Potential drug interactions in surgical patients at a university hospital
DOI:
https://doi.org/10.33448/rsd-v11i9.31544Keywords:
Pharmacology; Hospitalized patients; Clinical pharmacy.Abstract
This study aimed to identify, classify and quantify the potential for drug interactions in patients admitted to a surgical unit. This is a cross-sectional and retrospective study carried out at the surgical clinic of the Neuromuscular System Unit of the Getúlio Vargas University Hospital, located in Amazonas, from August to December 2019. In total, one hundred and ninety-six surgical patients were included in the study. There was a predominance of females (61.22%), the mean age of the patients was 49.7 ± 15.6 years, with a mean length of stay of 7.2 ± 10.1 days. It was observed that potential drug interactions occurred in one hundred and fifty-two patients (77.55%), with a mean of 3.4 ± 4.0 interactions per patient, totaling six hundred and fifty-nine potential interactions. According to our results, it appears that the role of the clinical pharmacist is important to prevent, detect and manage these possible interactions in surgical units, resulting in the optimization of pharmacological treatment and the improvement of care provided to patients.
References
Badin, R. C., Martins, C. S. M., & Manaças, L. R. A. (2022). Pharmacological profile and potential drug interactions in ovarian cancer hospitalized patients. Journal of Oncology Pharmacy Practice, 10781552221091298.
Bleich, G. W., Bleich, A., Chiamulera, P., Sanches, A. C. C., Schneider, D. S. L. G., & Teixera, J. J. V. (2009). Frequency of potential interactions between drugs in medical prescriptions in a city in southern Brazil. São Paulo Medical Journal, 127(4), 206-210.
Carvalho, R. E. F. L., Reis, A. M. M., Faria, L. M. P., Zago, K. S. A., & Cassiani, S. H. B. (2013). Prevalência de interações medicamentosas em unidades de terapia intensiva no Brasil. Acta Paul Enferm, 26(2), 150-7.
Cedraz, K.N., & Santos, J. M. C. (2014). Identificação e caracterização de interações medicamentosas em prescrições médicas da unidade de terapia intensiva de um hospital público da cidade de Feira de Santana, BA. Rev Soc Bras Clin Med., 12(2), 124-30.
Correr, C. J., Pontarolo, R., Ferreira, L. C., & Baptistão, S. A. (2007). Riscos de problemas relacionados com medicamentos em pacientes de uma instituição geriátrica. Revista Brasileira De Ciencias Farmaceuticas, 43, 55-62.
Cruciol-Souza, J. M., & Thomson, J. C. (2006). Prevalence of potential drug-drug interactions and its associated factors in a Brazilian teaching hospital. J Pharm Pharm Sci., 9(3), 427-433.
Ernst, F. R., & Grizzle, A. J. (2001). Drug-related morbidity and mortality: updating the cost-of-illness model. Journal of the American Pharmaceutical Association (Washington, D.C.: 1996), 41(2), 192–199. https://doi.org/10.1016/s1086-5802(16)31229-3
Garske, C. C. D., Brixner, B., Freitas, A. P., & Schneider, A. P. H. (2016). Avaliação das interações medicamentosas potenciais em prescrições de pacientes em unidade de terapia intensiva. Revista Saúde e Pesquisa, 9(3), 483-490.
Gonçalves, S. S., Rodrigues, H. M. S., Jesus, I. S., Carneiro, J. A. O., & Lemos, G. S. (2016). Ocorrência clínica de interações medicamentosas em prescrições de pacientes com suspeita de reação adversa internados em um hospital no interior da Bahia. Rev. Aten. Saúde, 14(48), 32-39.
https://www.micromedexsolutions.com/home/dispatch/ssl/true
Institute of Medicine (US) Committee on Quality of Health Care in America, Kohn, L. T., Corrigan, J. M., & Donaldson, M. S. (Eds.). (2000). To Err is Human: Building a Safer Health System. National Academies Press (US).
Juurlink, D. N., Mamdani, M., Kopp, A., Laupacis, A., & Redelmeier, D. A. (2003). Drug-drug interactions among elderly patients hospitalized for drug toxicity. JAMA, 289(13), 1652–1658. https://doi.org/10.1001/jama.289.13.1652
Kopp, B. J., Erstad, B. L., Allen, M. E., Theodorou, A. A., & Priestley, G. (2006). Medication errors and adverse drug events in an intensive care unit: direct observation approach for detection. Critical care medicine, 34(2), 415–425. https://doi.org/10.1097/01.ccm.0000198106.54306.d7
Leape, L. L., & Berwick, D. M. (2005). Five years after To Err Is Human: what have we learned?. JAMA, 293(19), 2384–2390. https://doi.org/10.1001/jama.293.19.2384
Locatelli, J. (2007). Interações medicamentosas em idosos hospitalizados. Rev. Einstein On Line, 5(4), 343-346.
Micromedex® Healthcare Series (Internet database). Greenwood Village, Colo: Thomson Healthcare. Retirado de: https://www.micromedexsolutions.com/home/dispatch/ssl/true
Moreira, M. B., Mesquita, M. G. R., Stipp, M. A. C., & Paes, G.O. (2017). Potential intravenous drug interactions in intensive care. Rev Esc Enferm USP, 51, e03233.
Passos, M. M. B., Santos, R. C., Bergamini, V. G., & Souza, D. C. (2012). Interações medicamentosas em pacientes internados na clínica médica de um hospital de ensino e fatores associados. Rev. Bras. Farm., 93(4), 450-456.
Petri, A. A., Schneider, A., Kleibert, K. R. U., Bittencourt, V. L. L., Winkelmann, E. R., & Colet, C. d. F. (2020). Interações medicamentosas potenciais em pacientes hospitalizados. Rev. Aten. Saúde, 18(63), 31-42.
Roblek, T., Vaupotic, T., & Mrhar, A. (2015). Drug-drug interaction software in clinical practice: a systematic review. Eur J Clin Pharmacol. 7, 131–142.
Santos, M. H. B. A. (2017). Análise de interações medicamentosas potenciais e de eventos adversos a medicamentos em uma unidade de terapia intensiva (Dissertação de mestrado não publicada). Escola Nacional de Saúde Pública Sergio Arouca/Fundação Oswaldo Cruz, Rio de Janeiro.
Silva, N. M. O., Carvalho, R. P., Bernardes, A. C. A., Moriel, P., Mazzola, P. G., & Franchini, C. C. (2010). Avaliação de potenciais interações medicamentosas em prescrições de pacientes internadas, em hospital público universitário especializado em saúde da mulher, em Campinas-SP. Rev Ciênc Farm Básica Apl., 31(2), 171-176.
Silva, U. D. A., Soeiro, C. L. S., Resque, R. L., Gomes, M. R. F., Costa, É. R. G., Fujishima, M. A. T., ... Dantas, D. S. (2018). Interações medicamentosas e consequentes intervenções farmacêuticas na Unidade de Terapia Intensiva de um hospital privado em Macapá, Amapá. Vigil. sanit. Debate, 6(2), 29-37.
Zheng, W. Y., Richardson, L. C., Li, L., Westbrook, J. I., & Baysari, M. T. (2018). Drug-drug interactions and their harmful effects in hospitalised patients: a systematic review and meta-analysis. Eur J Clin Pharmacol, 74, 15–27.
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Copyright (c) 2022 Lucas Alexandre da Silva; Sabrina Santarém de Moraes; Sandra Barros de Oliveira; Mírian Brasil Magalhães de Oliveira; Vívian do Nascimento Pereira; Gretry Preacy Vieira de Andrade; Rebeka Caribé Badin
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