Biochemical indicators of dairy cows affected by fermentative digestive disorders
DOI:
https://doi.org/10.33448/rsd-v11i5.28459Keywords:
Blood metabolites; Dairy cows; Fermentative digestive disorders.Abstract
The purpose of the present study was to evaluate blood metabolites in dairy cows affected by digestive disorders of fermentative nature. Sixty-six animals with clinical and laboratory diagnoses were distributed into six groups according to the diagnosis: G1 (n=5) acute ruminal acidosis; G2 (n=10) displacement of the abomasum to the right (RDA); G3 (n=16) displacement of the abomasum to the left (LDA); G4 (n=10) cecal dilation; G5 (n=6) simple indigestion; and G6 (n=19) frothy bloat. Biochemical variables related to the energy, protein, enzymatic, mineral, and hormonal profile were measured soon after diagnosis and at the time of clinical resolution. The data were submitted to analysis of variance (ANOVA) with the level of significance set at 5%. Abnormalities were found with the fermentative digestive disorders, such as a negative energy balance (NEB), liver and muscle damage, and a high level of stress. Among the conditions diagnosed, abnormalities were more evident in acute ruminal acidosis, displacement of the abomasum (RDA), and cecal dilation. The biochemical abnormalities reflected the impact caused by the digestive disorders. Thus, understanding of the dynamics of biochemical abnormalities is fundamental to the establishment of the diagnosis, evaluation of the therapeutic response, and a more precise assessment of the prognosis, thereby avoiding greater economic losses in dairy farming activities and contributing to the improvement in the animal welfare.
References
Afonso, J. A. B. (2017). Afecções intestinais em bovinos. Revista Acadêmica Ciência Animal.; 15, 15-20. DOI: doi.org/10.7213/academica.15.S02.2017.A03
Afonso, J. A. B., Mendonça, C. L., Costa, N. A., Souza, M. I., Simão, L. C. V. & Dantas, F. R. (2002). Alterações clínicas e laboratoriais na dilatação do ceco em bovinos. Análise de 10 casos. Revista Educação Continuada CRMV-SP, 5(3), 313-320. DOI: doi.org/10.36440/recmvz.v5i3.3298
Agenäs, S., Dahlborn, K. & Holtenius, K. (2003). Changes in metabolism and milk production during and after feed deprivation in primiparous cows selected for different milk fat content. Livestock Production Science, 83(2/3), 153-164. DOI: doi.org/10.1016/S0301-6226(03)00096-4
Allen, S. E. & Holm, J. L. (2008). Lactate: physiology and clinical utility. Journal of Veterinary Emergency and Critical Care, 18(2), 123-132. DOI: https://doi.org/10.1111/j.1476-4431.2008.00286.x
Al-Rawashdeh, O., Bani Ismail, Z., Talafha, A. & Al-Momani, A. (2017). Changes of hematological and biochemical parameters and levels of pepsinogen, histamine and prostaglandins in dairy cows affected with left displacement of the abomasums. Polish Journal of Veterinary Sciences, 20(1), 13-18. DOI: 10.1515/pjvs-2017-0002
Antanaitis, R., Stoskus, R. & Televicius, M. (2014). Change of biochemical parameters in cows with abomasal displacement after omentopexy. Zemes Ukio Mokslai, 21(4), 237-241. DOI: 10.6001/zemesukiomokslai.v21i4.3026
Ashmawy, N. A. (2015). Changes in peripheral plasma hormone concentrations and metabolites during the last trimester of pregnancy and around parturition in the Egyptian buffalo and baladi cows. International Journal of Advanced Research, 3(11), 1377-1390.
