Survival and factors related to death of patients with head and neck câncer
DOI:
https://doi.org/10.33448/rsd-v11i9.31483Keywords:
Head and neck cancer; Survival; Determination of death.Abstract
Introduction: Head and neck cancer is considered one of the most aggressive cancers, with low survival and a negative impact on patients' quality of life. Objetives: To evaluate the survival and death-related factors of patients with head and neck cancer in the State of Sergipe. Methods: Longitudinal study with patients diagnosed with head and neck cancer from August 2017 to June 2020. The minimum sample size was estimated at 47 patients, based on a non-parametric survival analysis of a sample. Data were examined for loss to follow-up, outliers, normality and linearity. Survival was calculated using the Kaplan-Meier limit product estimator, factors related to death by Cox regression. Results: Of the 79 patients followed, most were men, mean age 55 years, residents of the interior of the state, low income and schooling, smokers and diagnosed with advanced stage injuries. Overall survival at 12 and 24 months of follow-up was 50.6% and 39.4%, respectively. Being male and not having a partner was associated with death. Conclusion: Patients with head and neck cancer in Sergipe have a low 24-month survival and a higher risk of death among male and single, divorced and widowed individuals.
References
Barros-silva, P. G. De, Fontes-borges, M. M., Costa-dias, C., Mota-lemos, J. V., Socorro-saldanha-cunha, M. P., & Fernandes-souza, E. (2020). Clinical-pathological and sociodemographic factors associated with the distant metastasis and overall survival of oral cavity and oropharynx squamous cell carcinoma, 25(3). https://doi.org/10.4317/medoral.23410
Bashir, A., Kumar, D., Dewan, D., & Sharma, R. (2020). Radiobiological modeling of acute esophagitis after radiation therapy of head, neck, and thorax tumors: The influence of chemo‑radiation. Journal of Cancer Research and Therapeutics, 14(7), 1525–1534. https://doi.org/10.4103/jcrt.JCRT
Bertolucci, P. H. F., Brucki, S. M. D., Campacci, S. R., & Juliano, Y. (1994). O Mini-Exame do Estado Mental em uma população geral: impacto da escolaridade. Arquivos de Neuro-Psiquiatria, 52(1), 01–07. https://doi.org/10.1590/S0004-282X1994000100001
Bhattacharyya, P., Mukherjee, D., Barman, S., Dey, T. K., & Biswas, J. (2016). Factors Responsible for the Diagnostic Delay in Oral Cancer Patients: A Hospital Based Sociodemographic Study in Kolkata. Bengal Journal of Otolaryngology and Head Neck Surgery, 24(3), 141–147. https://doi.org/10.47210/bjohns.2016.v24i3.91
Bonfante, G. M. da S., Machado, C. J., Souza, P. E. A. de, Andrade, E. I. G., Acurcio, F. de A., & Cherchiglia, M. L. (2014). Sobrevida de cinco anos e fatores associados ao câncer de boca para pacientes em tratamento oncológico ambulatorial pelo Sistema Único de Saúde, Brasil. Cadernos de Saúde Pública, 30(5), 983–997. https://doi.org/10.1590/0102-311X00182712
Brandizzi, D., Gandolfo, M., Velazco, M. L., Cabrini, R. L., & Lanfranchi, H. E. (2008). Clinical features and evolution of oral cancer: A study of 274 cases in Buenos Aires, Argentina. Medicina Oral, Patologia Oral y Cirugia Bucal, 13(9), E544-8. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/18758396
BRASIL. (2004). Classificação de Tumores Malignos. Ministério da Saúde. Secretaria de Atenção à Saúde. Instituto Nacional de Câncer. Retrieved from http://www1.inca.gov.br/tratamento/tnm/index.asp
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 68(6), 394–424. https://doi.org/10.3322/caac.21492
Brouha, X., Tromp, D., Hordijk, G.-J., Winnubst, J., & De Leeuw, R. (2005). Role of alcohol and smoking in diagnostic delay of head and neck cancer patients. Acta Oto-Laryngologica, 125(5), 552–556. https://doi.org/10.1080/00016480510028456
Da Silva, F. A., Roussenq, S. C., Gonçalves de Souza Tavares, M., Pezzi Franco de Souza, C., Barreto Mozzini, C., Benetti, M., & Dias, M. (2020). Perfil Epidemiológico dos Pacientes com Câncer de Cabeça e Pescoço em um Centro Oncológico no Sul do Brasil. Revista Brasileira de Cancerologia, 66(1). https://doi.org/10.32635/2176-9745.RBC.2020v66n1.455
