Comparison between four hours and twenty-four hours endogenous creatinine clearances and exogenous creatinine in healthy dogs
Keywords:Chronic kidney disease; Function tests; Canine.
The chronic kidney disease is the main cause of kidney illness in dogs. The evaluation of glomerular filtration rate (GFR) is essential for the diagnosis of this disease, using endogenous or exogenous creatinine clearance tests. Two methods of evaluation can be found in Brazil, the dual twenty minutes, and the twenty-four hours one. Ten healthy (verified with hematological, urinalysis, biochemical and physical evaluation) animals with ages between one and eight years and weight around twelve kilograms from the kennel of veterinary hospital of Universidade de Franca was submitted to three kinds of GFR tests (twenty-four hours endogenous creatinine clearance, clearance of exogenous creatinine and four hour endogenous creatinine clearance). Significant difference was found between the results of the methods, indicating that the four-hour endogenous creatinine clearance has potential to be utilized in the veterinarian routine.
Baklouti, S., Concordet, D., Borromeo, V., Pocar, P., Scarpa, P., & Cagnardi, P. (2021). Population Pharmacokinetic Model of Iohexol in Dogs to Estimate Glomerular Filtration Rate and Optimize Sampling Time. Frontiers in pharmacology, 12.
Bovee, K. C., & Joyce, T. (1979). Clinical evaluation of glomerular function: 24-hour creatinine clearance in dogs. Journal of the American Veterinary Medical Association, 174(5), 488-491.
Brunetto, M. A., Ruberti, B., Halfen, D. P., Caragelasco, D. S., Vendramini, T. H. A., Pedrinelli, V., ... & Kogika, M. M. (2021). Healthy and Chronic Kidney Disease (CKD) Dogs Have Differences in Serum Metabolomics and Renal Diet May Have Slowed Disease Progression. Metabolites, 11(11), 782.
Braun, J. P., Lefebvre, H. P., & Watson, A. D. J. (2003). Creatinine in the dog: a review. Veterinary Clinical Pathology, 32(4), 162-179.
Carneiro, R. D. S. (2002). Contribuição ao estudo do clearance de creatinina e da excreção fracionada de sódio, potássio, e uréia e determinação de valores de referência de indicadores de função renal em cães.
De Santis, F., Boari, A., Dondi, F., & Crisi, P. E. (2022). Drug-Dosing Adjustment in Dogs and Cats with Chronic Kidney Disease. Animals, 12(3), 262.
Dibartolla, S. J. Abordagem clínica e avaliação laboratorial da doença renal. In: Ettinger, S. J., & Feldman, E. C. (2010). Veterinary internal medicine. Edn, 7, 2086-2088.
Elliot; J & Watson, A. D. J. Chronic kidney disease: stating and management. In: Bonagura, J. D., & Twedt, D. C. (2008). Kirk's Current Veterinary Therapy XIV-E-Book. Elsevier Health Sciences.
Finco, D. R. (1971). Simultaneous determination of phenolsulfonphthalein excretion and endogenous creatinine clearance in the normal dog. Journal of the American Veterinary Medical Association, 159(3), 336-340.
Finco, D. R., Brown, S. A., Crowell, W. A., & Barsanti, J. A. (1991). Exogenous creatinine clearance as a measure of glomerular filtration rate in dogs with reduced renal mass. American journal of veterinary research, 52(7), 1029-1032.
Finco, D. R. Evaluation of renal functions. In: Canine and feline nephrology and urology. Baltimore: Willians e Wilkins; 1995. p.29-46.
Galvão, A. L. B., & Carvalho, M. B. (2017). Estadiamento dos cães com doença renal crônica atendidos em um hospital veterinário no ano de 2013. Science And Animal Health, 5(2), 83-100.
Grauer, G. F. Testes diagnósticos para o sistema urinário. In: Nelson, R. W., & Couto, C. G. (2019). Small animal internal medicine-E-book. Elsevier Health Sciences.
Haller, M., Müller, W., Estelberger, W., & Arnold, P. (1998). Single-injection inulin clearance—a simple method for measuring glomerular filtration rate in dogs. Research in veterinary science, 64(2), 151-156.
International Renal Interest Society. (2022). IRIS treatment recommendations for CKD. Recuperado de http://www.iris-kidney.com/guidelines/recommendations.html. Deve concondar com o ano citado no texto.
McKenna, M., Pelligand, L., Elliott, J., Cotter, D., & Jepson, R. (2020). Relationship between serum iohexol clearance, serum SDMA concentration, and serum creatinine concentration in non‐azotemic dogs. Journal of Veterinary Internal Medicine, 34(1), 186-194.
Miyamoto, K. (1998). Evaluation of t.single-injection method of inulin and creatinine as a renal function test in normal cats. Journal of Veterinary Medical Science, 60(3), 327-332. J vet med sci. 1998;60(3):327-32.
How to Cite
Copyright (c) 2022 Amanda Chítero Silva; Flávio Henrique Rodrigues Stante; Alexandre Martini de Brum; Daniel Paulino Junior
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.