Ketogenic diet and cancer treatment

Authors

DOI:

https://doi.org/10.33448/rsd-v11i9.31806

Keywords:

Diet; Ketogenic diet; Cancer; Chronic diseases.

Abstract

Faced with an expressive increase in the last decades in the case of cancer in the world population, the need for a dietary strategy supporting conventional treatment for patients diagnosed with cancer has become evident, with the aim of obtaining positive results in the fight against the disease. This literature review study aimed to present the ketogenic diet (KD) as a nutritional intervention and its proposed mechanisms against cancer cells, as well as to characterize limitations in the literature currently available. The studies were selected from the BIREME, PUBMED, ScienceDirect databases, as well as books, institutional and government websites; using descriptors such as: ketogenic diet; chronic diseases; cancer; cancer treatment and oxidative stress; they were used in the English language. It has been proposed that, in the absence of blood glucose, cancer cells decrease their proliferation and enter a state of oxidative stress, as a consequence of a high-fat, carbohydrate-deficient diet, thus making them more sensitive to standardized treatments. such as radiation and chemotherapy. However, there is a need for further studies in humans in order to obtain better results and conclusions regarding this nutritional intervention.

Author Biographies

Daniel Donato de Sousa, Centro Universitário de Brasília

Discente do Centro Universitário de Brasília

João Gabriel Toledo Pacheco Silva, Centro Universitário de Brasília

Discente do Centro Universitário de Brasília

Dayanne da Costa Maynard, Centro Universitário de Brasília

Departamento de Nutrição

References

Allen, B. G. et. al. (2014). Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism. Redox Biology, 2, 963-970,https://doi.org/10.1016/j.redox.2014.08.002

Arends, J. et al. (2017) ESPEN guidelines on nutrition in cancer patients. Clinical Nutrition,36. 11-48,.https://doi.org/10.1016/j.clnu.2016.07.015

Cavalcanti (2017), A. Dieta Cetogênica: como colocar em prática? https://www.vponline.com.br/portal/noticia/pdf/1abbe95a4073913f5e17fdaa9fe0fe17.pdf

Fernandes, DP, Coutinho, VEA, Medeiros, L. de B., & Pereira, NLV (2020). Nutrientes e compostos bioativos na modulação epigenética associada à prevenção e combate ao câncer. Research, Society and development , 9 (4), e114942914. https://doi.org/10.33448/rsd-v9i4.2914

Gatenby, R., et al .(2004). Why do cancers have high aerobic glycolysis? Nat Rev Cancer,. 4, 891-899, https://doi.org/10.1038/nrc1478

Gray, A., Dang, B. N., Moore, T. B., Clemens, R., & Pressman, P. (2020). A review of nutrition and dietary interventions in oncology. SAGE Open Medicine. https://doi.org/10.1177/2050312120926877

INCA (2020). Estimativa 2020: incidência de câncer no Brasil. https://www.inca.gov.br/publicacoes/livros/estimativa-2020-incidencia-de-cancer-no-brasil .

Klement R. J. (2017). Beneficial effects of ketogenic diets for cancer patients: a realist review with focus on evidence and confirmation. Medical oncology (Northwood, London, England), 34(8), 132. https://doi.org/10.1007/s12032-017-0991-5

Liu, Y.-m.C. (2008). Medium-chain triglyceride (MCT) ketogenic therapy. Epilepsia, 49: 33-36. https://doi.org/10.1111/j.1528-1167.2008.01830.x

Liu, Y. M., & Wang, H. S. (2013). Medium-chain triglyceride ketogenic diet, an effective treatment for drug-resistant epilepsy and a comparison with other ketogenic diets. Biomedical journal, 36(1), 9–15. https://doi.org/10.4103/2319-4170.107154

Midori, L.(2008). Dieta Cetogênica e Dieta Atkins Modificada no Tratamento da Epilepsia Refratária em Crianças e Adultos. J. Epilepsy Clin Neurophysiol, 14(2), 65-69. https://doi.org/10.1590/S1676-26492008000200005

