Profile of Inflammatory Bowel Disease at reference service in gastropediatrics in Brazil Northeast
DOI:
https://doi.org/10.33448/rsd-v11i9.31563Keywords:
Pediatrics; Colitis; Crohn Disease.Abstract
Objective: To report the profile of patients with Inflammatory Bowel Disease followed up at a pediatric gastroenterology service in Brazil Northeast. Methodology: Series of cases through the active search of medical records from April to November 2020, with inclusion criteria the regular follow-up at the Gastropediatrics service and non-inclusion criteria the incomplete medical records (without clinical, laboratory, endoscopic and/or histopathological criteria of Inflammatory Bowel Disease), with a final sample of 22 participants. Results: Most were male (63.6%), had Ulcerative Colitis (59.1%) and came from the capital (63.6%). The main symptoms were: diarrhea with blood (63.6%), abdominal pain (27.3%) and diarrhea without blood (9%). Fecal Calprotectin was elevated (88.9%) and anemia was present (77.3%). Most were eutrophic (59.1%). Corticosteroids (72.7%) and Mesalazine (27.3%) were used in the remission phase, while Azathioprine (18.2%) and immunobiologicals (36.6%) in the follow-up. Conclusion: More studies on this topic are still expected, as well as trained professionals and effective health services are needed to receive precociously and to forward in long-term these patients to improve their quality of life and impact positively of the disease’s evolution.
References
Ananthakrishnan, A. N. (2015). Epidemiology and risk factors for IBD. Nature reviews Gastroenterology & hepatology, 12(4), 205-217.
Ashton, J. J., Batra, A., & Beattie, R. M. (2018). Paediatric inflammatory bowel disease-brief update on current practice. Paediatrics and child health, 28(11), 507-514.
Assa, A., Rinawi, F., & Shamir, R. (2018). The long-term predictive properties of the Paris classification in paediatric inflammatory bowel disease patients. Journal of Crohn's and Colitis, 12(1), 39-47.
Bailey, J., Sreepati, G., Love, J., Fischer, M., Vuppalanchi, R., Ghabril, M., ... & Lammert, C. (2014). Autoimmune Hepatitis With Inflammatory Bowel Disease Is Distinct and May Be More Refractory to Traditional Treatment: 504. Official journal of the American College of Gastroenterology| ACG, 109, S149.
Basturk, A., Yilmaz, A., Keceli, M., & Artan, R. (2017). Infliximab treatment in a paediatric patient with ulcerative colitis, who developed acute pancreatitis due to azathioprine during follow-up. Przeglad Gastroenterologiczny, 12(3), 235.
Birimberg-Schwartz, L., Wilson, D. C., Kolho, K. L., Karolewska-Bochenek, K., Afzal, N. A., Spray, C., ... & paediatric IBD Porto group of ESPGHAN. (2016). pANCA and ASCA in children with IBD-unclassified, Crohn's colitis, and ulcerative colitis—a longitudinal report from the IBD Porto Group of ESPGHAN. Inflammatory bowel diseases, 22(8), 1908-1914.
Bressler, B., Marshall, J. K., Bernstein, C. N., Bitton, A., Jones, J., Leontiadis, G. I., ... & Williams, C. (2015). Clinical practice guidelines for the medical management of nonhospitalized ulcerative colitis: the Toronto consensus. Gastroenterology, 148(5), 1035-1058.
Chaparro, M., & Gisbert, J. P. (2016). Maintenance therapy options for ulcerative colitis. Expert Opinion on Pharmacotherapy, 17(10), 1339-1349.
Chibbar, R., & Moss, A. C. (2020). Mesalamine in the Initial Therapy of Ulcerative Colitis. Gastroenterology Clinics, 49(4), 689-704.
de Souza, A. R., Negreiros, D. S., de Souza, I. F., Martinez, E. J. J., & Bitencourt, E. L. (2020). Perfil epidemiológico dos casos de Doença Inflamatória Intestinal em pacientes pediátricos na região Norte do Brasil entre 2010 e 2019. Revista de Patologia do Tocantins, 7(3), 7-10.
Duricova, D., Burisch, J., Jess, T., Gower-Rousseau, C., Lakatos, P. L., & ECCO-EpiCom. (2014). Age-related differences in presentation and course of inflammatory bowel disease: an update on the population-based literature. Journal of Crohn's and Colitis, 8(11), 1351-1361.
Eszter Müller, K., Laszlo Lakatos, P., Papp, M., & Veres, G. (2014). Incidence and paris classification of pediatric inflammatory bowel disease. Gastroenterology Research and Practice, 2014.Flynn, S., & Eisenstein, S. (2019). Inflammatory bowel disease presentation and diagnosis. Surgical Clinics, 99(6), 1051-1062.
