Effect of propolis extract on the skin healing process: a systematic review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i7.29696

Keywords:

Apis mellifera L.; Propolis extract; Healing; Teaching.

Abstract

Propolis is a natural resinous mixture produced by bees from substances collected from plant parts, shoots and exudates. Due to its waxy nature and mechanical properties, bees use propolis in the construction and repair of their hives and this substance is widely known to have a beneficial effect on human health, including wound healing. In this context, this research aimed to approach, through a systematic review, the use of propolis extract in the clinic of lesions and wound healing in the skin, taking into account its benefits. The research consisted of a systematic review, with a quantitative approach, which used the descriptors “Propolis” OR “Apis mellifera L.” and “Wound Healing”, also applying the time interval of the last five years. For data collection, the aforementioned inclusion and exclusion criteria were used. When using the descriptors and time interval in the three databases, a total of 378 articles was found, which after a filtering process using the inclusion and exclusion criteria mentioned above, a final result of eleven articles were selected. The studies demonstrated in this research present the propolis extract as a promising treatment in the healing of the skin, taking into account the therapeutic effect of its constituents that, in an effective way, accelerates the tissue repair process, significantly improving the quality of life for patients with lesions.

References

Afkhamizadeh, M., Aboutorabi, R., Ravari, H., Fathi Najafi, M., Ataei Azimi, S., Javadian Langaroodi, A., & Sahebkar, A. (2018). Topical propolis improves wound healing in patients with diabetic foot ulcer: a randomized controlled trial. Natural product research, 32(17), 2096-2099.

Ali, I. H., Daoud, A. S., & Shareef, A. Y. (2012). Physical properties and chemical analysis of Iraqi propolis. Tikrit Journal of Pure Science, 17(2), 26-31.

Astrada, A., Nakagami, G., Jais, S., & Sanada, H. (2019). Successful treatment of a diabetic foot ulcer with exposed bone using Trigona honey: a case study. Journal of Wound Care, 28(Sup12), S4-S8.

Bloor, S. J., & Mitchell, K. A. (2021). Metabolic products of European-type propolis. Synthesis and analysis of glucuronides and sulfates. Journal of Ethnopharmacology, 274, 114035.

Bonamigo, T., Campos, J. F., Oliveira, A. S., Torquato, H. F. V., Balestieri, J. B. P., Cardoso, C. A. L., & Dos Santos, E. L. (2017). Antioxidant and cytotoxic activity of propolis of Plebeia droryana and Apis mellifera (Hymenoptera, Apidae) from the Brazilian Cerrado biome. PLoS One, 12(9), e0183983.

Caldwell, M. D. (2020). Bacteria and antibiotics in wound healing. Surgical Clinics, 100(4), 757-776.

Cao, X. P., Chen, Y. F., Zhang, J. L., You, M. M., Wang, K., & Hu, F. L. (2017). Mechanisms underlying the wound healing potential of propolis based on its in vitro antioxidant activity. Phytomedicine, 34, 76-84.

Cusinato, D. A., Martinez, E. Z., Cintra, M. T., Filgueira, G. C., Berretta, A. A., Lanchote, V. L., & Coelho, E. B. (2019). Evaluation of potential herbal-drug interactions of a standardized propolis extract (EPP-AF®) using an in vivo cocktail approach. Journal of Ethnopharmacology, 245, 112174.

Ercole, F. F., Melo, L. S. D., & Alcoforado, C. L. G. C. (2014). Revisão integrativa versus revisão sistemática. Revista Mineira de Enfermagem, 18(1), 9-12.

Fidoski, J., Benedetti, A., Kirkov, A., Iliev, A., Stamatoski, A., & Baftijari, D. (2020). Nano-emulsion complex (propolis and vitamin C) promotes wound healing in the oral mucosa. Oral & Maxillofacial Pathology Journal, 11(1).

González-Serrano, J., López-Pintor, R. M., Cecilia-Murga, R., Torres, J., Hernández, G., & López-Quiles, J. (2021). Application of propolis extract, nanovitamin C and nanovitamin E to prevent alveolar osteitis after impacted lower third molar surgery. A randomized, double-blind, split-mouth, pilot study. Medicina oral, patologia oral y cirugia bucal, 26(2), e118.

Gümüş, K., & Özlü, Z. K. (2017). The effect of a beeswax, olive oil and Alkanna tinctoria (L.) Tausch mixture on burn injuries: an experimental study with a control group. Complementary therapies in medicine, 34, 66-73.

Kubat, M., Karabulut, Z., & Şengül, S. (2021). Effect of propolis on wound healing in sacrococcygeal pilonidal disease: A randomized controlled clinical trial. Pakistan Journal of Pharmaceutical Sciences, 34.

Leite¹, L. R. V., de Araújo, I. C. R., & de Sousa, F. (2020). Aspectos farmacêuticos da farmacoterapia de feridas: uma revisão de literatura.

Lourenço, A. R. N. (2013). Administração tópica de fármacos: das restrições aos desafios (Master's thesis).

Maia, K. D. S. (2020). Tratamentos estéticos utilizados após cirurgias plásticas em mulheres de Tubarão-SC. Tecnologia em Cosmetologia e Estética-Tubarão.

Moon, J. H., Lee, M. Y., Chung, Y. J., Rhee, C. K., & Lee, S. J. (2018). Effect of topical propolis on wound healing process after tonsillectomy: randomized controlled study. Clinical and experimental otorhinolaryngology, 11(2), 146.

Mostafa, D., & Mandil, O. A. (2021). Treatment of gingival recession defects using non-invasive pinhole technique with propolis application, a case report. International Journal of Surgery Case Reports, 83, 106042.

Mujica, V., Orrego, R., Fuentealba, R., Leiva, E., & Zúñiga-Hernández, J. (2019). Propolis as an adjuvant in the healing of human diabetic foot wounds receiving care in the diagnostic and treatment centre from the regional hospital of Talca. Journal of diabetes research, 2019.

Picoli, T., Peter, C. M., Hoffmann, J. F., Latosinski, G. S., Zani, J. L., Vargas, G. D. Á., & Fischer, G. (2016). Caracterização química e ação antibacteriana de extrato de própolis marrom da região sul do Brasil. Brazilian Journal of Veterinary Medicine, 38(4), 365-371.

Rodríguez-Archilla, A., & Raissouni, T. (2017). Ensayo clínico aleatorizado sobre la efectividad de tratamientos alternativos en la estomatitis aftosa recurrente. Medicina Clínica, 149(2), 55-60.

Sawaya, A. C. H. F., Barbosa da Silva Cunha, I., & Marcucci, M. C. (2011). Analytical methods applied to diverse types of Brazilian propolis. Chemistry Central Journal, 5(1), 1-10.

Susan, S., Ravalia, M., & Zulhendri, F. (2021). Unusual presentation of oral hemangioma in tongue and the potential use of propolis as an adjunctive treatment. Clinical Case Reports, 9(12), e05243.

Published

25/05/2022

How to Cite

PEREIRA, T. A. C. .; SILVA, F. L. da . Effect of propolis extract on the skin healing process: a systematic review . Research, Society and Development, [S. l.], v. 11, n. 7, p. e30111729696, 2022. DOI: 10.33448/rsd-v11i7.29696. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/29696. Acesso em: 7 jul. 2022.

Issue

Section

Health Sciences