Obtaining and characterizing a foot talc from a dry product obtained from the leaves of Cinnamomun zeylanicum
DOI:
https://doi.org/10.33448/rsd-v11i8.31044Keywords:
Cinnamomum zeylanicum; Factor Design; Spray Dry Product; Foot powder.Abstract
This work aims to obtain and characterize a spray-dried product (SDP) from an extractive solution of Cinnamomum zeylanicum leaves, to produce a talc for feet. Initially, the influence of the amount of drug, solvent and extractive method were verified, through factorial design (22), evaluating as responses the total flavonoid content (TFC), dry residue (DR) and extraction efficiency (EE). In the drying operation the following conditions were studied: inlet temperature and proportion of adjuvants. Three talc formulations containing cinnamon PES were also obtained and evaluated for Carr's Index (CI), Hausner Factor (HF), Angle of Repose (AR) and Moisture. According to the results, negative influence was observed using 5 g drug in relation to TFT (-1.02) and EE (-44.14), whereas the solvent ethanol (100%) showed positive influence on the responses, with better content. As for the extraction method, turbolysis showed positive responses for TFT (+2.03), RS (+3.21) and EE (+1.36), being chosen for the other experiments. In the drying operation, the best results were evidenced when 10% adjuvant and inlet temperature of 100 °C were used in relation to TFT and technological properties (CI, FH and AR). Finally, the determination of excipients and their proportions in the formulation presented satisfactory values for moisture and technological properties. The methodologies employed presented important results to produce a talc for feet based on SDP from C. zeylanicum, however further studies are needed to ensure the safety and efficacy of the finished product.
References
Araruna, S. M., Silva, A. H., Canuto, K. M., Silveira, E. R., & Leal, L. K. A. J. (2013). Influence of process conditions on the physicochemical characteristics of cumaru (Amburana cearensis) powder produced by spray drying. Revista Brasileira de Farmacognosia, 23, 132-137.
Brown, R., & Richards, J. (1970). Principles of Powder Mechanics. Pergamon Press. In: London.
Caliskan, G., & Dirim, S. N. (2013). The effects of the different drying conditions and the amounts of maltodextrin addition during spray drying of sumac extract. Food and bioproducts processing., 91(4), 539-548. doi:10.1016/j.fbp.2013.06.004
Casadebaig, J. (1987). Réalisation d'extraits secs nébulisés: optimisation de formes galéniques d'origine végétale à activité diurétique. Montpellier 1,
Cortés-Rojas, D. F., Souza, C. R. F., & Oliveira, W. P. (2015). Optimization of spray drying conditions for production of Bidens pilosa L. dried extract. Chemical Engineering Research and Design, 93, 366-376. doi:10.1016/j.cherd.2014.06.010
Cunha, F. P. d., Costa, L. J. L. d., Fernandes, A. J. D., Souza, T. P. d., Soares, L. A. L. (2009). Development and optimization of extractives from Astronium urundeuva (allemão) Engl. by factorial design. Brazilian Archives of Biology and Technology, 52, 647-652.
Do, Q. D., Angkawijaya, A. E., Tran-Nguyen, P. L., Huynh, L. H., Soetaredjo, F. E., Ismadji, S., & Ju, Y. H. (2014). Effect of extraction solvent on total phenol content, total flavonoid content, and antioxidant activity of Limnophila aromatica. J Food Drug Anal, 22(3), 296-302. doi:10.1016/j.jfda.2013.11.001
Fernandes, F. H. A. (2014). Desenvolvimento de forma sólida obtida a partir de extrato seco de Schinopsis brasiliensis Engler.
Flor, A. S. S. d. O., & Barbosa, W. L. R. (2015). Sabedoria popular no uso de plantas medicinais pelos moradores do bairro do sossego no distrito de Marudá-PA. Revista Brasileira de Plantas Medicinais, 17, 757-768.
Gallo, L., Ramírez-Rigo, M. V., Piña, J., Palma, S., Allemandi, D., & Bucalá, V. (2012). Valeriana officinalis Dry Plant Extract for Direct Compression: Preparation and Characterization. Sci Pharm, 80(4), 1013-1026. doi:10.3797/scipharm.1206-05
Jiménez, M., Domínguez, J. A., Pascual-Pineda, L. A., Azuara, E., & Beristain, C. I. (2018). Elaboration and characterization of O/W cinnamon (Cinnamomum zeylanicum) and black pepper (Piper nigrum) emulsions. Food Hydrocolloids, 77, 902-910. doi:https://doi.org/10.1016/j.foodhyd.2017.11.037
Klein, T., Longhini, R., Bruschi, M. L., & de Mello, J. C. J. (2015). Microparticles containing guaraná extract obtained by spray-drying technique: development and characterization. Revista Brasileira de Farmacognosia, 25, 292-300.
Lee, J.-E., Seo, S.-M., Huh, M.-J., Lee, S.-C., & Park, I.-K. (2020). Reactive oxygen species mediated-antifungal activity of cinnamon bark (Cinnamomum verum) and lemongrass (Cymbopogon citratus) essential oils and their constituents against two phytopathogenic fungi. Pesticide Biochemistry and Physiology, 168, 104644. doi: 10.1016/j.pestbp.2020.104644
Lima, M. d. P., Zoghbi, M. d. G. B., Andrade, E. H. A., Silva, T. M. D., & Fernandes, C. S. J. (2005). Constituintes voláteis das folhas e dos galhos de Cinnamomum zeylanicum Blume (Lauraceae). Acta Amazonica, 35, 363-366.