Aslan, V., Ok, M., Boydak, M., Sen, I., Birdane, F. M. & Alkan, F. (2003). The study on the relationship of abomasal displacement and fatty liver syndrome in dairy cows. Acta Veterinaria Scandinavica, 44, 139. DOI: doi.org/10.1186/1751-0147-44-S1-P139
Assis, R. N., Souza, L. M., Soares, G. S. L., Cajueiro, J. F. P., Souto, R. J. C., Afonso, J. A. B. & Mendonça, C. L. (2021). Systemic implications of metallic foreign body syndrome in dairy cattle. Research, Society and Development, 10(11), E516101119469. DOI: http://dx.doi.org/10.33448/rsd-v10i11.19469
Boink, A. B. T. J., Buckley, B. M., Christiansen, T. F., Covington, A. K., Mass, A. H., Müller-Plathe, O., Sachs, C. & Siggaard-Andersen, O. (1991). Recommendation on sampling, transport, and storage for the determination of the concentration of ionized calcium in whole blood, plasma, and serum. Journal of Automatic Chemistry, 13(5), 235-239. DOI: 10.1155/S1463924691000391
Braun, U., Beckmann, C., Gerspach, C., Hässig, M., Muggli, E., Schweizer, K. G. & Nuss, K. (2012). Clinical findings and treatment in cattle with caecal dilatation. Veterinary Research, 8(75), 2-9. DOI: 10.1186/1746-6148-8-75
Brown, M. S., Krehbiel, C. R., Galyean, M. L., Remmenga, M. D., Peters, J. P., Hibbard, B., Robinson, J. & Moseley, W. M. (2000). Evaluation of models of acute and subacute acidosis on dry matter intake, ruminal fermentation, blood chemistry, and endocrine profiles of beef steers. Journal of Animal Science, 78(12), 3155-3168. DOI: 10.2527/2000.78123155x
Buczinski, S., Boulay, G. & Francoz, D. (2015). Preoperative and Postoperative L-Lactatemia Assessment for the Prognosis of Right Abomasal Disorders in Dairy Cattle. Journal of Veterinary Internal Medicine, 29(1), 375-380. DOI: 10.1111/jvim.12490
Câmara, A. C. L., Afonso, J. A. B., Costa, N. A., Mendonça, C. L., Souza, M. I. & Borges, J. R. J. (2010). Fatores de risco, achados clínicos, laboratoriais e avaliação terapêutica em 36 bovinos com deslocamento de abomaso. Pesquisa Veterinária Brasileira, 30(5), 453-464. DOI: 10.1590/S0100-736X2010000500014
Cardoso, F. C., Esteves, V. S., Oliveira, S. T., Lasta, C. S., Valle, S. F., Campos, R. & González, F. H. D. (2008). Hematological, biochemical and ruminant parameters for diagnosis of left displacement of the abomasum in dairy cows from Southern Brazil. Pesquisa Agropecuária Brasileira, 43(1), 141-147. DOI: 10.1590/S0100-204X2008000100018
Chapinal, N., Carson, M., Duffield, T. F., Capel Godden, S., Overton, M., Santos, J. E. P. & Leblanc, S. J. (2011). The association of serum metabolites with clinical disease during the transition period. Journal Dairy Science, 94(10), 4897-4903. DOI: 10.3168/jds.2010-4075
Coutinho, L. T., Afonso, J. A. B., Costa, N. A., Mendonça, C. L., Farias, P. A. R. & Soares, P. C. (2009). Avaliação da conduta terapêutica em casos de timpanismo espumoso em bovinos. Ciência Animal Brasileira, 10(1), 288-293.
Coutinho, L. T., Afonso, J. A. B., Costa, N. A., Soares, P. C. & Mendonça, C. L. (2012). Fatores de risco relacionados à ocorrência do timpanismo espumoso em bovinos criados na região do Agreste Meridional do Estado de Pernambuco, Brasil. Ciência Animal Brasileira, 13(3), 368-376. DOI: 10.5216/cab.v13i3.9927
Coutinho, L. T., Mendonça, C. L., Soares, G. S. L., Oliveira Filho, E. F., Souto, R. J. C., Cajueiro, J. F. P., Souza, M. I., Silva, N. A. A., Costa, N. A., Soares, P. C. & Afonso, J. A. B. (2019). Avaliação da bioquímica sanguínea de vacas leiteiras acometidas por desordens digestivas de natureza mecânica. Revista Agraria Acadêmica, v.2(5), 67-100. DOI: 10.32406/v2n52019/87-100/agrariacad
Cray, C., Zaias, J. & Altman, N. H. (2009). Acute Phase Response in Animals: A Review. Comparative Medicine, 59(6), 517-526.
