Effects of spermidine polyamine on metabolism and longevity

Authors

DOI:

https://doi.org/10.33448/rsd-v11i14.32266

Keywords:

Spermidine; Longevity; Disease.

Abstract

The polyamine spermidine is found in all eukaryotic beings and in most prokaryotes. According to their polycationic nature, polyamines can easily join negatively charged biomolecules, especially DNA, RNA, proteins and phospholipids, modifying in many occasions the function of these macromolecules. Given their ability to bind to other molecules, they are associated in several functions, mainly linked to growth, autophagy, survival and cell proliferation. The aim of this study was to identify the effects of spermidine polyamine on metabolism and longevity.  This is an integrative literature review study, using the following databases SciELO, PUBMED, LILACS and journals of the Coordination for the Improvement of Higher Education Personnel (Capes). In addition to the induction of autophagy, the actions of spermidine have been related to the modulation of reactive oxygen species, DNA replication, transcription and translation, anti-inflammatory properties, modified mitochondrial activity, enhanced proteostasis, and hypusination growth. Polyamines have a complex and diffuse relationship to disease. They can be harmful, neutral or beneficial, varying according to the polyamine and the specific disease. However, it appears that spermidine expressed more positive effects, being in agreement with its expressed beneficial effects on lifespan and stress.

Author Biographies

Mauro Sergio Vieira Machado , Universidade Iguaçu

Autor 

Mauro Sérgio Vieira Machado , Universidade Estadual de Montes Claros

Autor 

References

Bachrach, U. (2010)The early history of polyamine research. Plant Physiol Biochem. Jul;48(7):490-5.

Bonhoure, N, Byrnes, A., Moir, R. D., Hodroj, W., Preitner, F., Praz, V., Marcelin, G., Chua, S. C. J.r.,Martinez-Lopez, N., Singh, R., Moullan, N., Auwerx, J., Willemin, G., Shah, H., Hartil ,K.,Vaitheesvaran, B., Kurland, I., Hernandez, N., & Willis, I. M. (2015) Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. Genes Dev. May 1;29(9):934-47.

Carabotti, M., Scirocco, A., Maselli, M. A., & Severi, C. (2015)The gut-brain axis: interactions betweenenteric microbiota, central and enteric nervous systems. Ann Gastroenterol. Apr-Jun;28(2):203-209.

Codoñer-Franch, P., Tavárez-Alonso, S., Murria-Estal, R., Herrera-Martín, G., & Alonso-Iglesias, E. (2011)Polyamines are increased in obese children and are related to markers of oxidative / nitrosative stress and angiogenesis. J Clin Endocrinol Metab. Sep;96(9):2821-5.

Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., Harge,r A.,Schipke, J., Zimmermann, A., Schmidt, A., Tong, M., Ruckenstuhl, C., Dammbrueck, C., Gross,A.S., Herbst, V., Magnes, C., Trausinger, G., Narath, S., Meinitzer, A., Hu, Z., Kirsch, A., Eller, K.,Carmona-Gutierrez, D., Büttner, S., Pietrocola, F., Knittelfelder, O., Schrepfer, E., Rockenfeller,P., Simonini, C., Rahn, A., Horsch, M., Moreth, K., Beckers, J., Fuchs, H., Gailus-Durner, V., Neff, F., Janik, D., Rathkolb, B., Rozman, J., De Angelis, M.H., Moustafa, T., Haemmerle, G., Mayr, M.,Willeit, P., Von Frieling-Salewsky, M., Pieske, B., Scorrano, L., Pieber, T., Pechlaner, R., Willeit. J., Sigrist, S. J., Linke, W. A., Mühlfeld, C., Sadoshima, J., Dengjel, J., Kiechl, S., Kroemer, G., Sedej, S., & Madeo, F.( 2016). Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. Dec;22(12):1428-1438. 10.1038/nm.4222. este tem q vem se tem no artigo?

Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., Ring, J., Schroeder, S., Magnes, C., Antonacci, L., Fussi, H., Deszcz, L., Hartl, R., Schraml, E., Criollo, A., Megalou, E., Weiskopf, D., Laun, P., Heeren, G., Breitenbach, M., Grubeck-Loebenstein, B.,Herker, E., Fahrenkrog, B., Fröhlich, K. U., Sinner, F., Tavernarakis, N., Minois, N., Kroemer, G., & Madeo, F.(2009). Induction of autophagy by spermidine promotes longevity. Nat Cell Biol.11(11):1305-14.

