Therapeutic effectiveness of probiotics in acne: integrative review
DOI:
https://doi.org/10.33448/rsd-v11i12.34335Keywords:
Skin Diseases; Skin; Acne vulgaris; Probiotics.Abstract
Probiotics are live microorganisms that beneficially affect the host when administered in adequate amounts, in addition to having an excellent safety profile. For this reason, probiotics have been used as immunomodulators in inflammatory skin diseases such as inflammatory acne. This study aimed to evaluate the therapeutic action of probiotics in acne. An integrative literature review was carried out. Quantitative and qualitative data performed in culture medium and in humans. Electronic searches were performed on PubMed/MEDLINE and BIREME, considering published studies without date limits. The search took place in October 2020, using a combination of the following terms and correlates: “probiotic” and “acne”. Ten studies were included, four in vivo and six in vitro. The studies used several probiotics known in the literature for supplementation, obtaining a positive result. However, there are still few studies that use probiotics to acne treatment as an adjunct with antibiotics or alone.
References
Al-Ghazzewi, F. H., & Tester, R. F. (2010). Effect of konjac glucomannan hydrolysates and probiotics on the growth of the skin bacterium Propionibacterium acnes in vitro. International journal of cosmetic science, 32(2), 139–142. https://doi.org/10.1111/j.1468-2494.2009.00555.x
Baldwin, H., & Tan, J. (2021). Effects of Diet on Acne and Its Response to Treatment. American journal of clinical dermatology, 22(1), 55–65. https://doi.org/10.1007/s40257-020-00542-y
Barnard, E., Shi, B., Kang, D., Craft, N., & Li, H. (2016). The balance of metagenomic elements shapes the skin microbiome in acne and health. Scientific reports, 6, 39491. https://doi.org/10.1038/srep39491
Bhate, K., Lin, L. Y., Barbieri, J. S., Leyrat, C., Hopkins, S., Stabler, R., Shallcross, L., Smeeth, L., Francis, N., Mathur, R., Langan, S. M., & Sinnott, S. J. (2021). Is there an association between long-term antibiotics for acne and subsequent infection sequelae and antimicrobial resistance? A systematic review. BJGP open, 5(3). https://doi.org/10.3399/BJGPO.2020.0181
Biswal, I., Gaind, R., Kumar, N., Mohanty, S., Manchanda, V., Khunger, N., V, R., & Deb, M. (2016). In vitro antimicrobial susceptibility patterns of Propionibacterium acnes isolated from patients with acne vulgaris. Journal of infection in developing countries, 10(10), 1140–1145. https://doi.org/10.3855/jidc.6862
Bowman, S., & Sadowski, C. K. (2022). Antibiotic use and bacterial resistance in patients with acne vulgaris. JAAPA : official journal of the American Academy of Physician Assistants, 35(8), 34–39. https://doi.org/10.1097/01.JAA.0000840500.37136.e5
Braun, V., & Clarke, V. (2006). Using thematic analysis in psychology. Qualitative research in psychology, 3(2), 77-101.
da Cunha, M. G., Fonseca, F. L., & Machado, C. D. (2013). Androgenic hormone profile of adult women with acne. Dermatology (Basel, Switzerland), 226(2), 167–171. https://doi.org/10.1159/000347196
Deidda, F., Amoruso, A., Nicola, S., Graziano, T., Pane, M., & Mogna, L. (2018). New Approach in Acne Therapy: A Specific Bacteriocin Activity and a Targeted Anti IL-8 Property in Just 1 Probiotic Strain, the L. salivarius LS03. Journal of clinical gastroenterology, 52 Suppl 1, Proceedings from the 9th Probiotics, Prebiotics and New Foods, Nutraceuticals and Botanicals for Nutrition & Human and Microbiota Health Meeting, held in Rome, Italy from September 10 to 12, 2017, S78–S81. https://doi.org/10.1097/MCG.0000000000001053
Fabbrocini, G., Bertona, M., Picazo, Ó., Pareja-Galeano, H., Monfrecola, G., & Emanuele, E. (2016). Supplementation with Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne. Beneficial microbes, 7(5), 625–630. https://doi.org/10.3920/BM2016.0089
Flohr, C., Pascoe, D., & Williams, H. C. (2005). Atopic dermatitis and the 'hygiene hypothesis': too clean to be true?. The British journal of dermatology, 152(2), 202–216. https://doi.org/10.1111/j.1365-2133.2004.06436.x
Fortuna, M. C., Garelli, V., Pranteda, G., Romaniello, F., Cardone, M., Carlesimo, M., & Rossi, A. (2016). A case of Scalp Rosacea treated with low dose doxycycline and probiotic therapy and literature review on therapeutic options. Dermatologic therapy, 29(4), 249–251. https://doi.org/10.1111/dth.12355
Fuchs-Tarlovsky, V., Marquez-Barba, M. F., & Sriram, K. (2016). Probiotics in dermatologic practice. Nutrition (Burbank, Los Angeles County, Calif.), 32(3), 289–295. https://doi.org/10.1016/j.nut.2015.09.001
Grice, E. A., & Segre, J. A. (2011). The skin microbiome. Nature reviews. Microbiology, 9(4), 244–253. https://doi.org/10.1038/nrmicro2537
Hsiao, K. H., Huang, C. M., & Lee, Y. H. (2018). Development of Rifampicin-Indocyanine Green-Loaded Perfluorocarbon Nanodroplets for Photo-Chemo-Probiotic Antimicrobial Therapy. Frontiers in pharmacology, 9, 1254. https://doi.org/10.3389/fphar.2018.01254
Hsieh, M. F., & Chen, C. H. (2011). Delivery of pharmaceutical agents to treat acne vulgaris: current status and perspectives. J Med Biol Eng, 32(4), 215-224.