Figueirêdo, A. A. D., Mota, J. A., Penna, F. J., & Silva, G. A. P. (2004). Colite ulcerativa inespecífica em crianças e adolescentes: análise de casuística. Revista Brasileira de Saúde Materno Infantil, 4(3), 309-315.
Flynn, S., & Eisenstein, S. (2019). Inflammatory bowel disease presentation and diagnosis. Surgical Clinics, 99(6), 1051-1062.
Fuller, M. K. (2019). Pediatric inflammatory bowel disease: special considerations. Surgical Clinics, 99(6), 1177-1183.
Ghersin, I., Khateeb, N., Katz, L. H., Daher, S., Shamir, R., & Assa, A. (2019). Anthropometric measures in adolescents with inflammatory bowel disease: a population-based study. Inflammatory Bowel Diseases, 25(6), 1061-1065.
Goodhand, J. R., Kamperidis, N., Rao, A., Laskaratos, F., McDermott, A., Wahed, M., ... & Rampton, D. S. (2012). Prevalence and management of anemia in children, adolescents, and adults with inflammatory bowel disease. Inflammatory bowel diseases, 18(3), 513-519.
Guariso, G., Gasparetto, M., Dalla Pozza, L. V., D'Incà, R., Zancan, L., Sturniolo, G., ... & Facchin, P. (2010). Inflammatory bowel disease developing in paediatric and adult age. Journal of pediatric gastroenterology and nutrition, 51(6), 698-707.
Karolewska-Bochenek, K., Lazowska-Przeorek, I., Albrecht, P., Grzybowska, K., Ryzko, J., Szamotulska, K., ... & Jarocka-Cyrta, E. (2009). Epidemiology of inflammatory bowel disease among children in Poland. Digestion, 79(2), 121-129.
Kleinubing-Júnior, H., Pinho, M. D. S., Ferreira, L. C., Bachtold, G. A., & Merki, A. (2011). Perfil dos pacientes ambulatoriais com doenças inflamatórias intestinais. ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo), 24, 200-203.
Koliani-Pace, J. L., & Siegel, C. A. (2019). Prognosticating the course of inflammatory bowel disease. Gastrointestinal Endoscopy Clinics, 29(3), 395-404.
Krzesiek, E. (2015). Fecal calprotectin as an activity marker of inflammatory bowel disease in children. Advances in Clinical and Experimental Medicine, 24(5), 815-822.
Kuipers, E. J. (2019). Encyclopedia of gastroenterology. Academic Press.
LAKATOS, E. M., & MARCONI, M. D. A. (2001). Ciência e conhecimento científico. Fundamentos da metodologia cientifica. São Paulo: Atlas, 74-81.
Lee, W. I., Subramaniam, K., Hawkins, C. A., & Randall, K. L. (2019). The significance of ANCA positivity in patients with inflammatory bowel disease. Pathology, 51(6), 634-639.
Levine, A., Koletzko, S., Turner, D., Escher, J. C., Cucchiara, S., de Ridder, L., ... & Wilson, D. C. (2014). ESPGHAN revised porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents. Journal of pediatric gastroenterology and nutrition, 58(6), 795-806.
Li, M., Wang, M., & Donovan, S. M. (2014, January). Early development of the gut microbiome and immune-mediated childhood disorders. In Seminars in reproductive medicine (Vol. 32, No. 01, pp. 074-086). Thieme Medical Publishers.
Lima, M. M., Silva, L. R., Franca, R. D. C. P., Santana, G. O., & Ribeiro, I. T. (2013). Perfil de pacientes pediátricos com doenças inflamatórias intestinais, atendidos em ambulatório de referência na cidade de salvador. Revista de Ciências Médicas e Biológicas, 12(3), 337-343.
Long, M. D., Crandall, W. V., Leibowitz, I. H., Duffy, L., Del Rosario, F., Kim, S. C., ... & ImproveCareNow Collaborative for Pediatric IBD. (2011). Prevalence and epidemiology of overweight and obesity in children with inflammatory bowel disease. Inflammatory bowel diseases, 17(10), 2162-2168.
Malik, T. A. (2015). Inflammatory bowel disease: historical perspective, epidemiology, and risk factors. Surgical Clinics, 95(6), 1105-1122.
Marcilio, C. A. (1995). Dicionário de pesquisa clínica. In Dicionário de pesquisa clínica (pp. 179-179).
Marques, M. L. A., & Patrício, M. P. F. (2019). Manifestações extra intestinais de espectros da doença inflamatória intestinal em crianças e adolescentes: artigo de revisão.
Martín-de-Carpi, J., Rodríguez, A., Ramos, E., Jiménez, S., Martínez-Gómez, M. J., Medina, E., & SPIRIT-IBD Working Group of SEGHNP (Sociedad Española de Gastroenterología, Hepatología y Nutricion Pediátrica). (2013). Increasing Incidence of Pediatric Inflammatory Bowel Disease in Spain (1996–2009) The SPIRIT Registry. Inflammatory bowel diseases, 19(1), 73-80.