Fernández, Á. F., Bárcena, C., Martínez-García, G. G., Tamargo-Gómez, I., Suárez, M. F., Pietrocola, F.,Castoldi, F., Esteban, L., Sierra-Filardi, E., Boya, P., López-Otín, C., Kroemer, G., & Mariño, G.(2017). Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic

regimens. Cell Death Dis. 3;8(8):e2970.

Fetterman, J. L., Holbrook, M., Flint, N., Feng, B., Bretón-Romero, R., Linder, E. A., Berk, B. D., Duess, M. A., Farb, M. G., Gokce, N., Shirihai, O. S., Hamburg, N. M., & Vita, J. A. (2016). Restoration of autophagy in endothelialcells from patients with diabetes mellitus improves nitric oxide signaling. Atherosclerosis. 247:207-17.

Greenwood-Van Meerveld, B., Johnson, A. C., & Grundy, D. (2017). Gastrointestinal Physiology and Function. Handb Exp Pharmacol. 239:1-16.

Gupta, V. K., Scheunemann, L., Eisenberg, T., Mertel, S., Bhukel, A., Koemans, T. S., Kramer, J. M., Liu, K. S., Schroeder, S., Stunnenberg, H.G., Sinner, F., Magnes, C., Pieber, T. R., Dipt, S., Fiala, A., Schenck, A., Schwaerzel, M., Madeo, F., Sigrist, S. J. (2013). Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner. Nat Neurosci. 16(10):1453-60.

Iacomino, G., Picariello, G., & Agostino, L. (2012).DNA and nuclear aggregates of polyamines. Biochim Biophys Acta. 1823(10):1745-55.

Igarashi K., & Kashiwagi K. (2010) Modulationofcellfunctionbypolyamines . Int. J. Biochem. CellBiol . 42 , 39–51

Igarashi, K., & Kashiwagi, K. (2010). Modulation of cellular function by polyamines. Int J Biochem Cell Biol. 42(1):39-51.

Ishii, I., Ikeguchi, Y., Mano, H., Wada, M., Pegg, A. E., & Shirahata, A.(2012). Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells. Amino Acids. 42(2-3):619-26.

Jandhyala, S. M., Talukdar, R., Subramanyam, C., Vuyyuru, H., Sasikala, M., & Nageshwar Reddy, D.(2015).Role of the normal gut microbiota. World J Gastroenterol. 7;21(29):8787-803.

Janne, J. supplementationofspermidine in mice.actaPhysiol.(1967). Scand. Suppl.

Kibe, R., Kurihara, S., Sakai, Y., Suzuki, H., Ooga, T., Sawaki, E., Muramatsu, K., Nakamura, A., Yamashita,A., Kitada, Y., Kakeyama, M., Benno, Y., & Matsumoto, M. (2014). Upregulation of colonic luminal polyaminesproduced by intestinal microbiota delays senescence in mice. Sci Rep. 1;4:4548.

Kiechl, S., Pechlaner, R., Willeit, P., Notdurfter, M., Paulweber, B., Willeit, K., Werner P., Ruckenstuhl, C., Iglseder. B., Weger. S., et al.(2018). Maior ingestão de espermidina está ligada a menor mortalidade: um estudo prospectivo de base populacional . Am J Clin Nutr.108 : 371–380.

La Rocca, T. J., Gioscia-Ryan, R. A., Hearon. C. M. Jr., & Seals, D. R. (2013).The autophagy enhancer spermidinereverses arterial aging. Mech Ageing Dev. 134(7-8):314-20.

Liu, H., Dong, J., Song, S., Zhao, Y., Wang, J., Fu, Z., & Yang, J.(2019). Spermidine ameliorates liver ischaemia-reperfusion injury through the regulation of autophagy by the AMPK-mTOR-ULK1 signallingpathway. Biochem Biophys Res Commun. 5;519(2):227-233.

Löser, C.(2000). Polyamines in human and animal milk. Br J Nutr. 84 Suppl 1:S55-8.

Madeo, F., Bauer, M. A, Carmona-Gutierrez, D., & Kroemer, G.(2019). Spermidine: a physiologicalautophagy inducer acting as an anti-aging vitamin in humans? Autophagy. 15(1):165-168.

