Corticosteroid therapy as adjuvant treatment of large Central Giant Cell Lesion: case report

Authors

DOI:

https://doi.org/10.33448/rsd-v11i6.29209

Keywords:

Giant Cell Granuloma; Corticosteroids; Oral surgery; Jaw.

Abstract

The central giant cell lesion of the maxillary is a rare intraosseous lesion, which presents a variable clinical and radiographic behavior. Its conventional treatment consists of surgical removal, however there are several associated factors, such as the patient's age, extension and behavior of the lesion that are taken. into account in choosing the appropriate treatment. The aim of the study is to report a clinical case of LCCG in the posterior region of the mandible, in a 35-year-old female patient, complaining of hardened increase in volume and tooth mobility of the elements close to the lesion, where an intralesional injection of 8mg of corticosteroids was do per weekly, fortnightly and monthly sessions for 6 months, after that, enucleation with curettage and total removal of the lesion, and extraction of elements affected and compromised by caries and periodontal lesions were performed. Central giant cell lesion requires a precise diagnosis, in order to select the appropriate treatment, taking into account the characteristics of the lesion in each patient. In aggressive lesions, the treatment is always surgical due to the higher success rate.

References

Almeida, H. M. S. et al (2021). Granuloma Central de Células Gigantes dos maxilares: Relato de caso. Brazilian Journal of Development, Curitiba, v.7, n.12, p. 118427-118437

Andrade, D. De., et al (2014). Terapêutica medicamentosa em odontologia. 3ª ed. São Paulo: Artes Médicas LTDA,. p. 50-51.Alsufyani, N. A. et al (2021). A systematic review of the clinical and radiographic features of hybrid central giant cell granuloma lesions of the jaws. Acta odontologica Scandinavica, 79(2), 124–131.

Arizpe, K. L. V. & González, M. F. P. (2018). Tratamiento conservador del granuloma central de células gigantes: A propósito de un caso. Revista Mexicana de Estomatología. 5(1)

Arizpe, K. L. V. & Leal, D. N. G. (2021). Inyección intralesional de corticoesteroides como tratamiento conservador del granuloma central de células gigantes: revisión de la literatura. Odontologia Sanmartin, 24(2): 131-140.

Balaji, P & Balaji, S. M. (2019). Central Giant Cell Granuloma- A case report. Indian Journal of Dental Research; 30:130-132.

Borges, M. V. et al (2020). Tratamento conservador de extensa lesão de células gigantes. Revista Portuguesa de Estomatologia, medicina dentária e cirurgia maxilofacial, 61(1):33-37.

Choe, M. et al. (2021). Treatment of central giant cell granuloma in children with denosumab. Pediatric blood & cancer, 68(3), e28778.

Chrcanovic, B. R., Gomes, C. C., & Gomez, R. S. (2018). Central giant cell lesion of the jaws: An updated analysis of 2270 cases reported in the literature. Journal of oral pathology & medicine: Official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 47(8), 731–739.

Dantas, J. B. L. et al (2021). Alternativas conservadoras no manejo do granuloma central de células gigantes dos maxilares: revisão de literatura. Revista Brasileira de Saúde Funcional, v.9, n.3.

El-Naggar, A. et al (2017). WHO Classification of Head and Neck Tumors. 4th edition. IARC: Lyon. 251-2.

Felin, G. C. et al (2014). Tratamento com corticosteroide de granuloma central de células gigantes mandibular em crianças: relato de caso. RFO, 19(3), 354-358.

Gonçalves, K. K. N. et al (2021). Ressecção segmentar de granuloma central de células gigantes: relato de caso. Odontologia Clínico Científica, Recife, 20(1) 94 – 98.

Hadidi Y. N, Ghanem A. A, & Helmy I. (2015). Injection of steroids intralesional in central giant cell granuloma cases (giant cell tumor): Is it free of systemic complications or not? A case report. Int J Surg Case Rep., ;8:166-70

Izgi, E. & Ogu,l H.(2019). Giant cell reparative granuloma of the mandible with an aggressive radiological appearance. Annals of the Royal College of Surgeons of England; 102:75–76.

Júnior, E. F. V. et al (2021). Manejo cirúrgico de granuloma central de células gigantes em região de seio maxilar: relato de caso. Brazilian journal of oral and maxillofacial surgery. 21(1), 40-43.

Kruse-Losler B, Diallo R, Gaertner C, Mischke KL, Joos U, & Kleinheinz J. (2006). Central giant cell granuloma of the jaws: a clinical, radiologic and histopathologic study of 26 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, ;101:346-54.

Loureiro, A. M. L. C. et al (2019). Abordagem farmacológica em lesão central de células gigantes: Relato de caso. Revista Eletrônica Acervo Saúde, 37.

Melo-Muniz, V. et al (2020). Central giant cell granuloma: A clinicopathological and immunohistochemical study of macrophages, blood vessels, lymphatic vessels and regulatory proteins. Annals of diagnostic pathology, 46, 151526.

Nagar, S. R. et al (2020). A Comparative Analysis of p63 Expression in Giant Cell Tumour (GCT), Central Giant Cell Granuloma (CGCG) and Peripheral Giant Cell Granuloma (PGCG). Head and neck pathology, 14(3), 733–741.

Neto, A. D. A. et al (2020). Granuloma central de células gigantes agressivo em maxila: caso clínico de paciente jovem. Brazilian Journal of Surgery and Clinical Research.31(3), 57-60.

Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da Pesquisa Científica (1 ed ed.). Núcleo de Tecnologia Educacional da Universidade Federal de Santa Maria.

Vásquez, S. A., Sfeir, M. Q. & Rivas, A. H. (2021). Granuloma central a células gigantes agresivo, de presentación atípica: reporte de un caso. Avances en odontoestomatologia, 37(4).

Wang, Y. et al (2019). An aggressive central giant cell granuloma in a pediatric patient: case report and review of literature. Journal of Otolaryngology-Head & Neck Surgery, 48(1), 32.

Downloads

Published

28/04/2022

How to Cite

NASCIMENTO, I. E. A. do .; MONTEIRO, J. M. .; JACINTO , R. L. G. .; BIZARRIA, G. de C. .; LÔBO, M. V. .; ANDRADE, T. I. de .; ALVES, K. C. .; SANTANA, A. F. de .; TORRES, B. C. A. . Corticosteroid therapy as adjuvant treatment of large Central Giant Cell Lesion: case report . Research, Society and Development, [S. l.], v. 11, n. 6, p. e28011629209, 2022. DOI: 10.33448/rsd-v11i6.29209. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/29209. Acesso em: 5 nov. 2024.

Issue

Vol. 11 No. 6

Section

Health Sciences

License

Copyright (c) 2022 Isabely Evelyn Andrade do Nascimento; Júlio Maciel Monteiro; Rafael Lucas Guilhermino Jacinto ; Geovanna de Castro Bizarria; Maelly Vicente Lôbo; Taysnara Ismaeley de Andrade; Kayo Costa Alves; Alexandre Freitas de Santana; Belmino Carlos Amaral Torres

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.