Comparative study between image obtaining techniques in the diagnostic of renal cell carcinoma




Carcinoma, renal cell; Diagnostic imaging; Kidney neoplasms.


Renal cell carcinoma is a type of malignant tumor that affects the renal tubules. Its incidence increases every year, and its diagnosis occurs incidentally through the imaging tests. Objective: To review the importance of imaging techniques used in the diagnosis of renal cell carcinoma. Methodology: Integrative review. Results and Discussion: Through the comparative tables elaborated for differentiation of the methods used in the diagnosis of renal cell carcinoma and the selected works, it was observed that the Computed Tomography is considered the method of choice for this diagnosis with its multiplanar reconstructions. Magnetic resonance imaging is the modality of choice in cases of allergy to contrast tomography, and / or the evaluation of the presence of thrombi. Ultrasound is not very efficient in assessing this diagnosis. On the other hand, scintigraphy is also recommended in this diagnosis and should not be adopted in routine practice.


AMERICAN CANCER SOCIETY (2017). Tests for Kidney Cancer [ Kidney Cancer Diagnosis.].

Bastos, M. G., Bregman, R., & Kirsztajn, G. M. (2010). Doença renal crônica: frequente e grave, mas também prevenível e tratável. Revista Da Associação Médica Brasileira, 56(2), 248–253.

BRASIL, Ministério da Saúde. Nota Técnica nº 2668/2018-CGJUD/SE/GAB/SE/MS. Doença: Tumor de Wilms (Nefroblastoma) – CID:C64. 20 de Junho de 2018.

BRASIL, Ministério da Saúde. Secretaria de Atenção á Saúde. Portaria nº 1.440, de 16 de Dezembro de 2014. Aprova as Diretrizes diagnósticas e terapêuticas do Carcinoma de células renais. Ficam aprovadas, na forma de anexo:, as diretrizes diagnósticas e terapêuticas – carcinoma células renais. <

Braunagel, M., Elisabeth, R., Michael, I., Michael, S., Christine, S.-T., Carsten, R., Konstantin, N., Maximilian, R., & Mike, N. (2015). Dynamic Contrast-Enhanced Magnetic Resonance Imaging Measurements in Renal Cell Carcinoma Effect of Region of Interest Size and Positioning on Interobserver and Intraobserver Variability [Review of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Measurements in Renal Cell Carcinoma Effect of Region of Interest Size and Positioning on Interobserver and Intraobserver Variability]. Investigative Radiology, 50o(1), 57–66.

Galvãoa., Castro, E. V., Zambelli Loyolaf. A., Campos Silva, R., Barbosa Reis, A., & Corradi Fonseca, C. E. (2021). Tratamento Do Câncer Renal Localizado – Protocolo Institucional Do Hospital Das Clínicas Da Ufmg [Review Of Tratamento Do Câncer Renal Localizado – Protocolo Institucional Do Hospital Das Clínicas Da Ufmg]. Rev. Cientifica de Urologia Da Sbu-MG.

Ganeshan, D., Morani, A., Ladha, H., Bathala, T., Kang, H., Gupta, S., Lalwani, N., & Kundra, V. (2014). Staging, surveillance, and evaluation of response to therapy in renal cell carcinoma: role of MDCT. Abdominal Imaging, 39(1), 66–85.

Giachini, E., Zanesco, C., Felipette Lima, J., Calciolari Rossi e Silva, R., & Tavares de Resende e Silva, D. (2017). Neoplasia renal maligna: carcinoma de células renais. Saú, 13(2).

Halefoglu, A., & Ozagari, A. (2021). Comparison of cortico-medullary phase contrast-enhanced MDCT and T2-weighted MR imaging in the histological subtype differentiation of renal cell carcinoma : radiology-pathology correlation. Polish Journal of Radiology, 86(1), 583–593.

Instituto Nacional de Câncer (INCA). Registro de câncer em base populacional incidência de cancer de rim. Instituto Oncoguia.

Kay, F. U., Canvasser, N. E., Xi, Y., Pinho, D. F., Costa, D. N., Diaz de Leon, A., Khatri, G., Leyendecker, J. R., Yokoo, T., Lay, A. H., Kavoussi, N., Koseoglu, E., Cadeddu, J. A., & Pedrosa, I. (2018). Diagnostic Performance and Interreader Agreement of a Standardized MR Imaging Approach in the Prediction of Small Renal Mass Histology. Radiology, 287(2), 543–553.