Dalto, A. G. C., Bandarra, P. M., Pedroso, P. M. O., Guagnini, F. S., Leal, J. S., Raymundo, D. L. & Driemeier, D. (2009). Timpanismo espumoso em bovinos leiteiros em pastagens de Trifolium spp. (Leg. Caesalpinoideae). Pesquisa Veterinária Brasileira, 29(5), 401-403. DOI: 10.1590/S0100-736X2009000500007
Daniel, R. C. W. (1983). Motility of rumen and abomasum during hypocalcaemia. Canadian Journal of Comparative Medicine, 47(3), 276-280.
Delgado-Lecaroz, R., Warnick, L. D., Guard, C. L., Smith, C. S. & Barry, D. A. (2000). Cross-sectional study of the association of abomasal displacement or volvulus with serum electrolyte and mineral concentrations in dairy cows. The Canadian Veterinary Journal, 41(4), 301-305.
Dezfouli, M. M., Eftekhari, Z., Sadeghian, S., Bahounar, A. & Jeloudari, M. (2013). Evaluation of hematological and biochemical profiles in dairy cows with left displacement of the abomasums. Comparative Clinical Pathology, 22(2), 175-179. DOI: 10.1007/s00580-011-1382-5
Dirksen, G., Gründer, H. D. & Stöber, M. (1993). Rosemberger exame clínico dos bovinos. 3ªed. Guanabara Koogan, Rio de Janeiro. 419p.
Dokovic, R., Samanc, H., Petrovic, M. D., Ilié, Z. & Kurcubic, V. (2012). Relationship among blood metabolites and lipid content in the liver in transitional dairy cows. Biotechnology in Animal Husbandry, 28(4), 705-714. DOI: 10.2298/BAH1204705D
Forslund, K. B., Ljungvall, O. A. & Jones, B. V. (2010). Low cortisol levels in blood from dairy cows with ketosis: a field study. Acta Veterinaria Scandinavica, 52(31), 1-6. DOI: doi.org/10.1186/1751-0147-52-31
Goff, J. P. (2008). The monitoring prevention and treatment of milk fever and subclinical hypocalcemia in dairy cows. Veterinary Journal, 176(1), 50-57. DOI: 10.1016/j.tvjl.2007.12.020
González, F. G., Muiño, R., Pereira, V., Campos, R. & Castellote, J. L. B. (2009). Indicadores sanguíneos de lipomobilização e função hepática no início da lactação em vacas leiteiras de alta produção. Ciência Animal Brasileira, 1, 64-69.
Grosche, A., Fürll, M. & Wittek, T. (2012). Peritoneal fluid analysis in dairy cows with left displaced abomasums and abomasal volvulus. Veterinary Record, 170(16), 413. DOI: 10.1136/vr.10038
Grummer, R. R. (1993). Etiology of lipid-related metabolic disorders in periparturient dairy cows. Journal of Animal Science, 76(12), 3882-3896. DOI: 10.3168/jds.S0022-0302(93)77729-2
Herdt, T. H. (2000). Ruminant adaptation to negative energy balance influences on the etiology of ketosis and fatty liver. Veterinary Clinics of North America: Food Animal Practice, 16(2), 215-230. DOI: 10.1016/s0749-0720(15)30102-x
Horst, R. L. & Jorgensen, N. A. (1982). Elevated plasma cortisol during induced and spontaneous hypocalcaemia in ruminants. Journal Dairy Science, 65(12), 2332-2337. DOI: 10.3168/jds.S0022-0302(82)82505-8
İssi, M., Gül, Y. & Başbuğ, O. (2016). Evaluation of renal and hepatic functions in cattle with subclinical and clinical ketosis. Turkish Journal of Veterinary and Animal Sciences, 40, 47-52. DOI: 10.3906/vet-1505-16
Kaneko, J. J., Harvey, J. W. & Bruss, M. L. (2008). Clinical biochemistry of domestic animals. 6st ed. Sand Diego: Academic Press, 928p.
Khalphallah, A., Aamer, A. A., Abdelall, T., Katoh, H., Oikawa, S., Nakada, K. & Elmeligy, E. (2015). Assessment of insulin and insulin resistance in dairy cattle with displaced abomasums pre and post-surgery. Scholar´s Advances in Animal and Veterinary Research, 2(3), 162-176.