Oliveira, C., Mattingly, S., Schirrmacher, R., Sawyer, M. B., Fine, E. J., & Prado, C. M. (2018). A Nutritional Perspective of Ketogenic Diet in Cancer: A Narrative Review. Journal of the Academy of Nutrition and Dietetics, 118(4), 668–688. https://doi.org/10.1016/j.jand.2017.02.003

Plotti, F., Terranova, C., Luvero, D., Bartolone, M., Messina, G., Feole, L., Cianci, S., Scaletta, G., Marchetti, C., Di Donato, V., Fagotti, A., Scambia, G., Benedetti Panici, P., & Angioli, R. (2020). Diet and Chemotherapy: The Effects of Fasting and Ketogenic Diet on Cancer Treatment. Chemotherapy, 65(3-4), 77–84. https://doi.org/10.1159/000510839

Schoeler, N. E., & Cross, J. H. (2016). Ketogenic dietary therapies in adults with epilepsy: a practical guide. Practical neurology, 16(3), 208–214. https://doi.org/10.1136/practneurol-2015-001288

Soares, J. A. et al. (2017). Dieta Cetogênica Como Terapia Adjuvante ao Tratamento do Câncer. Anais Do I Congresso Multidisciplinar De Oncologia, 1, 53-54. https://acervomais.com.br/index.php/saude/article/view/153/60

Stratton, M. R., Campbell, P. J., & Futreal, P. A. (2009). The cancer genome. Nature, 458(7239), 719–724. https://doi.org/10.1038/nature07943

Sousa, JC de, Altino, IP, Andrade, SM de, Cunha, MA, Araújo, BAC de, & Oliveira, EH de. (2020). Dieta cetogênica para pacientes com diabetes mellitus tipo II. Research, Society and development, 9 (7), e117973972. https://doi.org/10.33448/rsd-v9i7.3972.

Tan Shalaby, Jocelyn & Seyfried, Thomas. (2013). Ketogenic Diet in Advanced Cancer: A Pilot Feasibility and Safety Trial in the Veterans Affairs Cancer Patient Population. J Clinical Trials. 3. 10.4172/2167-0870.1000149.

Talib, W. H., Mahmod, A. I., Kamal, A., Rashid, H. M., Alashqar, A., Khater, S., Jamal, D., & Waly, M. (2021). Ketogenic Diet in Cancer Prevention and Therapy: Molecular Targets and Therapeutic Opportunities. Current issues in molecular biology, 43(2), 558–589. https://doi.org/10.3390/cimb43020042

Yang, Y. F., Mattamel, P. B., Joseph, T., Huang, J., Chen, Q., Akinwunmi, B. O., Zhang, C., & Ming, W. K. (2021). Efficacy of Low-Carbohydrate Ketogenic Diet as an Adjuvant Cancer Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 13(5), 1388. https://doi.org/10.3390/nu13051388

Yeou-mei, C. L. (2008). Medium-chain triglyceride (MCT) ketogenic therapy. Epilepsia, 49(8), 1-133 https://doi.org/10.1111/j.1528-1167.2008.01830.x

Warburg O. (1956). On the origin of cancer cells. Science (New York, N.Y.), 123(3191), 309–314. https://doi.org/10.1126/science.123.3191.309

Weber, D. D., Aminzadeh-Gohari, S., Tulipan, J., Catalano, L., Feichtinger, R. G., & Kofler, B. (2020). Ketogenic diet in the treatment of cancer - Where do we stand?. Molecular metabolism, 33, 102–121. https://doi.org/10.1016/j.molmet.2019.06.026

Published

10/07/2022

How to Cite

SOUSA, D. D. de .; SILVA, J. G. T. P. .; MAYNARD, D. da C. Ketogenic diet and cancer treatment. Research, Society and Development, [S. l.], v. 11, n. 9, p. e28211931806, 2022. DOI: 10.33448/rsd-v11i9.31806. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/31806. Acesso em: 4 oct. 2022.

Issue

Section

Health Sciences