Htwe, M. M., Teanpaisan, R., Khongkow, P., & Amnuaikit, T. (2019). Liposomes of probiotic's lyophilized cell free supernatant; a potential cosmeceutical product. Die Pharmazie, 74(8), 462–466. https://doi.org/10.1691/ph.2019.9030
Jung, G. W., Tse, J. E., Guiha, I., & Rao, J. (2013). Prospective, randomized, open-label trial comparing the safety, efficacy, and tolerability of an acne treatment regimen with and without a probiotic supplement and minocycline in subjects with mild to moderate acne. Journal of cutaneous medicine and surgery, 17(2), 114–122. https://doi.org/10.2310/7750.2012.12026
Kang, M. S., Oh, J. S., Lee, S. W., Lim, H. S., Choi, N. K., & Kim, S. M. (2012). Effect of Lactobacillus reuteri on the proliferation of Propionibacterium acnes and Staphylococcus epidermidis. Journal of microbiology (Seoul, Korea), 50(1), 137–142. https://doi.org/10.1007/s12275-012-1286-3
Khalfallah, G., Gartzen, R., Möller, M., Heine, E., & Lütticken, R. (2021). A New Approach to Harness Probiotics Against Common Bacterial Skin Pathogens: Towards Living Antimicrobials. Probiotics and antimicrobial proteins, 13(6), 1557–1571. https://doi.org/10.1007/s12602-021-09783-7
Khmaladze, I., Butler, É., Fabre, S., & Gillbro, J. M. (2019). Lactobacillus reuteri DSM 17938-A comparative study on the effect of probiotics and lysates on human skin. Experimental dermatology, 28(7), 822–828. https://doi.org/10.1111/exd.13950
Kong, H. H., Oh, J., Deming, C., Conlan, S., Grice, E. A., Beatson, M. A., Nomicos, E., Polley, E. C., Komarow, H. D., NISC Comparative Sequence Program, Murray, P. R., Turner, M. L., & Segre, J. A. (2012). Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome research, 22(5), 850–859. https://doi.org/10.1101/gr.131029.111
Lee, D. K., Kim, M. J., Ham, J. W., An, H. M., Cha, M. K., Lee, S. W., Park, C. I., Shin, S. H., Lee, K. O., Kim, K. J., & Ha, N. J. (2012). In vitro evaluation of antibacterial activities and anti-inflammatory effects of Bifidobacterium spp. addressing acne vulgaris. Archives of pharmacal research, 35(6), 1065–1071. https://doi.org/10.1007/s12272-012-0614-9
Loesche, M. A., Farahi, K., Capone, K., Fakharzadeh, S., Blauvelt, A., Duffin, K. C., DePrimo, S. E., Muñoz-Elías, E. J., Brodmerkel, C., Dasgupta, B., Chevrier, M., Smith, K., Horwinski, J., Tyldsley, A., & Grice, E. A. (2018). Longitudinal Study of the Psoriasis-Associated Skin Microbiome during Therapy with Ustekinumab in a Randomized Phase 3b Clinical Trial. The Journal of investigative dermatology, 138(9), 1973–1981. https://doi.org/10.1016/j.jid.2018.03.1501
Lomholt, H. B., & Kilian, M. (2010). Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne. PloS one, 5(8), e12277. https://doi.org/10.1371/journal.pone.0012277
Lopes, E. G., Moreira, D. A., Gullón, P., Gullón, B., Cardelle-Cobas, A., & Tavaria, F. K. (2017). Topical application of probiotics in skin: adhesion, antimicrobial and antibiofilm in vitro assays. Journal of applied microbiology, 122(2), 450–461. https://doi.org/10.1111/jam.13349
McLoughlin, I. J., Wright, E. M., Tagg, J. R., Jain, R., & Hale, J. (2022). Skin Microbiome-The Next Frontier for Probiotic Intervention. Probiotics and antimicrobial proteins, 14(4), 630–647. https://doi.org/10.1007/s12602-021-09824-1
Moura, I. B., Grada, A., Spittal, W., Clark, E., Ewin, D., Altringham, J., Fumero, E., Wilcox, M. H., & Buckley, A. M. (2022). Profiling the Effects of Systemic Antibiotics for Acne, Including the Narrow-Spectrum Antibiotic Sarecycline, on the Human Gut Microbiota. Frontiers in microbiology, 13, 901911. https://doi.org/10.3389/fmicb.2022.901911
Noble, H., & Smith, J. (2018). Reviewing the literature: choosing a review design. Evidence-based nursing, 21(2), 39-41.
