Impact of the COVID-19 pandemic on vitamin D levels in different age groups
DOI:
https://doi.org/10.33448/rsd-v11i10.32604Keywords:
COVID-19; Coronavirus; Vitamin D; Risk Factors; Pandemic.Abstract
Vitamin D plays an important role in the immune system, it is involved in various functions of the human system. That said, the objective is to compare the impacts of the COVID-19 pandemic under the vitamin D levels of lac PUC Goiás patients. It is an observational, cross-sectional, epidemiological study. Vitamin D data from 2208 patients from LAC PUC Goiás were analyzed for the prepandemic period (2016-2018) and pandemic (2020-2021), were divided into age groups and analyzed the relationship between hypovitaminosis and COVID-19 through the p-value of the Chi-square calculation in PAST version 4.03. The age group from 0 to 10 years (p= 0.058, 95% CI) was the only one that did not obtain a significant correlation and stated that the pandemic did not impact hypovitaminosis D in these patients. In the other age groups, from 11 to 20 years (p= 15.56. 10 -5, 95% CI%), from 21 to 60 years (p=: 4.84.10-20, CI 95%) and older than 60 years (p= 2.54. 10-9, 95% CI), confirmed the hypothesis that the covid-19 pandemic being related to hypovitaminosis D. The low levels of vitamin D are related to the COVID-19 pandemic in 3, of the 4 age groups investigated and, by bibliographic research, can define the course of the disease. Thus, supplementing the diet with vitamin D, under medical guidance, becomes a preventive and therapeutic measure in the case of COVID-19.
References
Alcala-Diaz, J. F., Limia-Perez, L., Gomez-Huelgas, R., Martin-Escalante, M. D., Cortes-Rodriguez, B., Zambrana-Garcia, J. L., ... & Lopez-Miranda, J. (2021). Calcifediol treatment and hospital mortality due to COVID-19: a cohort study. Nutrients, 13(6), 1760. doi: 10.3390/nu13061760
AlSafar, H., Grant, W. B., Hijazi, R., Uddin, M., Alkaabi, N., Tay, G., ... & Al Anouti, F. (2021). COVID-19 disease severity and death in relation to vitamin D status among SARS-CoV-2-positive UAE residents. Nutrients, 13(5), 1714. doi: 10.3390/nu13051714.
Castillo, M. E., Costa, L. M. E., Barrios, J. M. V., Díaz, J. F. A., Miranda, J. L., Bouillon, R., & Gomez, J. M. Q. (2020). Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study. The Journal of steroid biochemistry and molecular biology, 203, 105751. doi:10.1016/j.jsbmb.2020.105751
Castro, L. C. G. D. (2011). O sistema endocrinológico vitamina D. Arquivos Brasileiros de Endocrinologia & Metabologia, 55, 566-575. doi:10.1590/s0004-27302011000800010. doi: 10.1590/S0004-27302011000800010.
Ferreira, C. E. S., Maeda, S. S., Batista, M. C., Lazaretti-Castro, M., Vasconcellos, L. S., Madeira, M., ... & Moreira, C. A. (2017). Consensus-reference ranges of vitamin D [25 (OH) D] from the Brazilian medical societies. Brazilian Society of Clinical Pathology/Laboratory Medicine (SBPC/ML) and Brazilian Society of Endocrinology and Metabolism (SBEM). Jornal Brasileiro de Patologia e Medicina Laboratorial, 53, 377-381. doi: 10.5935/1676-2444.20170060
Lakkireddy, M., Gadiga, S. G., Malathi, R. D., Karra, M. L., & Raju ISSVPM, R. Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease. Sci Rep. 2021; 11 (1): 10641. doi:10.1038/s41598-021-90189-4
Lehninger, A., & Nelson, D. (2014). L.; COX, Michel M. Princípios de Bioquímica. 6ª Edição. Porto Alegre: Artmed.
