The main neurological manifestations resulting from Cerebral Malaria in Brazil: an integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i5.28334

Keywords:

Malaria; Nervous System Diseases; Brazil; Health teaching.

Abstract

Objective: To understand the main neurological manifestations of cerebral malaria in Brazil. Methodology: This is an integrative review that searched literature between the years 2007 to 2022, through the descriptors “malaria”, “diseases of the nervous system” and “Brazil”, researched on LILACS, PUBMED and SciELO platforms. Publications with full text available, published between 2007 and 2022, in English, Portuguese and Spanish were used. In addition, studies that did not address the research proposal, as well as repeated or duplicated studies were excluded. Results: The neurological manifestations most frequently reported in the studies presented are characterized by cerebral edema, seizures, coma, cognitive deficit, hippocampal impairment and disturbance of consciousness. Furthermore, the clinical signs and symptoms of severity differ in adults and children, and in both cases they can configure the lethal form of the pathology. Conclusion: The main neurological manifestations of the disease involve coma, seizures, changes in muscle tone, loss of reflexes, and unspecified behavioral and motor dysfunctions. Despite the neurological clinical signs and symptoms found, cerebral malaria is still a neglected disease, with differences in prognosis between child and adult age groups.

References

Andoh, N. E., & Gyan, B. A. (2021). The Potential Roles of Glial Cells in the Neuropathogenesis of Cerebral Malaria. Frontiers in Cellular and Infection Microbiology, 11, 741370. https://doi.org/10.3389/fcimb.2021.741370

Barbosa-Silva, M. C., Lima, M. N., Battaglini, D., Robba, C., Pelosi, P., Rocco, P. R. M., & Maron-Gutierrez, T. (2021). Infectious disease-associated encephalopathies. Critical Care, 25(1), 236. https://doi.org/10.1186/s13054-021-03659-6

Basílio, G. F. C., Santana, L. F. & Moreira, M. (2019). Qual o papel do sistema imune nas mortes por malária? Revista de Patologia do Tocantins, 6(1): 58-62

Barros, F. S. M. de, Honório, N. A., & Arruda, M. E. (2011). Survivorship of Anopheles darlingi (Diptera: Culicidae) in Relation with Malaria Incidence in the Brazilian Amazon. PLoS ONE, 6(8), e22388. https://doi.org/10.1371/journal.pone.0022388

Boivin, M. J., Bangirana, P., Byarugaba, J., Opoka, R. O., Idro, R., Jurek, A. M., & John, C. C. (2007). Cognitive impairment after cerebral malaria in children: a prospective study. Pediatrics, 119(2), e360–e366. https://doi.org/10.1542/peds.2006-2027

Braz, R., Andreozzi, V. L., & Kale, P. L. (2006). Detecção precoce de epidemias de malária no Brasil: uma proposta de automação. Epidemiologia e Serviços de Saúde, 15(2), 21-33. https://dx.doi.org/10.5123/S1679-49742006000200004

Bruneel, F. (2019). Human cerebral malaria: 2019 mini review. Revue Neurologique, 175(7–8), 445–450. https://doi.org/10.1016/j.neurol.2019.07.008

Cardoso, R. F., & Goldenberg, P. (2007). Malária no Estado do Amapá, Brasil, de 1970 a 2003: Trajetória e controle. Cadernos de Saúde Pública, 23(6), 1339–1348. https://doi.org/10.1590/S0102-311X2007000600009

Carlos, B. C., Rona, L. D. P., Christophides, G. K., & Souza-Neto, J. A. (2019). A comprehensive analysis of malaria transmission in Brazil. Pathogens and Global Health, 113(1), 1–13. https://doi.org/10.1080/20477724.2019.1581463

Confalonieri, U. E. C. (2005). Saúde na Amazônia: Um modelo conceitual para a análise de paisagens e doenças. Estudos Avançados, 19(53), 221–236. https://doi.org/10.1590/S0103-40142005000100014

de Miranda, A. S., Brant, F., Machado, F. S., Rachid, M. A., & Teixeira, A. L. (2011). Improving cognitive outcome in cerebral malaria: Insights from clinical and experimental research. Central Nervous System Agents in Medicinal Chemistry, 11(4), 285–295. https://doi.org/10.2174/1871524911106040285

de Souza, J. B., Hafalla, J. C. R., Riley, E. M., & Couper, K. N. (2010). Cerebral malaria: Why experimental murine models are required to understand the pathogenesis of disease. Parasitology, 137(5), 755–772. https://doi.org/10.1017/S0031182009991715