Madeo, F., Eisenberg, T., Pietrocola, F., & Kroemer. G. (2018). Spermidine in health and disease. Science.359(6374):eaan2788. 10.1126/science.aan2788. PMID: 29371440.

Matsumoto, M., Kibe, R., Ooga, T., Aiba, Y., Kurihara, S., Sawaki, E., Koga, Y., & Benno Y.(2012). Impact of intestinal microbiota on intestinal luminal metabolome. Sci Rep. 2:233.

McAnulty, P. A., & Williams, J. P.(1977). Polyamines and their biosynthetic decarboxylases in varioustissues of the young rat during recovery from undernutrition. Biochem J. 162(1):109-21.

Méndez, J. D., & Balderas, F. L.(2005). Inhibition by L-arginine and spermidine of hemoglobin glycationand lipid peroxidation in rats with induced diabetes. Biomed Pharmacother. 60(1):26-31.

Michiels, C. F., Kurdi, A., Timmermans, J. P., De Meyer, G. R. Y., & Martinet, W. (2016). Spermidine reduces lipid accumulation and necrotic core formation in atherosclerotic plaques via induction ofautophagy. Atherosclerosis.251:319-327.

Minois, N., (2011). Carmona-Gutierrez, D., & Madeo, F. Polyamines in aging and disease. Aging (AlbanyNY). 3(8):716-32.

Nishimura, K., Shiina, R., Kashiwagi, K., & Igarashi, K. (2006). Decrease in polyamines with aging and their ingestion from food and drink. J Biochem. 139(1):81-90.

Yang, Q., Zheng, C., Cao, J, Cao, G., Shou, P., Lin, L., Velletri, T., Jiang, M., Chen, Q., Han, Y., Li, F., Wang, Y.,Cao, W., & Shi, Y. (2016). Spermidine alleviates experimental autoimmune encephalomyelitis throughinducing inhibitory macrophages. Cell Death Differ.1;23(11):1850-1861.

Yun, K. U., Ryu, C. S., Lee, J. Y., Noh, J. R., Lee, C. H., Lee, H. S., Kang, J. S., Park, S. K., Kim, B. H., & Kim, S. K. Hepaticmetabolism of sulfur amino acids in db/db mice. Food Chem Toxicol. 2013 Mar;53:180-6.

Yuan, F., Zhang, L., Cao, Y., Gao, W., Zhao, C., Fang, Y., Zahedi, K., Soleimani, M., Lu, X., Fang, Z., & Yang, Q.( 2018). Spermidine/spermine N1-acetyltransferase-mediated polyamine catabolism regulates beigeadipocyte biogenesis. Metabolism. 85:298-304.

Soda, K., Kano, Y., Sakuragi, M., Takao, K., Lefor, A., & Konishi, F.(2009). Long-term oral polyamine intakeincreases blood polyamine concentrations. J Nutr Sci Vitaminol(Tokyo). 55(4):361-6.

Sugiyama, Y., Nara, M., Sakanaka, M., Gotoh, A., Kitakata, A., Okuda, S., & Kurihara, S. (2017). Comprehensiveanalysis of polyamine transport and biosynthesis in the dominant human gut bacteria:Potential presence of novel polyamine metabolism and transport genes. Int J Biochem CellBiol. 93:52-61.

Zhang, H., Alsaleh, G., Feltham, J., Sun, Y., Napolitano, G., Riffelmacher, T., Charles, Pç., Frau, L., Hublitz, P., Yu, Z., Mohammed, S., Ballabio, A., Balabanov, S., Mellor, J., & Simon, A. K. (2019). Polyamines Control e IF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence. Mol Cell. 3;76 (1):110-125.e9.

Published

07/11/2022

How to Cite

PEREIRA, J. A. .; ABREU, C. D. D. .; ABREU , L. D. .; MAGALHÃES, P. G. de A. .; ALMEIDA, D. S. .; ANTUNES, A. L. M. .; ROCHA, B. P. C. .; ANDRADE , F. M. P. .; SERGIO VIEIRA MACHADO , M.; MACHADO , M. S. V. .; GUSMÃO, Y. G. . Effects of spermidine polyamine on metabolism and longevity. Research, Society and Development, [S. l.], v. 11, n. 14, p. e03111432266, 2022. DOI: 10.33448/rsd-v11i14.32266. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/32266. Acesso em: 26 nov. 2022.

Issue

Section

Health Sciences