Effect of propolis extract on the skin healing process: a literature review
DOI:
https://doi.org/10.33448/rsd-v11i5.28284Keywords:
Apis mellifera L.; Propolis extract; Healing.Abstract
Propolis is a resinous substance obtained by bees from the buds, leaves, bark and exudates of many trees and plants. Propolis and its extracts have long been used for the prevention and treatment of a variety of infections and diseases due to their antimicrobial, anti-inflammatory, antiparasitic, antioxidant and healing activities. Thus, taking into account the numerous therapeutic properties and biological applications of propolis extract, this study aims to address, through a literature review, the benefits of using propolis extract in the treatment of injuries and wound healing in the skin. Data were obtained through a search in the Pubmed databases and in the Virtual Health Library covering the period 2017 to 2021, in Portuguese, English and Spanish, using the following descriptors: "propolis extract" and "healing" and “propolis extract” and “healing”. All articles were selected by reading the title and abstract that analyzed the role of the propolis extract in wound healing in the period 2017-2021. The 14 articles selected for the study showed, through clinical studies in humans, experimental "in vitro" and in animals, the effectiveness of propolis extract in the treatment of wounds, acting as a natural healing and antimicrobial agent, whose properties depend directly on the form and place of extraction and concentration of the product. In this perspective, the propolis extract has a promising application in the treatment of skin lesions.
References
Al-Waili, N. (2018). Mixing two different propolis samples potentiates their antimicrobial activity and wound healing property: A novel approach in wound healing and infection. Veterinary world, 11(8), 1188.
Batista, E. K. F., Batista, M. D. C. D. S., Sobrinho, J., Trindade, H. I. D., Silva, L. L. B., & Muller, J. B. (2015). Influência da própolis sobre os perfis leucocitário e proteico de camundongos e tempo de fechamento de feridas excisionais limpas e infectadas por Staphylococcus aureus. Revista Brasileira de Plantas Medicinais, 17, 413-419.
Bonamigo, T., Campos, J. F., Oliveira, A. S., Torquato, H. F. V., Balestieri, J. B. P., Cardoso, C. A. L., & Dos Santos, E. L. (2017). Antioxidant and cytotoxic activity of propolis of Plebeia droryana and Apis mellifera (Hymenoptera, Apidae) from the Brazilian Cerrado biome. PLoS One, 12(9), e0183983.
Cao, X. P., Chen, Y. F., Zhang, J. L., You, M. M., Wang, K., & Hu, F. L. (2017). Mechanisms underlying the wound healing potential of propolis based on its in vitro antioxidant activity. Phytomedicine, 34, 76-84.
Corrêa, F. R. S., Schanuel, F. S., Moura-Nunes, N., Monte-Alto-Costa, A., & Daleprane, J. B. (2017). Brazilian red propolis improves cutaneous wound healing suppressing inflammation-associated transcription factor NFκB. Biomedicine & Pharmacotherapy, 86, 162-171.
Costa, P., Somensi, L. B., da Silva, R. D. C. M. V. D., Fonseca, A., Mariano, L. N. B., Boeing, T., & da Silva, L. M. (2020). Role of the antioxidant properties in the gastroprotective and gastric healing activity promoted by Brazilian green propolis and the healing efficacy of Artepillin C. Inflammopharmacology, 28(4), 1009-1025.
El-Bassiony, T. A., Saad, N. M., & El-Zamkan, M. A. (2012). Study on the antimicrobial activity of Ethanol Extract of Propolisagainst enterotoxigenic Methicillin-Resistant Staphylococcus aureus in lab prepared Ice-cream. Veterinary World, 5(3).
Ernawati, D. S., & Puspa, A. (2018). Expression of vascular endothelial growth factor and matrix metalloproteinase-9 in Apis mellifera Lawang propolis extract gel-treated traumatic ulcers in diabetic rats. Veterinary world, 11(3), 304.
Franchin, M., Freires, I. A., Lazarini, J. G., Nani, B. D., da Cunha, M. G., Colón, D. F., & Rosalen, P. L. (2018). The use of Brazilian propolis for discovery and development of novel anti-inflammatory drugs. European journal of medicinal chemistry, 153, 49-55.
Kalil, M. A., Santos, L. M., Barral, T. D., Rodrigues, D. M., Pereira, N. P., Sá, M. D. C. A., & Portela, R. W. (2019). Brazilian green propolis as a therapeutic agent for the post-surgical treatment of caseous lymphadenitis in sheep. Frontiers in veterinary science, 6, 399.
Krupp, T., Dos Santos, B. D., Gama, L. A., Silva, J. R., Arrais-Silva, W. W., de Souza, N. C., & de Souza Souto, P. C. (2019). Natural rubber-propolis membrane improves wound healing in second-degree burning model. International journal of biological macromolecules, 131, 980-988.
Lotti, C., Campo Fernandez, M., Piccinelli, A. L., Cuesta-Rubio, O., Marquez Hernandez, I., & Rastrelli, L. (2010). Chemical constituents of red Mexican propolis. Journal of Agricultural and Food Chemistry, 58(4), 2209-2213.
Medeiros, H. H., Fachini, V., Pupin, M. A. F., Daneze, E. R., & de Paula, C. J. S. (2019). Uso de solução de extrato de própolis como antimicrobiano e cicatrizante em feridas cutâneas causadas por acidente automobilístico em cão. Archives of Veterinary Science, 24(2).
