Main clinical manifestations of Multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2
DOI:
https://doi.org/10.33448/rsd-v11i12.31053Keywords:
COVID-19; Inflammation; Pediatrics; Mucocutaneous Lymph Node Syndrome.Abstract
At the end of 2019, in Wuhan, China, the emergence of a new virus, called severe acute respiratory syndrome 2 (SARS-CoV-2, from Severe acute respiratory syndrome-associated coronavirus 2), which causes COVID, was identified. -19, an infectious disease. The clinical characteristics of patients with this disease are quite variable, and may present in a mild, severe and even fatal form. Although there are no major incidences in pediatrics, a new presentation, responsible for affecting children and adolescents and that may have a causal association with SARS-CoV-2, was called pediatric multisystem inflammatory syndrome (P-SIM). This condition refers to a serious involvement of children who need hospital intervention due to intense inflammatory conditions, associated with persistent fever, which can lead to shock and multiple organ failure. The aim is to identify the association between SIM-P and COVID-19 and its main clinical manifestations, through a systematic literature review, in order to collaborate in the medical approach and scientific knowledge about SIM-P, helping in optimizing its diagnosis and treatment, since data on the subject are still scarce. This work consists of a systematic literature review, quantitative and descriptive, in which were used as databases the Scientific Electronic Library Online (SciELO), US National Library of Medicine (PubMed) and Virtual Health Library (VHL), using keywords present in Health Sciences Descriptors (DeCS).
References
Bakadia, B. M., He, F., Souho, T., Lamboni, L., Ullah, M. W., Boni, B. O., ... & Yang, G. (2021). Prevention and treatment of COVID-19: Focus on interferons, chloroquine/hydroxychloroquine, azithromycin, and vaccine. Biomedicine & Pharmacotherapy, 133, 111008.
Barral-Netto, M., Barreto, M. L., Pinto Junior, E. P., & Aragão, E. Construção de conhecimento no curso da pandemia de COVID-19: aspectos biomédicos, clínico-assistenciais, epidemiológicos e sociais.
Brito, S. B. P., Braga, I. O., Cunha, C. C., Palácio, M. A. V., & Takenami, I. (2020). Pandemia da COVID-19: o maior desafio do século XXI. Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia (Health Surveillance under Debate: Society, Science & Technology) –Visa em Debate, 8(2), 54-63.
Campos, L. R., de-Almeida, R. G., Goldenzon, A. V., Rodrigues, M. C. F., Sztajnbok10, F., Lino12, K., ... & Fonseca17, A. R. (2021). SÍNDROME INFLAMATÓRIA MULTISSISTÊMICA PEDIÁTRICA (SIM-P) TEMPORALMENTE ASSOCIADA A COVID-19-ATUALIZAÇÃO.
Cano, M. E. B., Corrêa, A. L. J., de Oliveira, M. G., de Cássio, S. C. P., & da Costa, D. A. (2021). MANEJO DA SÍNDROME INFLAMATÓRIA MULTISSISTÊMICA PEDIÁTRICA ASSOCIADA AO COVID-19. Revista Multidisciplinar em Saúde, 2(4), 119-119.
Centers for Disease and Control Prevention (CDC). (2021, may 20). Case definition multisystem inflammatory syndrome in children (MIS-C). CDC. Recovered in august 23, 2021, in https://www.cdc.gov/mis-c/hcp/
Chiu, S. S., Hung Chan, K., Wing Chu, K., Kwan, S. W., Guan, Y., Man Poon, L. L., & Peiris, J. S. M. (2005). Human coronavirus NL63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in Hong Kong, China. Clinical infectious diseases, 40(12), 1721-1729.
Consiglio, C. R., Cotugno, N., Sardh, F., Pou, C., Amodio, D., Rodriguez, L., ... & CACTUS Study Team. (2020). The immunology of multisystem inflammatory syndrome in children with COVID-19. Cell, 183(4), 968-981.
De-la-Torre-Ugarte, M. C., Takahashi, R. F., & Bertolozzi, M. R. (2011). Revisão sistemática: noções gerais. Revista da Escola de Enfermagem da USP, 45(5), 1260-1266.
Dionne, A., Son, M. B. F., & Randolph, A. G. (2022). An Update on Multisystem Inflammatory Syndrome in Children Related to SARS-CoV-2. The Pediatric infectious disease journal, 41(1), e6.
Esper, F., Ou, Z., & Huang, Y. T. (2010). Human coronaviruses are uncommon in patients with gastrointestinal illness. Journal of Clinical Virology, 48(2), 131-133.
Emeksiz, S., Çelikel Acar, B., Kibar, A. E., Özkaya Parlakay, A., Perk, O., Bayhan, G. İ., ... & Şenel, E. (2021). Algorithm for the diagnosis and management of the multisystem inflammatory syndrome in children associated with COVID‐19. International Journal of Clinical Practice, 75(9), e14471.
