Prevalent dental manifestations in serumpositive for HIV: literature review
DOI:
https://doi.org/10.33448/rsd-v11i14.35981Keywords:
Oral manifestations; HIV; Dentistry.Abstract
Individuals with a deficiency in the immune system are more likely to develop oral lesions, which can be seen in 70-90% of patients with the Human Immunodeficiency Virus (HIV). Therefore, the objective of this study is to identify in the literature the oral manifestations prevalent in HIV-positive individuals, as well as the behavior of the dentist. This is a narrative literature review, of an explanatory nature, carried out by means of a survey in the electronic databases: PubMed, LILACS, SciELO, BVS, Scholar Google, in the period between 2010 and 2022. For the search, the Descriptors in Health Sciences (DeCS): "candidiasis", "periodontal diseases", "herpes simplex", "oral hairy leukoplakia", "kaposi's sarcoma", "non-hodgkin's lymphoma", with the association of the Boolean operators AND and OR for the terms “HIV” and “dentistry”. 42 references were selected for the study. According to the literature studied, it became evident that oral manifestations are present in patients with HIV, presenting lesions with clinical and intensity variations, which can develop according to the susceptibility of the immune system and the stage of natural evolution of the disease. These include candidiasis, herpes simplex, periodontal diseases, oral hairy leukoplakia, Kaposi's sarcoma and non-Hodgkin's lymphoma. Oral manifestations are usually the first evidence of the presence of HIV. In this way, the importance of the role of the dentist is evidenced, as this professional can act in the early diagnosis, favoring an appropriate therapy and reduction of morbidity.
References
American Cancer Society. (2018). Taxas de sobrevivência para Sarcoma de Kaposi. https://www.cancer.org/cancer/kaposi-sarcoma/detection-diagnosis-staging/survival.html
Araújo, J. F. D., Oliveira, A. E. F. D., Carvalho, H. L. C. C. D., Roma, F. R. V. D. O., & Lopes, F. F. (2018). Principais manifestações bucais em pacientes pediátricos HIV positivos e o efeito da terapia antirretroviral altamente ativa. Ciência & Saúde Coletiva, 23, 115-122. https://doi.org/10.1590/1413-81232018231.19072015
Aškinytė, D., Matulionytė, R., & Rimkevičius, A. (2015). Oral manifestations of HIV disease: A review. Stomatologija, 17(1), 21-8
Bajpai, S., & Pazare, A. R. (2010). Oral manifestations of HIV. Contemporary Clinical Dentistry, 1(1), 1. https://doi.org/10.4103/0976-237X.62510
Barros, A. V. M., Barros, A. M. I., Silva, R. K. S., de Carvalho, C. D. V. S., Filho, E. S. D. D., Donato, L. F. A., & Youssef, M. N. (2017). Doenças periodontais em pacientes hiv-positivos: uma revisão da literatura. Braz J Periodontol-June, 27(02)
Cáceres, C. V. B. L, Vargas, P. A., Sánchez-Romero, C., Bunn, B. K., Heerden, W. F. P. V., Fonseca, F. P. (2019). Distribution of Dendritic Cells in AIDS-Associated Oral Kaposi’s Sarcoma. Brazilian Dental Journal, 30 (6): 617-625. https://doi.org/10.1590/0103-6440201902599
Corti, M., Villafañe, M. F., Bistmans, A., Campitelli, A., & Narbaitz, M. (2013). Soft-tissue masses as presentation of non-Hodgkin's lymphoma in AIDS patients. Anais Brasileiros de Dermatologia, 88, 631-634. https://doi.org/10.1590/abd1806-4841.20132138
Cruz, J. A. G., Verdín, S. L., & Gómez, M. D. R. C. (2017). Manifestaciones en la cavidad bucal por infección del virus de la inmunodeficiencia humana: reporte de caso clínico. Revista ADM, 74(1), 51-53
Ferreira, C. M. S. D., Souza, N. G. O., Tostes, F. M., Bedram, L. G., & Segheto, N. N. (2013). Linfoma não-hodgkin de células t envolvendo a cavidade oral em paciente com o vírus da imunodeiciência humana positivo. Relato de caso. Rev Bras Clin Med, 11(3), 300-2. http://www.sbcm.org.br/ojs3/index.php/rsbcm/article/view/19/17
