guo, K., Ke, C. K., Cheng, Q. S., et al. (2013). Effects of lipid emulsions in parenteral nutrition of esophageal cancer surgical patients receiving enteral nutrition: a comparative analysis. Nutrients., 6(1):111–23.
Wińska, K., Mączka, W., Łyczko, J., Grabarczyk, M., Czubaszek, A., Szumny, A. (2020). Essential oils as antimicrobial agents—myth or real alternative?, Molecules. MDPI AG, 24.
Zhou, H.,Tao, N., Jia, L. (2014). Antifungal activity of citral, octanal and α-terpineol against Geotrichum citri-aurantii. Food Control., 37:277–83.
Zore, G. B., Thakre, A. D., Jadhav, S., Karuppayil, S. M. (2011). Terpenoids inhibit Candida albicans growth by affecting membrane integrity and arrest of cell cycle. Phytomedicine., 18(13):1181–90.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Julliana Cariry Palhano Freire; Ernani Canuto Figueiredo Júnior; Waleska Ohana Souza Melo; Bruna Palmeira Costa; Adyelle Dantas Ribeiro; Josinaldo Guedes Rodrigues Júnior; Mariana Mélani Alexandrino Costa; Jozinete Vieira Pereira
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