European Centre for Disease Prevention and Control (ECDC). (2021, september 09). COVID-19 situation update worldwide, as of week 35. ECDC. Recovered in 9 September, 2021, in https://www.ecdc.europa.eu/en/geographical-distribution-2019-ncov-cases
Falqueto, L. E., VISSOCI, C., Ferreira, I. C. B., Antunes, A. G., Amado, F. A. B., Avilla, S. A. G., ... & SILVA, E. D. (2022). COVID-19 associated multisystem inflammatory syndrome in children mimicking acute appendicitis-how to differentiate and conduct pediatric patients during the pandemic?-Proposal of a management flowchart. Revista do Colégio Brasileiro de Cirurgiões, 48.
Farias, E. C. F. D., Justino, M. C. A., & Mello, M. L. F. M. F. D. (2020). Multisystem inflammatory syndrome in a child associated with coronavirus disease 19 in the Brazilian Amazon: fatal outcome in an infant. Revista Paulista de Pediatria, 38.
Fliesler, N. (2020). COVID-19 and A Serious Inflammatory Syndrome in Children: Unpacking Recent Warnings. Boston Children’s Hospital.
Jiang, L., Tang, K., Levin, M., Irfan, O., Morris, S. K., Wilson, K., ... & Bhutta, Z. A. (2020). COVID-19 and multisystem inflammatory syndrome in children and adolescents. The Lancet Infectious Diseases.
JONES, Veena G. et al. COVID-19 and Kawasaki disease: novel virus and novel case. Hospital pediatrics, v. 10, n. 6, p. 537-540, 2020.
Lam, JY, Roberts, SC, Shimizu, C., Bainto, E., Sivilay, N., Tremoulet, AH, Gardiner, MA, Kanegaye, JT, Hogan, AH, Salazar, JC, Mohandas, S., Szmuszkovicz, JR, Mahanta, S., Dionne, A., Newburger, JW, Ansusinha, E., DeBiasi, RL, Hao, S., Ling, XB, Cohen, HJ, … CHARMS Study Group (2022). Validação multicêntrica de um algoritmo de aprendizado de máquina para diagnóstico de pacientes pediátricos com síndrome inflamatória multissistêmica e doença de Kawasaki. medRxiv: o servidor de pré-impressão para ciências da saúde , 2022.02.07.21268280
Licciardi, F., Pruccoli, G., Denina, M., Parodi, E., Taglietto, M., Rosati, S., & Montin, D. (2020). SARS-CoV-2–induced Kawasaki-like hyperinflammatory syndrome: a novel COVID phenotype in children. Pediatrics, 146(2).
Majumder, J., & Minko, T. (2021). Recent Developments on Therapeutic and Diagnostic Approaches for COVID-19. The AAPS Journal, 23(1), 1-22.
Mamishi, S., et al. (2020). Síndrome inflamatória multissistêmica associada à infecção por SARS-CoV-2 em 45 crianças: um primeiro relato do Irã. Epidemiology & Infection, 148.
McIntosh, K. (2020, june 11). Coronaviruses. UpToDate. Recovered in april 17, 2021, in https://www.uptodate.com/contents/coronaviruses?sectionName=VIROLOGY&search=undefined&topicRef=126981&anchor=H2&source=see_link#H2
McIntosh, K. (2021, april 08). COVID-19: Clinical features. UpToDate. Recovered in april 17, 2021, in https://www.uptodate.com/contents/covid-19-clinical-features?search=covid19&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1#H749004236
McIntosh, K. (2021, april 08). COVID-19: Epidemiology, virology, and prevention. UpToDate. Recovered in april 17, 2021, in https://www.uptodate.com/contents/covid-19-epidemiology-virology-and-prevention?search=undefined&topicRef=128323&source=see_link
Ministério da Saúde. (2022, maio 24). Painel Coronavírus. Atualizado em: 23/05/2022 17:30. Disponível em https://covid.saude.gov.br/
Smith, M. (2020, december 8). What Parents Should Know about Multisystem Inflammatory Syndrome in Children (MIS-C). Children’s hospital Los Angeles. Recovered in september, 2021, in https://www.chla.org/blog/covid-19/what-parents-should-know-about-multisystem-inflammatory-syndrome-children-mis-c
Microbiologia : fundamentos e perspectivas / Jacqueline G. Black, Laura J. Black; revisão técnica Roberto Lima ; tradução Patricia Lydie . - 10. ed. - Rio de Janeiro : Guanabara Koogan, 2021.
Microbiologia médica / Patrick R. Murray, Ken S. Rosenthal, Michael A. Pfaller; [tradução Andreza Martins]. 7. ed. Rio de Janeiro : Elsevier, 2014.
