Effects of phototherapy on tissues with dermal fillers: systematic review protocol





Dermal fillers; Phototherapy; Low-level light therapy; Intense pulsed light therapy; Lasers.


This systematic review protocol aims to verify the existence of synergistic effect of phototherapy in tissues that received dermal fillers. The review will be carried out through the stages of preparation of the research question, search for primary studies, selection of studies according to eligibility criteria, data extraction, analysis, and synthesis of evidence. The question will be based on the PICOS strategy: “Does the combined use of dermal fillers and phototherapy have a synergistic effect on facial rejuvenation?” The search in the literature will be carried out in seven databases and in sources of gray literature. The results will be exported to the Rayyan application for the purpose of deleting duplicate studies. The reading of the titles and abstracts will be carried out by two independent and blind reviewers. Randomized clinical studies that associated phototherapy in tissues that received dermal fillers will be selected for full reading. The data will be extracted and submitted to a narrative synthesis, and if possible, the meta-analysis. In the methodological quality analysis, the RoB2 tool will be used for the risk of bias and the GRADE tool for the quality of evidence.


Carruthers, J., Burgess, C., Day, D., Fabi, S. G., Goldie, K., Kerscher, M., Nikolis, A., Pavicic, T., Rho, N.-K., Rzany, B., Sattler, G., Sattler, S., Seo, K., Werschler, W. P., & Carruthers, A. (2016). Consensus Recommendations for Combined Aesthetic Interventions in the Face Using Botulinum Toxin, Fillers, and Energy-Based Devices. Dermatol Surg, 42(5), 586-597. Retrieved from http://dx.doi.org/10.1097/DSS.0000000000000754

Cotofana, S., Fratila, A. A. M., Schenck, T. L., Redka-Swoboda, W., Zilinsky, I., & Pavicic, T. (2016). The Anatomy of the Aging Face: A Review. Facial Plastic Surgery, 32(3), 253-260. doi:10.1055/s-0036-1582234

Donato, H., & Donato, M. (2019). Etapas na Condução de uma Revisão Sistemática. Acta Médica Portuguesa, 32(3), 227. doi:10.20344/amp.11923

EndNote , T., (2013). EndNote (Version EndNote 20) [64-bit]. Philadelphia, PA: Clarivate.

Escudero, J. S. B., Perez, M. G. B., de Oliveira Rosso, M. P., Buchaim, D. V., Pomini, K. T., Campos, L. M. G., Audi, M., & Buchaim, R. L. (2019). Photobiomodulation therapy (PBMT) in bone repair: A systematic review. Injury, 50(11), 1853-1867. doi:10.1016/j.injury.2019.09.031

Fabi, S. G., Burgess, C., Carruthers, A., Carruthers, J., Day, D., Goldie, K., Kerscher, M., Nikolis, A., Pavicic, T., Rho, N. K., Rzany, B., Sattler, S., Seo, K., Werschler, W. P., & Sattler, G. (2016). Consensus recommendations for combined aesthetic interventions using botulinum toxin, fillers, and microfocused ultrasound in the neck, décolletage, hands, and other areas of the body. Dermatologic Surgery, 42(10), 1199-1208. doi:10.1097/DSS.0000000000000869

Fedok, F. G. (1996). Aging face. Facial Plast Surg, Apr;12(2), 107-115. doi:10.1055/s-0028-1082402

Guyatt, G., Oxman, A. D., Akl, E. A., Kunz, R., Vist, G., Brozek, J., Norris, S., Falck-Ytter, Y., Glasziou, P., & Debeer, H. (2011). GRADE guidelines: 1. Introduction—GRADE evidence profiles and summary of findings tables. Journal of Clinical Epidemiology, 64(4), 383-394. doi:10.1016/j.jclinepi.2010.04.026

Hanna, R., Dalvi, S., Amaroli, A., De Angelis, N., & Benedicenti, S. (2021). Effects of photobiomodulation on bone defects grafted with bone substitutes: A systematic review of in vivo animal studies. J Biophotonics, 14(1), 41. doi:10.1002/jbio.202000267