Ferreira, G. L. S., Pérez, A. L. A. D. L., Rocha, Í. M., Pinheiro, M. A., Castro, R. D. D., Carlo, H. L., & Castellano, L. R. (2015). Does scientific evidence for the use of natural products in the treatment of oral candidiasis exist? A systematic review. Evidence-Based Complementary and Alternative Medicine, 2015. https://doi.org/10.1155/2015/147804
Ferreira, L. A. (2016). Sarcoma de Kaposi disseminado com manifestação intraoral em paciente soropositivo–relato de caso. Revista Fluminense de Odontologia. https://doi.org/10.22409/ijosd.v2i46.341
Gasner, N. S., & Schure, R. S. (2022). Necrotizing Periodontal Diseases. In StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK557417/
Geller, M., Neto, M. S., Ribeiro, M. G., Oliveira, L., Naliato, E. C., Abreu, C., & Schechtman, R. C. (2012). Herpes simples: atualização clínica, epidemiológica e terapêutica. Jornal Brasileiro de Doenças Sexualmente Transmissíveis, 24(4), 260-266. https://doi.org/10.5533/DST-2177-8264-201224408
Gil, R. L. (2017). Tipos de pesquisa. https://estatisticabel.files.wordpress.com/2017/03/tipos-de-pesquisa.pdf
Heron, S. E., Elahi, S. (2017). HIV infection and compromised mucosal immunity: oral manifestations and systemic inflammation. Frontiers in immunology. 8, 241. https://doi.org/10.3389/fimmu.2017.00241
Hirata, C. H. W. (2015). Manifestações orais na SIDA. Brazilian Journal of Otorhinolaryngology . 81(2), 120-123. https://doi.org/10.3389/fimmu.2017.00241
Kukhanova, M. K., Korovina, A. N., Kochetkov, S. N. (2014). Human herpes simplex virus: life cycle and development of inhibitors. Biochemistry (Moscow). 79(13), 1635-1652. https://doi.org/10.1134/S0006297914130124
Luchsinger, V., Luzoro, A., Martínez, M. J. (2010) Elevada seroprevalencia de citomegalovirus, virus herpes simplex tipo 1 y virus Epstein Barr en adultos con virus de la inmunodeficiencia humana. Revista médica de Chile, 138, (7), 809-814. https://doi.org/10.4067/S0034-98872010000700003
Machado, N. L. P., Gonçalves, T. H., Rocha, M. I. S., Mendes, E. M., & Andrade, C. M. O. (2019). Manifestações orais em pacientes hiv+. Psicologia E Saúde Em Debate, 5(Suppl.2), 60.
Malek, R., Gharibi, A., Khlil, N., & Kissa, J. (2017). Necrotizing ulcerative gingivitis. Contemporary clinical dentistry, 8(3), 496. https://doi.org/10.4103/ccd.ccd_1181_16
Marçal, C. S., Silva, L. C., Faker, K., Tostes, M. A., & Cancio, V. (2018). Síndrome da imunodeficiência adquirida na criança e no adolescente: conduta odontológica. Revista da Faculdade de Odontologia de Porto Alegre, 59(2), 72-82. https://doi.org/10.22456/2177-0018.87329
Melo, C. M. C. (2020). Infecções orais oportunistas e neoplasias em pacientes portadores de HIV. [Dissertação de Mestrado, Faculdade de Medicina Dentária]. Repositório aberto da Universidade do Porto. https://repositorio-aberto.up.pt/bitstream/10216/127943/2/409900.pdf
Ministério da Saúde. (2022). Doenças de condições crônicas e infecções sexualmente transmissíveis: o que é HIV. Gov.br. https://www.gov.br/aids/pt-br/assuntos/hiv-aids/o-que-e
Motta, W. K. D. S., Nóbrega, D. R. D. M., Santos, M. G. C. D., Gomes, D. Q. D. C., Godoy, G. P., & Pereira, J. V. (2014). Aspectos demográficos e manifestações clínicas bucais de pacientes soropositivos para o HIV/Aids. Revista de Odontologia da UNESP, 43, 61-67. https://doi.org/10.1590/S1807-25772014000100010
Munawwar, A., & Singh, S. (2016). Human herpesviruses as copathogens of HIV infection, their role in HIV transmission, and disease progression. Journal of laboratory physicians, 8(01), 5-18. https://doi.org/10.4103/0974-2727.176228
Nomura, Y., Okada, A., Tamaki, Y., & Miura, H. (2018). Salivary levels of hemoglobin for screening periodontal disease: A systematic review. International journal of dentistry, Vol. 2018. https://doi.org/10.1155/2018/2541204
