Evaluation of the chemical profile and antioxidant and toxicological potential of essential oils from Baccharis trimera samples sold in sachets
DOI:
https://doi.org/10.33448/rsd-v11i10.33270Keywords:
Baccharis trimera; Sachets; Essential oils; Toxicity; Bioactivity.Abstract
The bitter carqueja (Baccharis trimera) is widely used in alternative and herbal medicine. The essential oil components of its leaves could be included among the most important active principles of this herb and some of them can also be used as chemical markers of the species. Therefore, the aim of the present study is to establish the chemical composition and evaluate the toxicological potential and antioxidant capacity of essential oils from carqueja samples commercialized in Rio de Janeiro city as sachets, comparing these results with those obtained for essential oils classified as reference for this species. The essential oils from these sachet samples were isolated by hydrodistillation and analyzed by chromatographic techniques (GC/FID and GC/MS), spectrophotometric techniques (DPPH) and by the Artemia salina test. In the present study, 41 compounds were identified in the essential oils analyzed. Terpenic compounds were the majority and only carquejil acetate, palustrol, spathulenol and β-eudesmol were detected in all the samples evaluated. The chemical variability of the essential oils in the sachet samples turned difficult to assess their authenticity. The antioxidant potentials of all essential oils evaluated were much lower than the antioxidant capacities measured for the positive controls of rutin and gallic acid (IC50 = 0.093 mg mL-1 and 0.0085 mg mL-1, respectively). All essential oils analyzed can be classified as cytotoxic agents according to the Artemia salina toxicity test.
References
Alonso J. R. (1998). Tratado de Fitomedicina - bases clínicas y farmacológicas. ISIS Ediciones S. R. L., Buenos Aires, Argentina. págs. 350-354.
Amaral, A. S., Radünz, L. L., Mossi, A. J., Santi, A., Da Rosa, N. M. F. F., & Feiten, F. (2010). Rendimento de matéria seca e de óleo essencial de Baccharis trimera com adubação química e orgânica. Revista de Ciências Agroveterinárias. 9(1), 20-28.
Barroso, G. M. (1976). Compositae – Subtribo Baccharidinae Hoffmann – Estudo das espécies ocorrentes no Brasil. Rodriguésia, 28, 1-273.
Beltrame, F. L., Ferroni, D. C., Alves, B. R. V., Pereira, A. V., & Esmerino, L. A. (2009). Avaliação da qualidade das amostras comercias de Baccharis trimera L. (Carqueja) vendidas no Estado do Paraná. Acta Scientiarum. Health Sciences, 31(1), 37-43.
Borella, J. C., Donata, P. D., Novaretti, A. A. G., Menezes Junior, A., França, S. C., Rufalo, C. B., Santos, P. A. S., Veneziani, R. C. S., & Lopes, N. P. (2006) Variabilidade sazonal do teor de saponinas de Baccharis trimera (Less.) DC (Carqueja) e isolamento de flavona. Revista Brasileira de Farmacognosia, 16(4), 557-561.
Borges, L. P., & Amorim, V. A. (2020). Metabólitos secundários de plantas. Revista Agrotecnologia, 11(1), 54-67.
BRASIL, Política Nacional de Fitoterápicos e o Impacto nas Farmácia (Ministério da Saúde). (2008). Disponível em: http://bvsms.saude.gov.br/bvs/palestras/cancer/politica_nacional_fititerapicos.pdf. Acesso em 15 de junho de 2022.
Budel, J. M., Duarte, M. R., Santos, C. A. M., Farago, P. V., & Matzenbacher, N. I. (2005). O progresso da pesquisa sobre o gênero Baccharis, Asteraceae: I - Estudos botânicos. Brazilian Journal of Pharmacognosy, 15(3), 268-271.
De Souza, T. P., Lionzo, M. I. Z., Petrovick, P. R. (2006). Avaliação da redução da carga microbiana de droga vegetal através do processamento tecnológico: decocção e secagem por aspersão. Revista Brasileira de Farmacognosia, 16, 94-98.
Karam, T. K., Dalposso, L. M., Casa, D. M., & De Freitas, G. B. L. (2013). Carqueja (Baccharis trimera): utilização terapêutica e biossíntese. Revista Brasileira de Plantas Medicinais, 15(2), 280-286.
Lima, C. M. P., Soares, R. P. F., Bastos, I. V. G. A., Grangeiro, A. R. S., Gurgel, A. P. A. D., Silva, A. C. P., Silva, J. G., Oliveira, R. A. G., & Souza, I. A. (2014). Avaliação da toxicidade aguda do extrato das cascas de Pithecellobium cochliocarpum (Gomez) Macbr. Revista Brasileira de Plantas Medicinais, 16(4), 832-838.
