Mortality from epilepsy and status epilepticus in Brazil: analysis of the epidemiological profile

Authors

DOI:

https://doi.org/10.33448/rsd-v11i14.35922

Keywords:

Mortality; Epilepsy; Status epilepticus; Epidemiology.

Abstract

The objective of this article was to carry out an epidemiological analysis of the mortality profile from epilepsy and status epilepticus in Brazil. Methods: Retrospective transversal epidemiological study, with a quantitative and descriptive approach using data obtained from the Mortality Information System (MIS), according to sex and age group, between 2010 and 2019. Results: A total of 25,393 deaths were identified in Brazil, 89.8% of which were due to epilepsy (MPE) and 10.2% due to status epilepticus (EME). Of the total, 64.3% were male and 35.7% were female. The majority of cases were between 40 and 49 years. The North and Northeast regions presented the highest percentage of MPE and EME. In relation to the general mortality rates, an increase of 46.9% (MPE) and 68.4% (EME) was identified, with an increase in all geographic regions. The population mortality rate from epilepsy followed an upward trend with no statistically significant fluctuations. The mortality rate due to EME showed an increase between the general population and the male population, with an indication of a decrease among the female population. Conclusions: Contrary to the global parameter, Brazil showed an increase in the mortality rate from epilepsy, which may be related to the improvement in diagnosis, in the adequate recording of the underlying cause of death and in MIS in the last Years.

References

Abdel-Mannan, O., Hughes, E., & Dunkley, C. (2020). Epilepsy deaths in children: Improvements driven by data and surveillance in pediatrics. Epilepsy & behavior: E&B, 103(Pt B), 106493. https://doi.org/10.1016/j.yebeh.2019.106493

Beghi E. (2020). The Epidemiology of Epilepsy. Neuroepidemiology, 54(2), 185–191. https://doi.org/10.1159/000503831

Bell G. S., Neligan A., & Sander J. W. (2014). An unknown quantity–the worldwide prevalence of epilepsy. Epilepsia, 55(7), 958-962.

Bertolucci P. H. F., Ferraz H. B., Félix E. P. V., & Pedroso J. L. (2011). Neurologia. São Paulo: Manole. p. 1140.

Der-Nigoghossian, C., Rubinos, C., Alkhachroum, A., & Claassen, J. (2019). Status epilepticus - time is brain and treatment considerations. Current opinion in critical care, 25(6), 638–646. https://doi.org/10.1097/MCC.0000000000000661

Devinsky, O., Spruill, T., Thurman, D., & Friedman, D. (2016). Recognizing and preventing epilepsy-related mortality: A call for action. Neurology, 86(8), 779–786. https://doi.org/10.1212/WNL.0000000000002253

Dwivedi, R., Ramanujam, B., Chandra, P. S., Sapra, S., Gulati, S., Kalaivani, M., Garg, A., Bal, C. S., Tripathi, M., Dwivedi, S. N., Sagar, R., Sarkar, C., & Tripathi, M. (2017). Surgery for drug-resistant epilepsy in children. N Engl J Med, 377 (17), 1639–1647

Escalaya, A. L., Tellez-Zenteno, J. F., Steven, D. A., & Burneo, J. G. (2015). Epilepsy and mortality in Latin America. Seizure, 25, 99–103. https://doi.org/10.1016/j.seizure.2014.09.012

Fernandes M. J. S. (2013). Epilepsia do lobo temporal: mecanismos e perspectivas. Estudos Avançados, 27(77), 85-98.

Ferrari, C. M., de Sousa, R. M., & Castro, L. H. (2013). Factors associated with treatment non-adherence in patients with epilepsy in Brazil. Seizure, 22(5), 384–389. https://doi.org/10.1016/j.seizure.2013.02.006

Ferreira, I. L. M., & Silva, T. P. T. (2009). Mortalidade por epilepsia no Brasil, 1980-2003. Cien Saude Colet, 14(1), 89-94.

Fisher, R. S., Van Emde Boas, W., Blume, W., Elger, C., Genton, P., Lee, P., & Engel, J. Jr (2005). Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia, 46(4), 470-472.