Ghazanfari, N., Mueller, S. N., & Heath, W. R. (2018). Cerebral Malaria in Mouse and Man. Frontiers in Immunology, 9. https://doi.org/10.3389/fimmu.2018.02016

Gomes, A. P., Vitorino, R. R., Costa, A. de P., Mendonça, E. G. de, Oliveira, M. G. de A., & Siqueira-Batista, R. (2011). Malária grave por Plasmodium falciparum. Revista Brasileira de Terapia Intensiva, 23(3), 358–369. https://doi.org/10.1590/S0103-507X2011000300015

Guerra, C. A., Howes, R. E., Patil, A. P., Gething, P. W., Van Boeckel, T. P., Temperley, W. H., Kabaria, C. W., Tatem, A. J., Manh, B. H., Elyazar, I. R. F., Baird, J. K., Snow, R. W., & Hay, S. I. (2010). The International Limits and Population at Risk of Plasmodium vivax Transmission in 2009. PLoS Neglected Tropical Diseases, 4(8), e774. https://doi.org/10.1371/journal.pntd.0000774

Hirako, I. C., Assis, P. A., Galvão-Filho, B., Luster, A. D., Antonelli, L. R., & Gazzinelli, R. T. (2019). Monocyte-derived dendritic cells in malaria. Current Opinion in Microbiology, 52, 139–150. https://doi.org/10.1016/j.mib.2019.08.002

Idro, R., Marsh, K., John, C. C., & Newton, C. R. J. (2010). Cerebral Malaria: Mechanisms of Brain Injury and Strategies for Improved Neurocognitive Outcome. Pediatric Research, 68(4), 267–274. https://doi.org/10.1203/PDR.0b013e3181eee738

John, C. C., Bangirana, P., Byarugaba, J., Opoka, R. O., Idro, R., Jurek, A. M., Wu, B., & Boivin, M. J. (2008). Cerebral Malaria in Children Is Associated With Long-term Cognitive Impairment. Pediatrics, 122(1), e92–e99. https://doi.org/10.1542/peds.2007-3709

Kendjo, E., Houzé, S., Mouri, O., Taieb, A., Gay, F., Jauréguiberry, S., Tantaoui, I., Ndour, P. A., Buffet, P., Piarroux, M., Thellier, M., Piarroux, R., & for the French Imported Malaria Study Group. (2019). Epidemiologic Trends in Malaria Incidence Among Travelers Returning to Metropolitan France, 1996-2016. JAMA Network Open, 2(4), e191691. https://doi.org/10.1001/jamanetworkopen.2019.1691

Leão, L., Puty, B., Dolabela, M. F., Povoa, M. M., Né, Y. G. D. S., Eiró, L. G., Fagundes, N. C. F., Maia, L. C., & Lima, R. R. (2020). Association of cerebral malaria and TNF-α levels: A systematic review. BMC Infectious Diseases, 20(1), 442. https://doi.org/10.1186/s12879-020-05107-2

Luzolo, A. L., & Ngoyi, D. M. (2019). Cerebral malaria. Brain research bulletin, 145, 53–58. https://doi.org/10.1016/j.brainresbull.2019.01.010

Martins, Y. C., & Daniel-Ribeiro, C. T. (2013). A new hypothesis on the manifestation of cerebral malaria: The secret is in the liver. Medical Hypotheses, 81(5), 777–783. https://doi.org/10.1016/j.mehy.2013.08.005

