Evaluation of the gastroprotective activity of the ethanol extract and the hexane extract of residues from the fruits of Spondias mombin L.
DOI:
https://doi.org/10.33448/rsd-v11i8.30795Keywords:
Fruits; Gastroprotective; Mombin Spondias.Abstract
A peptic ulcer is an inflammatory lesion in the gastric mucosa. It is caused both by the imbalance between the factors that damage the mucosa and those that protect it, where those that damage stands out. Spondias mombin L. (Anacardiaceae), popularly known as cajazeiras, is used in folk medicine for the treatment of various diseases such as conjunctivitis, healing action, antidiarrheal, diuretic, among others. Some pharmacological activities have already been proven for the species, such as gastroprotective, anti-inflammatory, and antibacterial activities. The objective of this study was to compare the gastroprotective effect between the ethanol extract and the hexane extract of the residues of fruits of S. mombin L. For this, the residue of the fruits was obtained by donation of the association of rural producers of fruits of the boqueirão-Cajazeiras- PB Then the material was dried and crushed. The ethanolic and hexane extracts were obtained separately by maceration. The gastroprotective activity was performed in rats (n=5) by the method of inducing gastric injury with ethanol. The doses for the ethanol extract were 100 and 200 mg/kg and for the hexane extract, a dose of 100 mg/kg. Omeprazole (30 mg/kg) was used as a positive control and 0.9% NaCl was used as a negative control. The result obtained in this work showed a gastroprotective capacity of the hexane extract of cajá residues of 89.46% when compared to the control group. It can be concluded that the non-polar compounds were effective when compared to the polar compounds.
References
Abo, K. A., Ogunleye, V. O., & Ashidi, J. S. (1999). Antimicrobial potential of Spondias mombin, Croton zambesicus, and Zygotritonia crocea. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 13(6), 494-497.
Agra, M. D. F., Freitas, P. F. D., & Barbosa-Filho, J. M. (2007). Synopsis of the plants known as medicinal and poisonous in Northeast of Brazil. Revista Brasileira de Farmacognosia, 17(1), 114-140.
Albuquerque, H. C. P. (2017) Estudo da potencial atividade gastroprotetora do extrato etanolico bruto de Spondias mombin L. (Anacardiaceae). 31f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Universidade Estadual da Paraíba, Campina Grande.
Alvarez-Suarez, J. M., Dekanski, D., Ristić, S., Radonjić, N. V., Petronijević, N. D., Giampieri, F., & Battino, M. (2011). Strawberry polyphenols attenuate ethanol-induced gastric lesions in rats by activation of antioxidant enzymes and attenuation of MDA increase. PLoS One, 6(10), e25878.
Ayoka, A. O., Akomolafe, R. O., Akinsomisoye, O. S., & Ukponmwan, O. E. (2008). Medicinal and economic value of Spondias mombin. African Journal of Biomedical Research, 11(2).
Brito, S. A., de Almeida, C. L. F., de Santana, T. I., da Silva Oliveira, A. R., do Nascimento Figueiredo, J. C. B., Souza, I. T., ... & Wanderley, A. G. (2018). Antiulcer Activity and Potential Mechanism of Action of the Leaves of Spondias mombin L. Oxidative medicine and cellular longevity, 2018.
Brito, S. A., Barbosa, I. S., de Almeida, C. L., de Medeiros, J. W., Silva Neto, J. C., Rolim, L. A., ... & Wanderley, A. G. (2018). Evaluation of gastroprotective and ulcer healing activities of yellow mombin juice from Spondias mombin L. PloS one, 13(11), e0201561.
da Silva, G. A., de Brito, N. J. N., dos Santos, E. C. G., López, J. A., & Almeida, M. G. (2014). Gênero Spondias: aspectos botânicos, composição química e potencial farmacológico. Journal of Biology & Pharmacy and Agricultural Management, 10(1), 27-41.
de Sousa, E. O., dos Santos, A. M. M., da Silva Duarte, A. M., & da Silva, M. T. G. (2021). Uso da farinha da torta residual da polpa do pequi (caryocar coriacium wittm) no desenvolvimento e caracterização de biscoito tipo sequilho. Revista Brasileira de Engenharia de Biossistemas, 15(4), 632-643.
Franke, A., Teyssen, S., & Singer, M. V. (2005). Alcohol-related diseases of the esophagus and stomach. Digestive Diseases, 23(3-4), 204-213.
Hernandes, L. S. (2010). Farmacologia e Fitoquímica dos extratos de Pothomorphe umbellata (L.) Miq., direcionadas à atividade antiúlcera (Dissertação de Mestrado).
Malfertheiner, P., Chan, F, K.L & Mccoll, K, E.L. (2009) Úlcera péptica. A lanceta, 374(9699), 1449-1461.
Martins, A. O. B. P. B. Identificação do perfil químico e avaliação das atividades antioxidante, gastroprotetora, cicatrizante e antimicrobiana do extrato.
Moura, J. Z. D., Borges, S. A., Silva, P. R. R., Maia, V. C., & Borges, T. I. A. (2010). First record of galls in hog plum (Spondias mombin L.) panicles caused by Clinodiplosis (Diptera: Cecidomyiidae) and evaluation of genotypes in Piauí State. Revista Brasileira de Fruticultura, 32, 921-924.
Morimoto, Y., Shimohara, K., Oshima, S., Hara, H., & Sukamoto, T. (1994). Effects of KB-5492, a new anti-ulcer agent with a selective affinity for the sigma-receptor, on aspirin-induced disruption of the rat gastric mucosal barrier. The Japanese Journal of Pharmacology, 64(1), 49-55.
Nworu, Chukwuemeka S. et al. (2011) O extrato da folha de Spondias mombin L. exibe um efeito anti-inflamatório e suprime a formação induzível de fator de necrose tumoral-α e óxido nítrico (NO). Journal of Immunotoxicology 8(1), 16.
Strasser, M. (2011). Triagem fitoquímica e farmacológica e formulação de nanopartículas de produtos derivados de Passiflora serratodigitata L (Doctoral dissertation, Universidade de São Paulo).
Santos, P. A., & Oliveira, J. S. (2017) Chemical Composition of Essential Oils of Spondias mombin L. (Anacardiaceae) Leaves and Fruits collected in Salvador. 6th BCNP - Brazilian Conference on Natural Products.
Veiga Junior, V. F., Pinto, A. C., & Maciel, M. A. M. (2005). Plantas medicinais: cura segura? Química nova, 28(3), 519-528.
Villegas, L. F., Fernández, I. D., Maldonado, H., Torres, R., Zavaleta, A., Vaisberg, A. J., & Hammond, G. B. (1997). Evaluation of the wound-healing activity of selected traditional medicinal plants from Peru. Journal of ethnopharmacology, 55(3), 193-200.
Vomero, N. D., & Colpo, E. (2014). Cuidados nutricionais na úlcera péptica. ABCD. Arquivos Brasileiros de Cirurgia Digestiva, 27, 298-302.
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Copyright (c) 2022 Higor Braga Cartaxo; Maria Rayane Teodósio Alves; Danielle Rocha Silva; Gislayne Tacyana Santos Lucena; Samara Alves Brito
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