Leblanc, S. J., Leslie, K. E. & Duffield, T. F. (2005). Metabolic predictors of displaced abomasum in dairy cattle. Journal of Dairy Science, 88(1), 159-170. DOI: 10.3168/jds.S0022-0302(05)72674-6
Maden M., Ozturk, A. S., Bulbul, A., Avci, G. E. & Yazar, E. (2012). Acute-phase proteins, oxidative stress and enzyme activities of blood serum and peritoneal fluid in cattle with abomasal displacement. Journal of Veterinary Internal Medicine, 26(6), 1470-1475. DOI: 10.1111/j.1939-1676.2012.01018.x
Meyer, N. F. & Bryant, T. C. (2017). Diagnosis and Management of Rumen Acidosis and Bloat in Feedlots. Veterinary Clinics of North America: Food Animal Practice, 33, 481-498. DOI: 10.1016/j.cvfa.2017.06.005
Nagaraja, T. G. & Lechtenberg, K. F. (2007). Acidosis in feedlot cattle. Veterinary Clinics of North America: Food Animal Practice, 23(2), 333-350. DOI: 10.1016/j.cvfa.2007.04.002
Noro, M., Wagemann, C., Arnés, V. & Wittwer, F. (2013). Valoración diagnóstica de enzimas hepáticas en perfiles bioquímicos sanguíneos de vacas lecheras. Revista MVZ Córdoba, 18(2), 3474-3479. DOI: 10.21897/rmvz.170
Ortolani, E. L., Maruta, C. A. & Minervino, A. H. H. (2008). Influência da raça sobre a volemia e função renal de bovinos com acidose láctica aguda, induzida experimentalmente. Brazilian Journal of Veterinary Research and Animal Science, 45(6), 451-457.
Ortolani, E. L., Maruta, C. A. & Minervino, A. H. H. (2010). Aspectos clínicos da indução experimental de acidose láctica ruminal em zebuínos e taurinos. Brazilian Journal of Veterinary Research and Animal Science, 47(4), 253-261.
Patelli, T. H. C., Fragnani, R., Cunha Silva, L. F. C., Souza, F. A. A., Wolf, G. S., Cardoso, M. J. L., Seiva, F. R. F. & Matsuda, J. (2017). Hipocalcemia no deslocamento de abomaso de bovinos: estudo de 39 casos. Pesquisa Veterinária Brasileira, 37(1), 17-22. DOI: 10.1590/S0100-736X2017000100003
Perotta, J. H., Dyck, H. R., Ollhoff, R. D., Lisbôa, J. A. N., Vieira, N. & Barros Filho, I. R. (2018). One-step laparoscopic abomasopexy versus obomasopexy via right paralumbar fossa to treat left abomasal displacement in dairy cows. Pesquisa Veterinária Brasileira, 38(6), 1068-1076. DOI: 10.1590/1678-5150-PVB-4966
Pogliani, F. C. & Birgel Junior, E. (2007). Valores de referencia do lipidiograma de bovines da raça holandesa, criados no Estado de São Paulo. Brazilian Journal of Veterinary Research and Animal Science, 44(5), 373-383.
Ribeiro, A. C. S., Soares, G. S. L., Coutinho, L. T., Cajueiro, J. F. P.; Souto, R. J. C., Silva, B. H. S., Soares, P. C., Mendonça, C. L., & Afonso, J. A. B. (2020). Cardiac, Energy and Hormonal Blood Markers, and Lactatemia in Cows with Displaced Abomasum. Acta Scientiae Veterinariae, 48, 1752. DOI: 10.22456/1679-9216.103310
Russell, K. E. & Roussel, A. J. (2007). Evaluation of the ruminant serum chemistry profile. Veterinary Clinics Food and Animal Practice, 23(3), 403-426. DOI: 10.1016/j.cvfa.2007.07.003
Santos, J. F., Rego, R. O., Afonso, J. A. B., Soares, P. C. & Mendonça, C. L. (2020). Biomarkers blood and peritoneal fluid of bovines with intestinal diseases and traumatic reticulites. Ciencia Animal Brasileira, 21:e-50941. DOI: doi.org/10.1590/1809-6891v21e-50941
Sapolsky, R. M., Romero, M. L. & Munck, A. U. (2000). How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocrinology, 21(1), 55-89. DOI: 10.1210/edrv.21.1.0389
SAS Institute. (2009). Statistical Analysis System: user guide [CD-ROM]. Version 2009. Cary (NC): SAS Institute Inc.