Higgins, J. P., Altman, D. G., Gotzsche, P. C., Juni, P., Moher, D., Oxman, A. D., Savovic, J., Schulz, K. F., Weeks, L., Sterne, J. A., Cochrane Bias Methods, G., & Cochrane Statistical Methods, G. (2011). The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ, 343, d5928. doi:10.1136/bmj.d5928

International Society of Aesthetic Plastic Surgery (2021). Pesquisa global de 2020 da ISAPS observa mudanças significativas nos procedimentos estéticos durante a pandemia. https://www.isaps.org/wp-content/uploads/2021/12/Portuguese.pdf

Julian P.T. Higgins, J. T., Jacqueline Chandler, M. C., Tianjing Li,, & Welch, M. J. P. a. V. A. (2019). Cochrane Handbook for Systematic Reviews of Interventions (2 ed.). Hoboken, NJ: Wiley-Blackwell.

Loghem, J. V., Yutskovskaya, Y. A., & Werschler, W. M. P. (2015). Calcium hydroxylapatite Over a Decade of Clinical Experience. J Clin; Aesthet Dermatol, 8(1), 38-49. doi:10.2165/00128415-201012950-00034

Magri, A. M. P., Parisi, J. R., Andrade, A. L. M., & Rennó, A. C. M. (2021). Bone substitutes and photobiomodulation in bone regeneration: A systematic review in animal experimental studies. Journal of Biomedical Materials Research Part A, 109(9), 1765-1775. doi:10.1002/jbm.a.37170

Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., & Stewart, L. A. (2015). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic Reviews, 4(1), 1. doi:10.1186/2046-4053-4-1

Ouzzani, M., Hammady, H., Fedorowicz, Z., & Elmagarmid, A. (2016). Rayyan-a web and mobile app for systematic reviews. Syst Rev, 5(1), 210. doi:10.1186/s13643-016-0384-4

Ramos-e-Silva, M., & da Silva Carneiro, S. C. (2007). Elderly skin and its rejuvenation: products and procedures for the aging skin. J Cosmet Dermatol, 6(1), 40-50. doi:10.1111/j.1473-2165.2007.00289.x

Shah, A. R., & Kennedy, P. M. (2018). The Aging Face. Med Clin North Am, 102(6), 1041-1054. doi:10.1016/j.mcna.2018.06.006

Shamseer, L., Moher, D., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., Stewart, L. A., & Group, P.-P. (2015). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ, 350, g7647. doi:10.1136/bmj.g7647

Sterne, J. A. C., Savović, J., Page, M. J., Elbers, R. G., Blencowe, N. S., Boutron, I., Cates, C. J., Cheng, H. Y., Corbett, M. S., Eldridge, S. M., Emberson, J. R., Hernán, M. A., Hopewell, S., Hróbjartsson, A., Junqueira, D. R., Jüni, P., Kirkham, J. J., Lasserson, T., Li, T., McAleenan, A., Reeves, B. C., Shepperd, S., Shrier, I., Stewart, L. A., Tilling, K., White, I. R., Whiting, P. F., & Higgins, J. P. T. (2019). RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ, 366, l4898. doi:10.1136/bmj.l4898

U.S. Food & Drug Administration. (2020). FDA-Approved Dermal Fillers. https://www.fda.gov/medical-devices/aesthetic-cosmetic-devices/fda-approved-dermal-fillers

Urdiales-Galvez, F., Martin-Sanchez, S., Maiz-Jimenez, M., Castellano-Miralla, A., & Lionetti-Leone, L. (2019). Concomitant Use of Hyaluronic Acid and Laser in Facial Rejuvenation. Aesthetic Plast Surg, 43(4), 1061-1070. doi:10.1007/s00266-019-01393-7




How to Cite

SHIBASAKI, L. A. K.; SÁ, N. A. P. .; GRISI, M. P. V. .; REIS, S. R. de A. Effects of phototherapy on tissues with dermal fillers: systematic review protocol. Research, Society and Development, [S. l.], v. 11, n. 7, 2022. DOI: 10.33448/rsd-v11i7.30299. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/30299. Acesso em: 20 feb. 2024.



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