Organização Mundial da Saúde. (2019). HIV / Aids. https://www.who.int/news-room/fact-sheets/detail/hiv-aids
Pakfetrat, A., Falaki, F., Delavarian, Z., Dalirsani, Z., Sanatkhani, M., & Marani, M. Z. (2015). Oral manifestations of human immunodeficiency virus-infected patients. Iranian journal of otorhinolaryngology, 27(78), 43-54
Pires, C. A. A., Noronha, M. A. N., Costa, A. L. C. D., & Abreu Júnior, J. M. D. C. (2018). Kaposi’s sarcoma in persons living with HIV/AIDS: a case series in a tertiary referral hospital. Anais brasileiros de dermatologia, 93, 524-528. https://doi.org/10.1590/abd1806-4841.20186978
Plas, R. V. D. (2016). Candidíase oral: Manifestações clínicas e tratamento (Doctoral dissertation). http://hdl.handle.net/10284/5783
Ratnam, M. V. R., Nayyar, A. S., Reddy, D. S., Ruparani, B., Chalapathi, K. V., & Azmi, S. M. (2018). CD4 cell counts and oral manifestations in HIV infected and AIDS patients. Journal of Oral and Maxillofacial Pathology: JOMFP, 22(2), 282. https://doi.org/10.4103/jomfp.JOMFP_191_17
Ribeiro, M. (2018). Atendimento odontológico aos pacientes com HIV/AIDS. Revista de Odontologia Contemporânea., Patos de Minas, 2(1), 28-36
Rosa, M. C. D., Lobato, R. C., Gonçalves, C. V., Silva, N. M. O. D., Barral, M. F. M., Martinez, A. M. B. D., & Hora, V. P. D. (2015). Avaliação dos fatores associados à transmissão vertical de HIV-1. Jornal de Pediatria, 91, 523-528. https://doi.org/10.1016/j.jped.2014.12.005
Rostamzadeh, M., Afkhamzadeh, A., Afrooz, S., Mohamadi, K., & Rasouli, M. A. (2018). Dentists’ knowledge, attitudes and practices regarding Hepatitis B and C and HIV/AIDS in Sanandaj, Iran. BMC oral health, 18(1), 1-8. https://doi.org/10.1186/s12903-018-0685-1
Sena, L. G. (2012). Atendimento odontológico aos portadores de HIV na Atenção Básica de Saúde. https://ares.unasus.gov.br/acervo/handle/ARES/14264
Silva, S. M. D., Pereira, A. L., & Garcíazapata, M. T. A. (2011). Manifestações bucais na infecção pelo vírus da imunodeficiência humana: uma revisão sistemática da literatura. https://doi.org/10.22456/2177-0018.30650
Singh, A., Verma, R., Murari, A., & Agrawal, A. (2014). Oral candidiasis: An overview. Journal of oral and maxillofacial pathology: JOMFP, 18(Suppl 1), S81. https://doi.org/10.4103/0973-029X.141325
Siqueira, J. S., Batista, S. A., Silva Jr, A., Ferreira, M. F., Agostini, M., & Torres, S. R. (2015). Candidíase oral em pacientes internados em UTI. Revista Brasileira de Odontologia, 71(2), 176. http://dx.doi.org/10.18363/rbo.v71n2.p.176
Souza, A. J. D., Gomes-Filho, I. S., Silva, C. A. L. D., Passos-Soares, J. D. S., Cruz, S. S. D., Trindade, S. C., & Cerqueira, E. D. M. M. (2018). Factors associated with dental caries, periodontitis and intra-oral lesions in individuals with HIV/AIDS. AIDS care, 30(5), 578-585. https://doi.org/10.1080/09540121.2017.1400640
Tonelli, S. Q., de Freitas Oliveira, W., Oliveira, G. A., Popoff, D. A. V., de Quadros Coelho, M., & Júnior, E. D. S. B. (2013). Manifestações bucais em pacientes pediátricos infectados pelo HIV - uma revisão sistemática da literatura. Revista da Faculdade de Odontologia-UPF, 18(3). https://doi.org/10.5335/rfo.v18i3.3584
UNAIDS Brasil. (2021). Novo relatório do UNAIDS mostra que podemos acabar com a AIDS até 2030. https://unaids.org.br/2021/06/novo-relatorio-do-unaids-mostra-que-podemos-acabar-com-a-aids-ate-2030/
Velasco-Benitez, C. A., & López-López, P. (2018). Dental caries prevalence in children and youths with vertically-transmitted HIV/AIDS from the pediatric HIV clinic (Cali, Colombia) and its relationship with biological factors, 2013. Rev. Fac. Odontol. Univ. Antioq, 273-296. https://doi.org/10.17533/udea.rfo.v29n2a2
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