New evidence in the treatment of gastroesophageal reflux disease (GERD): an integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i11.33548

Keywords:

Gastroesophageal reflux disease; Treatment; Clinical trial; Evidence-based medicine.

Abstract

Gastroesophageal reflux disease (GERD) is a common clinical problem that affects millions of people worldwide. Advances in the therapeutic modality of the disease are essential to achieve the effectiveness of different imposed conditions, such as treatment refractoriness. The present review study sought to assess new evidence for the treatment of GERD, documented through clinical and randomized studies. This is an integrative review research carried out through an advanced search in the PubMed database, which took into account the following inclusion criteria: clinical trials and controlled and randomized trials; articles published in the last year; that had a full text available, in Portuguese, English or Spanish and that addressed the treatment of GERD. Duplicate articles in the database and those that did not address the topic under study were excluded. It was found that surgical techniques such as endoscopic surgery for PPI-refractory GERD and endoscopic fundoplication obtained good results in the analyzed context, in addition to techniques such as modified Xiaochaihu decoction and the use of JianpiQinghua granules in Traditional Chinese Medicine, in addition to the use of herbal species such as Opuntia ficus-indica and Olea europaea, which could demonstrate significant improvement in the main symptoms of GERD.

References

Chapelle, N., Ben Ghezala, I., Barkun, A., & Bardou, M. (2021). The pharmacotherapeutic management of gastroesophageal reflux disease (GERD). Expert Opinion on Pharmacotherapy, 22(2), 219-227.

Clarrett, D. M., & Hachem, C. (2018). Gastroesophageal reflux disease (GERD). Missouri medicine, 115(3), 214.

De Santiago, E. R., Albéniz, E., Estremera-Arevalo, F., Sanchez-Vegazo, C. T., & Lorenzo-Zúñiga, V. (2021). Endoscopic anti-reflux therapy for gastroesophageal reflux disease. World Journal of Gastroenterology, 27(39), 6601.

Gyawali, C. P., & Fass, R. (2018). Management of gastroesophageal reflux disease. Gastroenterology, 154(2), 302-318.

Kalapala, R., Karyampudi, A., Nabi, Z., Darisetty, S., Jagtap, N., Ramchandani, M., ... & Reddy, D. N. (2022). Endoscopic full-thickness plication for the treatment of PPI-dependent GERD: results from a randomised, sham controlled trial. Gut, 71(4), 686-694.

Katzka, D. A., & Kahrilas, P. J. (2020). Advances in the diagnosis and management of gastroesophageal reflux disease. Bmj, 371(23), 3786.

Kim, S. H., Cho, K. B., Chun, H. J., Lee, S. W., Kwon, J. G., Lee, D. H., ... & Song, G. S. (2021). Randomised clinical trial: comparison of tegoprazan and placebo in non‐erosive reflux disease. Alimentary Pharmacology & Therapeutics, 54(4), 402-411.

Koche, J.C. (2011). Fundamentos de metodologia científica: teoria da ciência e iniciação à pesquisa. 1 ed. Petrópolis, RJ: Vozes.

Li, Z., Tao, L., Zhang, S. S., Sun, X. H., Chen, S. N., & Wu, J. (2021). Modified Xiaochaihu Decoction for gastroesophageal reflux disease: A randomized double-simulation controlled trial. World Journal of Gastroenterology, 27(28), 4710-4721.

Lynen, A., Schömitz, M., Vahle, M., Jäkel, A., Rütz, M., & Schwerla, F. (2022). Osteopathic treatment in addition to standard care in patients with Gastroesophageal Reflux Disease (GERD) – A pragmatic randomized controlled trial. Journal of Bodywork and Movement Therapies, 29, 223-231.

Malfa, G. A., Di Giacomo, C., Cardia, L., Sorbara, E. E., Mannucci, C., & Calapai, G. (2021). A standardized extract of Opuntia ficus‐indica (L.) Mill and Olea europaea L. improves gastrointestinal discomfort: A double‐blinded randomized‐controlled study. Phytotherapy Research, 35(7), 3756-3768.

Maret-Ouda, J., Markar, S. R., & Lagergren, J. (2020). Gastroesophageal reflux disease: a review. Jama, 324(24), 2536-2547.

Mousa, H., & Hassan, M. (2017). Gastroesophageal reflux disease. Pediatric Clinics, 64(3), 487-505.

Ota, K., Takeuchi, T., Kojima, Y., Sugawara, N., Nishida, S., Iwatsubo, T., ... & Higuchi, K. (2021). Outcomes of endoscopic submucosal dissection for gastroesophageal reflux disease (ESD-G) for medication-refractory gastroesophageal reflux disease: 35 cases underwent ESD-G including 15 cases followed more than 5 years. BMC Gastroenterology, 21(1), 1-8.

Paknejad, M. S., Eftekhari, K., Rahimi, R., Vigeh, M., Naghizadeh, A., & Karimi, M. (2021). Myrtle (Myrtus communis L.) fruit syrup for gastroesophageal reflux disease in children: A double‐blind randomized clinical trial. Phytotherapy Research, 35(11), 6369-6376.

Rivière, P., Vauquelin, B., Rolland, E., Melchior, C., Roman, S., Bruley des Varannes, S., ... & Zerbib, F. (2021). Low FODMAPs diet or usual dietary advice for the treatment of refractory gastroesophageal reflux disease: An open‐labeled randomized trial. Neurogastroenterology & Motility, 33(9), e14181.

Roark, R., Sydor, M., Chatila, A. T., Umar, S., De La Guerra, R., Bilal, M., & Guturu, P. (2020). Management of gastroesophageal reflux disease. Disease-a-Month, 66(1), 100849.

Sandhu, D. S., & Fass, R. (2018). Current trends in the management of gastroesophageal reflux disease. Gut and Liver, 12(1), 7.

Sharma, P., & Yadlapati, R. (2021). Pathophysiology and treatment options for gastroesophageal reflux disease: looking beyond acid. Annals of the New York Academy of Sciences, 1486(1), 3-14.

Talley, N. J., & Irani, M. Z. (2021). Optimal management of severe symptomatic gastroesophageal reflux disease. Journal of Internal Medicine, 289(2), 162-178.

Yadlapati, R., & DeLay, K. (2019). Proton pump inhibitor–refractory gastroesophageal reflux disease. Medical Clinics, 103(1), 15-27.

Zhang, J., Che, H., Zhang, B., Zhang, C., Zhou, B., Ji, H., ... & Tang, X. (2021). JianpiQinghua granule reduced PPI dosage in patients with nonerosive reflux disease: A multicenter, randomized, double-blind, double-dummy, noninferiority study. Phytomedicine, 88, 153584.

Published

21/08/2022

How to Cite

SILVA, A. P. da .; SOUZA, P. Érico A. de; NEVES, H. R.; NUNES, V. E. P.; SILVA, N. M. de M.; RIBEIRO, W. A.; CUNHA, G. M.; PEREIRA, R. G.; GONÇALVES, G. G.; AMORIM, M. F.; DAMASO, C. R. S.; PINTO, A. dos S.; LUCAS, Íris C. New evidence in the treatment of gastroesophageal reflux disease (GERD): an integrative review. Research, Society and Development, [S. l.], v. 11, n. 11, p. e237111133548, 2022. DOI: 10.33448/rsd-v11i11.33548. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/33548. Acesso em: 3 oct. 2022.

Issue

Section

Health Sciences