IBGE. (2018). IBGE – Instituto Brasileiro de Geografia E Estatística. www.ibge.gov.br/cidade@
INCA. (2020). Instituto Nacional do Câncer: Atlas On-Line de Mortalidade. R https://mortalidade.inca.gov.br/MortalidadeWeb/pages/Modelo05/consultar.xhtml#panelResultado
Johnson, N. W., Warnakulasuriya, S., Gupta, P. C., Dimba, E., Chindia, M., Otoh, E. C., & Kowalski, L. (2011). Global Oral Health Inequalities in Incidence and Outcomes for Oral Cancer. Advances in Dental Research, 23(2), 237–246. https://doi.org/10.1177/0022034511402082
Le Campion, A. C. O. V., Santos, K. de C. B. dos, Carmo, E. S. do, Silva Júnior, F. F. da, Peixoto, F. B., Ribeiro, C. M. B., & Ferreira, S. M. S. (2016). Caracterização do atraso no diagnóstico do câncer de boca e orofaringe em dois centros de referência. Cadernos Saúde Coletiva, 24(2), 178–184. https://doi.org/10.1590/1414-462X201600020004
Liao, D. Z., Schlecht, N. F., Rosenblatt, G., Kinkhabwala, C. M., Leonard, J. A., Ference, R. S., & Mehta, V. (2019). Association of Delayed Time to Treatment Initiation With Overall Survival and Recurrence Among Patients With Head and Neck Squamous Cell Carcinoma in an Underserved Urban Population. JAMAOtolaryngology–Head&Neck Surgery, 10467. https://doi.org/10.1001/jamaoto.2019.2414
Martins Filho, P. R. S., Santos, T. de S., Silva, L. C. F. da, & Piva, M. R. (2014). Oral cancer in Brazil: a secular history of Public Health Policies. RGO - Revista Gaúcha de Odontologia, 62(2), 159–164. https://doi.org/10.1590/1981-8637201400020000091688
Melo-Filho, M. R. de, Rocha, B. A., Pires, M. B. de O., Fonseca, E. S., Freitas, E. M. de, Junior, H. M., & Santos, F. B. G. (2013). Quality of life of patients with head and neck cancer. Brazilian Journal of Otorhinolaryngology, 79(1), 82–88. https://doi.org/10.5935/1808-8694.20130014
Moro, J. da S., Maroneze, M. C., Ardenghi, T. M., Barin, L. M., & Danesi, C. C. (2018a). Oral and oropharyngeal cancer: epidemiology and survival analysis. Einstein (São Paulo), 16(2). https://doi.org/10.1590/s1679-45082018ao4248
Moro, J. da S., Maroneze, M. C., Ardenghi, T. M., Barin, L. M., & Danesi, C. C. (2018b). Oral and oropharyngeal cancer: epidemiology and survival analysis. Einstein (São Paulo), 16(2), 1–5. https://doi.org/10.1590/s1679-45082018ao4248
Muller, F., & Viani, G. A. (2019). Avaliação da sobrevida de pacientes com câncer de cabeça e pescoço localmente avançado tratados em um único centro, 87. https://doi.org/10.1016/j.bjorlp.2020.11.005
Nagashima, K., Noma, H., Sato, Y., & Gosho, M. (2021). Sample size calculations for single‐arm survival studies using transformations of the Kaplan–Meier estimator. Pharmaceutical Statistics, 20(3), 499–511. https://doi.org/10.1002/pst.2090
Pereira, A., Shitsuka, D., Parreira, F., & Shitsuka, R. (2018). Método Qualitativo, Quantitativo ou Quali-Quanti. Metodologia da Pesquisa Científica. Retrieved from https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1. Acesso em: 28 março 2020.
Robert H. Fletcher, Fletcher, S. W., & Fletcher, G. S. (2014). Epidemiologia clínica: elementos essenciais. (Artmed, Ed.) (5th ed.)
Saúde, O. M. da. (2008). CID-10 Classificação Estatística Internacional de Doenças e Problemas Relacionados á Saúde. (Edusp, Ed.) (10a ed.).
Scott, S. E., Grunfeld, E. A., & McGurk, M. (2005). The idiosyncratic relationship between diagnostic delay and stage of oral squamous cell carcinoma. Oral Oncology, 41(4), 396–403. https://doi.org/10.1016/j.oraloncology.2004.10.010
Sousa, A. R. de, Koury, G. V., Hennemann, E. B. L. B., Cavalcante, H. de A., & Araújo, C. N. F. (2016). Perfil clínico-epidemiológico de pacientes com câncer de cabeça e pescoço em hospital de referência. Revista Da Sociedade Brasileira de Clínica Médica, 14(98), 129–132. Retrieved from http://www.sbcm.org.br/revistas/RBCM/RBCM-2016-03.pdf
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Copyright (c) 2022 Claudiane Mahl; Andreia Centenaro Vaez; Carla Kalline Alves Cartaxo Freitas; Simone Yuriko Kameo; Sara Juliana de Abreu de Vasconcellos; Beatriz Santana Silva; Paulo Ricardo Saquete Martins Filho
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