Resin infiltration for esthetic improvement of mild fluorosis in a patient with autism spectrum disorder: A 36-month follow-up




Fluorosis, dental; Autism Spectrum Disorder; Resin infiltration; Enamel microabrasion; Infection control; Practice management.


Report a case using a minimally invasive technique (ICON®) to treat mild dental fluorosis in an adolescent with an autism spectrum disorder. Male patient, 15 years old, diagnosed with autism spectrum disorder, with the chief complaint of white spots on anterior teeth resulting in low self-esteem. Upon clinical examination, opaque white areas were observed in the enamel of all teeth, compatible with the diagnosis of mild dental fluorosis. As the patient has a mild degree of autism spectrum disorder and exhibits collaborative behavior, the treatment of choice was the resin infiltration in the maxillary incisors, canines, and first premolars. The step-by-step application was carried out according to the manufacturer’s recommendations under the rubber dam. An immediate improvement in the appearance of fluorosis was significant, and the aesthetic result was satisfactory, with color stability after 36 months of follow-up. Resin infiltration was excellent for treating mild dental fluorosis, improving aesthetics, and easy of application. Additionally, the infiltrant obtained color stability 36 months after treatment and met the expectations of the patient and his family. Aesthetics should be considered when they impact their lives, facilitating care in these cases is essential to complete treatment.


American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders (DSM-V) (A. P. Association (ed.); 5th ed.).

Aoba, T., & Fejerskov, O. (2002). Dental fluorosis: Chemistry and biology. Critical Reviews in Oral Biology and Medicine, 13(2), 155–170.

Auschill, T. M., Schmidt, K. E., & Arweiler, N. B. (2015). Resin Infiltration for Aesthetic Improvement of Mild to Moderate Fluorosis: A Six-month Follow-up Case Report. In Oral Health and Preventive Dentistry (Vol. 13, Issue 4, pp. 317–322).

Bhandary, S., & Hari, N. (2017). Salivary biomarker levels and oral health status of children with autistic spectrum disorders : a comparative study. European Archives of Paediatric Dentistry.

Borges, A. B., Caneppele, T. M. F., Masterson, D., & Maia, L. C. (2017). Is resin infiltration an effective esthetic treatment for enamel development defects and white spot lesions? A systematic review. Journal of Dentistry, 56, 11–18.

Cocco, A. R., Lund, R. G., Torre, E. N., & Martos, J. (2016). Treatment of fluorosis spots using a resin infiltration technique: 14-Month follow-up. Operative Dentistry, 41(4), 357–362.

Coffield, K. D., Phillips, C., Brady, M., Roberts, M. W., Strauss, R. P., & Wright, J. T. (2005). The psychosocial impact of developmental dental defects in people with hereditary amelogenesis imperfecta. Journal of the American Dental Association, 136(5), 620–630.

de Lacerda, A. J. F., da Silva Ávila, D. M., Borges, A. B., Pucci, C. R., & Rocha Gomes Torres, C. (2016). Adhesive Systems as an Alternative Material for Color Masking of White Spot Lesions: Do They Work? The Journal of Adhesive Dentistry, 18(1), 43–50.

Di Giovanni, T., Eliades, T., & Papageorgiou, S. N. (2018). Interventions for dental fluorosis: A systematic review. Journal of Esthetic and Restorative Dentistry, 30(6), 502–508.

Goddard, L., O’Dowda, H., & Pring, L. (2017). Knowing me, knowing you: Self defining memories in adolescents with and without an autism spectrum disorder. Research in Autism Spectrum Disorders, 37, 31–40.

Hasmun, N., Lawson, J., Vettore, M. V., Elcock, C., Zaitoun, H., & Rodd, H. (2018). Change in oral health-related quality of life following minimally invasive aesthetic treatment for children with molar incisor hypomineralisation: A prospective study. Dentistry Journal, 6(4).

Meireles, S. S., Goettems, M. L., Castro, K. S., Sampaio, F. C., & Demarco, F. F. (2018). Dental fluorosis treatment can improve the individuals’ OHRQoL? Results from a randomized clinical trial. Brazilian Dental Journal, 29(2), 109–116.

Meng, L., Hua, F., & Bian, Z. (2020). Coronavirus Disease 2019 (COVID-19): Emerging and Future Challenges for Dental and Oral Medicine. Journal of Dental Research, 99(5), 481–487.

Muñoz, M. A., Arana-Gordillo, L. A., Gomes, G. M., Gomes, O. M., Bombarda, N. H. C., Reis, A., & Loguercio, A. D. (2013). Alternative esthetic management of fluorosis and hypoplasia stains: Blending effect obtained with resin infiltration techniques. Journal of Esthetic and Restorative Dentistry, 25(1), 32–39.

Peng, X., Xu, X., Li, Y., Cheng, L., Zhou, X., & Ren, B. (2020). Transmission routes of 2019-nCoV and controls in dental practice. International Journal of Oral Science, 12(1), 1–6.

Perdigão, J., Lam, V. Q., Burseth, B. G., & Real, C. (2017). Masking of enamel fluorosis discolorations and tooth misalignment with a combination of at-home whitening, resin infiltration, and direct composite restorations. Operative Dentistry, 42(4), 347–356.

Revelo-Mejía, I. A., Hardisson, A., Rubio, C., Gutiérrez, Á. J., & Paz, S. (2021). Dental Fluorosis: the Risk of Misdiagnosis—a Review. Biological Trace Element Research, 199(5), 1762–1770.

Saxena, P., Grewal, M. S., Agarwal, P., Kaur, G., Verma, J., & Chhikara, V. (2021). Clinical Efficacy of Resin Infiltration Technique Alone or in Combination with Micro Abrasion and in-Office Bleaching in Adults with Mild-to-Moderate Fluorosis Stains. Journal of Pharmacy & Bioallied Sciences, 13(Suppl 1), S301–S305.

Schoppmeier, C. M., Derman, S. H. M., Noack, M. J., & Wicht, M. J. (2018). Power bleaching enhances resin infiltration masking effect of dental fluorosis. A randomized clinical trial. Journal of Dentistry, 79, 77–84.

Tchaconas, A., & Adesman, A. (2013). Autism spectrum disorders : a pediatric overview and update. 25(1), 130–143.

Torres, C. R. G., Borges, A. B., Torres, L. M. S., Gomes, I. S., & De Oliveira, R. S. (2011). Effect of caries infiltration technique and fluoride therapy on the colour masking of white spot lesions. Journal of Dentistry, 39(3), 202–207.

Zotti, F., Albertini, L., Tomizioli, N., Capocasale, G., & Albanese, M. (2021). Resin infiltration in dental fluorosis treatment—1-year follow-up. Medicina (Lithuania), 57(1), 1–14.




How to Cite

MORAES, R. R. .; LOTITO, M. C. F. .; ALLEGRETTO, M. J. .; MARQUES , V. de O. .; LETIERI , A. dos S. .; NEVES, A. de A. .; CASTRO , G. F. B. de A. . Resin infiltration for esthetic improvement of mild fluorosis in a patient with autism spectrum disorder: A 36-month follow-up. Research, Society and Development, [S. l.], v. 11, n. 9, p. e14511931540, 2022. DOI: 10.33448/rsd-v11i9.31540. Disponível em: Acesso em: 19 aug. 2022.



Health Sciences