Garzon, E. (2008). Estado de Mal Epiléptico. J Epilepsy Clin Neurophysiol, 14 (Suppl 2), 7-11.

GBD 2016 Epilepsy Collaborators (2019). Global, regional, and national burden of epilepsy, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet. Neurology, 18(4), 357–375. https://doi.org/10.1016/S1474-4422(18)30454-X

Gomes, M. M. (2010). Mortalidade atribuída à epilepsia, às suas doenças subjacentes ou às condições não relacionadas a ela: uma síntese. J. epilepsy clin. neurophysiol. 16(3), 100-105. https://doi.org/10.1590/S1676-26492010000300004

Gomes, M. M. (2011) Mortality from epilepsy: Brazil (capitals), 1980-2007. Arq. Neuropsiquiatr., 69(2), 166-169. https://doi.org/10.1590/S0004-282X2011000200004

Instituto Brasileiro de Geografia e Estatística. (2018). Projeção da População do IBGE.

Johnson, E. L., & Kaplan, P. W. (2020). Status Epilepticus: Definition, Classification, Pathophysiology, and Epidemiology. Seminars in neurology, 40(6), 647–651. https://doi.org/10.1055/s-0040-1718722

Kellinghaus, C., Rossetti, A. O., Trinka, E., Lang, N., May, T. W., Unterberger, I., Rüegg, S., Sutter, R., Strzelczyk, A., Tilz, C., Uzelac, Z., & Rosenow, F. (2019). Factors predicting cessation of status epilepticus in clinical practice: Data from a prospective observational registry (SENSE). Annals of neurology, 85(3), 421–432. https://doi.org/10.1002/ana.25416

Kwon, C. S., Ripa, V., Al-Awar, O., Panov, F., Ghatan, S., & Jetté, N. (2018). Epilepsy and neuromodulation - randomized controlled trials. Brain Sci, 8(4), 69

Leitinger, M., Trinka, E., Giovannini, G., Zimmermann, G., Florea, C., Rohracher, A., Kalss, G., Neuray, C., Kreidenhuber, R., Höfler, J., Kuchukhidze, G., Granbichler, C., Dobesberger, J., Novak, H. F., Pilz, G., Meletti, S., & Siebert, U. (2019). Epidemiology of status epilepticus in adults: A population-based study on incidence, causes, and outcomes. Epilepsia, 60(1), 53–62. https://doi.org/10.1111/epi.14607

Levira, F., Thurman, D. J., Sander, J. W., Hauser, W. A., Hesdorffer, D. C., Masanja, H., Odermatt, P., Logroscino, G., Newton, C. R., & Epidemiology Commission of the International League Against Epilepsy (2017). Premature mortality of epilepsy in low- and middle-income countries: A systematic review from the Mortality Task Force of the International League Against Epilepsy. Epilepsia, 58(1), 6–16. https://doi.org/10.1111/epi.13603

Lv, R. J., Wang, Q., Cui, T., Zhu, F., & Shao, X. Q. (2017). Status epilepticus-related etiology, incidence and mortality: A meta-analysis. Epilepsy research, 136, 12–17. https://doi.org/10.1016/j.eplepsyres.2017.07.006

Meyer, A. C., Dua, T., Ma, J., Saxena, S., & Birbeck, G. (2010). Global disparities in the epilepsy treatment gap: a systematic review. Bulletin of the World Health Organization, 88(4), 260–266. https://doi.org/10.2471/BLT.09.064147

Ministério da Saúde (2019). Protocolo Clínico e Diretrizes Terapêuticas para Epilepsia. Brasília: CONITEC.

Ministério da Saúde. Sistema de Informações sobre Mortalidade. http://www2.datasus.gov.br/DATASUS/index.php?area=060701

Moshé S. L., Perucca E., Ryvlin P., & Tomson T. (2015). Epilepsy: new advances. Lancet, 385(9971), 884-898.

National Institute for Health and Care Excellence. (2014). Transient loss of consciousness (‘blackouts’) in over 16s.

National Institute for Health and Care Excellence. (2018). Epilepsies: diagnosis and management. 1-636.