Marques, C. A. (2001). Importância econômica da família Lauraceae Lindl. Floresta e Ambiente, 8(1), 195-206.
Matshetshe, K. I., Parani, S., Manki, S. M., & Oluwafemi, O. S. (2018). Preparation, characterization and in vitro release study of β-cyclodextrin/chitosan nanoparticles loaded Cinnamomum zeylanicum essential oil. Int J Biol Macromol, 118(Pt A), 676-682. doi:10.1016/j.ijbiomac.2018.06.125
Neto, B. B., Scarminio, I. S., & Bruns, R. E. (2010). Como Fazer Experimentos: Pesquisa e Desenvolvimento na Ciência e na Indústria: Bookman Editora.
Oliveira, O. W., & Petrovick, P. R. J. (2010). Secagem por aspersão (spray drying) de extratos vegetais: bases e aplicações. Revista Brasileira de Farmacognosia, 20(4), 641-650.
Owen, S. (2005). Mineral Oil, dalam Rowe, RC, Sheskey, PJ, and Owen, SC, Handbook of Pharmaceutical Excipient, 471-473. In: Pharmaceutical Press, London.
Patil, V., Chauhan, A. K., & Singh, R. P. J. P. T. (2014). Optimization of the spray-drying process for developing guava powder using response surface methodology. Powder Technology, 253, 230-236.
Peralta-Zamora, P., Morais, J. L. d., & Nagata, N. J. (2005). Por que otimização multivariada? Engenharia Sanitária e Ambiental, 10(2), 106-110.
Poonam, M. (2014). Effect of maltodextrin concentration and inlet temperature during spray drying on physicochemical and antioxidant properties of amla (Emblica officinalis) juice powder. Food and bioproducts processing, v. 92(no. 3), pp. 252-258-2014 v.2092 no.2013. doi:10.1016/j.fbp.2013.08.003
Pourcelot, C. T.-Y. (1993). Preformulation of five commercial celluloses in drug development: Rheological and mechanical behaviour. Drug Development and Industrial Pharmacy, 19(15), 1947-1964.
Ramos, R. T. M., Bezerra, I. C. F., Ferreira, M. R. A., & Soares, L. A. L. (2017). Spectrophotometric Quantification of Flavonoids in Herbal Material, Crude Extract, and Fractions from Leaves of Eugenia uniflora Linn. Pharmacognosy Research, 9(3), 253-260. doi:10.4103/pr.pr_143_16
Silva, R., Martins, G., Nascimento, R., Viana, A., Aguiar, F., & Silva, B. (2019). Uso da metodologia de superfície de resposta na otimização da extração de compostos fenólicos da casca dos frutos de Hymenaea courbaril L. (Jatobá). Brazilian Journal of Food Technology, 22, 1-13. doi:10.1590/1981-6723.08918
Singh, S., Dixit, D. (2014). A review on spray drying: emerging technology in food industry. International Journal of Applied Engineering and Technology Technology. 4(1), 1-8.
Souza, V. B. d. (2016). Extração e encapsulação por coacervação complexa das proantocianidinas da canela (Cinnamomum zeylanicum Blume). Universidade de São Paulo,
Spaniol, B. (2007). Comparação do comportamento compressional de granulado contendo produto seco por aspersão de Phyllanthus niruri L. entre máquinas de comprimir alternativa e rotativa.
Tan, S. P., Tuyen, C. K., Parks, S. E., Stathopoulos, C. E., & Roach, P. D. (2015). Effects of the spray-drying temperatures on the physiochemical properties of an encapsulated bitter melon aqueous extract powder. Powder Technology, 281, 65-75.
Thakur, L., Ghodasra, U., Patel, N., & Dabhi, M. (2011). Novel approaches for stability improvement in natural medicines. Pharmacognosy reviews, 5(9), 48-54. doi:10.4103/0973-7847.79099
Tulini, F. L., Souza, V. B., Echalar-Barrientos, M. A., Thomazini, M., Pallone, E., & Favaro-Trindade, C. S. (2016). Development of solid lipid microparticles loaded with a proanthocyanidin-rich cinnamon extract (Cinnamomum zeylanicum): Potential for increasing antioxidant content in functional foods for diabetic population. Food Res Int, 85, 10-18. doi:10.1016/j.foodres.2016.04.006
Veiga Junior, V. F., Pinto, A. C., & Maciel, M. A. M. (2005). Plantas medicinais: cura segura? Química Nova, 28(3), 519-528.
Vetal, S., Bodhankar, S. L., Mohan, V., & Thakurdesai, P. A. (2013). Anti-inflammatory and anti-arthritic activity of type-A procyanidine polyphenols from bark of Cinnamomum zeylanicum in rats. Food Science and Human Wellness, 2(2), 59-67. doi: 10.1016/j.fshw.2013.03.003
York, P. J. (2005). Delineamento de formas farmacêuticas. 2, 17-28.
Zhang, G. G., Law, D., Schmitt, E. A., & Qiu, Y. (2004). Phase transformation considerations during process development and manufacture of solid oral dosage forms. Adv Drug Deliv Rev, 56(3), 371-390. doi:10.1016/j.addr.2003.10.009
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Wliana Alves Viturino da Silva; Magda Rhayanny Assunção Ferreira; Luiz Alberto Lira Soares
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