Martins-Campos, K. M., Pinheiro, W. D., Vítor-Silva, S., Siqueira, A. M., Melo, G. C., Rodrigues, Í. C., Fé, N. F., Barbosa, M., Tadei, W. P., Guinovart, C., Bassat, Q., Alonso, P. L., Lacerda, M. V., & Monteiro, W. M. (2012). Integrated vector management targeting Anopheles darlingi populations decreases malaria incidence in an unstable transmission area, in the rural Brazilian Amazon. Malaria Journal, 11(1), 351. https://doi.org/10.1186/1475-2875-11-351

Mendes, K. D. S., Silveira, R. C. de C. P., & Galvão, C. M. (2008). Revisão integrativa: Método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & Contexto - Enfermagem, 17(4), 758–764. https://doi.org/10.1590/S0104-07072008000400018

Mishra, S. K., & Newton, C. R. J. C. (2009). Diagnosis and management of the neurological complications of falciparum malaria. Nature Reviews Neurology, 5(4), 189–198. https://doi.org/10.1038/nrneurol.2009.23

Mohanty, S., Benjamin, L. A., Majhi, M., Panda, P., Kampondeni, S., Sahu, P. K., Mohanty, A., Mahanta, K. C., Pattnaik, R., Mohanty, R. R., Joshi, S., Mohanty, A., Turnbull, I. W., Dondorp, A. M., Taylor, T. E., & Wassmer, S. C. (2017). Magnetic Resonance Imaging of Cerebral Malaria Patients Reveals Distinct Pathogenetic Processes in Different Parts of the Brain. MSphere, 2(3). https://doi.org/10.1128/mSphere.00193-17

Mohanty, S., Mishra, S. K., Patnaik, R., Dutt, A. K., Pradhan, S., Das, B., Patnaik, J., Mohanty, A. K., Lee, S. J., & Dondorp, A. M. (2011). Brain Swelling and Mannitol Therapy in Adult Cerebral Malaria: A Randomized Trial. Clinical Infectious Diseases, 53(4), 349–355. https://doi.org/10.1093/cid/cir405

Maude, R. J., Barkhof, F., Hassan, M. U., Ghose, A., Hossain, A., Abul Faiz, M., Choudhury, E., Rashid, R., Sayeed, A. A., Charunwatthana, P., Plewes, K., Kingston, H., Maude, R. R., Silamut, K., Day, N. P. J., White, N. J., & Dondorp, A. M. (2014). Magnetic resonance imaging of the brain in adults with severe falciparum malaria. Malaria Journal, 13(1). https://doi.org/10.1186/1475-2875-13-177

Nishanth, G., & Schlüter, D. (2019). Blood–Brain Barrier in Cerebral Malaria: Pathogenesis and Therapeutic Intervention. Trends in Parasitology, 35(7), 516–528. https://doi.org/10.1016/j.pt.2019.04.010

Oliveira-Ferreira, J., Lacerda, M. V., Brasil, P., Ladislau, J. L., Tauil, P. L., & Daniel-Ribeiro, C. T. (2010). Malaria in Brazil: an overview. Malaria Journal, 9(1), 115. https://doi.org/10.1186/1475-2875-9-115

Pereira, D. M. S., Carvalho Júnior, A. R., Lacerda, E. M. da C. B., da Silva, L. C. N., Marinho, C. R. F., André, E., & Fernandes, E. S. (2020). Oxidative and nitrosative stresses in cerebral malaria: can we target them to avoid a bad prognosis? Journal of Antimicrobial Chemotherapy. https://doi.org/10.1093/jac/dkaa032

Pereira, D. M. S., Teixeira, S. A., Murillo, O., Peixoto, E. P. M., Araújo, M. C., Sousa, N. C. F., Monteiro-Neto, V., Calixto, J. B., Cunha, T. M., Marinho, C. R. F., Muscará, M. N., & Fernandes, E. S. (2019). TRPV1 Contributes to Cerebral Malaria Severity and Mortality by Regulating Brain Inflammation. Oxidative Medicine and Cellular Longevity, 2019, 1–15. https://doi.org/10.1155/2019/9451671

Potchen, M. J., Kampondeni, S. D., Seydel, K. B., Birbeck, G. L., Hammond, C. A., Bradley, W. G., DeMarco, J. K., Glover, S. J., Ugorji, J. O., Latourette, M. T., Siebert, J. E., Molyneux, M. E., & Taylor, T. E. (2012). Acute Brain MRI Findings in 120 Malawian Children with Cerebral Malaria: New Insights into an Ancient Disease. American Journal of Neuroradiology, 33(9), 1740–1746. https://doi.org/10.3174/ajnr.A3035