Schlumbohm, C. & Harmeyer, J. (2008). Twin-pregnancy increases susceptibility of ewes to hypoglycaemic stress and pregnancy toxaemia. Research in Veterrinary Science, 84, 286-299. DOI: 10.1016/j.rvsc.2007.05.001
Seifi, H. A., Leblanc, S. J., Leslie, K. E. & Duffield, T. F. (2011). Metabolic predictors of post-partum disease and culling risk in dairy cattle. The Veterinary Journal, 188(2), 216-220. DOI: 10.1016/j.tvjl.2010.04.007
Sevinc, M., Ok, M. & Basoglu, A. (2002). Liver function in dairy cows with abomasal displacement. Revue Médecine Vétérinaire, 153(7), 477-480.
Soares, G. S. L., Afonso, J. A. B., Costa, N. A., Coutinho, L. T., Souza, M. I. & Mendonça, C. L. (2018). Estudo retrospectivo da acidose láctica ruminal aguda em bovinos. Pesquisa Veterinária Brasileira, 38, 417-419.
Stengärde, L., Holtenius, K., Trávén, M., Hultgren, J., Niskanen, R. & Emanuelson, U. (2010). Blood profiles in dairy cows with displaced abomasums. Journal of Dairy Science, 93(10), 4691-4699. DOI: 10.3168/jds.2010-3295
Stengärde, L., Holtenius, K., Tråvén, M., Hultgren, J., Niskanen, R. & Emanuelson, U. (2010). Blood profiles in dairy cows with displaced abomasum. Journal of Dairy Science, 93(10), 4691-4699. DOI: 10.3168/jds.2010-3295
Trenkle, A. (1981). Endocrine regulation of energy metabolism in ruminants. Federation Proceedings, 40, 2536-2541.
Underwood, W. J. (1992). Rumen lactic acidosis. Part II. Clinical signs, diagnosis, treatment, and prevention. The Compendium, 14(9), 1265-1270.
Van Cleef, H. E., Patiño, P. R., Neiva Jr, P. A., Serafim, S. R., Rego, C. A. & Gonçalves, S. J. (2009). Distúrbios metabólicos por manejo alimentar inadequado em ruminantes: Novos conceitos. Revista Colombiana de Ciencia Animal, 1(2), 319-341. DOI: doi.org/10.24188/recia.v1.n2.2009.376
Van den Top, A. M., Van Tol, A., Jansen, H., Geelen, M. J. H. & Beynen, A. C. (2005). Fatty liver in dairy cows post partum is associated with decreased concentration of plasma triacylglycerols and decreased activity of lipoprotein lipase in adipocytes. Journal of Dairy Research, 72(2), 129-137. DOI: 10.1017/s0022029905000774
Van Meirhaege, H., Deprez, P., Van Den Hende, C. & Muylle. E. (1988). Plasma glucose clearance and insulin response in cows with abomasal displacement. Journal of Veterinary Medicine, 35(1/10), 221-224.
Wittek, T., Furll, M. & Constable, P. D. (2004). Prevalence of endotoxemia in healthy postparturient dairy cows and cows with abomasal volvulus or left displaced abomasum. Journal of Veterinary Internal Medicine, 18(4), 574–580. DOI: 10.1892/0891-6640(2004)18<574:poeihp>2.0.co;2.
Wittwer, F. (2000). Diagnóstico dos desequilíbrios metabólicos de energia em rebanhos bovinos. In: González, F. D. B., Ospina H., Barcelos, J. O & Ribeiro, L. A. Perfil metabólico em ruminantes: seu uso em nutrição e doenças nutricionais. Gráfica da UFRGS, Porto Alegre-RS. pp. 9-22.
Zadnik, T. (2003). A comparative study of the hemato-biochemical parameters between clinically healthy cows and cows with displacement of the abomasum. Acta Veterinaria (Beograd), 53(4/6), 297-309.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Luiz Teles Coutinho; Carla Lopes Mendonça; Gliere Silmara Leite Soares; Ângela Imperiano da Conceição; Emanuel Felipe de Oliveira Filho; Nivan Antonio Alves da Silva; Rodolfo José Cavaltanti Souto; Jobson Filipe de Paula Cajueiro; Pierre Castro Soares; José Augusto Bastos Afonso
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.