Relationship between gut microbiota and mood disorders and the influence that nutrition can exert on this mechanism: A systematic review
Keywords:Psychological Distress; Anxiety; Depression; Gastrointestinal Microbiome; Probiotics; Prebiotics; Feeding behavior.
Objective: This work seeks to analyze the relationship between the intestinal microbiota and the development of psychological pathologies. Methodology: Systematic review, carried out between February 2020 and March 2021. To develop the theoretical framework, a selection of articles was carried out through the search platforms PubMed, Science Direct, Scielo and Lilacs. Results: Experimental studies demonstrate that the intestinal microbiota interferes with the behavior of the host both through the synthesis of neuroactive substances such as serotonin, dopamine and gamma-aminobutyric acid, attenuating behaviors related to anxiety and stress, as well as through the regulation of the Hypothalamus- Pituitary-Adrenal, being the imbalance of the intestinal flora responsible for its hyperactivity, with consequent promotion of more anxious and stressed behavior, due to the release of adrenocorticoid and corticosterone hormones. Conclusion: More detailed studies are needed so that the real effects caused by the microorganisms that make up the intestinal microbiota on the functioning of the brain are elucidated in a clear and objective way.
Al-Sheraji, S. H., Ismail, A., Manap, M. Y., Mustafa, S., Yusof, R. M., & Hassan, F. A. (2013). Prebiotics as functional foods: A review. Journal of functional foods. 5(4), 1542-1553.
Barrett, E., Ross, R. P., O'toole, P. W., Fitzgerald, G. F., & Stanton, C. (2012). γ‐Aminobutyric acid production by culturable bacteria from the human intestine. Journal of applied microbiology. 113(2), 411-417.
Cheung. S., Goldenthal, A. R., Uhlemann, A. C., Mann, J. J., Miller, J. M., & Sublette, M. E. (2019). Systematic review of gut microbiota and major depression. Frontiers in psychiatry. 10, 34.
Clapp, M., Aurora, N., Herrera, L., Bhatia, M., Wilen, E., & Wakefield, S. (2017). Gut microbiota’s effect on mental health: the gut-brain axis. Clinics and practice. 7(4), 131-136.
Cryan, J. F., & Dinan, T. G. (2012). Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nature reviews neuroscience. 13(10), 701-712.
Dash, S., Clarke, G., Berk, M., & Jacka, F. N. (2015). The gut microbiome and diet in psychiatry: focus on depression. Current opinion in psychiatry. 28(1), 1-6.
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., & Lionetti, P. (2010). Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proceedings of the National Academy of Sciences. 107(33), 14691-14696.
Dinan, T. G., Stanton, C., & Cryan, J. F. (2013). Psychobiotics: a novel class of psychotropic. Biological psychiatry. 74(10), 720-726.
Forsythe, P., Sudo, N., Dinan, T., Taylor, V. H., & Bienenstock, J. (2010). Mood and gut feelings. Brain, behavior, and immunity. 24(1), 9-16.
Foster, J. A., Rinaman, L., & Cryan, J. F. (2017). Stress & the gut-brain axis: regulation by the microbiome. Neurobiology of stress. 7, 124-136.
Gomes, P. C., & Maynard, D. C. (2020). Relação entre o hábito alimentar, consumo de probiótico e prebiótico no perfil da microbiota intestinal: Revisão integrativa. Research, Society and Development, 9(8), 1-17.
Grenham, S., Clarke, G., Cryan, J. F., & Dinan, T. G. (2011). Brain–gut–microbe communication in health and disease. Frontiers in physiology. 2, 94.
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., & Pettersson, S. (2011). Normal gut microbiota modulates brain development and behavior. Proceedings of the National Academy of Sciences. 108(7), 3047-52.
Liu, W. H., Chuang, H. L., Huang, Y. T., Wu, C. C., Chou, G. T., Wang, S., & Tsai Y. C. (2016). Alteration of behavior and monoamine levels attributable to Lactobacillus plantarum PS128 in germ-free mice. Behavioural brain research. 298, 202-209.
Myint, A. M., Kim, Y. K., Verkerk, R., Scharpé, S., Steinbusch, H., & Leonard, B. (2007). Kynurenine pathway in major depression: evidence of impaired neuroprotection. Journal of affective disorders. 98(2), 143-151.
Raizel, R., Santini, E., Kopper, A. M., & Reis Filho, A. D. (2011). Effects of probiotics, prebiotics and synbiotics consumption on the human organism. Revista Ciência & Saúde. 4, 66-74.
Revoredo, C. M. S., Libânio, J., Frazão, K., & Cunha, M. (2017). Doença de Crohn e probióticos: uma revisão. Revista da Associação Brasileira de Nutrição-RASBRAN. 8(2), 67-73.
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009). Principles and clinical implications of the brain–gut–enteric microbiota axis. Nature reviews Gastroenterology & hepatology. 6(5), 306.
Savignac, H. M., Corona, G., Mills, H., Chen, L., Spencer, J. P., & Tzortzis, G. (2013). Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-D-aspartate receptor subunits and D-serine. Neurochem Int. 63(8), 756-64.
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X. N., & Koga, Y. (2004). Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice. The Journal of physiology. 558(1), 263-275.
Tonini, I.G.O., Vaz, D. S. S., & Mazur, C.E. (2020). Eixo intestino-cérebro: relação entre microbiota intestinal e desordens mentais. Research, Society and Development, 9(7). 1-14.
Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G.G., Ann, P., Ma, L., & Hsiao, E. Y. (2015). Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell. 161(2), 264-276.
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Copyright (c) 2022 Raiane da Silva Santos ; Maryane Gabriela Borba Tavares ; Agda Maryon Silva Pontes de Farias ; Lilian de Lucena Oliveira Pereira; Fernanda Lucia da Silva
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