The importance of folic acid for the prevention of myelomeningocele. An integrative literature review
DOI:
https://doi.org/10.33448/rsd-v11i6.29130Keywords:
Meningomyelocele; Folic Acid; Dietary Supplements; Review.Abstract
Introduction: Meningomyelocele is one of the most common and worrying spina bifida malformations during the fetal formation process. Therefore, it is necessary to think about measures that aim to minimize its prevalence, as well as to alleviate the possible associated sequelae during the neonatal process. Objective: To determine the role of the use of folic acid as a food supplement during pregnancy in order to prevent or alleviate the manifestation of myelomeningocele. Methodology: An integrative literature review was carried out in the electronic search engines Pubmed, Cochrane Library, Embase, Scopus and Web of Science using the search strategy based on the MeSH terms “(Meningomyelocele) AND (Folic Acid) AND (Dietary Supplements)”. Results and Discussion: A total of 47 articles were retrieved and of these, 34 were selected based on the inclusion and exclusion criteria. The articles listed folic acid as one of the main alternatives for preventing the manifestation of meningomyelocele, having an even more important context for countries with high social inequality. Its supplementation can be given through the addition of flours that are a low-cost food base for government distribution. In addition, the need for information and nutritional monitoring in a multidisciplinary context throughout the prenatal period was highlighted, in order to guarantee information to families. Conclusion: Folic acid supplementation is an effective and low-cost measure to prevent meningomyelocele, however, a multidisciplinary follow-up throughout the prenatal period is extremely important to really demonstrate good epidemiological results.Keywords: Meningomyelocele; Folic Acid; Dietary Supplements; Review.
References
Al-Ani, Z. R., Al-Hiali, S. J., & Al-Mehimdi, S. M. (2010). Neural tube defects among neonates delivered in Al-Ramadi Maternity and Children's Hospital, western Iraq. Saudi Med J., 31(2), 163-169.
Bannink, F., Larok, R., Kirabira, P., Bauwens, L., & Van Hove, G. (2015). Prevention of spina bifida: folic acid intake during pregnancy in Gulu district, northern Uganda. Pan Afr Med J., 20(90), 1-9.
Bizzi, J. W. J. (2012). Mielomeningocele: conceitos básicos e avanços recentes. Jornal Brasileiro de Neurocirurgia, 23(2), 138-151.
Blencowe, H., Kancherla, V., Moorthie, S., Darlison, M. W., & Modell, B. (2018). Estimates of global and regional prevalence of neural tube defects for 2015: a systematic analysis. Ann N Y Acad Sci., 1414(1), 31-46.
Boyles, A. L., Billups, A. V., Deak, K. L., Siegel, D. G., Mehltretter, L., Slifer, S. H., Bassuk, A. G., Kessler, J. A., Reed, M. C., Nijhout, H. F., George, T. M., Enterline, D. S., Gilbert, J. R., Speer, M. C.; & NTD Collaborative Group. (2006). Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. Environ Health Perspect., 114(10), 1547-52.
Carmichael, S. L., Shaw, G. M., Song, J., & Abrams, B. (2008). Markers of acculturation and risk of NTDs among Hispanic women in California. Birth Defects Res A Clin Mol Teratol., 82(11), 755-62.
Claude, K. M., Juvenal, K. L., & Hawkes, M. (2012). Applying a knowledge-to-action framework for primary prevention of spina bifida in tropical Africa. Matern Child Nutr., 8(2), 174-84.
Clemmensen, D., Thygesen, M., Rasmussen, M. M., Fenger-Grøn, M., Petersen, O. B., & Mosdal, C. (2011). Decreased incidence of myelomeningocele at birth: effect of folic acid recommendations or prenatal diagnostics? Childs Nerv Syst., 27(11), 1951-1955.
De la Fournière, B., Dhombres, F., Maurice, P., De Foucaud, S., Lallemant, P., Zérah, M., Guilbaud, L., & Jouannic, J. M. (2020). Prevention of Neural Tube Defects by Folic Acid Supplementation: A National Population-Based Study. Nutrients, 12(10), 1-10.
Deb, R., Arora, J., Meitei, S. Y., Gupta, S., Verma, V., Saraswathy, K. N., Saran, S., & Kalla, A. K. (2011). Folate supplementation, MTHFR gene polymorphism and neural tube defects: a community based case control study in North India. Metab Brain Dis., 26(3), 241-6.
