Relationship between gut microbiota and mood disorders and the influence that nutrition can exert on this mechanism: A systematic review




Psychological Distress; Anxiety; Depression; Gastrointestinal Microbiome; Probiotics; Prebiotics; Feeding behavior.


Objective: This work seeks to analyze the relationship between the intestinal microbiota and the development of psychological pathologies. Methodology: Systematic review, carried out between February 2020 and March 2021. To develop the theoretical framework, a selection of articles was carried out through the search platforms PubMed, Science Direct, Scielo and Lilacs. Results: Experimental studies demonstrate that the intestinal microbiota interferes with the behavior of the host both through the synthesis of neuroactive substances such as serotonin, dopamine and gamma-aminobutyric acid, attenuating behaviors related to anxiety and stress, as well as through the regulation of the Hypothalamus- Pituitary-Adrenal, being the imbalance of the intestinal flora responsible for its hyperactivity, with consequent promotion of more anxious and stressed behavior, due to the release of adrenocorticoid and corticosterone hormones. Conclusion: More detailed studies are needed so that the real effects caused by the microorganisms that make up the intestinal microbiota on the functioning of the brain are elucidated in a clear and objective way.


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How to Cite

SANTOS , R. da S. .; TAVARES , M. G. B. .; FARIAS , A. M. S. P. de .; PEREIRA, L. de L. O. . .; SILVA, F. L. da . Relationship between gut microbiota and mood disorders and the influence that nutrition can exert on this mechanism: A systematic review. Research, Society and Development, [S. l.], v. 11, n. 6, p. e48711628830, 2022. DOI: 10.33448/rsd-v11i6.28830. Disponível em: Acesso em: 28 may. 2022.



Health Sciences