Effects of ozone therapy on hematological and serum biochemical parameters in dogs affected by visceral leishmaniasis

Authors

DOI:

https://doi.org/10.33448/rsd-v11i7.29886

Keywords:

Dog; Leishmaniasis; Ozone; Haematological; Serum biochemistry.

Abstract

Visceral leishmaniasis (VL) is a zoonosis and chronic disease caused by the protozoan Leishmania spp. which is of great concern to public health. Currently, the drugs used to treat the disease are costly and present undesirable side effects. The use of ozone to treat chronic diseases in both humans and dogs has shown satisfactory results. The aim of this study was to evaluate the ozone therapy in dogs with VL (n=6), administered by intra-abdominal application (IAA), to evaluate hematological and serum biochemical parameters. The protocol involves one gas dose per week for four consecutive weeks. The immunomodulatory action of ozone was determined in the laboratory analyses, confirmed by the increase trend in the white series and maintenance of the renal and hepatic function. Ozone therapy was found to be well tolerated and no adverse effects were observed. Further studies are required to elucidate the mechanisms of action on the infected host.

References

Alves, A. L., Bevilaqua, C. M. L., Moraes, N. B., & Franco, S.O. (1998). Levantamento epidemiológico da leishmaniose visceral em cães vadios da cidade de Fortaleza, Ceará. Ciência Animal, 8 (2), 63-68.

Alves, G. E. S., Abreu, J. M. G., & Ribeiro Filho, J. D. et al. (2004). Efeitos do ozônio nas lesões de reperfusão do jejuno em equinos. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 56 (4), 433-437. https://doi.org/10.1590/S0102-09352004000400002

Baneth, G., Koutinas, A. F., & Solano-Gallego, L. et al. (2008). Canine leishmaniasis – new concepts and insights on an expanding zoonosis: part one. Trends in Parasitology, 24 (7), 324-330. 10.1016/j.pt.2008.04.001. https://doi.org/10.1016/j.pt.2008.04.001

Bocci, V. (1996). Ozone as a bioregulator. Pharmacology and toxicology of ozone therapy today. Journal of Biological Regulators and Homeostatic Agents, 10 (2-3), 31-53.

Brasil. Ministério da Saúde. Departamento de Vigilância Epidemiológica. (2014). Manual de vigilância e controle da leishmaniose visceral, Brasília: Ministério da Saúde – Secretaria de Vigilância em Saúde.

Cabral, I. L, Utzig, S. L., & Banhuk, F. W. et al. (2020). Aqueous ozone therapy improves the standard treatment of leishmaniasis lesions in animals leading to local and systemic alterations. Parasitology Research, 119 (12), 4243-4253. https://doi.org/10.1007/s00436-020-06925-8

Giunta, R., Coppola, A., & Sammartino, A. et al. (2001). Ozonized autohemotransfusion improves hemorheological parameters and oxygen delivery to tissues in patients with peripheral occlusive arterial disease. Annals of Hematology, 80 (12), 745-748. https://doi.org/10.1007/s002770100377

Gonçalves, J. O. S., Paiva, P. O., & Oliveira, L. B. G. (2020). Uso da ozonioterapia como auxiliar no tratamento de cão portador de leishmaniose: relato de caso. Pubvet, 14 (1), 1-5. https://doi.org/10.31533/pubvet.v14n1a495.1-4

Gontijo, B., & Carvalho, M. L. R. (2003). Leishmaniose tegumentar americana. Revista da Sociedade Brasileira de Medicina Tropical, 36 (1), 71-80. https://doi.org/10.1590/S0037-86822003000100011

Gontijo, C. M. F., & Melo, M. N. (2004). Leishmaniose visceral no Brasil: quadro atual, desafios e perspectivas. Revista Brasileira de Epidemiologia, 7 (3), 338-349. https://doi.org/10.1590/S1415-790X2004000300011

Haddad, M. A. (2006). Efeitos da ozonioterapia sobre parâmetros clínicos, hematológicos e da bioquímica sanguínea de equinos. 2006. 138f. Dissertação (Mestrado em Ciências), Universidade Federal de Viçosa, Viçosa.

Haddad, M. A., Souza, M. V., & Hincapie, J. J. et al. (2009). Comportamento de componentes bioquímicos do sangue em equinos submetidos à ozonioterapia. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 61(3), 539-546. https://doi.org/10.1590/S0102-09352009000300003

Ikeda, F. A., Luvizotto, M. C. R., & Gonçalves, M. E. et al. (2003). Perfil hematológico de cães naturalmente infectados por Leishmania chagasi no município de Araçatuba, São Paulo (Brasil): um estudo retrospectivo de191 casos. La Clínica Veterinaria, 47, 42-48.

Melo, G. D., & Machado, G. F. (2009). Choroid plexus involvement in dogs with spontaneous visceral leishmaniasis: a histopathological investigation. Brazilian Journal of Veterinary Pathology, 2(2), 69-74.

Murray, H. W., Berman, J. D., Davies, C. R., & Saravia, N. G. (2005). Advances in leishmaniasis. Lancet., 366(9496), 1561-1577. https://doi.org/10.1016/S0140-6736(05)67629-5

Ogata, A., & Nagahata, H. (2000). Intramammary application of ozone therapy to acute clinical mastitis in dairy cows. The Journal of Veterinary Medical Science, 62(7), 681-686. https://doi.org/10.1292/jvms.62.681.

Orlandin, J. R., Machado, L. C., Ambrósio, C. E., & Travagli. V. (2021). Ozone and its derivatives in veterinary medicine: a careful appraisal. Veterinary and Animal Science, 13, 100191. https://doi.org/10.1016/j.vas.2021.100191

Pereira, M. T. C., & Garcia, C. A. (2006). Eficácia da ozonioterapia no tratamento de mastite subclínica de vacas em lactação. Veterinária Notícias, 12(2), 109-115.

Sundar, S., & Chaterjee, M. (2006). Visceral leishmaniasis – current therapeutic modalities. The Indian Journal of Medical Research, 123(3), 345-352.

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Published

19/05/2022

How to Cite

MODA, T. F.; LIMA, C. J. de; CARVALHO, H. C.; SALGADO, M. A. C.; FERNANDES, A. B.; ZÂNGARO, R. A.; MOREIRA, L. H. Effects of ozone therapy on hematological and serum biochemical parameters in dogs affected by visceral leishmaniasis. Research, Society and Development, [S. l.], v. 11, n. 7, p. e16711729886, 2022. DOI: 10.33448/rsd-v11i7.29886. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/29886. Acesso em: 12 nov. 2024.

Issue

Vol. 11 No. 7

Section

Agrarian and Biological Sciences

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Copyright (c) 2022 Tiago Fávero Moda; Carlos José de Lima; Henrique Cunha Carvalho; Miguel Angel Castillo Salgado; Adriana Barrinha Fernandes; Renato Amaro Zângaro; Lívia Helena Moreira

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