Deb, R., Arora, J., Samtani, R., Garg, G., Saksena, D., Sharma, N., Kumar, K. A., & Nava, S. K. (2018). Folic acid, dietary habits, and homocysteine levels in relation to neural tube defects: A case-control study in North India. Birth Defects Res., 110(14), 1148-1152.
Eagles, M. E., & Gupta, N. (2020). Embryology of Spinal Dysraphism and its Relationship to Surgical Treatment. Can J Neurol Sci., 47(6), 736-746.
Esmaeili, A., Hanaei, S., Fadakar, K., Dadkhah, S., Arjipour, M., Habibi, Z., Nejat, F. E., & Khashab, M. (2013). Risk factors associated with lipomyelomeningocele: a case-control study. Pediatr Neurosurg., 49(4), 202-207.
Henderson, D. B. H., Ndossi, M., Majige, R., Sued, M., & Shabani, H. K. (2020). Understanding the Mothers of Children with Spina Bifida and Hydrocephalus in Tanzania. World Neurosurg., 142(1), e331-e336.
Honório, H. M., &, Santiago Junior, J. F. (2021). Fundamentos Das Revisões Sistemáticas em Saúde. São Paulo, SP: Santos Publishing.
Idowu, O. E., Disu, E. A., Anga, A. L., & Fabanwo, O. A. (2008). Clinical profile of cranial and spinal dysraphism in Lagos, Nigeria. Journal of Pediatric Neurology, 6(2), 145–150.
Jooma, R. (2004). Preventing neural tube defects by folic acid fortification of flour. J Pak Med Assoc., 54(11), 540-541.
Kancherla, V., Hasan, M. O. S. I., Hamid, R., Paul, L., Selhub, J., Oakley, G., Quamruzzaman, Q., & Mazumdar, M. (2017). Prenatal folic acid use associated with decreased risk of myelomeningocele: A case-control study offers further support for folic acid fortification in Bangladesh. Plos One, 11(2), 1-10.
Kirke, P. N., Molloy, A. M., Daly, L. E., Burke, H., Weir, D. G., & Scott, J. M. (1993). Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q J Med, 86(11), 703-708.
Lee, S., & Gleeson, J. G. (2020). Closing in on Mechanisms of Open Neural Tube Defects. Trends Neurosci., 43(7), 519-532.
Lewis, D. P., Van Dyke, D. C., Stumbo, P. J., & Berg, M. J. (1998). Drug and environmental factors associated with adverse pregnancy outcomes. Part III: Folic acid: pharmacology, therapeutic recommendations, and economics. Ann Pharmacother, 32(10), 1087-1095.
Lowry, R. B., Bedard, T., MacFarlane, A. J., Crawford, S., Sibbald, B., & Agborsangaya, B. C. (2019). Prevalence rates of spina bifida in Alberta, Canada: 2001-2015. Can we achieve more prevention? Birth Defects Res., 111(3), 151-158.
Lupo, P. J., & Zohn, I. (2017). Papers from the Ninth International Conference on Neural Tube Defects. Birth Defects Res., 109(2), 65-67.
Mahmud, I. C., Lerner, E. da R., Giergowicz, F. B., Emmanouilidis, J., Spengler, R. de C. B., & Schneider, R. H. (2021). Tobacco use disorder in the older people: An integrative view. Scientia Medica, 31(1), e41007.
Minns, R. A. (1996). Folic acid and neural tube defects. Spinal Cord Journal, 34(8), 460-465.
Mitchell, L. E. (2005). Epidemiology of neural tube defects. American Journal of Medical Genetics - Seminars in Medical Genetics, 135C(1), 88–94.
Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., Stewart, L. A., & PRISMA-P Group. (2015). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev., 4(1), 1-9.
Morrow, J. I., Hunt, S. J., Russell, A. J., Smithson, W. H., Parsons, L., Robertson, I., Waddell, R., Irwin, B., Morrison, P. J., & Craig, J. J. (2009). Folic acid use and major congenital malformations in offspring of women with epilepsy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry., 80(5), 506-511.
Nguyen, M. P., Lupo, P. J., Northrup, H., Morrison, A. C., Cirino, P. T., & Au, K. S. (2017). Maternal gene-micronutrient interactions related to one-carbon metabolism and the risk of myelomeningocele among offspring. Birth Defects Res., 109(2), 99-105.
