Association between hormonal contraceptive methods and mental health problems

Authors

DOI:

https://doi.org/10.33448/rsd-v11i14.35968

Keywords:

Mental disorders; Hormonal contraceptives; Mental health; Depression.

Abstract

Introduction: Mental disorders encompass a set of psychiatric dysfunctions with negative repercussions on the biological body. In this context, studies suggest that women present twice the risk of depressive disorders when compared to men. Objective: To conduct a literature review in order to assess the association between the use of hormonal contraceptives and the development of mental health disorders. Methodology: Integrative literature review on the PubMed database of productions from the last 12 years. The descriptors used were: "Hormonal Contraceptive", "Psychiatric Disorder", "Mental Health" and "Women's Health", which were combined to delimit the search. Result: Seven articles were selected at the end of the search steps. The year 2016 was the most prevalent with 28.57% of the publications. Regarding the country of origin of the studies, 42.85% were conducted in the United States of America. It was found, from the Integrative Review, that the use of hormonal contraceptives attenuates symptoms of the menstrual cycle, such as anger and irritability. However, worsening of depression-related symptoms, and reduced sexual desire, arousal, and pleasure have also been reported. It is also seen that the combination with antidepressants may not be effective in treating premenstrual depression. There is also an association of worsening mood in women with a history of mood, anxiety and eating disorders. Conclusion: mental state changes were evidenced with the use of hormonal contraceptives, with emphasis on the worsening of depressive symptoms, sexual pleasure and anxiety, especially in those patients with a previous history of mood disorders.

References

Bender, C. M., Sereika, S. M., Ryan, C. M., Brufsky, A. M., Puhalla, S. & Berga, S. L. (2013). Does lifetime exposure to hormones predict pretreatment cognitive function in women before adjuvant therapy for breast cancer? Menopause. 20(9): 922-9. 10.1097/GME.0b013e3182843eff.

Bengtsdotter H, Lundin C, Gemzell Danielsson K, Bixo M, Baumgart J, Marions L, Brynhildsen J, Malmborg A, Lindh I, Sundström Poromaa I. Ongoing or previous mental disorders predispose to adverse mood reporting during combined oral contraceptive use. Eur J Contracept Reprod Health Care. 2018 Feb;23(1):45-51. 10.1080/13625187.2017.1422239.

Botelho, L. L. R., Cunha, C. C. A., & Macedo, M. (2011). O método da revisão integrativa nos estudos organizacionais. Gestão e Sociedade. 5(11), 121-136. https://www.gestaoesociedade.org/gestaoesociedade/article/view/1220.

Brasil. (2022). Atividade Sexual e Anticoncepção. In Pesquisa Nacional de Demografia e Saúde da Criança e da Mulher. Ministério da Saúde. https://bvsms.saude.gov.br/bvs/pnds/atividade_sexual.php#:~:text=Para%20o%20total%20de%20mulheres,modernos%20e%204%25%20os%20tradicionais.

Ferreira, L. F.; D’ávila, A. M. F. C.; Saflater, G. C. B. (2019). O uso da pílula anticoncepcional e as alterações das principais vias metabólicas. Femina. p. 426-432. https://docs.bvsalud.org/biblioref/2019/12/1046533/femina-2019-477-426-432.pdf.

Marcelo, I.; Sousa Martins, C. S.; Becker, G. C. R.; Dos Santos, M. A.; Azevedo Dos Santos, S.; Falcao Padilha, J. (2020) Investigação sobre uso de anticoncepcionais hormonais: ciência dos riscos para saúde. Anais do Salão Internacional de Ensino, Pesquisa e Extensão. 8(1) https://periodicos.unipampa.edu.br/index.php/SIEPE/article/view/84702.

McKetta, S., & M Keyes, K. (s.d.). Oral contraceptive use and depression among adolescents - PubMed. PubMed. https://pubmed.ncbi.nlm.nih.gov/30674431/

Scheuringer, A., Lundinb, C., Dernetlcde, B., Pletzeraflnger, B., & Poromaa, S. (s.d.). Use of an estradiol-based combined oral contraceptives has no influence on attentional bias or depressive symptoms in healthy women. Psychoneuroendocrinology. https://www.sciencedirect.com/science/article/abs/pii/S0306453019312855

Steel Z, Marnane C, Iranpour C, Chey T, Jackson JW, Patel V, Silove D. (2014). The global prevalence of common mental disorders: a systematic review and meta-analysis 1980-2013. Int J Epidemiol; 43(2):476-493.

Smith, K., Nayyar, S., Rana, T., E. Archibong, A., R. Looney, K., & Nayyar, T. (s.d.). Do Progestin-Only Contraceptives Contribute to the Risk of Developing Depression as Implied by Beta-Arrestin 1 Levels in Leukocytes? A Pilot Study. PubMed Central (PMC). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163405/#B12-ijerph-15-01966

Teixeira, A. L. S. et al. (2012). Influência das diferentes fases do ciclo menstrual na flexibilidades de mulheres jovens. Clínica Médica do Exercício e do Esporte. 1-4. https://www.scielo.br/j/rbme/a/CwDJHts6hKJwFR9XZRMJjdJ/?format=pdf&lang=pt.

UFRGS. (2022). Anticoncepcionais orais. Trabalho apresentado na disciplina de Mídias Digitais. https://www.ufrgs.br/espmat/disciplinas/midias_digitais_II/modulo_II/pilulas.htm#:~:text=O%20principal%20mecanismo%20de%20a%C3%A7%C3%A3o,como%20ocorre%20durante%20a%20gesta%C3%A7%C3%A3o.

Yonkers, K., Cameron, B., Gueorguieva, R., Altemus, M., & G. Kornstein, S. (2017, 4 de abril). The Influence of Cyclic Hormonal Contraception on Expression of Premenstrual Syndrome. Journal of Women's Health. https://www.liebertpub.com/doi/10.1089/jwh.2016.5941

World Health Organization (WHO). Depression and Other Common Mental Disorders: Global Health Estimates. Geneva: WHO; 2017. https://apps.who.int/iris/bitstream/handle/10665/254610/WHO-MSD-MER-2017.2-eng.pdf

Zethraeus, N., Dreber, A., Ranehil, E., Blomberg, L., Labrie, F., Schoultz, B. V., Johannesson, M., & Lindén Hirschberg, A. (s.d.). Combined Oral Contraceptives and Sexual Function in Women-a Double-Blind, Randomized, Placebo-Controlled Trial - PubMed. PubMed. https://pubmed.ncbi.nlm.nih.gov/27525531/

Downloads

Published

21/10/2022

How to Cite

PIMENTEL, V. A. S. .; SANTOS, I. M. P. L. dos .; SILVEIRA, F. M. .; SILVA, J. H. P. G. da .; NASCIMENTO, A. L. B. F. do .; CASABURI, L. E. .; OLIVEIRA, M. N. .; ABDALLA, D. R. . Association between hormonal contraceptive methods and mental health problems. Research, Society and Development, [S. l.], v. 11, n. 14, p. e126111435968, 2022. DOI: 10.33448/rsd-v11i14.35968. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/35968. Acesso em: 22 nov. 2024.

Issue

Vol. 11 No. 14

Section

Health Sciences

License

Copyright (c) 2022 Vinicius Aparecido Souza Pimentel; Ingrid Mila Pereira Leite dos Santos; Frederico Marques Silveira; Joanyto Henrique Pinto Gomes da Silva; Ana Laura Borges Ferreira do Nascimento; Luiza Elena Casaburi; Mateus Nóbrega Oliveira; Douglas Reis Abdalla

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.