Müller, K. E., Lakatos, P. L., Arató, A., Kovács, J. B., Várkonyi, Á., Szucs, D., ... & Veres, G. (2013). Incidence, Paris classification, and follow-up in a nationwide incident cohort of pediatric patients with inflammatory bowel disease. Journal of pediatric gastroenterology and nutrition, 57(5), 576-582.
Murad, M. H., Sultan, S., Haffar, S., & Bazerbachi, F. (2018). Methodological quality and synthesis of case series and case reports. BMJ evidence-based medicine, 23(2), 60-63.
Nir, O., Rinawi, F., Amarilyo, G., Harel, L., Shamir, R., & Assa, A. (2017). Phenotypic features and longterm outcomes of pediatric inflammatory bowel disease patients with arthritis and arthralgia. The Journal of Rheumatology, 44(11), 1636-1643.
PASSOS, M. A. T., CHAVES, F. C., & CHAVES-JUNIOR, N. (2018). A importância da colonoscopia nas doenças inflamatórias intestinais. ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo), 31.
Plevinsky, J. M., & Greenley, R. N. (2020). Inflammatory bowel disease and gastrointestinal disorders. In Adherence and Self-Management in Pediatric Populations (pp. 263-286). Academic Press.
Sairenji, T., Collins, K. L., & Evans, D. V. (2017). An update on inflammatory bowel disease. Primary Care: Clinics in Office Practice, 44(4), 673-692.
Sandhu, B. K., Fell, J. M., Beattie, R. M., Mitton, S. G., Wilson, D. C., & Jenkins, H. (2010). Guidelines for the management of inflammatory bowel disease in children in the United Kingdom. Journal of pediatric gastroenterology and nutrition, 50, S1-S13.
Santos, G. M. D., Silva, L. R., & Santana, G. O. (2014). Repercussões nutricionais em crianças e adolescentes na presença de doenças inflamatórias intestinais. Revista Paulista de Pediatria, 32, 403-411.
Sdepanian, V. L., da Silva Catapani, A. N., Oba, J., Silva, L. R., Rodrigues, M., & da Rocha Carvalho, S. (2019). Doença inflamatória intestinal em Pediatria. São Paulo: Editora Mazzoni.
Sehgal, P., Colombel, J. F., Aboubakr, A., & Narula, N. (2018). Systematic review: safety of mesalazine in ulcerative colitis. Alimentary pharmacology & therapeutics, 47(12), 1597-1609.
Silveira, R. C., Baba, R. S., Pereira, A. C. S., Paim, S., Teixeira, M. G., & Habr-Gama, A. (2008). Doença de Crohn em recém-nascido. Revista Brasileira de Coloproctologia, 28, 338-341.
Stochel-Gaudyn, A., Fyderek, K., & Kościelniak, P. (2019). Serum trace elements profile in the pediatric inflammatory bowel disease progress evaluation. Journal of Trace Elements in Medicine and Biology, 55, 121-126.
Van Limbergen, J., Russell, R. K., Drummond, H. E., Aldhous, M. C., Round, N. K., Nimmo, E. R., ... & Wilson, D. C. (2008). Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease. Gastroenterology, 135(4), 1114-1122.
Wasielewska, Z., Dolińska, A., Wilczyńska, D., Szaflarska-Popławska, A., & Krogulska, A. (2019). Prevalence of allergic diseases in children with inflammatory bowel disease. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, 36(3), 282.
Wiskin, A. E., Fleming, B. J., Wootton, S. A., & Beattie, R. M. (2012). Anaemia and iron deficiency in children with inflammatory bowel disease. Journal of Crohn's and Colitis, 6(6), 687-691.
Yangyang, R. Y., & Rodriguez, J. R. (2017, December). Clinical presentation of Crohn’s, ulcerative colitis, and indeterminate colitis: Symptoms, extraintestinal manifestations, and disease phenotypes. In Seminars in pediatric surgery (Vol. 26, No. 6, pp. 349-355). WB Saunders.
YKL, K. (2011). Doença inflamatória intestinal. Porta G, Koda YKL, organizadores. Gastroenterologia e hepatologia pediátrica. Indianópolis-SP: Sarvier Editora de livros Médicos, 343-56.
ZANARDI, M. M. M., & NOWACKI, L. (2018). Doenças inflamatórias intestinais–uma revisão bibliográfica. Revista Eletrônica Biociências, Biotecnologia e Saúde, Curitiba, 20.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Aline Maria de Lemos Araujo; Cláudia Regina Nunes Eloi da Luz; Leandro Saldanha Nunes Mouzinho
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