Kim, J. H., Sun, H. Y., Hwang, J., Hong, S. S., Cho, Y. J., Doo, S. W., Yang, W. J., & Song, Y. S. (2016). Diagnostic accuracy of contrast-enhanced computed tomography and contrast-enhanced magnetic resonance imaging of small renal masses in real practice: sensitivity and specificity according to subjective radiologic interpretation. World Journal of Surgical Oncology, 14(1).

Mendes, K. D. S, Silveira, R. C. de C. P., & Galvão, C. M. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & Contexto - Enfermagem. 2008 Dec;17(4):758–64.

Muglia, V. F., & Prando, A. (2015). Renal cell carcinoma: histological classification and correlation with imaging findings. Radiologia Brasileira, 48(3), 166–174.

Pereira, S., Martinho, D., Mendonça, T., Fernandes, R., Correia, H., Pedro, L. M., Gama, A. D. da, & Lopes, T. (2011). Carcinoma de Células Renais com Envolvimento Venoso. Angiologia E Cirurgia Vascular, 7(1), 29–34.

Sankineni, S., Brown, A., Cieciera, M., Choyke, P. L., & Turkbey, B. (2016). Imaging of renal cell carcinoma. Urologic Oncology: Seminars and Original Investigations, 34(3), 147–155.

Sasaguri, K., & Takahashi, N. (2018). CT and MR imaging for solid renal mass characterization. European Journal of Radiology, 99, 40–54.

Silva, F. C. (2015). Recomendações clínicas no tratamento do carcinoma de células renais (1st ed., pp. 31–55) [Review of Recomendações clínicas no tratamento do carcinoma de células renais]. Grupo português Génito-Urinário.

Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249.

Tsili, A. C., & Argyropoulou, M. I. (2015). Advances of multidetector computed tomography in the characterization and staging of renal cell carcinoma. World Journal of Radiology, 7(6), 110–127.

Tsili, A. C., Andriotis, E., Gkeli, M. G., Krokidis, M., Stasinopoulou, M., Varkarakis, I. M., & Moulopoulos, L.-A. (2021). The role of imaging in the management of renal masses. European Journal of Radiology, 141, 109777.

Urso, L., Castello, A., Rocca, G. C., Lancia, F., Panareo, S., Cittanti, C., Uccelli, L., Florimonte, L., Castellani, M., Ippolito, C., Frassoldati, A., & Bartolomei, M. (2022). Role of PSMA-ligands imaging in Renal Cell Carcinoma management: current status and future perspectives. Journal of Cancer Research and Clinical Oncology.

Xie, P., Li, H.-L., Wei, L.-G., & Huang, J.-M. (2018). Incidental bone metastases identified by renal dynamic scintigraphy. Medicine, 97(32), e11483.

Wang, T., Zhao, J., & Xing, Y. (2015). Uptake of 99mTc-DTPA in Bone Metastases from Renal Cancer. Clinical Nuclear Medicine, 40(10), 840–841.

Zaytoun, O. M., Darweesh, R. M., Gaber, S. A., & Ibrahim, R. M. (2021). Role of non-contrast magnetic resonance imaging in pre-surgical evaluation of renal masses in renal impairment patients. African Journal of Urology, 27(1).

Zhang, J., Lefkowitz, R. A., Ishill, N. M., Wang, L., Moskowitz, C. S., Russo, P., Eisenberg, H., & Hricak, H. (2007). Solid Renal Cortical Tumors: Differentiation with CT. Radiology, 244(2), 494–504.



How to Cite

BARCELOS, V. H. P.; MARTINS, K. A. M.; MENDONÇA, P. H. F. de .; BARROS, R. J. R. Comparative study between image obtaining techniques in the diagnostic of renal cell carcinoma . Research, Society and Development, [S. l.], v. 11, n. 12, p. e493111234676, 2022. DOI: 10.33448/rsd-v11i12.34676. Disponível em: Acesso em: 25 jun. 2024.



Health Sciences