Bacterial resistance in the treatment of pneumonia in hospital patients: a systematic review
DOI:
https://doi.org/10.33448/rsd-v11i13.34930Keywords:
Bacterial drug resistance; Pneumonia; Antibacterial.Abstract
Objective: identify the main bacteria resistant to broad drugs associated with the development of pneumonia in hospital patients from 2017 to 2022 worldwide, comparing the agents identified before and during the pandemic due to COVID-19. Methodology: The articles were searched in the Scielo, PubMed and UpToDate databases following the guidelines of the Preferred ReportingItems for Systematic Reviews and Meta-Analyses (PRISMA). The ‘’PVOS’’ strategy (population, variables, outcomes and study) was used to select the articles analyzed in the review. The descriptors standardized by the ‘’Descritores em Ciências da Saúde’’ were used: pneumonia, antibacterials, bacterial drug resistance, bacterial multiple drug resistance for bibliographic survey. Included in this systematic review, analytical observational studies, articles of published research, case studies, systematic reviews and epidemiological, microbiological, and molecular surveillance studies. Results: After the screening process, removal of duplicate articles and analysis of inclusion criteria, 27 articles were identified as eligible for this systematic review. Conclusion: The results of this systematic review provide evidence of the main bacteria causing pneumonia in hospitalized patients worldwide, as well as the resistance profile in the case of multidrug-resistant organisms, in addition to identifying treatment alternatives for these agents.
References
Alecrim, R. X., Taminato, M., Belasco, A. G. S., Barbosa, D., Kusahara, D. M., & Fram, D. (2019). Boas práticas na prevenção de pneumonia associada à ventilação mecânica. Acta Paulista de Enfermagem, 32, 11-17.
Antibacterial drugs for community-acquired pneumonia. The Medical letter on drugs and therapeutics, 63,1616: 10-14. 2021.
Ashurst, J. V., & Dawson, A. (2018). Klebsiella pneumonia.
Azevedo, L. C. P. D., Taniguchi, L. U., Ladeira, J. P., Martins, H. S., & Velasco, I. T. (2018). Medicina intensiva: abordagem prática.
Bart, S. M., Rubin, D., Kim, P., Farley, J. J., & Nambiar, S. (2021). Trends in hospital-acquired and ventilator-associated bacterial pneumonia trials. Clinical Infectious Diseases, 73(3), e602-e608.
Bozorgmehr, R., Bahrani, V., & Fatemi, A. (2017). Ventilator-associated pneumonia and its responsible germs; an epidemiological study. Emergency, 5(1).
da Silva, J. E. B., de Souza, J. B., dos Santos Macêdo, D. C., Barros, M. C. D. S. A., de Almeida Campos, L. A., da Costa Júnior, S. D., ... & Cavalcanti, I. M. F. (2022). Utilização de aminoglicosídeos como estratégia terapêutica para combater infecções causadas por enterobactérias produtoras de β-lactamases de espectro estendido. Research, Society and Development, 11(2), e57711225680-e57711225680.
de Oliveira, M. F., de Araujo Lima, C. S., Sanches, R. D., da Silva, J. C., de Oliveira, T. M. F. C., Araújo, I. V. G., ... & Grillo, M. D. P. P. (2022). Revendo o tratamento para pneumonia causada por Staphylococcus aureus resistente à meticilina. Research, Society and Development, 11(1), e8411124338-e8411124338
El mekes, A. Zahlane, K., Ouafi, A. T., & Barakate, M. (2020). The clinical and epidemiological risk factors of infections due to multi-drug resistant bacteria in an adult intensive care unit of University Hospital Center in Marrakesh-Morocco. Journal of Infection and Public Health, 13(4), 637-643.
Ferreira, E. G., Kimura, A., de Ramos, D. F., de Albuquerque, P. L., Antunes, M. D., & de Oliveira, D. V. (2017). Prevalência de pneumonia associada à ventilação mecânica por meio de análise das secreções traqueobrônquicas. Rev Rene, 18(1), 114-120.
Forest, W. A. (2018) Pneumonia hospitalar. https://bestpractice.bmj.com/topics/pt-br/720?q=Pneumonia%20hospitalar&c=suggested
Gabriel, L. R. L. (2018). Resistência plasmidial do tipo AMPC na família enterobacteriaceae e métodos de detecção laboratorial]
Kanj, S., Sexton, D., & Daniel, M. D. (201521). Epidemiology, microbiology, and pathogenesis of Pseudomonas aeruginosa infection. UpToDate [Internet].