Microbiologia [recurso eletrônico] / Gerard J. Tortora, Berdell R. Funke, Christine L. Case ; tradução: Aristóbolo Mendes da Silva ... [et al.] ; revisão técnica: Flávio Guimarães da Fonseca. – 10. ed. – Dados eletrônicos. – Porto Alegre : Artmed, 2012.
Oliveira, A. C. D., Lucas, T. C., & Iquiapaza, R. A. (2020). What has the covid-19 pandemic taught us about adopting preventive measures?. Texto & contexto-enfermagem, 29.
Pumapillo Garcia, A. S., & Quispe Castillo, C. Z. (2021). Esquema de manejo de COVID-19 en adultos. Horizonte Médico (Lima), 21(1).
Panupattanapong, S., & Brooks, E. B. (2020). New spectrum of COVID-19 manifestations in children: Kawasaki-like syndrome and hyperinflammatory response. Cleveland Clinic journal of medicine.
Prata-Barbosa, A., Lima-Setta, F., Santos, G. R. D., Lanziotti, V. S., Castro, R. E. V. D., Souza, D. C. D., ... & Magalhães-Barbosa, M. C. D. (2020). Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study☆,☆☆. Jornal de pediatria, 96, 582-592.
Sampaio, C. A., Amorim, E. R. S., Sampaio, G. B. A., Bohrer, W. F. V. A., Vasconcelos, C. G., & Oliveira, I. F. Relato de caso: síndrome inflamatória multissistêmica associada à infecção pelo SARS-CoV-2 em pediatria. Resid Pediatr, 202(0), 0.
Sampaio, R. F., & Mancini, M. C. (2007). Estudos de revisão sistemática: um guia para síntese criteriosa da evidência científica. Brazilian Journal of Physical Therapy, 11, 83-89.
Santos, B. S. D., Santos, F. S. D., & Ribeiro, E. R. (2020). Clinical-epidemiological relation between sars-cov-2 and kawasaki disease: an integrative literature. Revista Paulista de Pediatria, 39.
Shulman, S. T., & Rowley, A. H. (2015). Kawasaki disease: insights into pathogenesis and approaches to treatment. Nature Reviews Rheumatology, 11(8), 475-482.
Son, M. B. F.; Friedman, K. (2021, may 15). COVID-19: Multisystem inflammatory syndrome in children (MIS-C) clinical features, evaluation, and diagnosis. UpToDate. Recovered in june 03, 2021, in https://www.uptodate.com/contents/covid-19-multisystem-inflammatory-syndrome-in-children-mis-c-clinical-features-evaluation-and-diagnosis?search=sindrome%20inflamatoria%20multissistemica%20pediatrica&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1
Son, M. B. F.; Friedman, K. (2021, may 26). Pediatric inflammatory syndrome temporally related to covid-19. UpToDate. Recovered in may 30, 2021, in https://www.uptodate.com/contents/covid-19-multisystem-inflammatory-syndrome-in-children-mis-c-management-and-outcome?search=pediatric%20inflammatory%20syndrome%20temporally%20related%20to%20Coronavirus%20infection&source=search_result&selectedTitle=4~150&usage_type=default&display_rank=4
Souza, A. C. S., Fernandes, J. S., Negraes, R. T., & de Azevedo, L. S. N. Síndrome inflamatória multissistêmica (MIS-C) em criança após infecção por SARS-CoV-2.
The Royal College of Paediatrics and Child Health (RCPCH). (2020, september). Paediatric multisystem inflammatory syndrome temporally associated with COVID-19 (PIMS). RCPCH. Recovered in august 23, 2021, in https://www.rcpch.ac.uk/resources/guidance-paediatric-multisystem-inflammatory-syndrome-temporally-associated-covid-19-pims
Grimaud, M., Starck, J., Levy, M., Marais, C., Chareyre, J., Khraiche, D., ... & Oualha, M. (2020). Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children. Annals of intensive care, 10(1), 1-5.
Umakanthan, S., Sahu, P., Ranade, A. V., Bukelo, M. M., Rao, J. S., Abrahao-Machado, L. F., ... & Dhananjaya, K. V. (2020). Origin, transmission, diagnosis and management of coronavirus disease 2019 (COVID-19). Postgraduate medical journal, 96(1142), 753-758.
World Health Organization. (2021). Living guidance for clinical management of COVID-19: living guidance, 23 November 2021 (No. WHO/2019-nCoV/clinical/2021.2). World Health Organization
Xavier, A. R., Silva, J. S., Almeida, J. P. C., Conceição, J. F. F., Lacerda, G. S., & Kanaan, S. (2020). COVID-19: manifestações clínicas e laboratoriais na infecção pelo novo coronavírus. Jornal Brasileiro de Patologia e Medicina Laboratorial, 56.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Ana Maria Santos Cardoso; Brenda Dias Araujo; Vitória Stéfanny Cunha Araujo; Tereza Cristina de Carvalho Souza Garcês; Ana Rachel Oliveira de Andrade
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
