The Aristolochia (Aristolochiaceae) genus: therapeutic properties, biological effects and toxicity

Authors

DOI:

https://doi.org/10.33448/rsd-v11i11.33504

Keywords:

Medicinal plants; Safe use; Bioactivities.

Abstract

The Brazilian flora harbors extensive plant biodiversity with the possibility of therapeutic use. In this context, the genus Aristolochia is widely used in folk medicine. From this perspective, the study aims to demonstrate important characteristics of these vegetables in the current literature. It was observed that the genus has promising medicinal properties that are directly related to its biological and chemical composition. However, it is notable that more research is needed to guide the safe use and encourage the synthesis of new pharmaceutical products derived from these herbs.

References

Asimi, O. A., Sahu, N. P., & Pal, A. K. (2013). Antioxidant activity and antimicrobial property of some Indian spices. International Journal of Scientific and Research Publications, 3(3), 1-8.

Badrie, N., & Schauss, A. G. (2010). Soursop (Annona muricata L.): composition, nutritional value, medicinal uses, and toxicology. In Bioactive foods in promoting health (pp. 621-643). Academic Press.

Brandão, M. G., Cosenza, G. P., Stanislau, A. M., & Fernandes, G. W. (2010). Influence of Brazilian herbal regulations on the use and conserva-tion of native medicinal plants. Environmental monitoring and assessment, 164(1), 369-377.

Brasil. Ministério da Saúde. (2015). Secretaria de Atenção à Saúde. Departamento de Atenção Básica. Política nacional de práticas integrativas e complementares no SUS: atitude de ampliação de acesso/Ministério da Saúde. Secretaria de Atenção à Saúde. Departamento de Atenção Básica. – 2. ed. – Brasília : Ministério da Saúde, .96 p.

Battu, G. R., Parimi, R., & Chandra Shekar, K. B. (2011). In vivo and in vitro pharmacological activity of Aristolochia tagala (syn: Aristolochia acuminata) root extracts. Pharmaceutical biology, 49(11), 1210-1214.

Bolla, S. R., Al-Subaie, A. M., Al-Jindan, R. Y., Balakrishna, J. P., Ravi, P. K., Veeraraghavan, V. P., ... & Surapaneni, K. M. (2019). In vitro wound healing potency of methanolic leaf extract of Aristolochia saccata is possibly mediated by its stimulatory effect on collagen-1 expression. Heliyon, 5(5), e01648.

Bourhia, M., Haj Said, A. A., Chaanoun, A., El Gueddari, F., Naamane, A., Benbacer, L., & Khlil, N. (2019). Phytochemical screening and toxico-logical study of Aristolochia baetica linn roots: histopathological and biochemical evidence. Journal of Toxicology, 2019.

Bourhia, M., Laasri, F. E., Moussa, S. I., Ullah, R., Bari, A., Saeed Ali, S., ... & Benbacer, L. (2019). Phytochemistry, antioxidant activity, anti-proliferative effect, and acute toxicity testing of two Moroccan Aristolochia species. Evidence-Based Complementary and Alternative Medicine, 2019.

Chung, Y. M., Chang, F. R., Tseng, T. F., Hwang, T. L., Chen, L. C., Wu, S. F., ... & Wu, Y. C. (2011). A novel alkaloid, aristopyridinone A and anti-inflammatory phenanthrenes isolated from Aristolochia manshuriensis. Bioorganic & medicinal chemistry letters, 21(6), 1792-1794.

Corell-Doménech, M. (2019). Terapeutas alternativos en México y la estrategia de la OMS sobre medicina tradicional 2014-2023: comunicación, creencias y factores socio-económicos. Perspectivas de la comunicación, 12(1), 59-77.

Devasagayam, T. P. A., Tilak, J. C., Boloor, K. K., Sane, K. S., Ghaskadbi, S. S., & Lele, R. D. (2004). Free radicals and antioxidants in human health: current status and future prospects. Japi, 52(794804), 4.

de Almeida Rodrigues, T., Neto, J. L., Carvalho, T. D. A. R., Barbosa, M. E., Guedes, J. C., & de Carvalho, A. V. (2020). A valorização das plantas medicinais como alternativa à saúde: um estudo etnobotânico. Revista Ibero-Americana de Ciências Ambientais, 11(1), 411-428.

Dey, A., & De, J. N. (2011). Aristolochia indica L.: A review. Asian Journal of Plant Sciences.

de Pascoli, I. C., Nascimento, I. R., & Lopes, L. M. (2006). Configurational analysis of cubebins and bicubebin from Aristolochia lagesiana and Aristolochia pubescens. Phytochemistry, 67(7), 735-742.

El Omari, N., Sayah, K., Fettach, S., El Blidi, O., Bouyahya, A., Faouzi, M. E. A., ... & Barkiyou, M. (2019). Evaluation of in vitro antioxidant and antidiabetic activities of Aristolochia longa extracts. Evidence-Based Complementary and Alternative Medicine, 2019.

Freitas, J., Lirio, E. J., Barros, F. & González, F. (2020). Aristolochiaceae in Flora do Brasil 2020. Jardim Botânico do Rio de Janeiro.

Khan, M. E., Amupitan, J. O., & Ndukwe, I. G. (2011). Bioactive evaluation and phytochemical screening of the roots of Aristolochia albida against some bacterial pathogens. Continental Journal of Applied Sciences, 6(1), 7-14.