Limberger, R.P, Sobral, M., & Henriques, A.T. (2004). Óleos voláteis de espécies de Myrcia nativas do Rio Grande do Sul. Quimica Nova, 27(6), 916-919.
Losqui, Y. R., Rozete, F. S. S., Almeida, M. B., Bittencourt, A. H. C., & Pereira, S. P. F. (2009). Atividade de Baccharis trimera (Less.) DC. (Asteraceae) sobre cultura de células in vitro. Revista Brasileira de Farmacognosia, 19(4), 931-936.
Mariano, X. M., de Souza, W. F. M., Rocha, C. B., Moreira, R. F. A. (2019). Bioactive volatile fraction of Chilean boldo (Peumus boldus Molina) – an overview. Journal of Essential Oil Research, 31(6), 474 – 486.
Meyer, B. N., Ferrigni, N. R., Putnan, J. E., Jacobsen, L. B., Nichols, D. E., & Aughlin, J. (1982). Brine shrimp: a convenient general bioassay for active plant constituents. Planta medica, 45(5), 31-34.
Miranda, C. A. S. F., Cardoso, M. G., Batista, L. R., Rodrigues, L. M. A., & Figueiredo, A. C. S. (2016). Óleos essenciais de folhas de diversas espécies: propriedades antioxidantes e antibacterianas no crescimento espécies patogênicas. Revista Ciência Agronômica, 47(1), 213-220.
Nascimento, E. M. G. C., Carvalho, C. W. P., Ascheri, J. L. R., Galdeano, M. C., Fontoura, L., & Souza, W. F. (2015). Bioensaio pelo teste da Artemia salina (T.A.S.) para determinação da toxicidade de cascas de maracujá (Passiflora edulis). Journal of Fruits and Vegetables, 1(2), 216-220.
Paroul, N., Rosa, R. L. D., Piazza, S. P., Bertella, T., Puton, B. M. S., Falcão, L., Backes, G. T., & Cansian, R. L. (2016). Chemical Composition and Antioxidant Activity of Baccharis trimera Pers and Baccharis dracunculifolia DC (Asteraceae). Perspectiva, 151(40), 55-64.
Rodrigues, V. E. G., & De Carvalho, D. A. (2001). Etnobotanical survey of medicinal plants in the dominion of meadows in the region of the Alto Rio Grande – Minas Gerais. Revista Ciência e Agrotecnologia, 25, 102-123.
Silva, F., Park, K. J., Magalhães, P. M., Martins, G. N., & Gama, E. V. S. (2013). Avaliação do teor de óleo essencial de Baccharis trimera (Less.) DC. em diferentes embalagens durante o armazenamento. Revista Brasileira de Plantas Medicinais, 15(1), 54-58.
Simões-Pires, C. A., Debenedetti, S., Spegazzini, S., Mentz, L. A., Matzenbacher, N. I., Limberger, R. P., & Henriques, A. T. (2005). Investigation of the essential oil from eight species of Baccharis belonging to sect. Caulopterae (Asteraceae, Astereae): a taxonomic approach. Plant Systematics And Evolution, 253 (1-4), 23-32.
Souza, W. F. M., Mariano, X. M., Isnard, J. L., Souza, G. S., Souza Gomes, A. L., Carvalho, R. J. T.,
Rocha, C. B., Junior, C. L. S., & Moreira, R. F. A. (2019). Evaluation of the volatile composition, toxicological and antioxidant potentials of the essential oils and teas of commercial Chilean boldo samples. Food Research International, 124, 27-33.
Van Den Dool, H, & Kratz, P. D. (1963). A generalization of the retention index system including linear temperature programmed gas—liquid partition chromatography. Journal of Chromatography A, 11, 463-471.
Verdi, L. G., Brighente, I. M. C., & Pizzolatti, M. G. (2005). Gênero Baccharis (Asteraceae): aspectos químicos, econômicos e biológicos. Química Nova, 28, 85-94.
Viana, M. P., & Avelar, W. E. P. (2010). Ocorrência da espécie invasora Corbicula flumínea (Bi-903 valvia, Corbiculidae) no rio Sapucaí (São Paulo, Brasil). Revista Biotemas, 23(3), 59-66.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Iara Elizabeth Abi-Zaid Teixeira; Ana Luisa de Souza Gomes; Luiz Fernando Rodrigues Júnior; Cristiane Barbosa Rocha; Ricardo Felipe Alves Moreira
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