Paetzold, B., Willis, J. R., Pereira de Lima, J., Knödlseder, N., Brüggemann, H., Quist, S. R., Gabaldón, T., & Güell, M. (2019). Skin microbiome modulation induced by probiotic solutions. Microbiome, 7(1), 95. https://doi.org/10.1186/s40168-019-0709-3
Puebla-Barragan, S., & Reid, G. (2021). Probi otics in Cosmetic and Personal Care Products: Trends and Challenges. Molecules (Basel, Switzerland), 26(5), 1249. https://doi.org/10.3390/molecules26051249
Rahmayani, T., Putra, I. B., & Jusuf, N. K. (2019). The Effect of Oral Probiotic on the Interleukin-10 Serum Levels of Acne Vulgaris. Open access Macedonian journal of medical sciences, 7(19), 3249–3252. https://doi.org/10.3889/oamjms.2019.718
Roudsari, M. R., Karimi, R., Sohrabvandi, S., & Mortazavian, A. M. (2015). Health effects of probiotics on the skin. Critical reviews in food science and nutrition, 55(9), 1219–1240. https://doi.org/10.1080/10408398.2012.680078
Saad, S. M. I. (2006). Probióticos e prebióticos: o estado da arte. Revista Brasileira de Ciências Farmacêuticas [online], 42 (1), 1-16. https://doi.org/10.1590/S1516-93322006000100002
Sanford, J. A., & Gallo, R. L. (2013). Functions of the skin microbiota in health and disease. Seminars in immunology, 25(5), 370–377. https://doi.org/10.1016/j.smim.2013.09.005
Simonart, T., Dramaix, M., & De Maertelaer, V. (2008). Efficacy of tetracyclines in the treatment of acne vulgaris: a review. The British journal of dermatology, 158(2), 208–216. https://doi.org/10.1111/j.1365-2133.2007.08286.x
Song, H. J., Kim, J. Y., Jung, S. A., Kim, S. E., Park, H. S., Jeong, Y., Hong, S. P., Cheon, J. H., Kim, W. H., Kim, H. J., Ye, B. D., Yang, S. K., Kim, S. W., Shin, S. J., Kim, H. S., Sung, J. K., & Kim, E. Y. (2010). Effect of probiotic Lactobacillus (Lacidofil® cap) for the prevention of antibiotic-associated diarrhea: a prospective, randomized, double-blind, multicenter study. Journal of Korean medical science, 25(12), 1784–1791. https://doi.org/10.3346/jkms.2010.25.12.1784
Szántó, M., Dózsa, A., Antal, D., Szabó, K., Kemény, L., & Bai, P. (2019). Targeting the gut-skin axis-Probiotics as new tools for skin disorder management?. Experimental dermatology, 28(11), 1210–1218. https://doi.org/10.1111/exd.14016
Vos, T., Flaxman, A. D., Naghavi, M., Lozano, R., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., Aboyans, V., Abraham, J., Ackerman, I., Aggarwal, R., Ahn, S. Y., Ali, M. K., Alvarado, M., Anderson, H. R., Anderson, L. M., Andrews, K. G., Atkinson, C., … Memish, Z. A. (2012). Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (London, England), 380(9859), 2163–2196. https://doi.org/10.1016/S0140-6736(12)61729-2
Wang, L., Clavaud, C., Bar-Hen, A., Cui, M., Gao, J., Liu, Y., Liu, C., Shibagaki, N., Guéniche, A., Jourdain, R., Lan, K., Zhang, C., Altmeyer, R., & Breton, L. (2015). Characterization of the major bacterial-fungal populations colonizing dandruff scalps in Shanghai, China, shows microbial disequilibrium. Experimental dermatology, 24(5), 398–400. https://doi.org/10.1111/exd.12684
Whittemore, R., & Knafl, K. (2005). The integrative review: updated methodology. Journal of advanced nursing, 52(5), 546–553. https://doi.org/10.1111/j.1365-2648.2005.03621.x
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