Repercussions of sleep deprivation on the immune system: an integrative literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i7.29795

Keywords:

Sleep deprivation; Imune system; Sleep-Wake Cycle Disorder; Immunosuppression; Immunity disorders.

Abstract

Introduction: Studies show an increase in pro-inflammatory cytokines in the initial phase of sleep. Nevertheless, inflammatory mediators have increased levels in situations of sleep deprivation. The increase in these levels is due to influences of the central nervous system disorder on the immune response. Objective: Review of the literature on the relationship between sleep and the immune system. Method: An active search was carried out on Scielo, EbscoHost and PubMed using the keywords “sleep and immune system”; “sleep and immunity”; “sleep-wake cycle and immunity” and “sleep and immune system”. Original articles published between 2007 and June 2021 were selected. Results: 25 articles were found, of which 15 were selected to compose the work. Discussion: Sleep deprivation causes loss of immune system integrity, with immunosuppression, decreased action of NK cells, helper T cells and phagocytic action. In addition, individuals who suffer from insomnia have an increase in pro-inflammatory cytokines, leading to an inflammatory process. The immune system produces several sleep-regulating substances, including IL-1 and TNF-a, components of innate immunity, which exert a significant influence on the sleep-wake cycle acting as somogenic molecules and modulating non-REM sleep. Conclusion: It is possible to perceive a relationship between the immune system and sleep, in which the first has sonogenic capacity and the second maintains the integrity of the immune system. Sleep deprivation triggers a decrease in the action of the immune system and exacerbation of inflammation.

References

Ackermann, K., et al. (2012). Diurnal rhythms in blood cell populations and the effect of acute sleep deprivation in healthy young men. Sleep, 35 (7), 933–940, 2012.

Almeida, C. M. O & Malheiros, A. (2016). Sleep, immunity and shift workers: A review. Sleep Science, 9 (3), 164–168.

Asif, N, Iqbal, R, & Nazir, C. F. (2017). Human immune system during sleep. American Journal of clinical and experimental immunology, 6 (6), 92–96.

Barros, R. B. A, Gallina, A. Z, & Radaelli, P. B. (2017). A influência do estresse e dos hábitos de vida imunidade dos acadêmicos de medicina do Centro Universitário Assis Gurgacz. Revista Thêma et Scientia, 7 (2).

Besedovsky, L, Lange, T, & Haack, M. (2019). The sleep-immune crosstalk in health and disease. Physiological Reviews, 99 (3), 1325–1380.

Carroll, J. E., Irwin, M. R., Seeman, T. E., Diez-Roux, A. V., Prather, A. A., Olmstead, R, Epel, E, Lin, J, & Redline, S. (2019). Obstructive sleep apnea, nighttime arousals, and leukocyte telomere length: The Multi-Ethnic Study of Atherosclerosis. Sleep, 42 (7), 1–10.

Di Comite, G., et al. (2007). Conversation galant: How the immune and the neuroendocrine systems talk to each other. Autoimmunity Reviews, 7 (1), 23-29.

Fernandes, E. R., et al. Sleep Disturbance during Infection Compromises Tfh Differentiation and Impacts Host Immunity. iScience, 23 (10).

Ibarra-Coronado, E. G., Pérez-Torres, A, Pantaleón-Martínez, A, M, Velazquéz-Moctezuma, J, Rodriguez-Mata, V, & Morales-Montor, J. (2016). Innate immunity modulation in the duodenal mucosa induced by REM sleep deprivation during infection with Trichinella spirallis. Scientific Reports, 7 (1), 1–14.

Irwin, M. R. & Opp, M. R. (2017). Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity. Neuropsychopharmacology, 42 (1), 129–155.

Lent, R. (2018). Neurociências da mente e do comportamento. Rio de Janeiro: Guanabara Koogan.

Martins, B, & Amaral, G. (2021). Sono e suas implicações na saúde e performance esportiva em adultos praticantes de atividade física. Tese de Doutorado - Centro Universitário de Brasília, 1-30.

Meira, E. Cruz, M, Miyazawa, M, & Gozal, D. (2020). Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection. European Respiratory Journal, 55 (6), 1–7.

Palma, B. D, Tiba, P. A, Machado, R. B, Tufik, S, & Suchecki, D. (2007). Repercussões imunológicas dos distúrbios do sono: o eixo hipotálamo-pituitária-adrenal como fator modulador. Revista Brasileira de Psiquiatria, 29 (1), 33–38.

Reinhardt, E. L. (2013). Avaliação do impacto do trabalho em turnos noturnos na produção de citocinas inflamatórias salivares e na secreção dos hormônios melatonina e cortisol. Tese de Doutorado - Universidade de São Paulo, 1-98.

Sánchez Cárdenas, A. G., et al. (2016). Insomnio: un grave problema de salud pública. Rev Med Inst Mex Seguro Soc, 54 (6), 760–769.

Santana, T. P., et al. (2021). Sono e imunidade: papel do sistema imune, distúrbios do sono e terapêuticas / Sleep and immunity: role of the immune system, sleep disorders and treatment. Brazilian Journal of Development, 7 (6), 55769–55784.

Silverthorn, D. U. (2017). Fisiologia Humana: uma abordagem integrada. (7a ed.), Artmed.

Sousa, M., et al. (2020). Invariant Natural Killer T cells resilience to paradoxical sleep deprivation-associated stress. Brain, Behavior, and Immunity, 90 (1), 208–215.

Vainer, A.M, Rocha, V. S, & Juvenale, M. (2021). Melatonina e sistema imune: uma relação com duas vias regulatórias. Brasilian Journal of Health Review. 4 (1), 2906-2929.

Zou, X., et al. (2017). The effects of Jiao-Tai-Wan on sleep, inflammation and insulin resistance in obesity-resistant rats with chronic partial sleep deprivation. BMC Complementary and Alternative Medicine, 17 (1), 1-9.

Published

17/05/2022

How to Cite

COIMBRA, C. O.; MATOS, B. A. de .; FARIA, M. C. de M.; MENEZES, E. A. G. Repercussions of sleep deprivation on the immune system: an integrative literature review. Research, Society and Development, [S. l.], v. 11, n. 7, p. e11011729795, 2022. DOI: 10.33448/rsd-v11i7.29795. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/29795. Acesso em: 4 nov. 2024.

Issue

Section

Health Sciences