Endometriosis and its impact on female infertility





Endometriosis; Infertility; Etiology; Treatment; Diagnosis.


This article sought to highlight the relationship between endometriosis and infertility, characterizing aspects of epidemiology, symptoms and diagnosis, focusing on possible causes of infertility in women affected by this pathology. Endometriosis is a chronic inflammatory disease that causes damage to women's health, reproduction, increases the risk of depression, brings limitations in daily life activities and consequent reduction of social and work activity, due to the symptoms that are so characteristic. Infertility caused by endometriosis can be associated with immunological, endocrine or anatomical distortions together with fibrous tissue adhesions. There are currently three therapeutic options available as therapy for endometriosis-associated infertility: clinical treatment, surgery, and technologies adapted for assisted reproduction. Finally, it is clear that endometriosis causes infertility, but requires more research due to the mechanisms by which it leads to this end are not yet fully elucidated and there is no standardized therapy for patients with the pathology.


Akhmatovna, J. Z. (2021). Current Issues of Infertility Diagnosis and Treatment in Women with Internal Genital Endometriosis, Journal of Ethics and Governance, 11 (5).

Almeida, S. C., et al. (2021). Reprodução assistida em pacientes inférteis com endometriose. Brazilian Journal of Health Review, 4 (2), 4524-4536.

Bafort, C., et al. (2020). Laparoscopic surgery for endometriosis. Cochrane Database of Systematic Reviews, 10 (3).

Bailleul, A., et al. (2021). Infertility management according to the Endometriosis Fertility Index in patients operated for endometriosis: I What is the optimal time frame? PLOS ONE, 1-11.

Borghese, B., et al. (2017). Recent insights on the genetics and epigenetics of endometriosis. Clinical genetics, 91 (2), 254-264.

Brito, B.T., et al. (2017). Infertilidade na endometriose: etiologia e terapêutica. HU Revista, 43 (12), 173-178.

Carson, S. A., et al. (2021). Diagnosis and Management of Infertility A Review. JAMA, 326 (1), 65-76.

Donatti, L., et al. (2017). Pacientes com endometriose que utilizam estratégias positivas de enfrentamento apresentam menos depressão, estresse e dor pélvica. Einstein (São Paulo),15 (1), 65-70.

Duarte, A. N., et al. (2021). A Associação entre endometriose e infertilidade feminina: uma revisão de literatura. Acta Elit Salutis, 9 (7).

Duccini, E. C., et al. (2019). Endometriose: Uma Causa Da Infertilidade Feminina E Seu Tratamento. Revista Caderno de Medicina, 2 (2), 46-55.

Ferrero, S., et al. (2021). Current and Emerging Therapeutics for the Management of Endometriosis. Drugs, 78 (8), 995–1012.

Garnica, A. (2019). The Role of the Molecular Genetic Approach in the Pathogenesis of Endometriosis. Integr. Res. Clin. Pract., 5 (3).

Lin, Y. H., et al. (2018). Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies. International Journal of Molecular Sciences, 19 (8), 2385-2390.

Malvezzi, H., et al. (2019). Interleukin in endometriosis-associated infertility-pelvic pain: systematic review and meta-analysis. Society for Reproduction and Fertility, 158 (22), 1-12.

Muzii, L., et al. (2021). Endometriosis-associated infertility: surgery or IVF? Minerva Obstetrics and Gynecology, 73 (2), 226-232.

Rasheed, H. H. A., et al. (2020). Inflammation to Infertility: Panoramic View on Endometriosis. Cureus, 12 (11), 1-10.

Sanjay, M. D., et al. (2019). Clinical diagnosis of endometriosis: a call to action. American Journal of Obstetrics and Gynecology, 221 (2), 170-171.

Tomás, C., et al. (2019). Endometriose e infertilidade – onde estamos? Acta Obstétrica e Ginecológica Portuguesa, 13 (4), 235-2341.

Tomassetti, C., et al. (2018). Endometriosis and infertility: Insights into the causal link and management strategies, Best Pract Res Clin Obstet Gynaecol, 51 (3), 25-33.

Torres, J. I., et al. (2021). Endometriosis, difficulties in early diagnosis and female infertility: A review. Research, Society and Development, 10 (6).



How to Cite

CRUZ, B. A. .; PINTO, F. O.; PRESOT, I. Q.; NAGATA, L.; FIGUEIREDO, B. Q. de . Endometriosis and its impact on female infertility. Research, Society and Development, [S. l.], v. 11, n. 9, p. e60011932371, 2022. DOI: 10.33448/rsd-v11i9.32371. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/32371. Acesso em: 5 oct. 2022.



Health Sciences