Latha, S., Selvamani, P., Dhivya, P. S., & Benaseer Begam, R. (2015). A review on pharmacological activities of Aristolochia species. European journal of biomedical and pharmaceutical sciences, 2(5), 160-167.

León-Díaz, R., Meckes, M., Said-Fernández, S., Molina-Salinas, G. M., Vargas-Villarreal, J., Torres, J., ... & Jiménez-Arellanes, A. (2010). Anti-mycobacterial neolignans isolated from Aristolochia taliscana. Memórias do Instituto Oswaldo Cruz, 105, 45-51.

Lerma-Herrera, M. A., Beiza-Granados, L., Ochoa-Zarzosa, A., López-Meza, J. E., Navarro-Santos, P., Herrera-Bucio, R., ... & García-Gutiérrez, H. A. (2022). Biological Activities of Organic Extracts of the Genus Aristolochia: A Review from 2005 to 2021. Molecules, 27(12), 3937.

Lorenzi, h.; Matos, f. J. A. Plantas medicinais no Brasil nativas e exóticas. 2. ed. Nova Odessa - SP: Plantarum, 2008. p. 102-103

Lopes, L. M. X., Nascimento, I. R., Silva, T. D., & Da, L. M. (2001). Phytochemistry of the Aristolochiaceae family. Research advances in phy-tochemistry, 2, 19-108.

Machado, M. B., & Lopes, L. M. (2005). Chalcone–flavone tetramer and biflavones from Aristolochia ridicula. Phytochemistry, 66(6), 669-674.

Machado, M. B., & Lopes, L. M. (2010). Dimeric alkaloids and flavonoids from Aristolochia ridicula. Biochemical Systematics and Ecology, 38(1), 110-115.

Marles, R. J., & Farnsworth, N. R. (1995). Antidiabetic plants and their active constituents. Phytomedicine, 2(2), 137-189.

Marmitt, D. J., Rempel, C., GIETTERT, M., & Silva, A. C. (2015). Análise sistemática da produção científica do zingiber officinale Roscoe após a criação da relação nacional de plantas medicinais de interesse ao sistema único de saúde. Arquivos de Ciências da Saúde, 22(4), 14-21.

Navickiene, H., & Lopes, L. M. (2001). Alkamides and phenethyl derivatives from Aristolochia gehrtii. Journal of the Brazilian Chemical Socie-ty, 12, 467-472.

Pacheco, A. G., Machado de Oliveira, P., Piló-Veloso, D., & Flávio de Carvalho Alcântara, A. (2009). 13C-NMR data of diterpenes isolated from Aristolochia species. Molecules, 14(3), 1245-1262.

Sati, H., Sati, B., Saklani, S., Bhatt, P. C., & Mishra, A. P. (2011). Phytochemical and pharmacological potential of Aristolochia indica: a review. Research journal of pharmaceutical, biological and chemical sciences, 2(4), 647-654.

Silva, J. D. A. D., Nogueira, C. R., Vieira, M. D. C., Heredia-Vieira, S. C., Barufatti, A., Crispim, B. D. A., ... & Cardoso, C. A. L. (2019). Toxico-logical properties of an aqueous extract of Aristolochia triangularis leaves, using the brine shrimp lethality and Allium cepa bioassays. Ciência Rural, 49.

Sreeharsha, N., Kathiravan, G., Rajagopal, K., Rajasekar, A., Rajangam, B., Aldhubiab, B. E., ... & Tratrat, C. (2020). Synthesis, characterization, and biological activity of silver nanoparticles synthesized from Aristolochia bracteolata lam. Pharmacognosy Magazine, 16(71), 568.

Tesser, C. D., Sousa, I. M. C. D., & Nascimento, M. C. D. (2018). Práticas integrativas e complementares na atenção primária à saúde brasileira. Saúde em debate, 42, 174-188.

Zhou, T., Xiao, X. H., Wang, J. Y., Chen, J. L., Xu, X. F., He, Z. F., & Li, G. K. (2012). Evaluation of microwave‐assisted extraction for aris-tolochic acid from Aristolochiae Fructus by chromatographic analysis coupled with nephrotoxicity studies. Biomedical Chromatography, 26(2), 166-171.

Zhai, H., Inoue, T., Moriyama, M., Esumi, T., Mitsumoto, Y., & Fukuyama, Y. (2005). Neuroprotective effects of 2, 5-diaryl-3, 4-dimethyltetrahydrofuran neolignans. Biological and Pharmaceutical Bulletin, 28(2), 289-293.

Wang, L., Ding, X., Li, C., Zhao, Y., Yu, C., Yi, Y., ... & Liang, A. (2018). Oral administration of Aristolochia manshuriensis Kom in rats induces tumors in multiple organs. Journal of ethnopharmacology, 225, 81-89.

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Published

23/08/2022

How to Cite

MUELLER, L. P. .; COELHO, D. V. B. S. de A. .; GARCIA, L. C. .; TANAKA, L. H. V. B. .; BACHEGA, T. G. .; MAIA, A. M. de S. .; FREITAS, V. G. .; BENAZET, L. F.; NOGUEIRA, C. R. .; OESTERREICH, S. A. . The Aristolochia (Aristolochiaceae) genus: therapeutic properties, biological effects and toxicity. Research, Society and Development, [S. l.], v. 11, n. 11, p. e293111133504, 2022. DOI: 10.33448/rsd-v11i11.33504. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/33504. Acesso em: 14 nov. 2024.

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Section

Health Sciences