Moon, J. H., Lee, M. Y., Chung, Y. J., Rhee, C. K., & Lee, S. J. (2018). Effect of topical propolis on wound healing process after tonsillectomy: randomized controlled study. Clinical and experimental otorhinolaryngology, 11(2), 146.
Moura, S. A. L. D., Ferreira, M. A. N. D., Andrade, S. P., Reis, M. L. C., Noviello, M. D. L., & Cara, D. C. (2011). Brazilian green propolis inhibits inflammatory angiogenesis in a murine sponge model. Evidence-Based Complementary and Alternative Medicine, 2011.
Ong, T. H., Chitra, E., Ramamurthy, S., Siddalingam, R. P., Yuen, K. H., Ambu, S. P., & Davamani, F. (2017). Chitosan-propolis nanoparticle formulation demonstrates anti-bacterial activity against Enterococcus faecalis biofilms. PloS one, 12(3), e0174888.
Oryan, A., Alemzadeh, E., & Moshiri, A. (2018). Potential role of propolis in wound healing: Biological properties and therapeutic activities. Biomedicine & Pharmacotherapy, 98, 469-483.
Pahlevanneshan, Z., Deypour, M., Kefayat, A., Rafienia, M., Sajkiewicz, P., Esmaeely Neisiany, R., & Enayati, M. S. (2021). Polyurethane-Nanolignin Composite Foam Coated with Propolis as a Platform for Wound Dressing: Synthesis and Characterization. Polymers, 13(18), 3191.
Patel, A. S., Patel, S. A., Fulzele, P. R., Mohod, S. C., Chandak, M., & Patel, S. S. (2020). Evaluation of the role of propolis and a new herbal ointment in promoting healing of traumatic oral ulcers: An animal experimental study. Contemporary Clinical Dentistry, 11(2), 121.
Picoli, T., Peter, C. M., Hoffmann, J. F., Latosinski, G. S., Zani, J. L., Vargas, G. D. Á., & Fischer, G. (2016). Caracterização química e ação antibacteriana de extrato de própolis marrom da região sul do Brasil. Brazilian Journal of Veterinary Medicine, 38(4), 365-371.
Puspasari, A., Harijanti, K., Soebadi, B., Hendarti, H. T., Radithia, D., & Ernawati, D. S. (2018). Effects of topical application of propolis extract on fibroblast growth factor-2 and fibroblast expression in the traumatic ulcers of diabetic Rattus norvegicus. Journal of oral and maxillofacial pathology: JOMFP, 22(1), 54.
Rebouças-Silva, J., Celes, F. S., Lima, J. B., Barud, H. S., de Oliveira, C. I., Berretta, A. A., & Borges, V. M. (2017). Parasite killing of Leishmania (V) braziliensis by standardized propolis extracts. Evidence-Based Complementary and Alternative Medicine, 2017.
Rodríguez-Archilla, A., & Raissouni, T. (2017). Randomized clinical trial of the effectiveness of complementary therapies for recurrent aphthous stomatitis. Medicina Clínica (English Edition), 149(2), 55-60.
Rosseto, H. C., de Toledo, L. D. A. S., de Francisco, L. M. B., Esposito, E., Lim, Y., Valacchi, G., ... & Bruschi, M. L. (2017). Nanostructured lipid systems modified with waste material of propolis for wound healing: design, in vitro and in vivo evaluation. Colloids and Surfaces B: Biointerfaces, 158, 441-452.
Sena-Lopes, A., Bezerra, F. S. B., das Neves, R. N., de Pinho, R. B., Silva, M. T. D. O., Savegnago, L., & Borsuk, S. (2018). Chemical composition, immunostimulatory, cytotoxic and antiparasitic activities of the essential oil from Brazilian red propolis. PLoS One, 13(2), e0191797.
Silva, A. P. R., Soares, A. P. S., da Silva Pessanha, C., Roza, C. M., Saint, L., Tavares, C., & Silva, A. T. M. F. (2017). Uso terapêutico da pomada de própolis em diferentes feridas crônicas. Biológicas & Saúde, 7(24).
Silva, J. B., Paiva, K. A., Costa, K. M., Viana, G. A., Araújo, H. N., Bezerra, L. S., & Batista, J. S. (2019). Hepatoprotective and antineoplastic potencial of red propolis produced by the bees Apis mellifera in the semiarid of Rio Grande do Norte, Brazil. Pesquisa Veterinária Brasileira, 39, 744-756.
Staniczek, J., Jastrzębska-Stojko, Ż., & Stojko, R. (2021). Biological Activity of Propolis Ointment with the Addition of 1% Nanosilver in the Treatment of Experimentally-Evoked Burn Wounds. Polymers, 13(14), 2312.
Susan, S., Ravalia, M., & Zulhendri, F. (2021). Unusual presentation of oral hemangioma in tongue and the potential use of propolis as an adjunctive treatment. Clinical Case Reports, 9(12), e05243.
Tylkowski, B., Trusheva, B., Bankova, V., Giamberini, M., Peev, G., & Nikolova, A. (2010). Extraction of biologically active compounds from propolis and concentration of extract by nanofiltration. Journal of Membrane Science, 348(1-2), 124-130
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