Venous thromboembolism associated with the use of oral contraceptives: an integrative review
DOI:
https://doi.org/10.33448/rsd-v11i13.35774Keywords:
Venous Thromboembolism; Oral contraceptives; Pulmonary embolism.Abstract
Objective: To analyze the association between venous thromboembolism and the use of oral contraceptives. Methodology: This is an integrative review. A bibliographic survey was conducted in the databases at the Virtual Health Library (VHL) and PUBMED, in Portuguese and English. The information extracted from the selected articles was referred to the following items: journal and article title; authors' titration; year, location, volume and publication number. In addition to these items, in the studies we observed information about the methodologies used, the results achieved and the conclusions to which the authors reached. Results: A total of 8 articles were found and after a refinement mechanism in the search on the platforms by the inclusion criteria, 7 papers were included, because one was outside the selected language. These were subject to a deep analysis and observed if the subject addressed is consistent with the recommendations of the present study, obeying the exclusion criteria. Conclusion: Based on the results obtained in the present study, it is observed that the high risk of DVT or PE are in patients who use combined contraceptives. Findings in the literature have not yet understood which oral contraceptive is more harmful to women's health, however, it is noted that the association of drospirinone and third-generation progestágens or the fourth generation combined oral contraceptive has a slightly higher risk of VTE when compared to patients who use first and second generation.
References
Abbas, A. K., Fausto, N., & Kumar, V. (2010). Robbins & Cotran Patologia: Bases Patológicas das Doenças. (9a ed.) Elsevier.
Baratloo, A., Safari, S., Rouhipour, A., Hashemi, B., Rahmati, F., Motamedi, M., Forouzanfar, M., & Haroutunian, P. (2014). The Risk of Venous Thromboembolism with Different Generation of Oral Contraceptives; a Systematic Review and Meta-Analysis. Emergency, 2(1), 1-11.
Blanco-Molina, A., & Monreal, M. (2010). Venous thromboembolism in women taking hormonal contraceptives. Expert Review of Cardiovascular Therapy, 8(2), 211–5.
Bloemenkamp, K. W., Rosendaal, F. R., Helmerhorst, F. M., Büller, H. R., & Vandenbroucke, J. P. (1995). Enhancement by factor V Leiden mutation of risk of deep-vein thrombosis associated with oral contraceptives containing a third-generation progestagen. Lancet, 346(8990), 1593-6.
Crous-Bou, M., Harrington, L. B., & Kabrhel, C. (2016). Environmental and Genetic Risk Factors Associated with Venous Thromboembolism. Seminars in Thrombosis and Hemostasis, 42(8), 808-20.
Farmer, R. D., Lawrenson, R. A., Thompson, C. R., Kennedy, J. G., & Hambleton, I. R. (1997). Population-based study of risk of venous thromboembolism associated with various oral contraceptives. Lancet, 349(9045), 83-8.
Jick, H., Jick, S. S., Gurewich, V., Myers, M. W., & Vasilakis, C. (1995). Risk of idiopathic cardiovascular death and nonfatal venous thromboembolism in women using oral contraceptives with differing progestagen components. Lancet, 346(8990), 1589-93.
Kobayashi, T., Sugiura, K., & Ojima, T. (2017). Risks of thromboembolism associated with hormone contraceptives in Japanese compared with Western women. Journal of Obstetrics and Gynaecology Research, 43(5), 789-97.
Lidegaard, Ø., Nielsen, L. H., Skovlund, C. W., Skjeldestad, F. E., & Løkkegaard, E. (2011). Risk of venous thromboembolism from use of oral contraceptives containing different progestogens and oestrogen doses: Danish cohort study, 2001-9. BMJ, 343, d6423.
McDaid, A., Logette, E., Buchillier, V., Muriset, M., Suchon, P., Pache, T. D., Tanackovic, G., Kutalik, Z., & Michaud, J. (2017). Risk prediction of developing venous thrombosis in combined oral contraceptive users. PloS One, 12(7), e0182041.
Parkin, L., Skegg, D. C., Wilson, M., Herbison, G. P., & Paul, C. (2000). Oral contraceptives and fatal pulmonary embolism. Lancet, 355(9221), 2133-4.
Phillippe, H. M. (2017). Overview of venous thromboembolism. The American Journal of Managed Care, 23(20 Suppl), S376–82.
Practice Committee of the American Society for Reproductive Medicine. (2017). Combined hormonal contraception and the risk of venous thromboembolism: a guideline. Fertility and Sterility, 107(1), 43-51.
Rosendaal, F. R., & Reitsma, P. H. (2009). Genetics of venous thrombosis. Journal of Thrombosis and Haemostasiz, (7 Suppl 1), 301-4.
Rott, H. (2012). Thrombotic risks of oral contraceptives. Current Opinion in Obstetrics & Gynecology, 24(4), 235-40.
Shafran, D. M., & Wu, C. (2017). Treatment of venous thromboembolism in a 22-year-old woman taking an oral contraceptive pill. CMAJ, 189(47), E1459-60.
Silva, G. M. D., Pesce, G. B., Martins, D. C., Carreira, L., Fernandes, C. A. M., & Jacques, A. E. (2021). Obesidade como fator agravante da COVID-19 em adultos hospitalizados: revisão integrativa. Acta Paulista de Enfermagem, 34, eAPE02321.
Sueta, D., Akahoshi, R., Okamura, Y., Kojima, S., Ikemoto, T., Yamamoto, E., Izumiya, Y., Tsujita, K., Kaikita, K., Katabuchi, H., & Hokimoto, S. (2017). Venous thromboembolism due to oral contraceptive intake and spending nights in a vehicle-a case from the 2016 Kumamoto earthquakes. Internal Medicine, 56(4), 409-12.
Sugiura, K., Kobayashi, T., & Ojima, T. (2021). The epidemiological characteristics of thromboembolism related to oral contraceptives in Japan: Results of a national survey. Journal of Obstetrics and Gynaecology Research, 47(1), 198-207.
Sugiura, K., Ojima, T., Urano, T., & Kobayashi, T. (2018). The incidence and prognosis of thromboembolism associated with oral contraceptives: Age‐dependent difference in Japanese population. Journal of Obstetrics and Gynaecology Research, 44(9), 1766-72.
Suissa, S., Spitzer, W. O., Rainville, B., Cusson, J., Lewis, M., & Heinemann, L. (2000). Recurrent use of newer oral contraceptives and the risk of venous thromboembolism. Human Reproduction, 15(4), 817-21.
Traven, S. A., Farley, K. X., Gottschalk, M. B., Goodloe, J. B., Woolf, S. K., Xerogeanes, J. W., & Slone, H. S. (2021). Combined oral contraceptive use increases the risk of venous thromboembolism after knee arthroscopy and anterior cruciate ligament reconstruction: an analysis of 64,165 patients in the Truven database. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 37(3), 924-31.
World Health Organization Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. (1995). Venous thromboembolic disease and combined oral contraceptives: results of international multicentre case-control study. Lancet, 346(8990), 1575-82.
World Health Organization Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. (1995). Effect of different progestagens in low oestrogen oral contraceptives on venous thromboembolic disease. Lancet, 346(8990), 1582-8.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Alisson Soares Junior ; Marina Chaves Nunes; Miguel Ribeiro Alves de Jesus; Itamar Magalhães Gonçalves
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.