O'Byrne, M. R., Au, K. S., Morrison, A. C., Lin, J. I., Fletcher, J. M., Ostermaier, K. K., Tyerman, G. H., Doebel, S., & Northrup, H. (2010). Association of folate receptor (FOLR1, FOLR2, FOLR3) and reduced folate carrier (SLC19A1) genes with meningomyelocele. Birth Defects Res A Clin Mol Teratol., 88(8), 689-694.
Obrycki, J. F., Lee, J. J., Kapur, K., Paul, L., Hasan, M. O. S. I., Mia, S., Quamruzzaman, Q., Christiani, D. C., & Mazumdar, M. (2019). A case-control analysis of maternal diet and risk of neural tube defects in Bangladesh. Birth Defects Res., 111(14), 967-981.
Organização Pan-Americana da Saúde. (2016). OMS divulga novas recomendações para grávidas. Recuperado de: https://saudeamanha.fiocruz.br/oms-divulga-novas-recomendacoes-para-gravidas/#.YdYNJmjMLIU
Poretti, A., Anheier, T., Zimmermann, R., Boltshauser, E., & Swiss Pediatric Surveillance Unit (SPSU). (2008). Neural tube defects in Switzerland from 2001 to 2007: are periconceptual folic acid recommendations being followed? Swiss Med Wkly., 138(41-42), 608-613.
Rabiu, T. B., & Adeleye, A. O. (2013). Prevention of myelomeningocele: African perspectives. Childs Nerv Syst., 29(9), 1533-1540.
Rehman, L., Shiekh, M., Afzal, A., & Rizvi, R. (2020). Risk factors, presentation and outcome of meningomyelocele repair. Pakistan Journal Of Medical Sciences, 36(3), 422-425.
Sachdeva, S., Nanda, S., Bhalla, K., & Sachdeva, R. (2014). Gross congenital malformation at birth in a government hospital. Indian J Public Health., 58(1), 54-56.
Santos, L. M. P., Lecca, R. C. R., Cortez-Escalante, J. J., Sanchez, M. N., & Rodrigues, H. G. (2016). Prévention des anomalies du tube neural par l’enrichissement en acide folique des farines: Étude rétrospective en population au Brésil. Bulletin of the World Health Organization, 94(1), 22–29.
Sebold, C. D., Melvin, E. C., Siegel, D., Mehltretter, L., Enterline, D. S., Nye, J. S., Kessler, J., Bassuk, A., Speer, M. C., George, T. M.; & NTD Collaborative Group. (2005). Recurrence risks for neural tube defects in siblings of patients with lipomyelomeningocele. Genet Med., 7(1), 64-67.
Shah, R. H., Northrup, H., Hixson, J. E., Morrison, A. C., & Au, K. S. (2016). Genetic association of the glycine cleavage system genes and myelomeningocele. Birth Defects Res A Clin Mol Teratol., 106(10), 847-853.
Sikander, M., Khan, M. S. G., Gull-e-faran, Khan, R. G., & Qurat-ul-Ain. (2017). Spina bifida and blessing of prenatal testing: A review. Biomedical Research, 28(8), 3445-3450.
Wald, N. J. (1994). Folic acid and neural tube defects: the current evidence and implications for prevention. Ciba Found Symp., 181(1), 192-208.
Wilson, R. D.; Désilets, V., Wyatt, P., Langlois, S., Gagnon, A., Allen, V., Blight, C., Johnson, J., Audibert, F., Brock, J., Koren, G., Goh, I., Nguyen, P., & Kapur, B. (2007). Pre-conceptional vitamin/folic acid supplementation 2007: the use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other congenital anomalies. J Obstet Gynaecol Can., 29(12), 1003-1013.
Wilson, R. D, Audibert, F., Brock, J. A., Carroll, J., Cartier, L., Gagnon, A., Johnson, J. A., Langlois, S., Murphy-Kaulbeck, L., Okun, N., Pastuck, M., Deb-Rinker, P., Dodds, L., Leon, J. A., Lowel, H. L., Luo, W., MacFarlane, A., McMillan, R., Moore, A., Mundle, W., O'Connor, D., Ray, J., & Van den Hof, M. (2015). Pre-conception Folic Acid and Multivitamin Supplementation for the Primary and Secondary Prevention of Neural Tube Defects and Other Folic Acid-Sensitive Congenital Anomalies. J Obstet Gynaecol Can., 37(6), 534-52.
World Health Organization. (2003). World Atlas of Birth Defects. Recuperado de: http://www.who.int/genomics/about/en/spinabifida.pdf
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