Sahu, P. K., Hoffmann, A., Majhi, M., Pattnaik, R., Patterson, C., Mahanta, K. C., Mohanty, A. K., Mohanty, R. R., Joshi, S., Mohanty, A., Bage, J., Maharana, S., Seitz, A., Bendszus, M., Sullivan, S. A., Turnbull, I. W., Dondorp, A. M., Gupta, H., Pirpamer, L., & Mohanty, S. (2020). Brain Magnetic Resonance Imaging Reveals Different Courses of Disease in Pediatric and Adult Cerebral Malaria. Clinical Infectious Diseases, 73(7), e2387–e2396. https://doi.org/10.1093/cid/ciaa1647

Sampaio, V. S., Siqueira, A. M., Alecrim, M. das G. C., Mourão, M. P. G., Marchesini, P. B., Albuquerque, B. C., Nascimento, J., Figueira, É. A. G., Alecrim, W. D., Monteiro, W. M., & Lacerda, M. V. G. (2015). Malaria in the State of Amazonas: a typical Brazilian tropical disease influenced by waves of economic development. Revista Da Sociedade Brasileira de Medicina Tropical, 48(suppl 1), 4–11. https://doi.org/10.1590/0037-8682-0275-2014

Schmidt, K. E., Kuepper, J. M., Schumak, B., Alferink, J., Hofmann, A., Howland, S. W., Rénia, L., Limmer, A., Specht, S., & Hoerauf, A. (2018). Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators. PLoS ONE, 13(2), e0192717. https://doi.org/10.1371/journal.pone.0192717

Seydel, K. B., Kampondeni, S. D., Valim, C., Potchen, M. J., Milner, D. A., Muwalo, F. W., Birbeck, G. L., Bradley, W. G., Fox, L. L., Glover, S. J., Hammond, C. A., Heyderman, R. S., Chilingulo, C. A., Molyneux, M. E., & Taylor, T. E. (2015). Brain Swelling and Death in Children with Cerebral Malaria. New England Journal of Medicine, 372(12), 1126–1137. https://doi.org/10.1056/NEJMoa1400116

Sierro, F., & Grau, G. E. R. (2019). The Ins and Outs of Cerebral Malaria Pathogenesis: Immunopathology, Extracellular Vesicles, Immunometabolism, and Trained Immunity. Frontiers in Immunology, 10, 830. https://doi.org/10.3389/fimmu.2019.00830

Tauil, P., Deane, L., Sabroza, P., & Ribeiro, C. (1985). A malária no Brasil. Cadernos de Saúde Pública, 1(1), 71–111. https://doi.org/10.1590/S0102-311X1985000100009

Vale, J., Matias, G., Canas, N., & Antunes, I. (2008). Síndrome neurológico agudo pós-malária. Acta Médica Portuguesa, 21(4), 387–390. http://hdl.handle.net/10362/24883

Valle, D., & Clark, J. (2013). Conservation Efforts May Increase Malaria Burden in the Brazilian Amazon. PLoS ONE, 8(3), e57519. https://doi.org/10.1371/journal.pone.0057519

World Health Organization. (2000). Severe falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 94, 1–90. https://doi.org/10.1016/s0035-9203(00)90300-6

World Health Organization. (2021). World malaria report 2021. World Health Organization. https://apps.who.int/iris/handle/10665/350147

Published

08/04/2022

How to Cite

ROCHA, V. L. .; VAZ , J. B. .; SILVA , J. G. da .; OLIVEIRA , T. R. J. .; MAGALHÃES, I. G. . The main neurological manifestations resulting from Cerebral Malaria in Brazil: an integrative review. Research, Society and Development, [S. l.], v. 11, n. 5, p. e32711528334, 2022. DOI: 10.33448/rsd-v11i5.28334. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/28334. Acesso em: 18 nov. 2024.

Issue

Section

Health Sciences