Kanafani, Z., & Kanj, S. (2021). Acinetobacter infection: Treatment and prevention. UpToDate.
Kanj, S. S., & Sexton, D. J. (2019). Principles of antimicrobial therapy of Pseudomonas aeruginosa infections. UpToDate Inc, Waltham, MA.
Khurana, S., Mathur, P., Kumar, S., Soni, K. D., Aggrawal, R., Batra, P., & Bhardwaj, N. (2017). Incidence of ventilator-associated pneumonia and impact of multidrug-resistant infections on patient’s outcome: Experience at an Apex Trauma Centre in North India. Indian Journal of Medical Microbiology, 35(4), 504-510.
Klompas, M., Thomas Jr, M. F., Bond, S., & Lee, S. (2019). Treatment of hospital-acquired and ventilator-associated pneumonia in adults. Bond (Red.), UpToDate. Hentet, 11, 2019.
Klompas, M., Thomas Jr, M. F., Bogorodskaya, M. (2019). Risk factors and prevention of hospital-acquired and ventilator-associated pneumonia in adults Bond (Red.), UpToDate. Hentet, 11, 2019.
Leal, R., & Nunes, C. P. (2019). Pneumonia associada à ventilação mecânica em pacientes internados nas unidades de terapia intensiva. Revista de Medicina de Família e Saúde Mental, 1(1).
Lima, C. C., Benjamim, S. C. C., & Santos, R. F. S. D. (2017). Mecanismo de resistência bacteriana frente aos fármacos: uma revisão. CuidArte, Enferm, 105-113.
Miller, L. O. L., de Souza Kern, L., Miller, R. G., Martini, C. D. D. T., da Rosa, M. P., & Hartwig, D. D. (2022). Complexo Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB): ocorrência e perfil de resistência aos carbapenêmicos e polimixina B durante pandemia de SARS-CoV-2 em Pelotas, RS. Research, Society and Development, 11(1), e42811125128-e42811125128.
Mota, É. C., Oliveira, S. P., Silveira, B. R., Silva, P. L., & Oliveira, A. C. (2017). Incidência da pneumonia associada à ventilação mecânica em unidade de terapia intensiva. Medicina (Ribeirão Preto), 50(1), 39-46.
Mota, F. S., Oliveira, H. A. D., & Souto, R. C. F. (2018). Perfil e prevalência de resistência aos antimicrobianos de bactérias Gram-negativas isoladas de pacientes de uma unidade de terapia intensiva. RBAC, 50(3), 270-277.
OPAS (2020). Lista de medicamentos essenciais para tratamento de pacientes admitidos nas unidade de terapia intensiva com suspeita ou diagnóstico confirmado da COVID-19 (LMEUTI-COVID-19).
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., ... & Moher, D. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Systematic reviews, 10(1), 1-11.
Quale, J., Spelman, D., Hooper, D., & Bloom, A. (2016). Overview of carbapenemase producing gram-negative bacilli. UpToDate: Waltham, MA, USA, Accessed On, 21.
Rosa, L. N., de Castro, A. P., de Lima, W. G., Simião, D. C., & de Paiva, M. C. (2021). Pneumonia associada à ventilação mecânica por Pseudomonas aeruginosa resistente a polimixina: Uma revisão sistemática. Research, Society and Development, 10(13), e555101321480-e555101321480.
Titov, I., Wunderink, R. G., Roquilly, A., Rodríguez Gonzalez, D., David-Wang, A., Boucher, H. W., ... & Chen, L. F. (2021). A randomized, double-blind, multicenter trial comparing efficacy and safety of imipenem/cilastatin/relebactam versus piperacillin/tazobactam in adults with hospital-acquired or ventilator-associated bacterial pneumonia (RESTORE-IMI 2 Study). Clinical Infectious Diseases, 73(11), e4539-e4548.
Wang, Y., Zhang, R., & Liu, W. (2018). Distribution and drug resistance of pathogenic bacteria in ventilator-associated pneumonia at a local hospital of North-eastern China. Infection and Drug Resistance, 11, 2249.
Westblade, L. F., Simon, M. S., & Satlin, M. J. (2021). Bacterial coinfections in coronavirus disease 2019. Trends in microbiology, 29(10), 930-941
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Copyright (c) 2022 Lucas Cerqueira Gomes Barbosa do Nascimento; Gledson Lima Alves Junior; Vitor Moura Pereira; Gerlan da Silva Rodrigues ; Adriano Bezerra da Silva Júnior; André Luís Conceição Lemos; Rafael Valença de Souza Santos; Adriel Barbosa do Nascimento
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