Neligan, A., Hauser, W. A., & Sander, J. W. (2012). The epidemiology of the epilepsies. Handb Clin Neurol, 107, 113-133.

Neligan, A., Noyce, A. J., Gosavi, T. D., Shorvon, S. D., Köhler, S., & Walker, M. C. (2019). Change in Mortality of Generalized Convulsive Status Epilepticus in High-Income Countries Over Time: A Systematic Review and Meta-analysis. JAMA neurology, 76(8), 897–905. https://doi.org/10.1001/jamaneurol.2019.1268

Panelli, R. J., & O'Brien, T. J. (2019). Epilepsy and seizure-related deaths: Mortality statistics do not tell the complete story. Epilepsy & behavior: E&B, 98(Pt A), 266–272. https://doi.org/10.1016/j.yebeh.2019.07.003

Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Método Qualitativo, Quantitativo ou Quali-Quanti. In: Metodologia da Pesquisa Científica. Santa Maria, 67-69.

Rede Interagencial de Informações para Saúde (RIPSA). (2020). Taxa de mortalidade específica por causas externas (coeficiente de mortalidade específica por causas externas). Brasília – DF.

Ryvlin, P., Cross, J. H., & Rheims, S. (2014). Epilepsy surgery in children and adults. Lancet Neurol, 13(11), 1114-1126.

Sella, F., Seisdedos, R. A., & Barros, C. R. M. R. (2016). Perfil epidemiológico dos membros de uma associação de epilepsia em Santa Catarina. Arquivos Catarinenses de Medicina, 45(2), 59-66.

Shorvon, S., & Sem, A. (2020) What is status epilepticus and what do we know about its epidemiology? Seizure, 75, 131-136.

Singh, A., & Trevick, S. (2016). The epidemiology of global epilepsy. Neurol Clin, 34(4), 837-847.

Singh, G., & Sander, J. W. (2020). The global burden of epilepsy report: Implications for low- and middle-income countries. Epilepsy & behavior: E&B, 105, 106949. https://doi.org/10.1016/j.yebeh.2020.106949

Soares, D. A., Andrade, S. M., & Campos, J. J. B. (2017). Epidemiologia e indicadores de saúde. In: Andrade, S. M., Cordoni Jr, L. et al. Bases da saúde coletiva. Londrina: Eduel, 183-210.

Stelzer, F. G., Bustamante, G. O., Sander, H., Sakamoto, A. C., & Fernandes, R. M. F. (2015) Short-term mortality and prognostic factors related to status epilepticus. Arq. Neuropsiquiatr., 73(8), 670-675. https://doi.org/10.1590/0004-282X20150082

Sveinsson, O., Andersson, T., Mattsson, P., Carlsson, S., & Tomson, T. (2020). Clinical risk factors in SUDEP: A nationwide population-based case-control study. Neurology, 94(4), e419–e429. https://doi.org/10.1212/WNL.0000000000008741

Watila, M. M., Balarabe, S. A., Ojo, O., Keezer, M. R., & Sander, J. W. (2018). Overall and cause-specific premature mortality in epilepsy: A systematic review. Epilepsy & behavior: E&B, 87, 213–225. https://doi.org/10.1016/j.yebeh.2018.07.017

Wiebe, S., Blume, W. T., Girvin, J. P., & Eliasziw, M. (2001). Effectiveness and Efficiency of Surgery for Temporal Lobe Epilepsy Study Group. A randomized, controlled trial of surgery for temporal-lobe epilepsy. N Engl J Med, 345(5), 311–318.

World Health Organization. (2019). Epilepsy: a public health imperative. Summary. WHO.

Published

19/10/2022

How to Cite

TAVARES, L. J. R. dos S.; DUARTE, F. G. da S.; MARTINS, R. S. .; FERREIRA, E. de N. M. .; CABRAL, I. F. Mortality from epilepsy and status epilepticus in Brazil: analysis of the epidemiological profile. Research, Society and Development, [S. l.], v. 11, n. 14, p. e50111435922, 2022. DOI: 10.33448/rsd-v11i14.35922. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/35922. Acesso em: 5 nov. 2024.

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Section

Health Sciences