Ling, S. F., Broad, E., Murphy, R., Pappachan, J. M., Pardesi-Newton, S., Kong, M. F., & Jude, E. B. (2020). High-dose cholecalciferol booster therapy is associated with a reduced risk of mortality in patients with COVID-19: a cross-sectional multi-centre observational study. Nutrients, 12(12), 3799. doi:10.3390/nu12123799
Liu, N., Sun, J., Wang, X., Zhang, T., Zhao, M., & Li, H. (2021). Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis. International Journal of Infectious Diseases, 104, 58-64. doi:10.1016/j.ijid.2020.12.077
Maeda, S. S., Borba, V. Z., Camargo, M. B. R., Silva, D. M. W., Borges, J. L. C., Bandeira, F., & Lazaretti-Castro, M. (2014). Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D. Arquivos Brasileiros de Endocrinologia & Metabologia, 58, 411-433. doi: 10.1590/0004-2730000003388
McCartney, D. M. & Byrne, D. G. (2020). Optimisation of Vitamin D Status for Enhanced Immuno-protection Against Covid-19. Jr Med J. 113(4): 58-61."
McDonald L. T. (2021). Healing after COVID-19: are survivors at risk for pulmonary fibrosis?. American journal of physiology. Lung cellular and molecular physiology, 320(2), L257–L265. doi: 10.1152/ajplung.00238.2020.
Medeiros, A. C. P., Campos, P. T. S., Francescantonio, I. C. C. M., Siqueira, E. de F., Faleiro, I. de F., de Paula, A. G., & Filho, M. C. M. (2021, January 11). ANÁLISE DA PRÁTICA MÉDICA DE RASTREAMENTO DA DEFICIÊNCIA DE VITAMINA D. Laes & Haes, 86–90. https://laes-haes.com.br. https://www.flipsnack.com/revistalaesehaes/revista-laes-haes-248.html
Organização Mundial de Saúde declara pandemia do novo Coronavírus. ANA SUS, 2020. <https://www.unasus.gov.br/noticia/organizacao-mundial-de-saude-declara-pandemia-de-coronavirus>.
Pena, H. C., Takahashi, V. T., Moraes, F. D., Santos, F. L., & Dutra, J. K. S. (2021). Suplementação de vitamina d: uma estratégia no combate à covid-19?.
Petrelli, F., Luciani, A., Perego, G., Dognini, G., Colombelli, P. L., & Ghidini, A. (2021). Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and meta-analysis of 43 observational studies. The Journal of steroid biochemistry and molecular biology, 211, 105883. doi: 10.1016/j.jsbmb.2021.105883.
Schuch, N. J., Garcia, V. C., & Martini, L. A. (2009). Vitamina D e doenças endocrinometabólicas. Arquivos Brasileiros de Endocrinologia & Metabologia, 53, 625-633. doi: 10.1590/s0004-27302009000500015.
Sulzbach, C. C., Martins, R. B., da Rosa Camargo, L., & Bós, Â. J. G. (2020). Exposição solar e suplementação de vitamina d em longevos durante a pandemia de covid-19. Revista Brasileira de Ciências do Envelhecimento Humano, 17(2).
Tan, C. W., Ho, L. P., Kalimuddin, S., Cherng, B. P. Z., Teh, Y. E., Thien, S. Y., ... & Ng, H. J. (2020). Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19). Nutrition, 79, 111017. doi: 10.1016/j.nut.2020.111017.
Köche, J. C. (2016). Fundamentos de metodologia científica. Editora Vozes.
Teshome, A., Adane, A., Girma, B., & Mekonnen, Z. A. (2021). The impact of vitamin D level on COVID-19 infection: systematic review and meta-analysis. Frontiers in public health, 9, 624559. doi: 10.3389/fpubh.2021.624559.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Ronair Rosa Dias Filho; Marília Teresa Ferreira da Silva; Isabel Cristina Carvalho Medeiros Francescantonio; Leonardo Luiz Borges; Roberpaulo Anacleto Neves; Andrea Alves Ribeiro
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
