Efficacy of Silexan compared with other anxiolytic drugs in the controlo of anxiety: na integrative review
Keywords:Lavandula; Anti-Anxiety agent; Phytotherapy.
Anxiety disorders are the most prevalent group of psychiatric pathologies. Within the context of new therapies for anxiety, phytotherapy has stood out positively. Thus, this review aims to study the action of Silexan in anxiety disorders, based on the Hamilton Anxiety Scale (HAM-A), making a parallel with other anxiolytic drugs of well-defined use in psychiatry. This is an integrative review type research, which included clinical trials with human beings. The search was carried out through online access to the databases PUBMED, SciELO, LILACS, Scopus, Web of Science, and Science Direct. The strategy for selection of articles followed the steps: search of the selected databases, reading of the title and abstract of all articles and exclusion of those that did not address the review topic, critical reading of the articles in full, and exclusion of those that did not meet the inclusion criteria. Thus, a total of 5 articles were selected. In all clinical trials, the use of Silexan showed higher response and remission rates compared to other interventions. Thus, it can be concluded that Silexan has some effectiveness in controlling anxiety. However, this study has limitations in that the included studies varied in number of participants, patient health status, and comparison. In addition, it would be interesting to test the use of Silexan in higher doses, making a comparison with the use of anxiolytic drugs in therapeutic doses already consolidated.
Antonio, G. D., Tesser, C. D., & Moretti-Pires, R. O. (2014). Phytotherapy in primary health care. Revista de Saúde Pública, 48, 541-553.
Associação Psiquiátrica Americana. (2014). Manual Diagnóstico e Estatístico de Transtornos Mentais (5a ed.). Porto Alegre, RS: Artmed.
Bortoluzzi, M. M., Schmitt, V., & Mazur, C. E. (2020). Efeito fitoterápico de plantas medicinais sobre a ansiedade: uma breve revisão. Research, Society and Development, 9(2), 47.
Cardoso, H. C. W., Marin, D. R., de Barros, N. B., & Lugtenburg, C. A. B. (2021). Lavandula angustifolia: uso da aromaterapia por massagem com óleo essencial de lavanda em várias patologias. Brazilian Journal of Development, 7(5), 46320-46340.
Cordioli, A. V., Gallois, C. B., Isolan, L. (Eds). (2015). Psicofármacos: consulta rápida (5a ed.). Porto Alegre, RS: Artmed.
Costa, C. O. D., Branco, J. C., Vieira, I. S., Souza, L. D. D. M., & Silva, R. A. D. (2019). Prevalência de ansiedade e fatores associados em adultos. Jornal Brasileiro de Psiquiatria, 68, 92-100.
Guimarães-Fernandes, F., Humes, E. C., Cardoso, F., Hortêncio, L. O. S. & Miguel, E. C. (Eds). (2021). Clínica psiquiátrica: guia prático (2a ed.). Santana de Parnaíba, SP: Manole.
Kasper, S., Anghelescu, I., & Dienel, A. (2015). Efficacy of orally administered Silexan in patients with anxiety-related restlessness and disturbed sleep–A randomized, placebo-controlled trial. European neuropsychopharmacology, 25(11), 1960-1967.
Kasper, S., Möller, H. J., Volz, H. P., Schläfke, S., & Dienel, A. (2017). Silexan in generalized anxiety disorder: investigation of the therapeutic dosage range in a pooled data set. International clinical psychopharmacology, 32(4), 195-204.
Kasper, S., Gastpar, M., Müller, W. E., Volz, H. P., Möller, H. J., Schläfke, S., & Dienel, A. (2014). Lavender oil preparation Silexan is effective in generalized anxiety disorder–a randomized, double-blind comparison to placebo and paroxetine. International Journal of Neuropsychopharmacology, 17(6), 859-869.
Kasper, S., Gastpar, M., Müller, W. E., Volz, H. P., Möller, H. J., Dienel, A., & Schläfke, S. (2010). Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of ‘subsyndromal’ anxiety disorder: a randomized, double-blind, placebo controlled trial. International clinical psychopharmacology, 25(5), 277-287.
Kasper, S., Müller, W. E., Volz, H. P., Möller, H. J., Koch, E., & Dienel, A. (2018). Silexan in anxiety disorders: Clinical data and pharmacological background. The world journal of biological psychiatry, 19(6), 412-420.
Kasper, S., Volz, H. P., Dienel, A., & Schläfke, S. (2016). Efficacy of Silexan in mixed anxiety–depression–A randomized, placebo-controlled trial. European neuropsychopharmacology, 26(2), 331-340.
Kumar, V. (2013). Characterization of anxiolytic and neuropharmacological activities of Silexan. Wiener Medizinische Wochenschrift, 163(3), 89-94.
Mendes, L. F. da S. ., Piauilino , B. C. N. ., Sá Filho, D. P. de, Almada, A. G. C. ., Dantas , G. M. L. N. ., Batista, I. L. de S. ., Oliveira , I. R. L. ., Sousa, L. L. de, Nogueira , M. G. S. ., Silva, P. H. S. da ., Nascimento Júnior, G. K. S., Araújo Junior, S. J. . F. ., Lima, E. C. S. ., Moita, A. P. da S., & Vasconcelos , M. S. . (2022). The impact of physical exercise as a coadjuvant in the treatment of Type 2 Diabetes Mellitus: An Integrative Review. Research, Society and Development, 11(5), e1811527809.
Ministério da Saúde. (2012). Cadernos de Atenção Básica: Plantas Medicinais e Fitoterapia na Atenção Básica (n. 31.). Brasília, DF: Ministério da Saúde.
Policarpo, H. N. (2021). Plantas medicinais e preparações tradicionais à base de plantas usadas como ansiolítico (Doctoral dissertation).
Sadock, B. J., Sadock, V. A., Ruiz, P. (2017). Compêndio de Psiquiatria (11a ed.). Porto Alegre, RS: Artmed.
Seifritz, E., Schläfke, S., & Holsboer-Trachsler, E. (2019). Beneficial effects of Silexan on sleep are mediated by its anxiolytic effect. Journal of psychiatric research, 115, 69-74.
Silva, J. S., & Uhlmann, L. A. C. (2021). Florais de Bach para o Tratamento da Ansiedade Bach Flower Essences for the Treatment of Anxiety. Brazilian Journal of Development, 7(6), 64017-64028.
da Silva Oliveira, F. G., & Lehn, C. R. (2015). Riscos e perspectivas na utilização de fitoterápicos no Brasil. Opará: Etnicidades, Movimentos Sociais e Educação, 3(4), 35-44.
Souza, Â. M. A., Fraga, M. D. N. D. O., Moraes, L. M. P., Garcia, M. L. P., Moura, K. D. R., & Almeida, P. C. D. (2008). Grupo Terapêutico com mulheres com Transtornos de Ansiedade: Avaliação pela escala de ansiedade de Hamilton.
Woelk, H., & Schläfke, S. (2010). A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder. Phytomedicine, 17(2), 94-99.
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